EA201991304A1 - 5-[[4-[2-[5-(1-гидроксиэтил)пиридин-2-ил]этокси]фенил]метил]-1,3-тиазолидин-2,4-дион для лечения неалкогольной жировой болезни печени - Google Patents
5-[[4-[2-[5-(1-гидроксиэтил)пиридин-2-ил]этокси]фенил]метил]-1,3-тиазолидин-2,4-дион для лечения неалкогольной жировой болезни печениInfo
- Publication number
- EA201991304A1 EA201991304A1 EA201991304A EA201991304A EA201991304A1 EA 201991304 A1 EA201991304 A1 EA 201991304A1 EA 201991304 A EA201991304 A EA 201991304A EA 201991304 A EA201991304 A EA 201991304A EA 201991304 A1 EA201991304 A1 EA 201991304A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- disease
- thiazolidine
- pyridin
- ethoxy
- hydroxyethyl
- Prior art date
Links
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical class C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 title 1
- 229920004518 DION® Polymers 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 210000004185 liver Anatomy 0.000 title 1
- 208000019423 liver disease Diseases 0.000 title 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 abstract 4
- OXVFDZYQLGRLCD-UHFFFAOYSA-N hydroxypioglitazone Chemical compound N1=CC(C(O)C)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 OXVFDZYQLGRLCD-UHFFFAOYSA-N 0.000 abstract 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 102100025621 Cytochrome b-245 heavy chain Human genes 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 abstract 1
- 201000005746 Pituitary adenoma Diseases 0.000 abstract 1
- 206010061538 Pituitary tumour benign Diseases 0.000 abstract 1
- 208000024770 Thyroid neoplasm Diseases 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 208000010928 autoimmune thyroid disease Diseases 0.000 abstract 1
- 208000016532 chronic granulomatous disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000021310 pituitary gland adenoma Diseases 0.000 abstract 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 201000002510 thyroid cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16382584 | 2016-12-01 | ||
| PCT/IB2017/057587 WO2018100557A1 (en) | 2016-12-01 | 2017-12-01 | 5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine- 2,4-dione for treating nonalcoholic fatty liver disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201991304A1 true EA201991304A1 (ru) | 2019-12-30 |
Family
ID=57517838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201991304A EA201991304A1 (ru) | 2016-12-01 | 2017-12-01 | 5-[[4-[2-[5-(1-гидроксиэтил)пиридин-2-ил]этокси]фенил]метил]-1,3-тиазолидин-2,4-дион для лечения неалкогольной жировой болезни печени |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US11938122B2 (https=) |
| EP (1) | EP3548026B1 (https=) |
| JP (1) | JP7040798B2 (https=) |
| KR (1) | KR102595034B1 (https=) |
| CN (1) | CN110022877B (https=) |
| AU (1) | AU2017370003B2 (https=) |
| BR (1) | BR112019011334A2 (https=) |
| CA (1) | CA3044364A1 (https=) |
| CY (1) | CY1124116T1 (https=) |
| DK (1) | DK3548026T3 (https=) |
| EA (1) | EA201991304A1 (https=) |
| ES (1) | ES2867300T3 (https=) |
| HR (1) | HRP20210576T1 (https=) |
| HU (1) | HUE054346T2 (https=) |
| LT (1) | LT3548026T (https=) |
| MX (1) | MX379710B (https=) |
| PL (1) | PL3548026T3 (https=) |
| PT (1) | PT3548026T (https=) |
| SI (1) | SI3548026T1 (https=) |
| WO (1) | WO2018100557A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7040798B2 (ja) | 2016-12-01 | 2022-03-23 | ミノリックス セラピューティクス エセ．エレ． | 非アルコール性脂肪性肝疾患を処置するための５－［［４－［２－［５－（１－ヒドロキシエチル）ピリジン－２－イル］エトキシ］フェニル］メチル］－１，３－チアゾリジン－２，４－ジオン |
| EP3801515B1 (en) | 2018-06-06 | 2025-04-09 | Minoryx Therapeutics S.L. | 5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione and its salts for use in the treatment of mitochondrial diseases |
| US20230172921A1 (en) * | 2020-04-30 | 2023-06-08 | Minoryx Therapeutics S.L. | Leriglitazone for treating lung inflammation and interstitial lung disease |
| EP4642456A1 (en) | 2022-12-28 | 2025-11-05 | Minoryx Therapeutics S.L. | Optimized dosing of leriglitazone |
| WO2024231881A2 (en) | 2023-05-09 | 2024-11-14 | Minoryx Therapeutics S.L. | Polymorphic forms and formulations of leriglitazone |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5441971A (en) | 1991-04-11 | 1995-08-15 | The Upjohn Company | Thiazolidinedione derivatives, production and use thereof |
| DE69231886T2 (de) | 1991-04-11 | 2002-03-28 | Pharmacia & Upjohn Co., Kalamazoo | Thiazolidindionderivate, herstellung und anwendung |
| WO1993022445A1 (en) | 1992-05-05 | 1993-11-11 | The Upjohn Company | A process for producing pioglitazone metabolite |
| US5952509A (en) | 1996-06-27 | 1999-09-14 | Takeda Chemical Industries, Ltd. | Production of benzaldehyde compounds |
| US6191154B1 (en) | 1998-11-27 | 2001-02-20 | Case Western Reserve University | Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases |
| US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| US6720001B2 (en) | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| AU2002367154A1 (en) | 2001-12-21 | 2003-07-15 | Smithkline Beecham Corporation | Dosing regimen for ppar-gamma activators |
| US8993773B2 (en) | 2002-07-16 | 2015-03-31 | Cadila Healthcare Limited | Process to prepare pioglitazone via several novel intermediates |
| GB0510469D0 (en) | 2005-05-23 | 2005-06-29 | Leuven K U Res & Dev | Insulin sensitization to slow down pubertal tempo and to augment pubertal growth |
| PL2001468T3 (pl) | 2006-03-16 | 2013-03-29 | Metabolic Solutions Dev Co Llc | Analogi tiazolidynodionu |
| US8722710B2 (en) | 2007-09-26 | 2014-05-13 | Deuterx, Llc | Deuterium-enriched pioglitazone |
| US8895537B2 (en) | 2010-10-29 | 2014-11-25 | Infirst Healthcare Ltd. | Compositions and methods for treating cardiovascular diseases |
| WO2013040419A1 (en) | 2011-09-14 | 2013-03-21 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for treating hyperprolinemia-associated mental disorders |
| US8865747B2 (en) | 2012-03-23 | 2014-10-21 | Fundació Institute D'Investigació Biomėdica de Bellvitge (IDIBELL) | Pioglitazone for use in the treatment of adrenoleukodystrophy |
| US20140178456A1 (en) | 2012-08-30 | 2014-06-26 | Udaya Sankar Devanaboyina | Methods and compositions for treating type 2 diabetes and related conditions |
| WO2014152843A1 (en) | 2013-03-14 | 2014-09-25 | Deuterx, Llc | Deuterium-enriched 2,4-thiazolidinediones and methods of treatment |
| EP3094328B1 (en) | 2014-01-15 | 2020-08-19 | Poxel SA | Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone |
| EA202091120A3 (ru) * | 2014-04-02 | 2020-12-30 | Минорикс Терапьютикс С.Л. | Производные 2,4-тиазолинидона в лечении расстройств центральной нервной системы |
| JP7040798B2 (ja) | 2016-12-01 | 2022-03-23 | ミノリックス セラピューティクス エセ．エレ． | 非アルコール性脂肪性肝疾患を処置するための５－［［４－［２－［５－（１－ヒドロキシエチル）ピリジン－２－イル］エトキシ］フェニル］メチル］－１，３－チアゾリジン－２，４－ジオン |
-
2017
- 2017-12-01 JP JP2019529165A patent/JP7040798B2/ja not_active Expired - Fee Related
- 2017-12-01 EP EP17817175.7A patent/EP3548026B1/en active Active
- 2017-12-01 DK DK17817175.7T patent/DK3548026T3/da active
- 2017-12-01 LT LTEP17817175.7T patent/LT3548026T/lt unknown
- 2017-12-01 ES ES17817175T patent/ES2867300T3/es active Active
- 2017-12-01 KR KR1020197019093A patent/KR102595034B1/ko active Active
- 2017-12-01 CN CN201780074388.1A patent/CN110022877B/zh active Active
- 2017-12-01 AU AU2017370003A patent/AU2017370003B2/en not_active Ceased
- 2017-12-01 HU HUE17817175A patent/HUE054346T2/hu unknown
- 2017-12-01 US US16/465,043 patent/US11938122B2/en active Active
- 2017-12-01 HR HRP20210576TT patent/HRP20210576T1/hr unknown
- 2017-12-01 WO PCT/IB2017/057587 patent/WO2018100557A1/en not_active Ceased
- 2017-12-01 EA EA201991304A patent/EA201991304A1/ru unknown
- 2017-12-01 BR BR112019011334A patent/BR112019011334A2/pt not_active Application Discontinuation
- 2017-12-01 MX MX2019006066A patent/MX379710B/es unknown
- 2017-12-01 PL PL17817175T patent/PL3548026T3/pl unknown
- 2017-12-01 SI SI201730714T patent/SI3548026T1/sl unknown
- 2017-12-01 PT PT178171757T patent/PT3548026T/pt unknown
- 2017-12-01 CA CA3044364A patent/CA3044364A1/en active Pending
-
2021
- 2021-04-16 CY CY20211100335T patent/CY1124116T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2019006066A (es) | 2019-09-10 |
| CY1124116T1 (el) | 2022-05-27 |
| MX379710B (es) | 2025-03-11 |
| BR112019011334A2 (pt) | 2019-10-15 |
| DK3548026T3 (da) | 2021-04-19 |
| US20200093812A1 (en) | 2020-03-26 |
| WO2018100557A1 (en) | 2018-06-07 |
| CN110022877B (zh) | 2023-06-23 |
| EP3548026A1 (en) | 2019-10-09 |
| SI3548026T1 (sl) | 2021-07-30 |
| US11938122B2 (en) | 2024-03-26 |
| JP2020500868A (ja) | 2020-01-16 |
| LT3548026T (lt) | 2021-05-25 |
| KR20190086766A (ko) | 2019-07-23 |
| CN110022877A (zh) | 2019-07-16 |
| JP7040798B2 (ja) | 2022-03-23 |
| HUE054346T2 (hu) | 2021-08-30 |
| AU2017370003A1 (en) | 2019-06-06 |
| CA3044364A1 (en) | 2018-06-07 |
| AU2017370003B2 (en) | 2023-04-13 |
| PT3548026T (pt) | 2021-04-22 |
| ES2867300T3 (es) | 2021-10-20 |
| HRP20210576T1 (hr) | 2021-05-28 |
| PL3548026T3 (pl) | 2021-08-23 |
| KR102595034B1 (ko) | 2023-10-26 |
| EP3548026B1 (en) | 2021-01-20 |
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