DK3548026T3 - 5-[[4-[2-[5-(1-Hydroxyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolinidin-2,4-dion til behandling af ikke-alkoholisk fedtleversygdom - Google Patents
5-[[4-[2-[5-(1-Hydroxyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolinidin-2,4-dion til behandling af ikke-alkoholisk fedtleversygdom Download PDFInfo
- Publication number
- DK3548026T3 DK3548026T3 DK17817175.7T DK17817175T DK3548026T3 DK 3548026 T3 DK3548026 T3 DK 3548026T3 DK 17817175 T DK17817175 T DK 17817175T DK 3548026 T3 DK3548026 T3 DK 3548026T3
- Authority
- DK
- Denmark
- Prior art keywords
- thiazolinidine
- dione
- pyridin
- ethoxy
- hydroxyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16382584 | 2016-12-01 | ||
| PCT/IB2017/057587 WO2018100557A1 (en) | 2016-12-01 | 2017-12-01 | 5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine- 2,4-dione for treating nonalcoholic fatty liver disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3548026T3 true DK3548026T3 (da) | 2021-04-19 |
Family
ID=57517838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17817175.7T DK3548026T3 (da) | 2016-12-01 | 2017-12-01 | 5-[[4-[2-[5-(1-Hydroxyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolinidin-2,4-dion til behandling af ikke-alkoholisk fedtleversygdom |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US11938122B2 (da) |
| EP (1) | EP3548026B1 (da) |
| JP (1) | JP7040798B2 (da) |
| KR (1) | KR102595034B1 (da) |
| CN (1) | CN110022877B (da) |
| AU (1) | AU2017370003B2 (da) |
| BR (1) | BR112019011334A2 (da) |
| CA (1) | CA3044364A1 (da) |
| CY (1) | CY1124116T1 (da) |
| DK (1) | DK3548026T3 (da) |
| EA (1) | EA201991304A1 (da) |
| ES (1) | ES2867300T3 (da) |
| HR (1) | HRP20210576T1 (da) |
| HU (1) | HUE054346T2 (da) |
| LT (1) | LT3548026T (da) |
| MX (1) | MX2019006066A (da) |
| PL (1) | PL3548026T3 (da) |
| PT (1) | PT3548026T (da) |
| SI (1) | SI3548026T1 (da) |
| WO (1) | WO2018100557A1 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3548026T1 (sl) | 2016-12-01 | 2021-07-30 | Minoryx Therapeutics S.L. | 5-((4-(2-(5-(1-hidroksietil)piridin-2-il)etoksi)fenil)metil)-1,3- tiazolidin-2,4-dion za zdravljenje nealkoholne maščobne jetrne bolezni |
| JP7376934B2 (ja) | 2018-06-06 | 2023-11-09 | ミノリックス セラピューティクス エセ．エレ． | ミトコンドリア性疾患の処置における使用のための５－［［４－［２－［５－（１－ヒドロキシエチル）ピリジン－２－イル］エトキシ］フェニル］メチル］－１，３－チアゾリジン－２，４－ジオンおよびその塩 |
| EP4142720A1 (en) | 2020-04-30 | 2023-03-08 | Minoryx Therapeutics S.L. | Leriglitazone for treating lung inflammation and interstitial lung disease |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5441971A (en) | 1991-04-11 | 1995-08-15 | The Upjohn Company | Thiazolidinedione derivatives, production and use thereof |
| CZ196693A3 (en) * | 1991-04-11 | 1994-05-18 | Upjohn Co | Thiazolidinedione derivatives, and process for preparing thereof |
| WO1993022445A1 (en) | 1992-05-05 | 1993-11-11 | The Upjohn Company | A process for producing pioglitazone metabolite |
| US5952509A (en) | 1996-06-27 | 1999-09-14 | Takeda Chemical Industries, Ltd. | Production of benzaldehyde compounds |
| US6191154B1 (en) | 1998-11-27 | 2001-02-20 | Case Western Reserve University | Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases |
| US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| US6720001B2 (en) | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| DE60209824T2 (de) | 2001-12-21 | 2006-10-19 | Smithkline Beecham Corp. | Dosierschema für ppar-gamma-aktivatoren |
| US8993773B2 (en) | 2002-07-16 | 2015-03-31 | Cadila Healthcare Limited | Process to prepare pioglitazone via several novel intermediates |
| GB0510469D0 (en) | 2005-05-23 | 2005-06-29 | Leuven K U Res & Dev | Insulin sensitization to slow down pubertal tempo and to augment pubertal growth |
| UA96441C2 (ru) | 2006-03-16 | 2011-11-10 | Метаболик Солюшнз Девелопмент Компани | Фармацевтическая композиция, которая содержит аналог тиазолидиндиона митоглитазон, для лечения заболеваний, опосредованных метаболическим воспалением |
| US8722710B2 (en) | 2007-09-26 | 2014-05-13 | Deuterx, Llc | Deuterium-enriched pioglitazone |
| US8895536B2 (en) | 2010-10-29 | 2014-11-25 | Infirst Healthcare Ltd. | Compositions and methods for treating chronic inflammation and inflammatory diseases |
| US20150224120A1 (en) | 2011-09-14 | 2015-08-13 | Catherine Clelland | Compositions and methods for treating hyperprolinemia-associated mental disorders |
| US8865747B2 (en) | 2012-03-23 | 2014-10-21 | Fundació Institute D'Investigació Biomėdica de Bellvitge (IDIBELL) | Pioglitazone for use in the treatment of adrenoleukodystrophy |
| US20140178456A1 (en) | 2012-08-30 | 2014-06-26 | Udaya Sankar Devanaboyina | Methods and compositions for treating type 2 diabetes and related conditions |
| US8969581B2 (en) | 2013-03-14 | 2015-03-03 | Deuterx, Llc | 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same |
| EP3666273A3 (en) | 2014-01-15 | 2020-10-28 | Poxel SA | Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone |
| WO2015150476A1 (en) * | 2014-04-02 | 2015-10-08 | Minoryx Therapeutics S.L. | 2,4-thiazolidinedione derivatives in the treatment of central nervous system disorders |
| SI3548026T1 (sl) | 2016-12-01 | 2021-07-30 | Minoryx Therapeutics S.L. | 5-((4-(2-(5-(1-hidroksietil)piridin-2-il)etoksi)fenil)metil)-1,3- tiazolidin-2,4-dion za zdravljenje nealkoholne maščobne jetrne bolezni |
-
2017
- 2017-12-01 SI SI201730714T patent/SI3548026T1/sl unknown
- 2017-12-01 EA EA201991304A patent/EA201991304A1/ru unknown
- 2017-12-01 KR KR1020197019093A patent/KR102595034B1/ko active IP Right Grant
- 2017-12-01 AU AU2017370003A patent/AU2017370003B2/en active Active
- 2017-12-01 HU HUE17817175A patent/HUE054346T2/hu unknown
- 2017-12-01 PL PL17817175T patent/PL3548026T3/pl unknown
- 2017-12-01 CA CA3044364A patent/CA3044364A1/en active Pending
- 2017-12-01 MX MX2019006066A patent/MX2019006066A/es unknown
- 2017-12-01 CN CN201780074388.1A patent/CN110022877B/zh active Active
- 2017-12-01 PT PT178171757T patent/PT3548026T/pt unknown
- 2017-12-01 LT LTEP17817175.7T patent/LT3548026T/lt unknown
- 2017-12-01 US US16/465,043 patent/US11938122B2/en active Active
- 2017-12-01 WO PCT/IB2017/057587 patent/WO2018100557A1/en active Search and Examination
- 2017-12-01 ES ES17817175T patent/ES2867300T3/es active Active
- 2017-12-01 BR BR112019011334A patent/BR112019011334A2/pt unknown
- 2017-12-01 JP JP2019529165A patent/JP7040798B2/ja active Active
- 2017-12-01 EP EP17817175.7A patent/EP3548026B1/en active Active
- 2017-12-01 DK DK17817175.7T patent/DK3548026T3/da active
-
2021
- 2021-04-12 HR HRP20210576TT patent/HRP20210576T1/hr unknown
- 2021-04-16 CY CY20211100335T patent/CY1124116T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LT3548026T (lt) | 2021-05-25 |
| WO2018100557A1 (en) | 2018-06-07 |
| KR102595034B1 (ko) | 2023-10-26 |
| US20200093812A1 (en) | 2020-03-26 |
| CY1124116T1 (el) | 2022-05-27 |
| BR112019011334A2 (pt) | 2019-10-15 |
| EP3548026B1 (en) | 2021-01-20 |
| MX2019006066A (es) | 2019-09-10 |
| EA201991304A1 (ru) | 2019-12-30 |
| JP2020500868A (ja) | 2020-01-16 |
| JP7040798B2 (ja) | 2022-03-23 |
| SI3548026T1 (sl) | 2021-07-30 |
| US11938122B2 (en) | 2024-03-26 |
| CA3044364A1 (en) | 2018-06-07 |
| CN110022877B (zh) | 2023-06-23 |
| AU2017370003A1 (en) | 2019-06-06 |
| AU2017370003B2 (en) | 2023-04-13 |
| PT3548026T (pt) | 2021-04-22 |
| EP3548026A1 (en) | 2019-10-09 |
| KR20190086766A (ko) | 2019-07-23 |
| ES2867300T3 (es) | 2021-10-20 |
| CN110022877A (zh) | 2019-07-16 |
| HRP20210576T1 (hr) | 2021-05-28 |
| HUE054346T2 (hu) | 2021-08-30 |
| PL3548026T3 (pl) | 2021-08-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA202091120A2 (ru) | Производные 2,4-тиазолинидона в лечении расстройств центральной нервной системы | |
| CO6811863A2 (es) | Compuestos de 2-(2,4,5-anilino sustituido)pirimidina | |
| DK3548026T3 (da) | 5-[[4-[2-[5-(1-Hydroxyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolinidin-2,4-dion til behandling af ikke-alkoholisk fedtleversygdom | |
| DK2598501T3 (da) | N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamidmesylat-monohydrat | |
| DK3559010T3 (da) | Fremgangsmåde til fremstilling af 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedion og salte deraf | |
| IL239940B (en) | History of 2-[3-(diazolyl)phenyl]-3,1-thiazole-5-carboxylic acid and intermediates obtained in the process for their preparation | |
| HK1255438A1 (zh) | 用於治療癌症的(s，e)-3-(6-氨基吡啶-3-基)-n-((5-(4-(3-氟-3-甲基吡咯烷-l-羰基)苯基)-7-(4-氟苯基)苯並呋喃-2-基)甲基)丙烯酰胺 | |
| DK3515910T3 (da) | 5-[2-(pyridin-2-ylamino)-1,3-thiazol-5-yl]-2,3-dihydro-1h-isoindol-1-onderivater og deres anvendelse som dobbelte inhibitorer af phosphatidylinositol-3-kinase-delta & gamma | |
| CL2013002971A1 (es) | Compuestos derivados de 5-(fenil/piridinil-etinil)-2-piridina/2-pirimidina-carboxamida, moduladores mglur5; composición farmacéutica que los comprende; proceso de preparación de ellos; y su uso en el tratamiento de esquizofrenia o enfermedades cognitivas. | |
| IL272992A (en) | Solid structures of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide | |
| DK3658547T3 (da) | Fremgangsmåde til fremstilling af n-(5-(4-(4-formyl-3-phenyl-1h-pyrazol-1-yl)pyrimidin-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamid | |
| DK3298008T3 (da) | Krystallinsk form af forbindelsen (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propan-1,2-diol | |
| DK3601265T3 (da) | Fast form af (s)-[2-chlor-4-fluor-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxy-pyridazin-3-yl)methanol | |
| DK3820849T3 (da) | Phenyl/pyridyl-nh-phenyl/pyridyl-derivater til behandling af rna-virusinfektion | |
| CL2014003003A1 (es) | Proceso para la preparacion de 1-[6-(morfolin—4-il)pirimidin-4-il]-4-(1h-1,2,3-triazol-1-il)-1h-pirazol-5-ol (i – forma enol) o de 2-[6-(morfolin-4-il)pirimidin-4-il]-4-(1h-1,2,3-triazol-1-il)-1,2-dihidro-3h-pirazol-3-ona (i – forma ceto); y compuesto intermediario (2e/z)-3-(dimetilamino)-2-(1h-1,2,3-triazol-1-il) acrilato de metilo. | |
| MA42039A (fr) | Procédé de préparation de monohydrochlorure de 2-{4-[2-({[2-(4-chlorophényl)-1,3-thiazol-4-yl]méthyl}sulfanyl)-3,5-dicyan-6-(pyrrolidin-1-yl)pyridin-4-yl]phénoxy}éthyl-l-alanyl-l-alaninate | |
| NZ716494A (en) | Processes and intermediates for the preparation of a pde10 inhibitor | |
| HK1222655A1 (zh) | -{ }- -{ -嗎啉基甲基 -吡咯- -基 亞甲基}- -氧代- -二氫- -吲哚- -基 甲基 -噻唑烷- -二酮的新型鹽、其製備以及包含其的製劑 | |
| IL279186A (en) | Use of 5-[[4-[2-[5-acetylpyridin-2-yl]ethoxy]benzyl]-1, 3-thiazolidine-2, 4-dione and their salts | |
| IL279183A (en) | Method for administering a therapeutically effective amount of 5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1, 3-thiazolidine-2, 4-dione | |
| UA97632U (xx) | Ферум(іі) 2-(5-(3-нітрофеніл)-4-аміно-1,2,4-триазол-3-ілтіо)ацетат, що виявляє гіпоглікемічну активність | |
| TH1601002744A (th) | องค์ประกอบ 1,5-ไดเมทิล-6-ไธออกโซ-3-(2,2,7-ไทรฟลูออโร-3-ออกโซ-4- (พรอพ-2-อินอิล)-3,4-ไดไฮโดร-2H-เบนโซ[b][1,4]ออกซาซิน-6-อิล)-1,3,5- ไทรอะซิเนน-2,4-ไดโอน |