EA201900246A1 - Ингибитор атф-зависимых обратных транспортеров клеток и способ его получения - Google Patents
Ингибитор атф-зависимых обратных транспортеров клеток и способ его полученияInfo
- Publication number
- EA201900246A1 EA201900246A1 EA201900246A EA201900246A EA201900246A1 EA 201900246 A1 EA201900246 A1 EA 201900246A1 EA 201900246 A EA201900246 A EA 201900246A EA 201900246 A EA201900246 A EA 201900246A EA 201900246 A1 EA201900246 A1 EA 201900246A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- glycol
- inhibitor
- oep
- conjugate
- polyoxypropylenehexol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/25—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids with polyoxyalkylated alcohols, e.g. esters of polyethylene glycol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
- C08G65/2606—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups
- C08G65/2609—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups containing aliphatic hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2696—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds characterised by the process or apparatus used
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
- C08G2650/30—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type branched
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Furan Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Изобретение относится к химии лекарственных соединений, а именно к группе хиральных конъюгатов (оптически активных гибридных молекул) олигоэфирполиольной природы, являющихся ингибиторами АТФ-зависимых обратных транспортеров клеток (ОЭП-ингибитор). ОЭП-ингибитор представляет собой конъюгат с эквимольным соотношением оптически активного полиоксипропиленгексола и полиоксипропиленгликоля. Заявленный способ, по которому получается конъюгат, обеспечивает возможность получения препарата, увеличивающего эффективность действия лекарственных средств посредством ингибирования механизмов множественной лекарственной устойчивости клеток. Полученный препарат может быть использован в области биологии, фармакологии, фармацевтики, медицины, сельского хозяйства. ОЭП-ингибитор получают оксипропилированием смеси сорбита и бифункционального кислородсодержащего соединения в присутствии гидроокиси щелочного или щелочноземельного металла. Бифункциональное кислородсодержащее соединение может быть водой, пропиленгликолем, дипропиленгликолем, трипропиленгликолем, тетрапропиленгликолем, пентапропиленгликолем, гексапропиленгликолем, гептапропиленгликолем или их смесью. Ингибитор представляет собой коньюгат полиоксипропиленгликоля с молекулярной массой от 300 до 500 Да и полиоксипропиленгексола с молекулярной массой от 1000 до 1500 Да в эквимольном соотношении, с гидроксильным числом в пределах 215-240 мг KOH/г.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2016143074A RU2641304C1 (ru) | 2016-11-02 | 2016-11-02 | Ингибитор атф-зависимых обратных транспортеров клеток и способ его получения |
PCT/RU2017/000809 WO2018084749A1 (ru) | 2016-11-02 | 2017-10-31 | Ингибитор атф-зависимых обратных транспортеров клеток и способ его получения |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201900246A1 true EA201900246A1 (ru) | 2019-07-31 |
EA034579B1 EA034579B1 (ru) | 2020-02-21 |
Family
ID=62075563
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201900246A EA034579B1 (ru) | 2016-11-02 | 2017-10-31 | Ингибитор атф-зависимых обратных транспортеров клеток и способ его получения |
Country Status (7)
Country | Link |
---|---|
US (1) | US10987429B2 (ru) |
EP (1) | EP3536315B1 (ru) |
JP (1) | JP6861424B2 (ru) |
CN (1) | CN109890375B (ru) |
EA (1) | EA034579B1 (ru) |
RU (1) | RU2641304C1 (ru) |
WO (1) | WO2018084749A1 (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2680834C1 (ru) * | 2018-05-23 | 2019-02-28 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Противоопухолевая композиция доксорубицина с ингибитором АТФ-зависимых обратных транспортеров клеток |
AU2021366966A1 (en) * | 2020-10-19 | 2023-03-02 | Oxiteno S.A. Indústria E Comércio | Composition, agrochemical formulation, methods for increasing water and nutrient availability and for improving pest control in plants and seeds, and uses of the composition and the agrochemical formulation |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE523934C2 (sv) * | 2001-09-24 | 2004-06-01 | Perstorp Specialty Chem Ab | Förfarande för av alkoxylering av di-, tri och polyalkoholer |
CN101497559A (zh) * | 2008-12-30 | 2009-08-05 | 浙江皇马科技股份有限公司 | 山梨醇和甘油混合醇聚氧丙烯醚的制备方法 |
RO127401B1 (ro) * | 2010-10-06 | 2013-04-30 | Oltchim S.A. | Procedeu de obţinere a polieter poliolilor pe bază de sorbită |
CN101974149B (zh) * | 2010-10-21 | 2012-07-25 | 句容宁武新材料发展有限公司 | 一种聚醚多元醇的制备方法 |
CN102585201B (zh) * | 2011-12-30 | 2014-04-02 | 高春青 | 一种用餐厨废弃物制备硬泡聚氨酯用多元醇的方法 |
RU2501570C1 (ru) * | 2012-05-11 | 2013-12-20 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) федеральный университет" (ФГАОУВПО КФУ) | Трехфункциональные блоксополимеры этиленоксида и пропиленоксида для доставки активных веществ в живые клетки |
RU127401U1 (ru) * | 2012-10-16 | 2013-04-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кузбасский государственный технический университет имени Т.Ф. Горбачева" (КузГТУ) | Проходческий комбайн |
MX337785B (es) * | 2013-02-22 | 2016-03-18 | Bayer Materialscience Ag | Procedimiento de preparacion de polioles de polieter. |
EP3130924B1 (en) * | 2014-04-08 | 2019-06-12 | Kyoto University | Method for screening for inhibitor of atp11c or cdc50a |
CN104610060A (zh) * | 2015-02-05 | 2015-05-13 | 南京工业大学 | 一种高羟值植物油多元醇及其制备方法与应用 |
-
2016
- 2016-11-02 RU RU2016143074A patent/RU2641304C1/ru active
-
2017
- 2017-10-31 WO PCT/RU2017/000809 patent/WO2018084749A1/ru unknown
- 2017-10-31 JP JP2019545237A patent/JP6861424B2/ja active Active
- 2017-10-31 CN CN201780067634.0A patent/CN109890375B/zh active Active
- 2017-10-31 EA EA201900246A patent/EA034579B1/ru unknown
- 2017-10-31 EP EP17867579.9A patent/EP3536315B1/en active Active
-
2019
- 2019-04-30 US US16/399,472 patent/US10987429B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2018084749A1 (ru) | 2018-05-11 |
EP3536315A4 (en) | 2019-11-20 |
US20190255184A1 (en) | 2019-08-22 |
CN109890375B (zh) | 2022-03-22 |
CN109890375A (zh) | 2019-06-14 |
JP6861424B2 (ja) | 2021-04-21 |
JP2020503370A (ja) | 2020-01-30 |
EP3536315B1 (en) | 2021-03-31 |
EP3536315A1 (en) | 2019-09-11 |
US10987429B2 (en) | 2021-04-27 |
RU2641304C1 (ru) | 2018-01-17 |
EA034579B1 (ru) | 2020-02-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201900246A1 (ru) | Ингибитор атф-зависимых обратных транспортеров клеток и способ его получения | |
ES2834131T3 (es) | Nuevas sales de profármacos | |
CO6710904A2 (es) | Formulación farmaceútica para inhibir la hipermeabilidad vascular en un ánimal | |
CL2013002794A1 (es) | Compuestos derivados de espiro(indazol-5,4’-piperidin) sustituidos, inhibidores de acetil-coa carboxilasa y su composicion farmaceutica, util para tratar una enfermedad, afeccion o trastorno modulado por la inhibicion de acetil-coa carboxilasa tal como diabetes, enfermedad de higado graso no alcoholico (hgna) o resistencia hepatica a insulina. | |
CO6470841A2 (es) | Preparación de sólido que presenta propiedad de disolución mejorada de un medicamento a partir de la misma | |
EA201101603A1 (ru) | Гиперразветвленные поликарбонаты для солюбилизации труднорастворимых действующих веществ | |
NI201300034A (es) | Conjugado de naloxol - peg cristalino | |
CO6640051A1 (es) | Sistemas de catalizadores para la produccion de biodiesel | |
CY1116297T1 (el) | Ενωσεις αρυλοτριαζολιου με αντικαρκινικη δραστικοτητα | |
EA201650048A1 (ru) | Способ получения конъюгата гиалуронидазы с производными полиэтиленпиперазина и применение полученного конъюгата | |
CY1111129T1 (el) | Στερεη φαρμακευτικη ενωση που περιεχει τελιθρομυκινη | |
UA109544C2 (uk) | Фармацевтична композиція, що містить парацетамол, та спосіб її виготовлення | |
EA201501165A1 (ru) | Модифицированный липополисахарид эндотоксичных бактерий (варианты), комбинация модифицированных липополисахаридов (варианты) и включающие их вакцина (варианты) и фармацевтическая композиция (варианты) | |
AR074725A1 (es) | Sal de maleato de 11-(2-pirrolidin-1-il-etoxi)-14,19- dioxa-5,7,26-triaza-tetraciclo(19.3.1.1 (2,6).1 (8,12) heptacosa-1(25),2 (26),3,5,8,10,12 (27),16,21,23-decaeno | |
TR201820925T4 (tr) | Azaindol türevi. | |
CN102336700B (zh) | 一类氨基取代苊并杂环类化合物及其应用 | |
Egorova et al. | Ionic liquid tags as a tool for investigating drugs at the single-cell level | |
Hytham et al. | Chitosan microspheres as potential carriers for colon targeting | |
TH130278A (th) | ไพโรลิดีน-2-คาร์บอกซาไมด์ | |
TH1701005042A (ru) | ||
TH1601003958A (th) | สารยับยั้งเซลล์มะเร็งท่อน้ำดีและเซลล์มะเร็งอื่นๆ ในกลุ่มอนุพันธ์ของไคลสแตนธินเอ (Cleistanthin A) และไคลสแตนโธไซต์เอ (Cleistanthoside A) | |
TH175872A (th) | การใช้ของผสมของเกลือและน้ำตาลในการผลิตของยาที่ใช้ในการบำบัดกลุ่มอาการ ช่องคลอดหย่อนยานหรือโรคโคลโพซีโรซิสในสัตว์เลี้ยงลูกด้วยนม | |
PL419153A1 (pl) | Ester kwasu betulonowego i sposób jego otrzymywania | |
TH154821A (th) | สารประกอบฟิวจ์ริงควิโนลิลไพร์โรโลไพริมิดิล หรือเกลือของสารนี้ | |
TH1601007114A (th) | "ผลึกโลบาปลาติน วิธีการเตรียม และการใช้ทางเภสัชกรรม" |