EA201691661A1 - Способ получения производных 21-метокси-11-бета- фенил-19-норпрегна-4,9-диен-3,20-диона - Google Patents

Способ получения производных 21-метокси-11-бета- фенил-19-норпрегна-4,9-диен-3,20-диона

Info

Publication number
EA201691661A1
EA201691661A1 EA201691661A EA201691661A EA201691661A1 EA 201691661 A1 EA201691661 A1 EA 201691661A1 EA 201691661 A EA201691661 A EA 201691661A EA 201691661 A EA201691661 A EA 201691661A EA 201691661 A1 EA201691661 A1 EA 201691661A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fenil
diona
norpregna
dien
methoxy
Prior art date
Application number
EA201691661A
Other languages
English (en)
Other versions
EA032651B1 (ru
Inventor
Шандор Махо
Чаба Санта
Янош Чёргей
Габор Сабо
Тамас Шафер
Золтан Бени
Original Assignee
Рихтер Гедеон Нирт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рихтер Гедеон Нирт. filed Critical Рихтер Гедеон Нирт.
Publication of EA201691661A1 publication Critical patent/EA201691661A1/ru
Publication of EA032651B1 publication Critical patent/EA032651B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Abstract

Настоящее изобретение относится к способу синтеза соединений формулы (I), где R является диметиламино или ацетильной группой, с использованием соединения формулы (III) или (IV), в которой R' означает диметиламино или 2-метил-1,3-диоксан-2-ильную группу, в качестве исходного материала и метоксиметиллития в качестве реагента.
EA201691661A 2014-02-17 2015-02-16 Способ получения производных 21-метокси-11-бета-фенил-19-норпрегна-4,9-диен-3,20-диона EA032651B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU1400080A HU230381B1 (hu) 2014-02-17 2014-02-17 Ipari eljárás szteroid intermedier előállítására
PCT/IB2015/051124 WO2015121840A1 (en) 2014-02-17 2015-02-16 Process for the production of 21 -methoxy-11 -beta-phenyl-19-nor-pregna-4,9-diene-3,20-dione derivatives

Publications (2)

Publication Number Publication Date
EA201691661A1 true EA201691661A1 (ru) 2016-12-30
EA032651B1 EA032651B1 (ru) 2019-06-28

Family

ID=89991401

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691661A EA032651B1 (ru) 2014-02-17 2015-02-16 Способ получения производных 21-метокси-11-бета-фенил-19-норпрегна-4,9-диен-3,20-диона

Country Status (7)

Country Link
US (1) US9683010B2 (ru)
EP (1) EP3107925B1 (ru)
CN (1) CN106414475B (ru)
EA (1) EA032651B1 (ru)
ES (1) ES2682939T3 (ru)
HU (2) HU230381B1 (ru)
WO (1) WO2015121840A1 (ru)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6900193B1 (en) 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
ES2152671T3 (es) 1996-05-01 2001-02-01 Us Gov Health & Human Serv Derivados de progesterona sustituidos en posicion 21 como nuevos agentes antiprogestacionales.
AU775831B2 (en) 1999-12-29 2004-08-19 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Process for preparing 17alpha-acetoxy-11beta-(4-N,N-(dimethylamino)phenyl)-21- methoxy-19-norpregna-4,9-diene-3,20-dione, intermediates useful in the process, and processes for preparing such intermediates
EP2348031B9 (en) 2000-03-17 2016-08-10 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services 17-Alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregnadienediones as antiprogestational agents
HU228636B1 (en) 2007-06-27 2013-04-29 Richter Gedeon Nyrt Industrial method for the synthesis of 17-acetoxy-11betha-4[-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process
TWI477276B (zh) * 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
TWI539953B (zh) * 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
HU230319B1 (hu) * 2013-10-01 2016-01-28 Richter Gedeon Nyrt. Ipari eljárás szteroid hatóanyagok előállítására

Also Published As

Publication number Publication date
ES2682939T3 (es) 2018-09-24
EA032651B1 (ru) 2019-06-28
CN106414475A (zh) 2017-02-15
EP3107925A1 (en) 2016-12-28
US9683010B2 (en) 2017-06-20
HU230381B1 (hu) 2016-03-29
WO2015121840A1 (en) 2015-08-20
HUE039403T2 (hu) 2018-12-28
EP3107925B1 (en) 2018-05-16
US20160326211A1 (en) 2016-11-10
CN106414475B (zh) 2018-04-10
HUP1400080A2 (en) 2015-09-28

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU