HUE039403T2 - Eljárás 21-metoxi-llß-fenil-19-nor-pregna -4,9-dien-3,20-dion származékok elõállítására - Google Patents
Eljárás 21-metoxi-llß-fenil-19-nor-pregna -4,9-dien-3,20-dion származékok elõállításáraInfo
- Publication number
- HUE039403T2 HUE039403T2 HUE15708050A HUE15708050A HUE039403T2 HU E039403 T2 HUE039403 T2 HU E039403T2 HU E15708050 A HUE15708050 A HU E15708050A HU E15708050 A HUE15708050 A HU E15708050A HU E039403 T2 HUE039403 T2 HU E039403T2
- Authority
- HU
- Hungary
- Prior art keywords
- pregna
- diene
- methoxy
- beta
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1400080A HU230381B1 (hu) | 2014-02-17 | 2014-02-17 | Ipari eljárás szteroid intermedier előállítására |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE039403T2 true HUE039403T2 (hu) | 2018-12-28 |
Family
ID=89991401
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU1400080A HU230381B1 (hu) | 2014-02-17 | 2014-02-17 | Ipari eljárás szteroid intermedier előállítására |
| HUE15708050A HUE039403T2 (hu) | 2014-02-17 | 2015-02-16 | Eljárás 21-metoxi-llß-fenil-19-nor-pregna -4,9-dien-3,20-dion származékok elõállítására |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU1400080A HU230381B1 (hu) | 2014-02-17 | 2014-02-17 | Ipari eljárás szteroid intermedier előállítására |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9683010B2 (hu) |
| EP (1) | EP3107925B1 (hu) |
| CN (1) | CN106414475B (hu) |
| EA (1) | EA032651B1 (hu) |
| ES (1) | ES2682939T3 (hu) |
| HU (2) | HU230381B1 (hu) |
| WO (1) | WO2015121840A1 (hu) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6900193B1 (en) | 1996-05-01 | 2005-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
| CA2668824A1 (en) | 1996-05-01 | 1997-11-06 | The Government Of The United States Of America, Represented By The Secre Tary Of The Department Of Health And Human Services | 21-substituted progesterone derivatives as new antiprogestational agents |
| WO2001047945A1 (en) | 1999-12-29 | 2001-07-05 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Process for preparing 17alpha-acetoxy-11beta-[4-n,n-(dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-diene-3,20-dione, intermediates useful in the process, and processes for preparing such intermediates |
| ES2546291T3 (es) | 2000-03-17 | 2015-09-22 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | 17-Alfa-sustituida, 11-beta-sustituida-4-arilo y 21-sustituida 19-norpregnadienodionas como agentes antiprogestacionales |
| HU228636B1 (en) * | 2007-06-27 | 2013-04-29 | Richter Gedeon Nyrt | Industrial method for the synthesis of 17-acetoxy-11betha-4[-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process |
| TWI539953B (zh) * | 2008-04-28 | 2016-07-01 | 瑞波若斯治療學公司 | 用於治療乳癌之組成物和方法 |
| TWI477276B (zh) * | 2008-04-28 | 2015-03-21 | Repros Therapeutics Inc | 抗黃體素給藥方案 |
| HU230319B1 (hu) * | 2013-10-01 | 2016-01-28 | Richter Gedeon Nyrt. | Ipari eljárás szteroid hatóanyagok előállítására |
-
2014
- 2014-02-17 HU HU1400080A patent/HU230381B1/hu unknown
-
2015
- 2015-02-16 US US15/108,026 patent/US9683010B2/en active Active
- 2015-02-16 CN CN201580005238.6A patent/CN106414475B/zh not_active Expired - Fee Related
- 2015-02-16 EP EP15708050.8A patent/EP3107925B1/en active Active
- 2015-02-16 HU HUE15708050A patent/HUE039403T2/hu unknown
- 2015-02-16 ES ES15708050.8T patent/ES2682939T3/es active Active
- 2015-02-16 WO PCT/IB2015/051124 patent/WO2015121840A1/en active Application Filing
- 2015-02-16 EA EA201691661A patent/EA032651B1/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2682939T3 (es) | 2018-09-24 |
| HUP1400080A2 (en) | 2015-09-28 |
| HU230381B1 (hu) | 2016-03-29 |
| WO2015121840A1 (en) | 2015-08-20 |
| CN106414475B (zh) | 2018-04-10 |
| EP3107925B1 (en) | 2018-05-16 |
| EA201691661A1 (ru) | 2016-12-30 |
| CN106414475A (zh) | 2017-02-15 |
| EA032651B1 (ru) | 2019-06-28 |
| US20160326211A1 (en) | 2016-11-10 |
| EP3107925A1 (en) | 2016-12-28 |
| US9683010B2 (en) | 2017-06-20 |
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