EA201600146A1 - Картридж для текучей среды для обработки жидкого образца и способ обработки жидкого образца в картридже для текучей среды (варианты) - Google Patents

Картридж для текучей среды для обработки жидкого образца и способ обработки жидкого образца в картридже для текучей среды (варианты)

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Publication number
EA201600146A1
EA201600146A1 EA201600146A EA201600146A EA201600146A1 EA 201600146 A1 EA201600146 A1 EA 201600146A1 EA 201600146 A EA201600146 A EA 201600146A EA 201600146 A EA201600146 A EA 201600146A EA 201600146 A1 EA201600146 A1 EA 201600146A1
Authority
EA
Eurasian Patent Office
Prior art keywords
liquid sample
cartridge
processing
branch
channel
Prior art date
Application number
EA201600146A
Other languages
English (en)
Russian (ru)
Inventor
Джей Кэндл Тейлор
Бен Арлетт
Original Assignee
Этлас Дженетикс Лимитид
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Этлас Дженетикс Лимитид filed Critical Этлас Дженетикс Лимитид
Publication of EA201600146A1 publication Critical patent/EA201600146A1/ru

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/567—Valves, taps or stop-cocks
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2300/08—Geometry, shape and general structure
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    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/18—Means for temperature control
    • B01L2300/1883—Means for temperature control using thermal insulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2400/00—Moving or stopping fluids
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/159—Microreactors, e.g. emulsion PCR or sequencing, droplet PCR, microcapsules, i.e. non-liquid containers with a range of different permeability's for different reaction components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/629—Detection means characterised by use of a special device being a microfluidic device

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EA201600146A 2013-07-29 2014-07-28 Картридж для текучей среды для обработки жидкого образца и способ обработки жидкого образца в картридже для текучей среды (варианты) EA201600146A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1313515.7A GB2516669B (en) 2013-07-29 2013-07-29 A method for processing a liquid sample in a fluidic cartridge
PCT/GB2014/052306 WO2015015179A1 (en) 2013-07-29 2014-07-28 A fluidic cartridge and method for processing a liquid sample

Publications (1)

Publication Number Publication Date
EA201600146A1 true EA201600146A1 (ru) 2016-06-30

Family

ID=49167103

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201600146A EA201600146A1 (ru) 2013-07-29 2014-07-28 Картридж для текучей среды для обработки жидкого образца и способ обработки жидкого образца в картридже для текучей среды (варианты)

Country Status (11)

Country Link
US (1) US9662650B2 (enExample)
EP (1) EP3027319B1 (enExample)
JP (1) JP2016527511A (enExample)
CN (1) CN105658332B (enExample)
AU (1) AU2014298183B2 (enExample)
BR (1) BR112016001818A2 (enExample)
CA (1) CA2918671A1 (enExample)
EA (1) EA201600146A1 (enExample)
ES (1) ES2635330T3 (enExample)
GB (1) GB2516669B (enExample)
WO (1) WO2015015179A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016089477A1 (en) * 2014-10-16 2016-06-09 Cepheid Biosecurity screening system and method
EP3554704A1 (en) * 2016-12-13 2019-10-23 Koninklijke Philips N.V. Microfluidic device for accommodating, isolating, treating and/or processing cells having an inlet chamber with a chute structure.
CN106676000A (zh) * 2016-12-30 2017-05-17 上海星耀医学科技发展有限公司 多腔室基因分析反应装置
WO2018153950A1 (en) * 2017-02-22 2018-08-30 Selfdiagnostics Deutschland Gmbh Microfluidic test device
AU2018227436A1 (en) * 2017-02-28 2019-09-12 Abbott Diagnostics Scarborough, Inc. Microfluidic devices and related methods
US11213824B2 (en) 2017-03-29 2022-01-04 The Research Foundation For The State University Of New York Microfluidic device and methods
GB2566002B (en) * 2017-06-22 2019-10-23 Sphere Fluidics Ltd Droplet dispensing systems
US11007523B2 (en) * 2017-09-01 2021-05-18 Mgi Tech Co., Ltd. Injection molded microfluidic/fluidic cartridge integrated with silicon-based sensor
CN108165483A (zh) * 2017-12-29 2018-06-15 山东省医疗器械产品质量检验中心 标称孔径1.2μm药液过滤器白色念珠菌截留试验装置及方法
TWI699494B (zh) * 2018-01-24 2020-07-21 美商伊路米納有限公司 流體緩衝
DE102018111834A1 (de) * 2018-05-16 2019-11-21 Mildendo Gesellschaft für mikrofluidische Systeme mbH Mikrofluidische Vorrichtung und Verfahren zur Nutzung derselben zur Trennung, Aufreinigung und Konzentration von Komponenten von fluidischen Medien,
DE102018111822B4 (de) 2018-05-16 2021-10-07 Microfluidic Chipshop Gmbh Fluidisches System zur Aufnahme, Abgabe und Bewegung von Flüssigkeiten, Verfahren zur Verarbeitung von Fluiden in einem fluidischen System
CN209069695U (zh) * 2018-07-24 2019-07-05 江苏苏净集团有限公司 一种气溶胶稀释装置
JP7066043B2 (ja) * 2018-09-11 2022-05-12 エフ．ホフマン－ラ ロシュ アーゲー 液体パックを備えたカートリッジ
CN113897283A (zh) * 2021-05-18 2022-01-07 成都万众壹芯生物科技有限公司 一种微流控核酸检测试剂盒及检测装置
WO2023102900A1 (zh) * 2021-12-10 2023-06-15 深圳华大生命科学研究院 一种微流体装置及微流体检测装置
CN115683746B (zh) * 2023-01-04 2023-03-21 中储粮成都储藏研究院有限公司 一种扦样分样机
WO2024159226A2 (en) * 2023-01-28 2024-08-02 The General Hospital Corporation Systems and methods for high-efficiency microfluidic analysis of blood
WO2025078446A1 (en) * 2023-10-09 2025-04-17 Carl Olsson Microfluidic device and method thereof for rapid assays in samples

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990067304A (ko) 1995-11-03 1999-08-16 윌리암 제이. 버크 검정을 수행하기 위한 검정 시스템 및 방법
US7514046B2 (en) * 2000-10-31 2009-04-07 Caliper Life Sciences, Inc. Methods and systems for processing microscale devices for reuse
US6729352B2 (en) * 2001-06-07 2004-05-04 Nanostream, Inc. Microfluidic synthesis devices and methods
US7338760B2 (en) * 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US7223371B2 (en) * 2002-03-14 2007-05-29 Micronics, Inc. Microfluidic channel network device
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
AU2003224817B2 (en) * 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US6877528B2 (en) * 2002-04-17 2005-04-12 Cytonome, Inc. Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
DE10242110A1 (de) 2002-09-11 2004-03-25 Thinxxs Gmbh Mikropumpe und Verfahren zu ihrer Herstellung
TW590982B (en) * 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
KR101216828B1 (ko) * 2002-12-30 2013-01-04 더 리전트 오브 더 유니버시티 오브 캘리포니아 병원균 검출과 분석을 위한 방법과 기구
ATE439187T1 (de) 2003-08-04 2009-08-15 Caliper Life Sciences Inc Verfahren und system zur bearbeitung von bauelementen im mikromassstab zur wiederverwendung
DE10336849A1 (de) 2003-08-11 2005-03-10 Thinxxs Gmbh Flusszelle
DE10336850B4 (de) 2003-08-11 2006-10-26 Thinxxs Gmbh Mikrospeicher
DE20313727U1 (de) 2003-09-04 2005-01-13 Thinxxs Gmbh Piezoaktor
DE20315371U1 (de) 2003-10-02 2005-02-17 Thinxxs Gmbh Verbinder zur Herstellung von Fluidverbindungen
GB2416030B (en) * 2004-01-28 2008-07-23 Norchip As A diagnostic system for carrying out a nucleic acid sequence amplification and detection process
CA2994321C (en) * 2004-05-03 2023-08-08 Handylab, Inc. A microfluidic device and methods for processing polynucleotide-containing samples
US7832429B2 (en) * 2004-10-13 2010-11-16 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
WO2006076567A2 (en) * 2005-01-13 2006-07-20 Micronics, Inc. Microfluidic rare cell detection device
WO2006122311A2 (en) * 2005-05-11 2006-11-16 The Trustees Of The University Of Pennsylvania Microfluidic chip
DK1883474T3 (da) * 2005-05-25 2021-06-21 Boehringer Ingelheim Vetmedica Gmbh System til integreret og automatiseret dna- eller proteinanalyse og fremgangsmåde til at drive et sådan system
EP1945793A4 (en) * 2005-08-11 2015-11-25 Eksigent Technologies Llc METHOD FOR MEASURING BIOCHEMICAL REACTIONS
WO2007024914A2 (en) * 2005-08-22 2007-03-01 Applera Corporation Device and method for microfluidic control of a first fluid in contact with a second fluid, wherein the first and second fluids are immiscible
JP2009511059A (ja) * 2005-10-11 2009-03-19 ハンディーラブ インコーポレイテッド ポリヌクレオチドサンプル調製装置
US20110136252A1 (en) * 2006-03-02 2011-06-09 The Regents Of The University Of California Integrated Microfluidics for Parallel Screening of Chemical Reactions
WO2007106580A2 (en) * 2006-03-15 2007-09-20 Micronics, Inc. Rapid magnetic flow assays
US20070280857A1 (en) * 2006-06-02 2007-12-06 Applera Corporation Devices and Methods for Positioning Dried Reagent In Microfluidic Devices
DE102006031475A1 (de) 2006-07-07 2008-01-10 Universität des Saarlandes Verfahren und Vorrichtung zur Untersuchung des Adhäsionsverhaltens von Thrombozyten
WO2008147382A1 (en) * 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
US8594848B2 (en) 2006-11-28 2013-11-26 Lester F. Ludwig Reconfigurable chemical process systems
WO2008079320A1 (en) * 2006-12-22 2008-07-03 The Regents Of The University Of California Microfluidic platform for cell culture and assay
US8338166B2 (en) * 2007-01-04 2012-12-25 Lawrence Livermore National Security, Llc Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
JPWO2008087828A1 (ja) * 2007-01-18 2010-05-06 コニカミノルタエムジー株式会社 マイクロチップ
DE102007051487A1 (de) 2007-10-27 2009-04-30 Thinxxs Microtechnology Ag Düsen-, Filter- oder/und Positionierelement
DE102007059533A1 (de) 2007-12-06 2009-06-10 Thinxxs Microtechnology Ag Mikrofluidische Speichervorrichtung
WO2009108260A2 (en) 2008-01-22 2009-09-03 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
US8122901B2 (en) * 2008-06-30 2012-02-28 Canon U.S. Life Sciences, Inc. System and method for microfluidic flow control
US8697007B2 (en) * 2008-08-06 2014-04-15 The Trustees Of The University Of Pennsylvania Biodetection cassette with automated actuator
JP5155800B2 (ja) * 2008-09-29 2013-03-06 富士フイルム株式会社 反応方法及び反応装置
DE102009005874A1 (de) 2009-01-21 2010-07-22 Thinxxs Microtechnology Ag Ventil, insbesondere für ein Bauelement der Mikrofluidtechnik
DE102009009728A1 (de) 2009-02-19 2010-09-02 Thinxxs Microtechnology Ag Flusszelle mit integriertem Fluidspeicher
DE102009015395B4 (de) 2009-03-23 2022-11-24 Thinxxs Microtechnology Gmbh Flusszelle zur Behandlung und/oder Untersuchung eines Fluids
EP2440672B1 (en) * 2009-06-12 2016-03-30 Micronics, Inc. Compositions and methods for dehydrated storage of on-board reagents in microfluidic devices
GB0910759D0 (en) 2009-06-22 2009-08-05 Ucl Business Plc Microfluidic device
DE102009032744A1 (de) 2009-07-11 2011-01-13 Thinxxs Microtechnology Ag Fluidspeicher
TWI421495B (zh) * 2009-10-30 2014-01-01 Univ Nat Cheng Kung 微流體晶片
DE102010013752A1 (de) 2010-03-31 2011-10-06 Roche Diagnostics Gmbh Multifunktionelle Detektionsküvette
DE102011015184B4 (de) 2010-06-02 2013-11-21 Thinxxs Microtechnology Ag Vorrichtung für den Transport kleiner Volumina eines Fluids, insbesondere Mikropumpe oder Mikroventil
US20110312759A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Genetic analysis loc with reagent reservoir
US10272436B2 (en) * 2010-12-03 2019-04-30 Meso Scale Technologies, Llc. Assay cartridge valve system
GB201021896D0 (en) 2010-12-22 2011-02-02 Atlas Genetics Ltd Novel compounds and their use in analytical methods
WO2012096480A2 (en) * 2011-01-10 2012-07-19 Lg Electronics Inc. Diagnostic cartridge and control method for diagnostic cartridge
US20120283108A1 (en) * 2011-05-03 2012-11-08 Sampas Nicholas M Method for phased genotyping of a diploid genome
US9101930B2 (en) * 2012-02-13 2015-08-11 Neumodx Molecular, Inc. Microfluidic cartridge for processing and detecting nucleic acids
US9067189B2 (en) * 2012-03-30 2015-06-30 General Electric Company Microfluidic device and a related method thereof
EP2647435B1 (de) 2012-04-05 2020-08-05 ThinXXS Microtechnology AG Anordnung aus einer flusszelle und einem temperierelement
GB201211157D0 (en) 2012-06-22 2012-08-08 Atlas Genetics Ltd Novel compounds and their use in analytical methods
EP2679307B1 (de) 2012-06-28 2015-08-12 Thinxxs Microtechnology Ag Mikrospeicher, insbesondere zur Integration in eine mikrofluidische Flusszelle
DE102012112306A1 (de) 2012-12-14 2014-06-18 Thinxxs Microtechnology Ag Verfahren zur Verbindung von Komponenten einer mikrofluidischen Flusszelle
DK2821138T4 (da) 2013-07-05 2022-05-16 Thinxxs Microtechnology Gmbh Flydecelle med integreret tørstof
GB2516675A (en) * 2013-07-29 2015-02-04 Atlas Genetics Ltd A valve which depressurises, and a valve system
GB2516672B (en) * 2013-07-29 2015-05-20 Atlas Genetics Ltd A system and method for expelling liquid from a fluidic cartridge
EP2851121B1 (en) 2013-09-20 2022-11-02 thinXXS Microtechnology GmbH Devices for and methods of forming microchannels or microfluid reservoirs
US9399216B2 (en) * 2013-12-30 2016-07-26 General Electric Company Fluid transport in microfluidic applications with sensors for detecting fluid presence and pressure
EP2962758B1 (de) 2014-07-01 2017-07-19 ThinXXS Microtechnology AG Flusszelle mit einem speicherbereich und einem an einer sollbruchstelle aufschliessbaren transportkanal

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CN105658332A (zh) 2016-06-08
WO2015015179A1 (en) 2015-02-05
GB2516669A (en) 2015-02-04
US9662650B2 (en) 2017-05-30
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GB2516669B (en) 2015-09-09

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