CN105658332B - 用于处理液体样本的射流卡盘和方法 - Google Patents

用于处理液体样本的射流卡盘和方法 Download PDF

Info

Publication number
CN105658332B
CN105658332B CN201480052583.0A CN201480052583A CN105658332B CN 105658332 B CN105658332 B CN 105658332B CN 201480052583 A CN201480052583 A CN 201480052583A CN 105658332 B CN105658332 B CN 105658332B
Authority
CN
China
Prior art keywords
gas
liquid
branched bottom
valve
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201480052583.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN105658332A (zh
Inventor
J·肯德尔泰勒
B·阿莱特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Binx Health Ltd
Original Assignee
Atlas Genetics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atlas Genetics Ltd filed Critical Atlas Genetics Ltd
Publication of CN105658332A publication Critical patent/CN105658332A/zh
Application granted granted Critical
Publication of CN105658332B publication Critical patent/CN105658332B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/567—Valves, taps or stop-cocks
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1883—Means for temperature control using thermal insulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/159—Microreactors, e.g. emulsion PCR or sequencing, droplet PCR, microcapsules, i.e. non-liquid containers with a range of different permeability's for different reaction components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/629—Detection means characterised by use of a special device being a microfluidic device

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201480052583.0A 2013-07-29 2014-07-28 用于处理液体样本的射流卡盘和方法 Expired - Fee Related CN105658332B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1313515.7 2013-07-29
GB1313515.7A GB2516669B (en) 2013-07-29 2013-07-29 A method for processing a liquid sample in a fluidic cartridge
PCT/GB2014/052306 WO2015015179A1 (en) 2013-07-29 2014-07-28 A fluidic cartridge and method for processing a liquid sample

Publications (2)

Publication Number Publication Date
CN105658332A CN105658332A (zh) 2016-06-08
CN105658332B true CN105658332B (zh) 2017-10-13

Family

ID=49167103

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480052583.0A Expired - Fee Related CN105658332B (zh) 2013-07-29 2014-07-28 用于处理液体样本的射流卡盘和方法

Country Status (11)

Country Link
US (1) US9662650B2 (enExample)
EP (1) EP3027319B1 (enExample)
JP (1) JP2016527511A (enExample)
CN (1) CN105658332B (enExample)
AU (1) AU2014298183B2 (enExample)
BR (1) BR112016001818A2 (enExample)
CA (1) CA2918671A1 (enExample)
EA (1) EA201600146A1 (enExample)
ES (1) ES2635330T3 (enExample)
GB (1) GB2516669B (enExample)
WO (1) WO2015015179A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11587686B2 (en) * 2014-10-16 2023-02-21 Cepheid Biosecurity screening system and method
WO2018109008A1 (en) * 2016-12-13 2018-06-21 Koninklijke Philips N.V. Microfluidic device for accommodating, isolating, treating and/or processing cells having an inlet chamber with a chute structure.
CN106676000A (zh) * 2016-12-30 2017-05-17 上海星耀医学科技发展有限公司 多腔室基因分析反应装置
WO2018153950A1 (en) * 2017-02-22 2018-08-30 Selfdiagnostics Deutschland Gmbh Microfluidic test device
US10632464B2 (en) * 2017-02-28 2020-04-28 Alere San Diego, Inc. Microfluidic devices and related methods
US11213824B2 (en) 2017-03-29 2022-01-04 The Research Foundation For The State University Of New York Microfluidic device and methods
GB2566002B (en) * 2017-06-22 2019-10-23 Sphere Fluidics Ltd Droplet dispensing systems
US11007523B2 (en) * 2017-09-01 2021-05-18 Mgi Tech Co., Ltd. Injection molded microfluidic/fluidic cartridge integrated with silicon-based sensor
CN108165483A (zh) * 2017-12-29 2018-06-15 山东省医疗器械产品质量检验中心 标称孔径1.2μm药液过滤器白色念珠菌截留试验装置及方法
TWI699494B (zh) * 2018-01-24 2020-07-21 美商伊路米納有限公司 流體緩衝
DE102018111822B4 (de) 2018-05-16 2021-10-07 Microfluidic Chipshop Gmbh Fluidisches System zur Aufnahme, Abgabe und Bewegung von Flüssigkeiten, Verfahren zur Verarbeitung von Fluiden in einem fluidischen System
DE102018111834A1 (de) 2018-05-16 2019-11-21 Mildendo Gesellschaft für mikrofluidische Systeme mbH Mikrofluidische Vorrichtung und Verfahren zur Nutzung derselben zur Trennung, Aufreinigung und Konzentration von Komponenten von fluidischen Medien,
CN209069695U (zh) * 2018-07-24 2019-07-05 江苏苏净集团有限公司 一种气溶胶稀释装置
WO2020053111A1 (en) 2018-09-11 2020-03-19 F. Hoffmann-La Roche Ag Cartridge with liquid pack
CN116323901A (zh) * 2020-11-06 2023-06-23 豪夫迈·罗氏有限公司 板清洁装置
CN113897283A (zh) 2021-05-18 2022-01-07 成都万众壹芯生物科技有限公司 一种微流控核酸检测试剂盒及检测装置
AU2021477173B2 (en) * 2021-12-10 2026-01-08 BGI Hangzhou CycloneSEQ Technology Co., Ltd. Microfluidic device and microfluidic detection device
US20250019687A1 (en) * 2022-05-31 2025-01-16 Beijing Boe Technology Development Co., Ltd. Microfluidic chip, nucleic acid extraction apparatus and nucleic acid extraction method
CN115683746B (zh) * 2023-01-04 2023-03-21 中储粮成都储藏研究院有限公司 一种扦样分样机
WO2024159226A2 (en) * 2023-01-28 2024-08-02 The General Hospital Corporation Systems and methods for high-efficiency microfluidic analysis of blood
WO2025078446A1 (en) * 2023-10-09 2025-04-17 Carl Olsson Microfluidic device and method thereof for rapid assays in samples

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050019213A1 (en) * 2000-10-31 2005-01-27 Caliper Life Sciences, Inc. Methods and systems for processing microscale devices for reuse
US20080069739A1 (en) * 2006-11-28 2008-03-20 Ludwig Lester F Reconfigurable chemical process systems
CN101282789A (zh) * 2005-10-03 2008-10-08 奇奥尼公司 微流体膜片泵和阀
US20100035349A1 (en) * 2008-08-06 2010-02-11 The Trustees Of The University Of Pennsylvania Biodetection Cassette with Automated Actuator
US20120178179A1 (en) * 2011-01-10 2012-07-12 Ji Tae Kim Diagnostic cartridge and control method for diagnostic cartridge

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0862647A1 (en) 1995-11-03 1998-09-09 Sarnoff Corporation Assay system and method for conducting assays
US6729352B2 (en) * 2001-06-07 2004-05-04 Nanostream, Inc. Microfluidic synthesis devices and methods
US7338760B2 (en) * 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US7223371B2 (en) * 2002-03-14 2007-05-29 Micronics, Inc. Microfluidic channel network device
EP1499706A4 (en) * 2002-04-01 2010-11-03 Fluidigm Corp MICROFLUIDIC PARTICLE ANALYSIS SYSTEMS
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US6877528B2 (en) * 2002-04-17 2005-04-12 Cytonome, Inc. Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
DE10242110A1 (de) 2002-09-11 2004-03-25 Thinxxs Gmbh Mikropumpe und Verfahren zu ihrer Herstellung
TW590982B (en) * 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
JP2006512092A (ja) * 2002-12-30 2006-04-13 ザ・リージェンツ・オブ・ジ・ユニバーシティ・オブ・カリフォルニア 病原体の検出および分析のための方法および装置
JP4217739B2 (ja) * 2003-08-04 2009-02-04 カリパー・ライフ・サイエンシズ・インク. 再使用のためにマイクロスケールデバイスを処理する方法およびシステム
DE10336850B4 (de) 2003-08-11 2006-10-26 Thinxxs Gmbh Mikrospeicher
DE10336849A1 (de) 2003-08-11 2005-03-10 Thinxxs Gmbh Flusszelle
DE20313727U1 (de) 2003-09-04 2005-01-13 Thinxxs Gmbh Piezoaktor
DE20315371U1 (de) 2003-10-02 2005-02-17 Thinxxs Gmbh Verbinder zur Herstellung von Fluidverbindungen
GB2416030B (en) * 2004-01-28 2008-07-23 Norchip As A diagnostic system for carrying out a nucleic acid sequence amplification and detection process
EP2345739B8 (en) * 2004-05-03 2016-12-07 Handylab, Inc. A microfluidic device for processing polynucleotide-containing samples
US20060246575A1 (en) * 2005-01-13 2006-11-02 Micronics, Inc. Microfluidic rare cell detection device
WO2006122312A2 (en) * 2005-05-11 2006-11-16 The Trustees Of The University Of Pennsylvania Methods of testing using a microfluidic cassette
CN101218032A (zh) * 2005-05-25 2008-07-09 西门子公司 综合和自动化的dna或蛋白质分析系统及其运行方法
WO2007021820A2 (en) * 2005-08-11 2007-02-22 Eksigent Technologies, Llc Methods for measuring biochemical reactions
US20070068573A1 (en) * 2005-08-22 2007-03-29 Applera Corporation Device and method for microfluidic control of a first fluid in contact with a second fluid, wherein the first and second fluids are immiscible
JP2009511059A (ja) * 2005-10-11 2009-03-19 ハンディーラブ インコーポレイテッド ポリヌクレオチドサンプル調製装置
CA2644206A1 (en) * 2006-03-02 2007-09-13 The Regents Of The University Of California Integrated microfluidics for parallel screening of chemical reactions
JP5254949B2 (ja) * 2006-03-15 2013-08-07 マイクロニクス, インコーポレイテッド 一体型の核酸アッセイ
US20070280857A1 (en) * 2006-06-02 2007-12-06 Applera Corporation Devices and Methods for Positioning Dried Reagent In Microfluidic Devices
DE102006031475A1 (de) 2006-07-07 2008-01-10 Universität des Saarlandes Verfahren und Vorrichtung zur Untersuchung des Adhäsionsverhaltens von Thrombozyten
WO2008147382A1 (en) * 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
US20110129850A1 (en) * 2006-12-22 2011-06-02 UCLA Office of Intellectual Property Microfluidic platform for cell culture and assay
US8338166B2 (en) * 2007-01-04 2012-12-25 Lawrence Livermore National Security, Llc Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
JPWO2008087828A1 (ja) * 2007-01-18 2010-05-06 コニカミノルタエムジー株式会社 マイクロチップ
DE102007051487A1 (de) 2007-10-27 2009-04-30 Thinxxs Microtechnology Ag Düsen-, Filter- oder/und Positionierelement
DE102007059533A1 (de) 2007-12-06 2009-06-10 Thinxxs Microtechnology Ag Mikrofluidische Speichervorrichtung
EP2234916A4 (en) 2008-01-22 2016-08-10 Integenx Inc UNIVERSAL SPECIMEN PREPARATION SYSTEM AND ITS USE IN AN INTEGRATED ANALYSIS SYSTEM
US8122901B2 (en) * 2008-06-30 2012-02-28 Canon U.S. Life Sciences, Inc. System and method for microfluidic flow control
JP5155800B2 (ja) * 2008-09-29 2013-03-06 富士フイルム株式会社 反応方法及び反応装置
DE102009005874A1 (de) 2009-01-21 2010-07-22 Thinxxs Microtechnology Ag Ventil, insbesondere für ein Bauelement der Mikrofluidtechnik
DE102009009728A1 (de) 2009-02-19 2010-09-02 Thinxxs Microtechnology Ag Flusszelle mit integriertem Fluidspeicher
DE102009015395B4 (de) 2009-03-23 2022-11-24 Thinxxs Microtechnology Gmbh Flusszelle zur Behandlung und/oder Untersuchung eines Fluids
AU2010258716B2 (en) * 2009-06-12 2015-11-12 Revvity Health Sciences, Inc. Compositions and methods for dehydrated storage of on-board reagents in microfluidic devices
GB0910759D0 (en) 2009-06-22 2009-08-05 Ucl Business Plc Microfluidic device
DE102009032744A1 (de) 2009-07-11 2011-01-13 Thinxxs Microtechnology Ag Fluidspeicher
TWI421495B (zh) * 2009-10-30 2014-01-01 Univ Nat Cheng Kung 微流體晶片
DE102010013752A1 (de) 2010-03-31 2011-10-06 Roche Diagnostics Gmbh Multifunktionelle Detektionsküvette
DE102011015184B4 (de) 2010-06-02 2013-11-21 Thinxxs Microtechnology Ag Vorrichtung für den Transport kleiner Volumina eines Fluids, insbesondere Mikropumpe oder Mikroventil
US20110312798A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Test module with inbuilt lancet
US10272436B2 (en) * 2010-12-03 2019-04-30 Meso Scale Technologies, Llc. Assay cartridge valve system
GB201021896D0 (en) 2010-12-22 2011-02-02 Atlas Genetics Ltd Novel compounds and their use in analytical methods
US20120283108A1 (en) * 2011-05-03 2012-11-08 Sampas Nicholas M Method for phased genotyping of a diploid genome
EP2814942B1 (en) * 2012-02-13 2024-07-03 Neumodx Molecular, Inc. Microfluidic cartridge for processing and detecting nucleic acids
US9067189B2 (en) * 2012-03-30 2015-06-30 General Electric Company Microfluidic device and a related method thereof
EP2647435B1 (de) 2012-04-05 2020-08-05 ThinXXS Microtechnology AG Anordnung aus einer flusszelle und einem temperierelement
GB201211157D0 (en) 2012-06-22 2012-08-08 Atlas Genetics Ltd Novel compounds and their use in analytical methods
EP2679307B1 (de) 2012-06-28 2015-08-12 Thinxxs Microtechnology Ag Mikrospeicher, insbesondere zur Integration in eine mikrofluidische Flusszelle
DE102012112306A1 (de) 2012-12-14 2014-06-18 Thinxxs Microtechnology Ag Verfahren zur Verbindung von Komponenten einer mikrofluidischen Flusszelle
ES2704424T5 (es) 2013-07-05 2022-05-20 Thinxxs Microtechnology Gmbh Célula de flujo con sustancia seca integrada
GB2516672B (en) * 2013-07-29 2015-05-20 Atlas Genetics Ltd A system and method for expelling liquid from a fluidic cartridge
GB2516675A (en) * 2013-07-29 2015-02-04 Atlas Genetics Ltd A valve which depressurises, and a valve system
EP2851121B1 (en) 2013-09-20 2022-11-02 thinXXS Microtechnology GmbH Devices for and methods of forming microchannels or microfluid reservoirs
US9399216B2 (en) * 2013-12-30 2016-07-26 General Electric Company Fluid transport in microfluidic applications with sensors for detecting fluid presence and pressure
EP2962758B1 (de) 2014-07-01 2017-07-19 ThinXXS Microtechnology AG Flusszelle mit einem speicherbereich und einem an einer sollbruchstelle aufschliessbaren transportkanal

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050019213A1 (en) * 2000-10-31 2005-01-27 Caliper Life Sciences, Inc. Methods and systems for processing microscale devices for reuse
CN101282789A (zh) * 2005-10-03 2008-10-08 奇奥尼公司 微流体膜片泵和阀
US20080069739A1 (en) * 2006-11-28 2008-03-20 Ludwig Lester F Reconfigurable chemical process systems
US20100035349A1 (en) * 2008-08-06 2010-02-11 The Trustees Of The University Of Pennsylvania Biodetection Cassette with Automated Actuator
US20120178179A1 (en) * 2011-01-10 2012-07-12 Ji Tae Kim Diagnostic cartridge and control method for diagnostic cartridge

Also Published As

Publication number Publication date
EP3027319A1 (en) 2016-06-08
WO2015015179A1 (en) 2015-02-05
BR112016001818A2 (pt) 2017-08-01
JP2016527511A (ja) 2016-09-08
CA2918671A1 (en) 2015-02-05
GB2516669A (en) 2015-02-04
ES2635330T3 (es) 2017-10-03
US20160175835A1 (en) 2016-06-23
US9662650B2 (en) 2017-05-30
EA201600146A1 (ru) 2016-06-30
EP3027319B1 (en) 2017-05-31
GB201313515D0 (en) 2013-09-11
GB2516669B (en) 2015-09-09
CN105658332A (zh) 2016-06-08
AU2014298183A1 (en) 2016-03-03
AU2014298183B2 (en) 2017-12-07

Similar Documents

Publication Publication Date Title
CN105658333B (zh) 用于核酸扩增和检测的射流卡盘
EP3027319B1 (en) A fluidic cartridge and method for processing a liquid sample
CN105636696B (zh) 减压阀门和阀门系统
CN105636695B (zh) 卡盘、卡盘阅读器以及用于防止卡盘的再使用的方法
US9999883B2 (en) System and method for processing fluid in a fluidic cartridge
WO2015015181A1 (en) Valve with latching mechanism
CN110769934A (zh) 微流体装置和相关方法
GB2516670A (en) Fluid control device and method of manufacture

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20171013

Termination date: 20200728