EA201592096A1 - Ингибиторы никотинамид фосфорибозилтрансферазы, композиции, продукты и их применение - Google Patents

Ингибиторы никотинамид фосфорибозилтрансферазы, композиции, продукты и их применение

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Publication number
EA201592096A1
EA201592096A1 EA201592096A EA201592096A EA201592096A1 EA 201592096 A1 EA201592096 A1 EA 201592096A1 EA 201592096 A EA201592096 A EA 201592096A EA 201592096 A EA201592096 A EA 201592096A EA 201592096 A1 EA201592096 A1 EA 201592096A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nicotinamide
phosphoribosiltransferase
inhibitors
compositions
products
Prior art date
Application number
EA201592096A
Other languages
English (en)
Other versions
EA028303B1 (ru
Inventor
Армандо А. Дженадзани
Джан Чезаре Трон
Убалдина Галли
Кристина Травелли
Сальваторе Куццокреа
Джоржо Гроза
Джованни Сорба
Пьер Луиджи Канонико
Original Assignee
Университа Дельи Студи Дель Пьемонте Орьентале "Амедео Авогадро"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Университа Дельи Студи Дель Пьемонте Орьентале "Амедео Авогадро" filed Critical Университа Дельи Студи Дель Пьемонте Орьентале "Амедео Авогадро"
Publication of EA201592096A1 publication Critical patent/EA201592096A1/ru
Publication of EA028303B1 publication Critical patent/EA028303B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

Соединения формулы (I)способные ингибировать никотинамид фосфорибозилтрансферазу. Изобретение также относится к применению соединений формулы (I) для лечения патологических состояний, при которых ингибирование NAMPT (никотинамид фосфорибозилтрансфераза) может быть полезным, например острое и хроническое воспаление, рак и нарушение обмена веществ.
EA201592096A 2013-05-03 2014-04-29 Ингибиторы никотинамид фосфорибозилтрансферазы, композиции, продукты и их применение EA028303B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000356A ITTO20130356A1 (it) 2013-05-03 2013-05-03 Inibitori di nicotinamide fosforibosil transferasi, relative composizioni, prodotti ed usi
PCT/IB2014/061080 WO2014178001A1 (en) 2013-05-03 2014-04-29 "inhibitors of nicotinamide phosphoribosyltransferase, compositions, products and uses thereof"

Publications (2)

Publication Number Publication Date
EA201592096A1 true EA201592096A1 (ru) 2016-03-31
EA028303B1 EA028303B1 (ru) 2017-10-31

Family

ID=48748449

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201592096A EA028303B1 (ru) 2013-05-03 2014-04-29 Ингибиторы никотинамид фосфорибозилтрансферазы, композиции, продукты и их применение

Country Status (14)

Country Link
US (1) US20160075682A1 (ru)
EP (1) EP2991975B1 (ru)
JP (1) JP2016517879A (ru)
KR (1) KR20160003196A (ru)
CN (1) CN105531269A (ru)
AR (1) AR096160A1 (ru)
AU (1) AU2014261094A1 (ru)
BR (1) BR112015027629A2 (ru)
CA (1) CA2910255A1 (ru)
EA (1) EA028303B1 (ru)
IT (1) ITTO20130356A1 (ru)
MX (1) MX2015015200A (ru)
SG (1) SG11201508677QA (ru)
WO (1) WO2014178001A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105153020A (zh) * 2015-07-20 2015-12-16 湖南华腾制药有限公司 一种芳香叠氮化合物的制备方法
CA3039203A1 (en) 2016-10-03 2018-04-12 Sigilon Therapeutics, Inc. Compounds, devices, and uses thereof
CN109843334A (zh) 2016-10-18 2019-06-04 西雅图基因公司 烟酰胺腺嘌呤二核苷酸补救途径抑制剂的靶向递送
TW201904613A (zh) 2017-04-27 2019-02-01 美商西雅圖遺傳學公司 季鹼化菸鹼醯胺腺二核苷酸補救合成抑制劑結合物
AU2019371161A1 (en) * 2018-10-31 2021-06-17 Arizona Board Of Regents On Behalf Of The University Of Arizona Biomarkers and methods of use for radiation-induced lung injury

Also Published As

Publication number Publication date
JP2016517879A (ja) 2016-06-20
WO2014178001A1 (en) 2014-11-06
CA2910255A1 (en) 2014-11-06
EP2991975B1 (en) 2017-07-19
MX2015015200A (es) 2016-06-06
ITTO20130356A1 (it) 2014-11-04
AR096160A1 (es) 2015-12-09
KR20160003196A (ko) 2016-01-08
AU2014261094A1 (en) 2015-11-12
EA028303B1 (ru) 2017-10-31
US20160075682A1 (en) 2016-03-17
CN105531269A (zh) 2016-04-27
EP2991975A1 (en) 2016-03-09
SG11201508677QA (en) 2015-11-27
BR112015027629A2 (pt) 2017-08-22

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU