EA201591787A1 - Таблетки совапревира - Google Patents
Таблетки совапревираInfo
- Publication number
- EA201591787A1 EA201591787A1 EA201591787A EA201591787A EA201591787A1 EA 201591787 A1 EA201591787 A1 EA 201591787A1 EA 201591787 A EA201591787 A EA 201591787A EA 201591787 A EA201591787 A EA 201591787A EA 201591787 A1 EA201591787 A1 EA 201591787A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- description
- tablets
- pvp
- crystal growth
- growth inhibitor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Описание включает ядра таблеток, содержащие совапревир и ингибитор роста кристаллов, выбранный из гидроксипропил метилцеллюлозы (НРМС), НРС (гидроксипропилцеллюлоза), гипромеллозы ацетат-сукцината (HPMCAS), поливинилпирролидона (PVP), коповидона (PVP-VA), сополимера метакриловой кислоты и этилакрилата или любой комбинации из перечисленных компонентов, где соотношение совапревира и ингибитора роста кристаллов составляет от примерно 40:60 (вес./вес.) до примерно 60:40 (вес./вес.). Описание включает также таблетки с пленочным покрытием. Описание включает также способы лечения HCV описанными в тексте таблетками.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361790645P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/025969 WO2014151547A1 (en) | 2013-03-15 | 2014-03-13 | Sovaprevir tablets |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201591787A1 true EA201591787A1 (ru) | 2015-12-30 |
Family
ID=50439520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201591787A EA201591787A1 (ru) | 2013-03-15 | 2014-03-13 | Таблетки совапревира |
Country Status (12)
Country | Link |
---|---|
US (1) | US20140271855A1 (ru) |
EP (1) | EP2968171A1 (ru) |
JP (1) | JP2016512845A (ru) |
KR (1) | KR20160005022A (ru) |
CN (1) | CN105358137A (ru) |
AU (1) | AU2014233897A1 (ru) |
BR (1) | BR112015023381A2 (ru) |
CA (1) | CA2905423A1 (ru) |
EA (1) | EA201591787A1 (ru) |
IL (1) | IL241350A0 (ru) |
SG (1) | SG11201507468TA (ru) |
WO (1) | WO2014151547A1 (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0714343A2 (pt) | 2006-07-13 | 2013-03-19 | Achillion Pharmaceuticals Inc | peptÍdeos de 4-amino-4-oxobutanoil como inibidores de replicaÇço viral |
AU2014227849A1 (en) | 2013-03-15 | 2015-10-01 | Achillion Pharmaceuticals, Inc. | Sovaprevir polymorphs and methods of manufacture thereof |
CN104258411A (zh) * | 2014-09-19 | 2015-01-07 | 安徽山河药用辅料股份有限公司 | 一种硅化微晶纤维素复合辅料及其制备方法 |
CN105943536A (zh) * | 2016-05-06 | 2016-09-21 | 杭州容立医药科技有限公司 | 一种固体分散体的制备方法及其应用 |
CA3115516C (en) * | 2018-10-05 | 2023-04-25 | Isp Investments Llc | Smooth high solids film coating composition comprising water soluble cellulose ether, process for preparing the same and method of use thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI2041156T1 (sl) * | 2006-07-13 | 2014-04-30 | Achillion Pharmacetuticals, Inc. | Peptidi 4-amino-4-oksobutanoila kot inhibitorji virusne replikacije |
AR072991A1 (es) * | 2008-08-07 | 2010-10-06 | Schering Corp | Formulaciones farmaceuticas de un inhibidor de la enzima proteasa de hcv en una dispersion molecular solida |
US8927576B2 (en) * | 2009-04-06 | 2015-01-06 | PTC Therpeutics, Inc. | HCV inhibitor and therapeutic agent combinations |
EP2797586A1 (en) * | 2011-12-29 | 2014-11-05 | AbbVie Inc. | Solid compositions comprising an hcv inhibitor |
WO2013116592A1 (en) * | 2012-02-01 | 2013-08-08 | Kadmon Pharmaceuticals, Llc | Once daily treatment of hepatitis c with ribavirin and taribavirin |
-
2014
- 2014-03-13 BR BR112015023381A patent/BR112015023381A2/pt not_active IP Right Cessation
- 2014-03-13 CN CN201480028573.3A patent/CN105358137A/zh active Pending
- 2014-03-13 EA EA201591787A patent/EA201591787A1/ru unknown
- 2014-03-13 CA CA2905423A patent/CA2905423A1/en not_active Abandoned
- 2014-03-13 US US14/208,195 patent/US20140271855A1/en not_active Abandoned
- 2014-03-13 WO PCT/US2014/025969 patent/WO2014151547A1/en active Application Filing
- 2014-03-13 JP JP2016502012A patent/JP2016512845A/ja active Pending
- 2014-03-13 EP EP14715515.4A patent/EP2968171A1/en not_active Withdrawn
- 2014-03-13 KR KR1020157028999A patent/KR20160005022A/ko not_active Application Discontinuation
- 2014-03-13 AU AU2014233897A patent/AU2014233897A1/en not_active Abandoned
- 2014-03-13 SG SG11201507468TA patent/SG11201507468TA/en unknown
-
2015
- 2015-09-09 IL IL241350A patent/IL241350A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2014151547A1 (en) | 2014-09-25 |
CN105358137A (zh) | 2016-02-24 |
CA2905423A1 (en) | 2014-09-25 |
SG11201507468TA (en) | 2015-10-29 |
IL241350A0 (en) | 2015-11-30 |
KR20160005022A (ko) | 2016-01-13 |
US20140271855A1 (en) | 2014-09-18 |
JP2016512845A (ja) | 2016-05-09 |
BR112015023381A2 (pt) | 2017-07-18 |
AU2014233897A1 (en) | 2015-10-01 |
EP2968171A1 (en) | 2016-01-20 |
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