EA201591690A1 - Управление доминантной мужской стерильностью - Google Patents

Управление доминантной мужской стерильностью

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Publication number
EA201591690A1
EA201591690A1 EA201591690A EA201591690A EA201591690A1 EA 201591690 A1 EA201591690 A1 EA 201591690A1 EA 201591690 A EA201591690 A EA 201591690A EA 201591690 A EA201591690 A EA 201591690A EA 201591690 A1 EA201591690 A1 EA 201591690A1
Authority
EA
Eurasian Patent Office
Prior art keywords
plant
male fertility
presented
sterility
management
Prior art date
Application number
EA201591690A
Other languages
English (en)
Inventor
Эндрю М. Сиган
Original Assignee
Пайонир Хай-Бред Интернэшнл, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пайонир Хай-Бред Интернэшнл, Инк. filed Critical Пайонир Хай-Бред Интернэшнл, Инк.
Publication of EA201591690A1 publication Critical patent/EA201591690A1/ru

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8222Developmentally regulated expression systems, tissue, organ specific, temporal or spatial regulation
    • C12N15/823Reproductive tissue-specific promoters
    • C12N15/8231Male-specific, e.g. anther, tapetum, pollen
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8287Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for fertility modification, e.g. apomixis
    • C12N15/8289Male sterility
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01HNEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H6/00Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
    • A01H6/46Gramineae or Poaceae, e.g. ryegrass, rice, wheat or maize
    • A01H6/4678Triticum sp. [wheat]
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01HNEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H6/00Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
    • A01H6/46Gramineae or Poaceae, e.g. ryegrass, rice, wheat or maize
    • A01H6/4684Zea mays [maize]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8222Developmentally regulated expression systems, tissue, organ specific, temporal or spatial regulation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8287Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for fertility modification, e.g. apomixis

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Представлены композиции и способы для модулирования мужской фертильности у растения. Композиции содержат нуклеотидные последовательности и их активные фрагменты и варианты, которые модулируют мужскую фертильность. Дополнительно представлены кассеты экспрессии, содержащие полинуклеотиды, определяющие мужскую фертильность, или их активные фрагменты или варианты, функционально связанные с промотором, где экспрессия полинуклеотидов модулирует мужскую фертильность растения. Представлены различные способы, при помощи которых осуществляют модулирование уровня и/или активности последовательностей, влияющих на мужскую фертильность, в растении или части растения. В определенных вариантах осуществления растение является полиплоидным.
EA201591690A 2013-03-12 2014-03-12 Управление доминантной мужской стерильностью EA201591690A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361778069P 2013-03-12 2013-03-12
US201361788950P 2013-03-15 2013-03-15
PCT/US2014/023932 WO2014164961A2 (en) 2013-03-12 2014-03-12 Manipulation of dominant male sterility

Publications (1)

Publication Number Publication Date
EA201591690A1 true EA201591690A1 (ru) 2016-02-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591690A EA201591690A1 (ru) 2013-03-12 2014-03-12 Управление доминантной мужской стерильностью

Country Status (7)

Country Link
US (6) US9803214B2 (ru)
EP (1) EP2970998A2 (ru)
CN (1) CN105209623B (ru)
AU (3) AU2014248841B2 (ru)
CA (1) CA2903222C (ru)
EA (1) EA201591690A1 (ru)
WO (1) WO2014164961A2 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9803214B2 (en) 2013-03-12 2017-10-31 Pioneer Hi-Bred International, Inc. Breeding pair of wheat plants comprising an MS45 promoter inverted repeat that confers male sterility and a construct that restores fertility
CA2971425A1 (en) * 2014-12-16 2016-06-23 Pioneer Hi-Bred International, Inc. Restoration of male fertility in wheat
DE102015004187A1 (de) * 2015-04-02 2016-10-06 Kws Saat Se Männlich sterile Pflanze der Gattung Triticum
WO2017139309A1 (en) 2016-02-12 2017-08-17 Ceres, Inc. Methods and materials for high throughput testing of mutagenized allele combinations
CN106305410A (zh) * 2016-08-24 2017-01-11 安徽省东昌农业科技有限公司 一种适合沿淮地区麦茬直播水稻品种的快速选育方法
EP3301111A1 (de) * 2016-10-02 2018-04-04 Kws Saat Se Pflanze der gattung triticum, in der das tdf-gen durch ein markergen inaktiviert ist
MX2020008563A (es) * 2018-02-15 2021-01-08 Monsanto Technology Llc Métodos mejorados para la producción de semillas de maíz híbridas.
CN108486112B (zh) * 2018-04-13 2021-07-27 沈阳农业大学 一种具有花药组织特异性的启动子
US20220056472A1 (en) * 2018-09-14 2022-02-24 Pioneer Hi-Bred International, Inc. Fertility restoration in plants
CN112094862B (zh) * 2019-12-17 2022-04-19 华中农业大学 一种带有标记的棉花雄性不育系的创制方法

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ201918A (en) 1981-09-18 1987-04-30 Genentech Inc N-terminal methionyl analogues of bovine growth hormone
US5380831A (en) 1986-04-04 1995-01-10 Mycogen Plant Science, Inc. Synthetic insecticidal crystal protein gene
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5569597A (en) 1985-05-13 1996-10-29 Ciba Geigy Corp. Methods of inserting viral DNA into plant material
US4918006A (en) 1985-07-01 1990-04-17 E. I. Du Pont De Nemours And Company Gene coding for insecticidal crystal protein
US5268463A (en) 1986-11-11 1993-12-07 Jefferson Richard A Plant promoter α-glucuronidase gene construct
US5608142A (en) 1986-12-03 1997-03-04 Agracetus, Inc. Insecticidal cotton plants
US4873192A (en) 1987-02-17 1989-10-10 The United States Of America As Represented By The Department Of Health And Human Services Process for site specific mutagenesis without phenotypic selection
US5728926A (en) 1988-02-03 1998-03-17 Pioneer Hi-Bred International, Inc. Antisense gene systems of pollination control for hybrid seed production
US6198023B1 (en) 1988-02-03 2001-03-06 Pioneer Hi-Bred International, Inc. Molecular methods of hybrid seed production
US6162964A (en) 1988-02-03 2000-12-19 Pioneer Hi-Bred International, Inc. Molecular methods of hybrid seed production
US5356799A (en) 1988-02-03 1994-10-18 Pioneer Hi-Bred International, Inc. Antisense gene systems of pollination control for hybrid seed production
US5316931A (en) 1988-02-26 1994-05-31 Biosource Genetics Corp. Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes
US5990387A (en) 1988-06-10 1999-11-23 Pioneer Hi-Bred International, Inc. Stable transformation of plant cells
US5879918A (en) 1989-05-12 1999-03-09 Pioneer Hi-Bred International, Inc. Pretreatment of microprojectiles prior to using in a particle gun
US5240855A (en) 1989-05-12 1993-08-31 Pioneer Hi-Bred International, Inc. Particle gun
US5322783A (en) 1989-10-17 1994-06-21 Pioneer Hi-Bred International, Inc. Soybean transformation by microparticle bombardment
EP0452269B1 (en) 1990-04-12 2002-10-09 Syngenta Participations AG Tissue-preferential promoters
US5478369A (en) 1990-06-12 1995-12-26 Pioneer Hi-Bred International, Inc. Nucleotide sequences mediating male fertility and method of using same
US6297426B1 (en) 1990-06-12 2001-10-02 Pioneer Hi-Bred International, Inc. Methods of mediating female fertility in plants
US5498830A (en) 1990-06-18 1996-03-12 Monsanto Company Decreased oil content in plant seeds
US5932782A (en) 1990-11-14 1999-08-03 Pioneer Hi-Bred International, Inc. Plant transformation method using agrobacterium species adhered to microprojectiles
US5399680A (en) 1991-05-22 1995-03-21 The Salk Institute For Biological Studies Rice chitinase promoter
HU219057B (hu) 1991-08-27 2001-02-28 Novartis Ag. Inszekticid hatású proteinek Homoptera rovarok ellen és alkalmazásuk a növényvédelemben
TW261517B (ru) 1991-11-29 1995-11-01 Mitsubishi Shozi Kk
US5324646A (en) 1992-01-06 1994-06-28 Pioneer Hi-Bred International, Inc. Methods of regeneration of Medicago sativa and expressing foreign DNA in same
EP0651814B1 (en) 1992-07-09 1997-01-08 Pioneer Hi-Bred International, Inc. Maize pollen-specific polygalacturonase gene
EP0652965A1 (en) 1992-07-27 1995-05-17 Pioneer Hi-Bred International, Inc. An improved method of agrobacterium-mediated transformation of cultured soybean cells
US5332808A (en) 1992-09-08 1994-07-26 North Carolina State University DNA encoding a ribosome inactivating protein
IL108241A (en) 1992-12-30 2000-08-13 Biosource Genetics Corp Plant expression system comprising a defective tobamovirus replicon integrated into the plant chromosome and a helper virus
GB9324707D0 (en) 1993-12-02 1994-01-19 Olsen Odd Arne Promoter
CA2178729A1 (en) 1993-12-09 1995-06-15 Eric B. Kmiec Compounds and methods for site-directed mutations in eukaryotic cells
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5470359A (en) 1994-04-21 1995-11-28 Pioneer Hi-Bred Internation, Inc. Regulatory element conferring tapetum specificity
US6013859A (en) 1994-07-14 2000-01-11 Pioneer Hi-Bred International, Inc. Molecular methods of hybrid seed production
US5736369A (en) 1994-07-29 1998-04-07 Pioneer Hi-Bred International, Inc. Method for producing transgenic cereal plants
US5608144A (en) 1994-08-12 1997-03-04 Dna Plant Technology Corp. Plant group 2 promoters and uses thereof
US5763243A (en) 1994-12-08 1998-06-09 Pioneer Hi-Bred International, Inc. Reversible nuclear genetic system for male sterility in transgenic plants
US5750868A (en) 1994-12-08 1998-05-12 Pioneer Hi-Bred International, Inc. Reversible nuclear genetic system for male sterility in transgenic plants
US5659026A (en) 1995-03-24 1997-08-19 Pioneer Hi-Bred International ALS3 promoter
US5760012A (en) 1996-05-01 1998-06-02 Thomas Jefferson University Methods and compounds for curing diseases caused by mutations
US5731181A (en) 1996-06-17 1998-03-24 Thomas Jefferson University Chimeric mutational vectors having non-natural nucleotides
US6072050A (en) 1996-06-11 2000-06-06 Pioneer Hi-Bred International, Inc. Synthetic promoters
US5981840A (en) 1997-01-24 1999-11-09 Pioneer Hi-Bred International, Inc. Methods for agrobacterium-mediated transformation
WO1998049350A1 (en) 1997-04-30 1998-11-05 Regents Of The University Of Minnesota In vivo use of recombinagenic oligonucleobases to correct genetic lesions in hepatocytes
GB9710475D0 (en) 1997-05-21 1997-07-16 Zeneca Ltd Gene silencing
US6037523A (en) 1997-06-23 2000-03-14 Pioneer Hi-Bred International Male tissue-preferred regulatory region and method of using same
US7154024B2 (en) * 1997-06-23 2006-12-26 Pioneer Hi-Bred, Inc. Male tissue-preferred regulatory sequences of Ms45 gene and method of using same
WO1999007865A1 (en) 1997-08-05 1999-02-18 Kimeragen, Inc. The use of mixed duplex oligonucleotides to effect localized genetic changes in plants
WO1999025855A1 (en) 1997-11-18 1999-05-27 Pioneer Hi-Bred International, Inc. Mobilization of viral genomes from t-dna using site-specific recombination systems
DE69833457T2 (de) 1997-11-18 2006-09-14 Pioneer Hi-Bred International, Inc. Neuartige methode zur integration von fremd-dna ins eukaryotische genom
EP1032692A1 (en) 1997-11-18 2000-09-06 Pioneer Hi-Bred International, Inc. Targeted manipulation of herbicide-resistance genes in plants
AU760113C (en) 1997-11-18 2004-04-22 Pioneer Hi-Bred International, Inc. Compositions and methods for genetic modification of plants
AU762993C (en) 1998-02-26 2004-06-10 Pioneer Hi-Bred International, Inc. Constitutive maize promoters
WO1999053050A1 (en) 1998-04-08 1999-10-21 Commonwealth Scientific And Industrial Research Organisation Methods and means for obtaining modified phenotypes
WO2001060997A2 (en) 2000-02-15 2001-08-23 Pioneer Hi-Bred International, Inc. Male tissue-specific regulatory region and method of using same
DE69928264T2 (de) 1998-08-20 2006-07-13 Pioneer Hi-Bred International, Inc. Samen-bevorzugende promotoren
WO2000012733A1 (en) 1998-08-28 2000-03-09 Pioneer Hi-Bred International, Inc. Seed-preferred promoters from end genes
IL142736A0 (en) 1998-11-09 2002-03-10 Pioneer Hi Bred Int Transcriptional activator lec 1 nucleic acids, polypeptides and their uses
AU6406800A (en) 1999-03-16 2000-10-04 Pioneer Hi-Bred International, Inc. SF3 promoter and methods of use
US6384304B1 (en) * 1999-10-15 2002-05-07 Plant Genetic Systems N.V. Conditional sterility in wheat
JP4310104B2 (ja) 2002-09-28 2009-08-05 英俊 猪子 マイクロサテライト遺伝多型マーカを用いる遺伝子のマッピング方法
US7612251B2 (en) 2000-09-26 2009-11-03 Pioneer Hi-Bred International, Inc. Nucleotide sequences mediating male fertility and method of using same
US7214786B2 (en) 2000-12-14 2007-05-08 Kovalic David K Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
US6956118B2 (en) 2001-02-08 2005-10-18 Pioneer Hi-Bred International, Inc. Promoter sequences providing male tissue-preferred expression in plants
TW525063B (en) 2001-09-03 2003-03-21 Via Tech Inc General accelerated graphic port interface system and the operation method thereof
US7074985B2 (en) 2002-02-15 2006-07-11 Pioneer Hi-Bred International, Inc. Development of a stress-responsive promoter from maize
PT1696721E (pt) 2003-12-16 2010-05-06 Pioneer Hi Bred Int Transgénicos com supressão de gene dominante e processos para a sua utilização
US20070169227A1 (en) * 2003-12-16 2007-07-19 Pioneer Hi-Bred International Inc. Dominant Gene Suppression Transgenes and Methods of Using Same
EP2325332B1 (en) 2005-08-26 2012-10-31 DuPont Nutrition Biosciences ApS Use of CRISPR associated genes (CAS)
NL1033850C2 (nl) 2007-05-15 2008-11-18 3Force B V Brandersysteem met voorgemengde branders en vlam-overdrachtsmiddelen.
US7919676B2 (en) 2007-08-03 2011-04-05 Pioneer Hi-Bred International, Inc. Msca1 nucleotide sequences impacting plant male fertility and method of using same
EP2825552A2 (en) 2012-03-13 2015-01-21 Pioneer Hi-Bred International Inc. Genetic reduction of male fertility in plants
WO2013138309A1 (en) 2012-03-13 2013-09-19 Pioneer Hi-Bred International, Inc. Genetic reduction of male fertility in plants
WO2014039815A2 (en) 2012-09-06 2014-03-13 Pioneer Hi-Bred International, Inc. Compositions and methods comprising male fertility sequences
US9803214B2 (en) * 2013-03-12 2017-10-31 Pioneer Hi-Bred International, Inc. Breeding pair of wheat plants comprising an MS45 promoter inverted repeat that confers male sterility and a construct that restores fertility
CN104911194B (zh) * 2015-06-04 2019-03-08 山东农业大学 小麦雄性不育基因wms及其花药特异性启动子的应用

Also Published As

Publication number Publication date
CA2903222C (en) 2023-10-17
US20190010513A1 (en) 2019-01-10
WO2014164961A2 (en) 2014-10-09
EP2970998A2 (en) 2016-01-20
US20160017365A1 (en) 2016-01-21
US10113181B2 (en) 2018-10-30
AU2020202241B2 (en) 2022-10-20
AU2014248841B2 (en) 2020-01-02
US20140298510A1 (en) 2014-10-02
CN105209623A (zh) 2015-12-30
AU2023200211A1 (en) 2023-02-16
US20210079411A1 (en) 2021-03-18
AU2014248841A1 (en) 2015-08-06
AU2020202241A1 (en) 2020-04-23
US20180010145A1 (en) 2018-01-11
US10822614B2 (en) 2020-11-03
US9803214B2 (en) 2017-10-31
US20200255848A1 (en) 2020-08-13
CN105209623B (zh) 2021-04-20
US10604762B2 (en) 2020-03-31
CA2903222A1 (en) 2014-10-09
WO2014164961A3 (en) 2014-12-11

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