EA201591199A1 - Бензазепины в качестве лигандов серотониновых 5-ht-рецепторов и их применение - Google Patents
Бензазепины в качестве лигандов серотониновых 5-ht-рецепторов и их применениеInfo
- Publication number
- EA201591199A1 EA201591199A1 EA201591199A EA201591199A EA201591199A1 EA 201591199 A1 EA201591199 A1 EA 201591199A1 EA 201591199 A EA201591199 A EA 201591199A EA 201591199 A EA201591199 A EA 201591199A EA 201591199 A1 EA201591199 A1 EA 201591199A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- benzapetine
- sertonin
- application
- receptor ligands
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретение в целом относится к ряду соединений, к фармацевтическим композициям, содержащим указанные соединения, а также к применению указанных соединений и композиций в качестве терапевтических агентов. В частности, соединения согласно изобретению представляют собой соединения бензазепина. Указанные соединения представляют собой лиганды серотониновых рецепторов (5-HT) и подходят для лечения заболеваний, нарушений и патологических состояний, при которых требуется модуляция активности серотониновых рецепторов (5-HT) (например, зависимость, тревога, депрессия, ожирение и др.).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261745241P | 2012-12-21 | 2012-12-21 | |
PCT/US2013/077501 WO2014100815A2 (en) | 2012-12-21 | 2013-12-23 | Benzazepines as serotonin 5-ht2c receptor ligands and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201591199A1 true EA201591199A1 (ru) | 2015-10-30 |
EA026397B1 EA026397B1 (ru) | 2017-04-28 |
Family
ID=50979422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201591199A EA026397B1 (ru) | 2012-12-21 | 2013-12-23 | Бензазепины в качестве лигандов серотониновых 5-ht-рецепторов и их применение |
Country Status (14)
Country | Link |
---|---|
US (1) | US9284277B2 (ru) |
EP (1) | EP2938345B1 (ru) |
JP (1) | JP2016503808A (ru) |
KR (1) | KR20150108840A (ru) |
CN (1) | CN105101967B (ru) |
AU (1) | AU2013364022A1 (ru) |
BR (1) | BR112015014674A2 (ru) |
CA (1) | CA2894552A1 (ru) |
EA (1) | EA026397B1 (ru) |
IL (1) | IL239206B (ru) |
MX (1) | MX2015008034A (ru) |
SG (1) | SG11201504749TA (ru) |
WO (1) | WO2014100815A2 (ru) |
ZA (1) | ZA201503955B (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
CN105859536B (zh) * | 2016-05-06 | 2018-08-14 | 蚌埠中实化学技术有限公司 | 一种3,4-二氟苯甲醛的制备方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4255445A (en) * | 1980-03-07 | 1981-03-10 | Smithkline Corporation | 8-Hydroxy-6,7-(2-methyl-2,3-dihydrofuro)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
ZA821020B (en) | 1981-02-18 | 1983-10-26 | Thomae Gmbh Dr K | Azepine derivatives, process for their preparation and pharmaceutical compositions thereof |
DE3230696A1 (de) | 1982-08-18 | 1984-02-23 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue thieno-thiazol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
GB8800891D0 (en) | 1988-01-15 | 1988-02-17 | Lilly Industries Ltd | Pharmaceutical compounds |
GB9025890D0 (en) | 1990-11-28 | 1991-01-09 | Lilly Industries Ltd | Pharmaceutical compounds |
EP0596125A4 (en) | 1991-12-26 | 1994-10-05 | Yoshitomi Pharmaceutical | Condensed thiophene compound and pharmaceutical use thereof. |
US5532240A (en) | 1991-12-26 | 1996-07-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Condensed thiophene compound and pharmaceutical use thereof |
DK26793D0 (da) * | 1993-03-10 | 1993-03-10 | Novo Nordisk As | Benzofuranyl- eller dihydrobenzofuranyl-substituerede tricycliske benzazepiner, der anvendelse og fremstilling |
US5998433A (en) | 1994-10-11 | 1999-12-07 | Takeda Chemical Industries, Ltd. | Condensed compounds, their production and use |
EP1343796A4 (en) * | 2000-10-23 | 2005-01-12 | Smithkline Beecham Corp | COMPOUNDS AND METHODS |
CA2498106A1 (en) | 2002-09-12 | 2004-03-25 | Merck & Co., Inc. | Substituted bicyclic thiophene derivatives, compositions containing such compounds and methods of use |
CN1805938B (zh) | 2003-06-17 | 2010-06-16 | 艾尼纳制药公司 | 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物 |
JP4920409B2 (ja) | 2003-06-17 | 2012-04-18 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 3−ベンズアゼピンを調製する方法 |
AU2004283196B2 (en) | 2003-09-17 | 2011-08-25 | Janssen Pharmaceutica, N.V. | Fused heterocyclic compounds |
WO2005042491A1 (en) | 2003-10-22 | 2005-05-12 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases |
WO2005042490A1 (en) | 2003-10-22 | 2005-05-12 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases |
CA2565683C (en) * | 2004-06-30 | 2013-04-02 | Athersys, Inc. | Substituted azepine derivatives as serotonin receptor modulators |
CN102482292B (zh) * | 2009-04-23 | 2017-07-18 | Abbvie 公司 | 5‑ht受体的调节剂和其使用方法 |
-
2013
- 2013-12-23 CN CN201380067174.3A patent/CN105101967B/zh not_active Expired - Fee Related
- 2013-12-23 EP EP13864916.5A patent/EP2938345B1/en not_active Not-in-force
- 2013-12-23 BR BR112015014674A patent/BR112015014674A2/pt not_active IP Right Cessation
- 2013-12-23 KR KR1020157019895A patent/KR20150108840A/ko not_active Application Discontinuation
- 2013-12-23 JP JP2015549861A patent/JP2016503808A/ja active Pending
- 2013-12-23 EA EA201591199A patent/EA026397B1/ru not_active IP Right Cessation
- 2013-12-23 AU AU2013364022A patent/AU2013364022A1/en not_active Abandoned
- 2013-12-23 SG SG11201504749TA patent/SG11201504749TA/en unknown
- 2013-12-23 CA CA2894552A patent/CA2894552A1/en not_active Abandoned
- 2013-12-23 US US14/138,866 patent/US9284277B2/en not_active Expired - Fee Related
- 2013-12-23 MX MX2015008034A patent/MX2015008034A/es unknown
- 2013-12-23 WO PCT/US2013/077501 patent/WO2014100815A2/en active Application Filing
-
2015
- 2015-06-02 ZA ZA2015/03955A patent/ZA201503955B/en unknown
- 2015-06-04 IL IL239206A patent/IL239206B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP2938345A4 (en) | 2016-10-05 |
EP2938345A2 (en) | 2015-11-04 |
WO2014100815A2 (en) | 2014-06-26 |
US20140194411A1 (en) | 2014-07-10 |
EP2938345B1 (en) | 2018-08-22 |
EA026397B1 (ru) | 2017-04-28 |
WO2014100815A3 (en) | 2014-08-21 |
SG11201504749TA (en) | 2015-07-30 |
BR112015014674A2 (pt) | 2017-07-11 |
IL239206A0 (en) | 2015-07-30 |
CN105101967B (zh) | 2019-06-28 |
CN105101967A (zh) | 2015-11-25 |
IL239206B (en) | 2018-12-31 |
KR20150108840A (ko) | 2015-09-30 |
ZA201503955B (en) | 2016-05-25 |
JP2016503808A (ja) | 2016-02-08 |
US9284277B2 (en) | 2016-03-15 |
MX2015008034A (es) | 2016-03-07 |
CA2894552A1 (en) | 2014-06-26 |
AU2013364022A1 (en) | 2015-07-02 |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM RU |