EA201590920A1 - Гетероарилзамещённые пиридильные соединения, применимые в качестве модуляторов киназ - Google Patents

Гетероарилзамещённые пиридильные соединения, применимые в качестве модуляторов киназ

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Publication number
EA201590920A1
EA201590920A1 EA201590920A EA201590920A EA201590920A1 EA 201590920 A1 EA201590920 A1 EA 201590920A1 EA 201590920 A EA201590920 A EA 201590920A EA 201590920 A EA201590920 A EA 201590920A EA 201590920 A1 EA201590920 A1 EA 201590920A1
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EA
Eurasian Patent Office
Prior art keywords
heteroaryl
substituted pyridyl
compounds applied
kinase modulators
pyridyl compounds
Prior art date
Application number
EA201590920A
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English (en)
Other versions
EA024940B1 (ru
Inventor
Раджив С. Бхайд
Джон В. Дунсиа
Джон Хайнс
Сатиш К. Наир
Уильям Дж. Питтс
Шриканта Р. Кумар
Дэниел С. Гарднер
Натесан Муругесан
Венкатрам Рэдди Паиди
Джозеф Б. Сантелла
Рамеш Систла
Хун У
Original Assignee
Бристол-Майерс Сквибб Компани
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Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA201590920A1 publication Critical patent/EA201590920A1/ru
Publication of EA024940B1 publication Critical patent/EA024940B1/ru

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    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)

Abstract

В изобретении предусматриваются соединения формулыили их стереоизомеры или фармацевтически приемлемые соли, где Rобозначает моноциклическую гетероарильную группу, a R, R, R, Rи Rимеют значение по определению в данной заявке, применимые в качестве модуляторов киназ, включая ингибирование IRAK-4.
EA201590920A 2012-11-08 2013-11-07 Гетероарилзамещённые пиридильные соединения, применимые в качестве модуляторов киназ EA024940B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261723848P 2012-11-08 2012-11-08
US201361774824P 2013-03-08 2013-03-08
PCT/US2013/068875 WO2014074675A1 (en) 2012-11-08 2013-11-07 Heteroaryl substituted pyridyl compounds useful as kinase modulators

Publications (2)

Publication Number Publication Date
EA201590920A1 true EA201590920A1 (ru) 2015-09-30
EA024940B1 EA024940B1 (ru) 2016-11-30

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EA201590920A EA024940B1 (ru) 2012-11-08 2013-11-07 Гетероарилзамещённые пиридильные соединения, применимые в качестве модуляторов киназ

Country Status (21)

Country Link
US (3) US9657009B2 (ru)
EP (1) EP2917206B1 (ru)
JP (1) JP6204484B2 (ru)
KR (1) KR20150079963A (ru)
CN (1) CN104781254B (ru)
AU (1) AU2013341200A1 (ru)
BR (1) BR112015009850A2 (ru)
CA (1) CA2890983A1 (ru)
CL (1) CL2015001249A1 (ru)
CO (1) CO7400871A2 (ru)
EA (1) EA024940B1 (ru)
ES (1) ES2615302T3 (ru)
HK (1) HK1213895A1 (ru)
IL (1) IL238609A0 (ru)
MX (1) MX2015005562A (ru)
PE (1) PE20150953A1 (ru)
PH (1) PH12015501005A1 (ru)
SG (1) SG11201503397YA (ru)
TN (1) TN2015000175A1 (ru)
TW (1) TW201427953A (ru)
WO (1) WO2014074675A1 (ru)

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