EA201590709A1 - Комбинированная терапия и ее применение для лечения димиелинизирующих расстройств - Google Patents
Комбинированная терапия и ее применение для лечения димиелинизирующих расстройствInfo
- Publication number
- EA201590709A1 EA201590709A1 EA201590709A EA201590709A EA201590709A1 EA 201590709 A1 EA201590709 A1 EA 201590709A1 EA 201590709 A EA201590709 A EA 201590709A EA 201590709 A EA201590709 A EA 201590709A EA 201590709 A1 EA201590709 A1 EA 201590709A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- dimielinizing
- disorders
- application
- combined therapy
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
- A61B5/112—Gait analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
- A61B5/1124—Determining motor skills
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
- A61B5/4088—Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
Описаны способы и композиции для улучшения одного или нескольких эффектов, таких как миелинизация, повторная миелинизация, количество олигодендроцитов или защита нейроаксонов, а также снижение степени воспаления у человека. В некоторых вариантах осуществления изобретения в описанных способах и композициях используется комбинация репаративного агента (например, антагониста LINGO-1) и иммуномодулирующего средства. Таким образом, описанные способы, композиции и наборы могут быть применены для лечения демиелинизирующего заболевания ЦНС.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261711638P | 2012-10-09 | 2012-10-09 | |
PCT/US2013/063873 WO2014058875A2 (en) | 2012-10-09 | 2013-10-08 | Combination therapies and uses for treatment of demyelinating disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201590709A1 true EA201590709A1 (ru) | 2015-09-30 |
Family
ID=49484444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201590709A EA201590709A1 (ru) | 2012-10-09 | 2013-10-08 | Комбинированная терапия и ее применение для лечения димиелинизирующих расстройств |
Country Status (13)
Country | Link |
---|---|
US (4) | US20150238602A1 (ru) |
EP (2) | EP3750560A3 (ru) |
JP (4) | JP2015534564A (ru) |
KR (2) | KR20210063443A (ru) |
CN (2) | CN109364250A (ru) |
AU (3) | AU2013329421A1 (ru) |
BR (1) | BR112015007780A2 (ru) |
CA (1) | CA2887682A1 (ru) |
EA (1) | EA201590709A1 (ru) |
HK (1) | HK1213794A1 (ru) |
IL (2) | IL238117B (ru) |
MX (2) | MX2015004436A (ru) |
WO (1) | WO2014058875A2 (ru) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8058406B2 (en) | 2008-07-09 | 2011-11-15 | Biogen Idec Ma Inc. | Composition comprising antibodies to LINGO or fragments thereof |
CA2873623C (en) | 2012-05-14 | 2021-11-09 | Biogen Idec Ma Inc. | Lingo-2 antagonists for treatment of conditions involving motor neurons |
EP3194628A4 (en) * | 2014-09-19 | 2018-02-14 | Ionis Pharmaceuticals, Inc. | Antisense compounds and uses thereof |
MA41139A (fr) | 2014-12-11 | 2017-10-17 | Actelion Pharmaceuticals Ltd | Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1 |
MX2017009038A (es) * | 2015-01-08 | 2017-10-25 | Biogen Ma Inc | Antagonistas de proteina 1 de interacción con el receptor de nogo que contiene el dominio de inmunoglobulina y repeticiones ricas en leucina (lingo-1) y usos para el tratamiento de trastornos desmielinizantes. |
EP3302465A1 (en) | 2015-06-05 | 2018-04-11 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
AU2017297404A1 (en) * | 2016-07-13 | 2019-01-24 | Biogen Ma Inc. | Dosage regimens of LINGO-1 antagonists and uses for treatment of demyelinating disorders |
WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
US11167003B2 (en) | 2017-03-26 | 2021-11-09 | Mapi Pharma Ltd. | Methods for suppressing or alleviating primary or secondary progressive multiple sclerosis (PPMS or SPMS) using sustained release glatiramer depot systems |
US20200181235A1 (en) * | 2017-05-15 | 2020-06-11 | Oncoimmune, Inc. | Methods of use of soluble cd24 for neuroprotection and remyelination |
US11412968B2 (en) | 2017-09-12 | 2022-08-16 | Get Together, Inc | System and method for a digital therapeutic delivery of generalized clinician tips (GCT) |
SG11202010087UA (en) * | 2018-04-13 | 2020-11-27 | Mordechai Chevion | Compositions and methods for treatment of demyelination |
EP3986931A1 (en) | 2019-06-21 | 2022-04-27 | Sorriso Pharmaceuticals, Inc. | Polypeptides |
CA3144567A1 (en) | 2019-06-21 | 2020-12-24 | Scott Crowe | Polypeptides |
CN113584041A (zh) * | 2021-04-15 | 2021-11-02 | 浙江警察学院 | 一种转基因斑马鱼(mbp:egfp)脱脊髓疾病模型的构建方法 |
KR20230171226A (ko) * | 2022-06-13 | 2023-12-20 | 고려대학교 산학협력단 | 키나아제 저해제를 유효성분으로 포함하는 탈수초성 질환 예방 또는 치료용 약학적 조성물 |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
GB2183662B (en) | 1985-04-01 | 1989-01-25 | Celltech Ltd | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
EP1026240A3 (en) | 1988-09-02 | 2004-04-07 | Dyax Corp. | Generation and selection of recombinant varied binding proteins |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
WO1991000906A1 (en) | 1989-07-12 | 1991-01-24 | Genetics Institute, Inc. | Chimeric and transgenic animals capable of producing human antibodies |
SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
ATE185601T1 (de) | 1990-07-10 | 1999-10-15 | Cambridge Antibody Tech | Verfahren zur herstellung von spezifischen bindungspaargliedern |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
JPH06506105A (ja) | 1990-08-29 | 1994-07-14 | ファーミング ビーブイ | 哺乳動物細胞における相同性組換え |
ES2113940T3 (es) | 1990-12-03 | 1998-05-16 | Genentech Inc | Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas. |
JP4146512B2 (ja) | 1991-03-01 | 2008-09-10 | ダイアックス コープ. | 小型タンパク質 |
EP0580737B1 (en) | 1991-04-10 | 2004-06-16 | The Scripps Research Institute | Heterodimeric receptor libraries using phagemids |
EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
PT1498427E (pt) | 1992-08-21 | 2010-03-22 | Univ Bruxelles | Imunoglobulinas desprovidas de cadeias leves |
US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
DK0669986T3 (da) | 1992-11-13 | 2003-07-28 | Idec Pharma Corp | Fuldstændigt inaktiverede kozac-sekvenser til ekspression i pattedyr |
JPH08507680A (ja) | 1993-01-12 | 1996-08-20 | バイオジェン インコーポレイテッド | 組換え抗vla4抗体分子 |
EP0682529B2 (en) | 1993-02-09 | 2005-12-28 | Biogen Idec MA, Inc. | Antibody for the treatment of insulin dependent diabetes |
DE4343034C1 (de) * | 1993-12-16 | 1995-06-08 | Rentschler Arzneimittel | Verwendung von Pentoxifyllin zur Behandlung von Multipler Sklerose |
US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
GB9524973D0 (en) | 1995-12-06 | 1996-02-07 | Lynxvale Ltd | Viral vectors |
US20030143204A1 (en) | 2001-07-27 | 2003-07-31 | Lewis David L. | Inhibition of RNA function by delivery of inhibitors to animal cells |
BR9808584A (pt) | 1997-03-14 | 2000-05-23 | Idec Pharma Corp | Processo para integrar genes em sìtios especìficos em células de mamìferos via recombinação homóloga e vetores para obter os mesmos |
AU2001245793A1 (en) | 2000-03-16 | 2001-09-24 | Cold Spring Harbor Laboratory | Methods and compositions for rna interference |
EP2281837B1 (en) | 2001-08-10 | 2016-10-05 | Aberdeen University | Antigen binding domains from fish |
US20030157641A1 (en) | 2001-11-16 | 2003-08-21 | Idec Pharmaceuticals Corporation | Polycistronic expression of antibodies |
EP1572902B1 (en) | 2002-02-01 | 2014-06-11 | Life Technologies Corporation | HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES |
DK1471974T3 (da) * | 2002-02-06 | 2007-12-03 | Ares Trading Sa | Tumornekrose-faktor kombineret med interferon ved demyeliniserende sygdomme |
WO2003093430A2 (en) | 2002-05-03 | 2003-11-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for use in preparing sirnas |
ATE435303T1 (de) | 2002-08-12 | 2009-07-15 | New England Biolabs Inc | Verfahren und zusammensetzungen in verbindung mit gen-silencing |
ZA200505869B (en) * | 2003-01-24 | 2006-11-29 | Elan Pharm Inc | Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents |
CA2514117A1 (en) * | 2003-01-24 | 2004-08-12 | Elan Pharmaceuticals, Inc. | Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents |
SI2248899T1 (sl) | 2003-03-19 | 2015-07-31 | Biogen Ma Inc. | Vezavni protein receptorja Nogo |
KR20040086884A (ko) | 2003-03-22 | 2004-10-13 | 제일모직주식회사 | 난연성 열가소성 수지 조성물 |
EP2474317A1 (en) | 2004-06-24 | 2012-07-11 | Biogen Idec MA Inc. | Treatment of conditions involving demyelination |
US8128926B2 (en) | 2007-01-09 | 2012-03-06 | Biogen Idec Ma Inc. | Sp35 antibodies and uses thereof |
EP2740744B1 (en) * | 2007-01-09 | 2018-03-28 | Biogen MA Inc. | Sp35 antibodies and uses thereof |
US8058406B2 (en) | 2008-07-09 | 2011-11-15 | Biogen Idec Ma Inc. | Composition comprising antibodies to LINGO or fragments thereof |
IT1395574B1 (it) | 2009-09-14 | 2012-10-16 | Guala Dispensing Spa | Dispositivo di erogazione |
ME02556B (me) | 2011-02-07 | 2017-02-20 | Biogen Ma Inc | Agensi koji moduliraju s1 p |
GB201103526D0 (en) * | 2011-03-02 | 2011-04-13 | Summit Corp Plc | Selective glycosidase inhibitors and uses thereof |
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2013
- 2013-10-08 MX MX2015004436A patent/MX2015004436A/es unknown
- 2013-10-08 EA EA201590709A patent/EA201590709A1/ru unknown
- 2013-10-08 KR KR1020217015388A patent/KR20210063443A/ko not_active Application Discontinuation
- 2013-10-08 US US14/434,292 patent/US20150238602A1/en not_active Abandoned
- 2013-10-08 CA CA2887682A patent/CA2887682A1/en not_active Abandoned
- 2013-10-08 BR BR112015007780A patent/BR112015007780A2/pt not_active Application Discontinuation
- 2013-10-08 KR KR1020157012062A patent/KR102257645B1/ko active IP Right Grant
- 2013-10-08 CN CN201811360254.9A patent/CN109364250A/zh active Pending
- 2013-10-08 EP EP20173044.7A patent/EP3750560A3/en active Pending
- 2013-10-08 JP JP2015535889A patent/JP2015534564A/ja not_active Withdrawn
- 2013-10-08 EP EP13780458.9A patent/EP2906240A2/en not_active Withdrawn
- 2013-10-08 CN CN201380063471.0A patent/CN104870014A/zh active Pending
- 2013-10-08 WO PCT/US2013/063873 patent/WO2014058875A2/en active Application Filing
- 2013-10-08 AU AU2013329421A patent/AU2013329421A1/en not_active Abandoned
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2015
- 2015-04-02 IL IL23811715A patent/IL238117B/en active IP Right Grant
- 2015-04-08 MX MX2020006431A patent/MX2020006431A/es unknown
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2016
- 2016-02-18 HK HK16101834.0A patent/HK1213794A1/zh unknown
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2017
- 2017-12-25 JP JP2017247590A patent/JP2018044014A/ja not_active Withdrawn
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2018
- 2018-02-20 US US15/900,369 patent/US20190038744A1/en not_active Abandoned
- 2018-05-25 AU AU2018203688A patent/AU2018203688A1/en not_active Abandoned
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2019
- 2019-10-06 IL IL269852A patent/IL269852B/en unknown
- 2019-12-10 US US16/708,695 patent/US20200276303A1/en not_active Abandoned
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2020
- 2020-01-16 JP JP2020004952A patent/JP2020055881A/ja not_active Withdrawn
- 2020-05-15 AU AU2020203196A patent/AU2020203196A1/en not_active Abandoned
- 2020-11-30 US US17/107,554 patent/US20210260185A1/en not_active Abandoned
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2021
- 2021-10-28 JP JP2021176294A patent/JP2022023182A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2013329421A1 (en) | 2015-04-30 |
EP3750560A3 (en) | 2021-03-24 |
IL269852B (en) | 2021-08-31 |
EP2906240A2 (en) | 2015-08-19 |
WO2014058875A3 (en) | 2014-06-12 |
JP2018044014A (ja) | 2018-03-22 |
EP3750560A2 (en) | 2020-12-16 |
CN109364250A (zh) | 2019-02-22 |
US20150238602A1 (en) | 2015-08-27 |
MX2020006431A (es) | 2020-09-17 |
CA2887682A1 (en) | 2014-04-17 |
US20210260185A1 (en) | 2021-08-26 |
JP2020055881A (ja) | 2020-04-09 |
CN104870014A (zh) | 2015-08-26 |
AU2020203196A1 (en) | 2020-06-04 |
JP2015534564A (ja) | 2015-12-03 |
US20200276303A1 (en) | 2020-09-03 |
IL238117A0 (en) | 2015-05-31 |
IL269852A (en) | 2019-11-28 |
MX2015004436A (es) | 2015-06-24 |
BR112015007780A2 (pt) | 2017-11-28 |
KR102257645B1 (ko) | 2021-06-01 |
HK1213794A1 (zh) | 2016-07-15 |
WO2014058875A2 (en) | 2014-04-17 |
JP2022023182A (ja) | 2022-02-07 |
AU2018203688A1 (en) | 2018-06-14 |
KR20150064752A (ko) | 2015-06-11 |
US20190038744A1 (en) | 2019-02-07 |
IL238117B (en) | 2019-10-31 |
KR20210063443A (ko) | 2021-06-01 |
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