EA201500646A1 - Применение смесей e/z-изомеров для количественного получения определенных продуктов посредством комбинированной асимметрической гидрогенизации - Google Patents

Применение смесей e/z-изомеров для количественного получения определенных продуктов посредством комбинированной асимметрической гидрогенизации

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Publication number
EA201500646A1
EA201500646A1 EA201500646A EA201500646A EA201500646A1 EA 201500646 A1 EA201500646 A1 EA 201500646A1 EA 201500646 A EA201500646 A EA 201500646A EA 201500646 A EA201500646 A EA 201500646A EA 201500646 A1 EA201500646 A1 EA 201500646A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hydrogenization
application
isomer mixtures
certain products
quantitative production
Prior art date
Application number
EA201500646A
Other languages
English (en)
Other versions
EA029733B1 (ru
Inventor
Вернер Бонрат
Джонатан Алан Медлок
Рене Тобиас Штемлер
Герардус Карел Мария Верзейл
Андреас Хендрикус Мария Врис де
Томас Нечер
Original Assignee
ДСМ АйПи АССЕТС Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ДСМ АйПи АССЕТС Б.В. filed Critical ДСМ АйПи АССЕТС Б.В.
Publication of EA201500646A1 publication Critical patent/EA201500646A1/ru
Publication of EA029733B1 publication Critical patent/EA029733B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/303—Compounds having groups having acetal carbon atoms bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C07C45/82—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/10—Quinones the quinoid structure being part of a condensed ring system containing two rings
    • C07C50/14—Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Настоящее изобретение касается способа получения соединений, содержащих стереогенные центры, из смеси E/Z-изомеров ненасыщенных соединений, содержащих прохиральные двойные связи. Продукты гидрогенизации обладают заданной конфигурацией по стереогенным центрам. Способ включает две стадии асимметрической гидрогенизации. Способ дает большие преимущества тем, что в нем из смеси стереоизомеров исходного соединения эффективно образуется требуемый хиральный продукт.
EA201500646A 2012-12-18 2013-12-18 Применение смесей e/z-изомеров для количественного получения определенных продуктов посредством комбинированной асимметрической гидрогенизации EA029733B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12197850 2012-12-18
PCT/EP2013/077245 WO2014096106A1 (en) 2012-12-18 2013-12-18 Using mixtures of e/z isomers to obtain quantitatively specific products by combined asymmetric hydrogenations

Publications (2)

Publication Number Publication Date
EA201500646A1 true EA201500646A1 (ru) 2015-11-30
EA029733B1 EA029733B1 (ru) 2018-05-31

Family

ID=47500976

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201500646A EA029733B1 (ru) 2012-12-18 2013-12-18 Применение смесей e/z-изомеров для количественного получения определенных продуктов посредством комбинированной асимметрической гидрогенизации

Country Status (7)

Country Link
US (1) US9458076B2 (ru)
EP (1) EP2935188B1 (ru)
JP (1) JP6390048B2 (ru)
CN (1) CN104918909B (ru)
BR (1) BR112015014197B1 (ru)
EA (1) EA029733B1 (ru)
WO (1) WO2014096106A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6476496B2 (ja) * 2012-12-18 2019-03-06 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． ケタールおよびアセタールの不斉水素化の方法
CN104884420A (zh) * 2012-12-18 2015-09-02 帝斯曼知识产权资产管理有限公司 使用e/z异构体的混合物通过联合不对称氢化和异构化定量获得特定产物
WO2014096098A1 (en) * 2012-12-18 2014-06-26 Dsm Ip Assets B.V. (6r,10r)-6,10,14-trimetylpentadecan-2-one prepared from 6,10,14-trimetylpentadeca-5,9,13-trien-2-one or 6,10,14-trimetylpentadeca-5,9-dien-2-one
EA028852B1 (ru) * 2012-12-18 2018-01-31 ДСМ АйПи АССЕТС Б.В. (6r,10r)-6,10,14-триметилпентадекан-2-он, получаемый из 6,10-диметилундец-5-ен-2-она или 6,10-диметилундека-5,9-диен-2-она
JP7502446B2 (ja) 2020-07-29 2024-06-18 富士フイルム株式会社 バインダー組成物、化合物、バインダー層、光学積層体、光学積層体の製造方法、および、画像表示装置

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2455975A1 (de) * 1973-11-30 1975-07-10 Firmenich & Cie Verwendung von neuen acetalen als riech- und geschmacksstoffe
JPS6036479A (ja) * 1983-08-08 1985-02-25 Kotobuki Seiyaku Kk １，３−ジオキサン誘導体、本化合物を有効成分とする抗潰瘍剤及びその製造方法
JP2771866B2 (ja) * 1989-11-01 1998-07-02 エーザイ株式会社 不飽和テルペン類の製造方法
JP3725233B2 (ja) * 1995-04-18 2005-12-07 株式会社カネボウ化粧品 トレハロース誘導体及び界面活性剤
EP1179531A1 (en) * 2000-08-11 2002-02-13 Aventis Animal Nutrition S.A. Intermediates for use in the preparation of vitamin E
JP5090926B2 (ja) * 2004-12-22 2012-12-05 ディーエスエム アイピー アセッツ ビー．ブイ． キラルイリジウム錯体を使用するアルケンの不斉水素化
CN101565366B (zh) * 2008-04-25 2013-04-17 浙江九洲药业股份有限公司 铱络合物在不饱和羧酸不对称催化氢化中的应用
WO2010006954A1 (en) * 2008-07-15 2010-01-21 Dsm Ip Assets B.V. Novel n-substituted beta-amino acid esters
EP2543437A4 (en) * 2010-03-04 2014-09-03 Takasago Perfumery Co Ltd HOMOGENEOUS ASYMMETRIC HYDROGENATION CATALYST
EP2535323A1 (en) * 2011-06-14 2012-12-19 DSM IP Assets B.V. Hydrogenation of ketones having at least a carbon-carbon double bond in the gamma-,delta-position
CN104884420A (zh) * 2012-12-18 2015-09-02 帝斯曼知识产权资产管理有限公司 使用e/z异构体的混合物通过联合不对称氢化和异构化定量获得特定产物
BR112015014106B1 (pt) * 2012-12-18 2020-11-17 Dsm Ip Assets B.V. processo de uma isomerização cis/trans de um composto insaturado, processos de produção de isômeros cis e trans, composição, cetal ou acetal e uso de um politiol
WO2014096098A1 (en) * 2012-12-18 2014-06-26 Dsm Ip Assets B.V. (6r,10r)-6,10,14-trimetylpentadecan-2-one prepared from 6,10,14-trimetylpentadeca-5,9,13-trien-2-one or 6,10,14-trimetylpentadeca-5,9-dien-2-one
MY175343A (en) * 2012-12-18 2020-06-22 Dsm Ip Assets Bv Efficient process of asymmetric hydrogenation of unsaturated ketones using additives
JP6476496B2 (ja) * 2012-12-18 2019-03-06 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． ケタールおよびアセタールの不斉水素化の方法
MY170264A (en) * 2012-12-18 2019-07-15 Dsm Ip Assets Bv Nitrogen monoxide as cis/trans isomerization catalysts for unsaturated compounds
EA028852B1 (ru) * 2012-12-18 2018-01-31 ДСМ АйПи АССЕТС Б.В. (6r,10r)-6,10,14-триметилпентадекан-2-он, получаемый из 6,10-диметилундец-5-ен-2-она или 6,10-диметилундека-5,9-диен-2-она

Also Published As

Publication number Publication date
BR112015014197B1 (pt) 2021-05-18
BR112015014197A2 (pt) 2017-07-11
US9458076B2 (en) 2016-10-04
CN104918909B (zh) 2018-05-11
CN104918909A (zh) 2015-09-16
EP2935188B1 (en) 2018-08-01
JP2015537055A (ja) 2015-12-24
WO2014096106A1 (en) 2014-06-26
EP2935188A1 (en) 2015-10-28
US20150321986A1 (en) 2015-11-12
EA029733B1 (ru) 2018-05-31
JP6390048B2 (ja) 2018-09-19

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Designated state(s): AM AZ BY KZ KG TJ TM RU