BR112015014197A2 - uso de misturas de isômeros e/z para obter produtos quantitativamente específicos por hidrogenações assimétricas combinadas - Google Patents

uso de misturas de isômeros e/z para obter produtos quantitativamente específicos por hidrogenações assimétricas combinadas

Info

Publication number
BR112015014197A2
BR112015014197A2 BR112015014197A BR112015014197A BR112015014197A2 BR 112015014197 A2 BR112015014197 A2 BR 112015014197A2 BR 112015014197 A BR112015014197 A BR 112015014197A BR 112015014197 A BR112015014197 A BR 112015014197A BR 112015014197 A2 BR112015014197 A2 BR 112015014197A2
Authority
BR
Brazil
Prior art keywords
isomers
mixtures
specific products
obtain quantitatively
asymmetric hydrogenations
Prior art date
Application number
BR112015014197A
Other languages
English (en)
Other versions
BR112015014197B1 (pt
Inventor
Hendrikus Maria De Vries Andreas
Karel Maria Verzijl Gerardus
Alan Medlock Jonathan
Tobias STEMMLER René
Netscher Thomas
Bonrath Werner
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BR112015014197A2 publication Critical patent/BR112015014197A2/pt
Publication of BR112015014197B1 publication Critical patent/BR112015014197B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/303—Compounds having groups having acetal carbon atoms bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C07C45/82—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/10—Quinones the quinoid structure being part of a condensed ring system containing two rings
    • C07C50/14—Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

resumo uso de misturas de isômeros e/z para obter produtos quantitativamente específicos por hidrogenações assimétricas combinadas a presente invenção está relacionada a um processo de fabricação de um composto que possui centros estereogênicos a partir de uma mistura de isômeros e/z de compostos insaturados que possuem ligações duplas pró-quirais. o produto da hidrogenação tem uma configuração específica desejada nos centros estereogênicos. o processo envolve duas etapas de hidrogenação assimétrica. o processo é muito vantajoso pois ele forma o produto quiral desejado a partir de uma mistura de estereoisômeros do produto de partida em uma via eficiente.
BR112015014197-8A 2012-12-18 2013-12-18 processo de fabricação de um composto, cetal, acetal,composição e uso BR112015014197B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12197850.6 2012-12-18
EP12197850 2012-12-18
PCT/EP2013/077245 WO2014096106A1 (en) 2012-12-18 2013-12-18 Using mixtures of e/z isomers to obtain quantitatively specific products by combined asymmetric hydrogenations

Publications (2)

Publication Number Publication Date
BR112015014197A2 true BR112015014197A2 (pt) 2017-07-11
BR112015014197B1 BR112015014197B1 (pt) 2021-05-18

Family

ID=47500976

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015014197-8A BR112015014197B1 (pt) 2012-12-18 2013-12-18 processo de fabricação de um composto, cetal, acetal,composição e uso

Country Status (7)

Country Link
US (1) US9458076B2 (pt)
EP (1) EP2935188B1 (pt)
JP (1) JP6390048B2 (pt)
CN (1) CN104918909B (pt)
BR (1) BR112015014197B1 (pt)
EA (1) EA029733B1 (pt)
WO (1) WO2014096106A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6476496B2 (ja) * 2012-12-18 2019-03-06 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． ケタールおよびアセタールの不斉水素化の方法
CN104884420A (zh) * 2012-12-18 2015-09-02 帝斯曼知识产权资产管理有限公司 使用e/z异构体的混合物通过联合不对称氢化和异构化定量获得特定产物
WO2014096098A1 (en) * 2012-12-18 2014-06-26 Dsm Ip Assets B.V. (6r,10r)-6,10,14-trimetylpentadecan-2-one prepared from 6,10,14-trimetylpentadeca-5,9,13-trien-2-one or 6,10,14-trimetylpentadeca-5,9-dien-2-one
EA028852B1 (ru) * 2012-12-18 2018-01-31 ДСМ АйПи АССЕТС Б.В. (6r,10r)-6,10,14-триметилпентадекан-2-он, получаемый из 6,10-диметилундец-5-ен-2-она или 6,10-диметилундека-5,9-диен-2-она
JP7502446B2 (ja) 2020-07-29 2024-06-18 富士フイルム株式会社 バインダー組成物、化合物、バインダー層、光学積層体、光学積層体の製造方法、および、画像表示装置

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DE2455975A1 (de) * 1973-11-30 1975-07-10 Firmenich & Cie Verwendung von neuen acetalen als riech- und geschmacksstoffe
JPS6036479A (ja) * 1983-08-08 1985-02-25 Kotobuki Seiyaku Kk １，３−ジオキサン誘導体、本化合物を有効成分とする抗潰瘍剤及びその製造方法
JP2771866B2 (ja) * 1989-11-01 1998-07-02 エーザイ株式会社 不飽和テルペン類の製造方法
JP3725233B2 (ja) * 1995-04-18 2005-12-07 株式会社カネボウ化粧品 トレハロース誘導体及び界面活性剤
EP1179531A1 (en) * 2000-08-11 2002-02-13 Aventis Animal Nutrition S.A. Intermediates for use in the preparation of vitamin E
JP5090926B2 (ja) * 2004-12-22 2012-12-05 ディーエスエム アイピー アセッツ ビー．ブイ． キラルイリジウム錯体を使用するアルケンの不斉水素化
CN101565366B (zh) * 2008-04-25 2013-04-17 浙江九洲药业股份有限公司 铱络合物在不饱和羧酸不对称催化氢化中的应用
WO2010006954A1 (en) * 2008-07-15 2010-01-21 Dsm Ip Assets B.V. Novel n-substituted beta-amino acid esters
EP2543437A4 (en) * 2010-03-04 2014-09-03 Takasago Perfumery Co Ltd HOMOGENEOUS ASYMMETRIC HYDROGENATION CATALYST
EP2535323A1 (en) * 2011-06-14 2012-12-19 DSM IP Assets B.V. Hydrogenation of ketones having at least a carbon-carbon double bond in the gamma-,delta-position
CN104884420A (zh) * 2012-12-18 2015-09-02 帝斯曼知识产权资产管理有限公司 使用e/z异构体的混合物通过联合不对称氢化和异构化定量获得特定产物
BR112015014106B1 (pt) * 2012-12-18 2020-11-17 Dsm Ip Assets B.V. processo de uma isomerização cis/trans de um composto insaturado, processos de produção de isômeros cis e trans, composição, cetal ou acetal e uso de um politiol
WO2014096098A1 (en) * 2012-12-18 2014-06-26 Dsm Ip Assets B.V. (6r,10r)-6,10,14-trimetylpentadecan-2-one prepared from 6,10,14-trimetylpentadeca-5,9,13-trien-2-one or 6,10,14-trimetylpentadeca-5,9-dien-2-one
MY175343A (en) * 2012-12-18 2020-06-22 Dsm Ip Assets Bv Efficient process of asymmetric hydrogenation of unsaturated ketones using additives
JP6476496B2 (ja) * 2012-12-18 2019-03-06 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． ケタールおよびアセタールの不斉水素化の方法
MY170264A (en) * 2012-12-18 2019-07-15 Dsm Ip Assets Bv Nitrogen monoxide as cis/trans isomerization catalysts for unsaturated compounds
EA028852B1 (ru) * 2012-12-18 2018-01-31 ДСМ АйПи АССЕТС Б.В. (6r,10r)-6,10,14-триметилпентадекан-2-он, получаемый из 6,10-диметилундец-5-ен-2-она или 6,10-диметилундека-5,9-диен-2-она

Also Published As

Publication number Publication date
BR112015014197B1 (pt) 2021-05-18
US9458076B2 (en) 2016-10-04
CN104918909B (zh) 2018-05-11
EA201500646A1 (ru) 2015-11-30
CN104918909A (zh) 2015-09-16
EP2935188B1 (en) 2018-08-01
JP2015537055A (ja) 2015-12-24
WO2014096106A1 (en) 2014-06-26
EP2935188A1 (en) 2015-10-28
US20150321986A1 (en) 2015-11-12
EA029733B1 (ru) 2018-05-31
JP6390048B2 (ja) 2018-09-19

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09W Correction of the decision to grant [chapter 9.1.4 patent gazette]

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B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/12/2013, OBSERVADAS AS CONDICOES LEGAIS.