EA201400634A1 - Способ получения новых антибиотиков и основанная на нём рамочная система - Google Patents

Способ получения новых антибиотиков и основанная на нём рамочная система

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Publication number
EA201400634A1
EA201400634A1 EA201400634A EA201400634A EA201400634A1 EA 201400634 A1 EA201400634 A1 EA 201400634A1 EA 201400634 A EA201400634 A EA 201400634A EA 201400634 A EA201400634 A EA 201400634A EA 201400634 A1 EA201400634 A1 EA 201400634A1
Authority
EA
Eurasian Patent Office
Prior art keywords
new antibiotics
framework system
system based
obtaining new
presented
Prior art date
Application number
EA201400634A
Other languages
English (en)
Inventor
Сяоцин Цю
Original Assignee
Протеин Дизайн Лаб, Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Протеин Дизайн Лаб, Лтд. filed Critical Протеин Дизайн Лаб, Лтд.
Publication of EA201400634A1 publication Critical patent/EA201400634A1/ru

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)

Abstract

Представлены способ получения новых антибиотиков и рамочная система, основанная на способе, относящемся к способам разработки новых лекарств. Этот способ основан на фиксированной структурной формуле: F-R, где F - это действующий участок, a R - это идентифицирующий участок. На известном уровне техники настоящее изобретение позволяет быстро разрабатывать специфичные новые антибиотики против большинства патогенных микроорганизмов и биологических клеток. Также представлена рамочная система для применения этого способа, обеспечивающая разработку новых антибиотиков в рамках эффективного оптимизированного процесса.
EA201400634A 2011-12-08 2012-12-10 Способ получения новых антибиотиков и основанная на нём рамочная система EA201400634A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201110405775 2011-12-08
PCT/CN2012/086296 WO2013083095A1 (zh) 2011-12-08 2012-12-10 一种制备新型抗生素的方法及依据该方法的平台系统

Publications (1)

Publication Number Publication Date
EA201400634A1 true EA201400634A1 (ru) 2014-12-30

Family

ID=48573572

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400634A EA201400634A1 (ru) 2011-12-08 2012-12-10 Способ получения новых антибиотиков и основанная на нём рамочная система

Country Status (21)

Country Link
US (1) US10071358B2 (ru)
EP (1) EP2789632B1 (ru)
JP (2) JP2015507471A (ru)
KR (2) KR20140104475A (ru)
CN (1) CN103159856B (ru)
AP (1) AP2014007769A0 (ru)
AU (1) AU2012349080B2 (ru)
BR (1) BR112014013735A2 (ru)
CA (1) CA2857976A1 (ru)
CO (1) CO7101191A2 (ru)
DK (1) DK2789632T3 (ru)
EA (1) EA201400634A1 (ru)
ES (1) ES2686341T3 (ru)
HK (1) HK1197247A1 (ru)
IL (1) IL232995B (ru)
IN (1) IN2014KN01420A (ru)
PH (1) PH12014501276A1 (ru)
SG (1) SG11201402990YA (ru)
TW (1) TWI557225B (ru)
WO (1) WO2013083095A1 (ru)
ZA (1) ZA201404527B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9200251B1 (en) 2011-03-31 2015-12-01 David Gordon Bermudes Bacterial methionine analogue and methionine synthesis inhibitor anticancer, antiinfective and coronary heart disease protective microcins and methods of treatment therewith
CN102747041B (zh) 2011-04-21 2014-07-16 畿晋庆三联（北京）生物技术有限公司 抗蓝藻重组抗体多肽及其基因与制备方法
CN108341869A (zh) * 2016-12-26 2018-07-31 畿晋庆三联（北京）生物技术有限公司 抗结核分枝杆菌（Mycobacterium tuberculosis）及其感染的药物及其应用
US11125750B2 (en) * 2018-06-28 2021-09-21 The University Of Toledo Methods, assays and kits for detecting exposure to cyanotoxins

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1274829C (zh) * 2004-12-10 2006-09-13 四川大学华西医院 抗eb病毒所致肿瘤多肽及其应用与制备方法
DE102007036128A1 (de) * 2007-07-23 2009-02-12 Universität Leipzig Antibiotische Peptide
CN101200727B (zh) 2007-12-21 2013-06-26 畿晋庆堂国际生物技术有限公司 抗农作物真菌多肽及其制备方法
CN101215568B (zh) * 2008-01-18 2010-06-23 畿晋庆三联（北京）生物技术有限公司 抗炭疽多肽及其应用与制备方法
CN101643501B (zh) * 2008-11-07 2012-06-20 畿晋庆三联（北京）生物技术有限公司 一种新型抗生素及其核苷酸序列、制备方法与应用
CN101633699B (zh) 2009-09-02 2012-02-15 畿晋庆堂国际生物技术有限公司 一种含抗体模拟物的新型抗生素及其制备方法与应用
CN102101888B (zh) * 2009-12-17 2013-03-20 畿晋庆三联（北京）生物技术有限公司 一种新型抗eb病毒所致肿瘤多肽及其应用与制备方法
CN102747041B (zh) 2011-04-21 2014-07-16 畿晋庆三联（北京）生物技术有限公司 抗蓝藻重组抗体多肽及其基因与制备方法

Also Published As

Publication number Publication date
KR20160130531A (ko) 2016-11-11
EP2789632A4 (en) 2015-07-22
AU2012349080B2 (en) 2016-06-02
TWI557225B (zh) 2016-11-11
EP2789632A1 (en) 2014-10-15
HK1197247A1 (en) 2015-01-09
CA2857976A1 (en) 2013-06-13
US10071358B2 (en) 2018-09-11
KR20140104475A (ko) 2014-08-28
KR101916205B1 (ko) 2018-11-08
IL232995A0 (en) 2014-07-31
NZ627116A (en) 2016-07-29
ES2686341T3 (es) 2018-10-17
CN103159856B (zh) 2015-02-25
PH12014501276A1 (en) 2014-09-08
SG11201402990YA (en) 2014-09-26
JP2015507471A (ja) 2015-03-12
WO2013083095A1 (zh) 2013-06-13
CO7101191A2 (es) 2014-10-31
IL232995B (en) 2018-01-31
EP2789632B1 (en) 2018-06-06
AU2012349080A1 (en) 2014-07-24
ZA201404527B (en) 2017-04-26
JP6412077B2 (ja) 2018-10-24
BR112014013735A2 (pt) 2017-06-13
US20140349880A1 (en) 2014-11-27
IN2014KN01420A (ru) 2015-10-23
DK2789632T3 (en) 2018-08-06
TW201331363A (zh) 2013-08-01
AP2014007769A0 (en) 2014-07-31
CN103159856A (zh) 2013-06-19
JP2017023150A (ja) 2017-02-02

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