EA201290536A1 - Улучшенный способ получения фармацевтического соединения - Google Patents

Улучшенный способ получения фармацевтического соединения

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Publication number
EA201290536A1
EA201290536A1 EA201290536A EA201290536A EA201290536A1 EA 201290536 A1 EA201290536 A1 EA 201290536A1 EA 201290536 A EA201290536 A EA 201290536A EA 201290536 A EA201290536 A EA 201290536A EA 201290536 A1 EA201290536 A1 EA 201290536A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
acetylation
obtaining
improved method
pharmaceutical compound
Prior art date
Application number
EA201290536A
Other languages
English (en)
Other versions
EA021934B1 (ru
Inventor
Марта Порч-Маккаи
Тамаш Грегор
Балаж Волк
Габор Немет
Йожеф Баркоци
Балинт Ньюлаши
Тибор Мезеи
Дьёрдь Ружич
Ангела Пандур
Эрика Силадьи
Кальман Надь
Петер Шлегель
Эникё Мольнар
Йожеф Дебрецени
Original Assignee
Эгиш Дьёдьсердьяр Ньильваношан Мюкеде Ресвеньтаршашаг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эгиш Дьёдьсердьяр Ньильваношан Мюкеде Ресвеньтаршашаг filed Critical Эгиш Дьёдьсердьяр Ньильваношан Мюкеде Ресвеньтаршашаг
Publication of EA201290536A1 publication Critical patent/EA201290536A1/ru
Publication of EA021934B1 publication Critical patent/EA021934B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Изобретение заключается в способе получения 2-ацетокси-5-(2-фтор-α-циклопропилкарбонилбензил)-4,5,6,7-тетрагидро-4Н-тиено[3,2-c]пиридина (прасугреля) формулы (I) в одной емкости путем взаимодействия 5,6,7,7а-тетрагидро-4Н-тиено[3,2-c]пиридин-2-она формулы (II) с 2-бром-1-циклопропил-2-(2-фторфенил)этаноном формулы (III) или с 2-хлор-1-циклопропил-2-(2-фторфенил)этаноном формулы (IIIa) и ацетилирования полученного соединения формулы (IV), причем реакцию выполняют в присутствии органического основания с агентом ацетилирования без выделения соединения формулы (IV). Присоединение и ацетилирование выполняют в присутствии того же органического основания, такого как триэтиламин, N,N-диизопропилэтиламин или пиридин. По завершении способа прасугрель формулы (I) очищают перекристаллизацией из органического растворителя или смеси растворителей.
EA201290536A 2009-12-21 2010-12-21 Улучшенный способ получения фармацевтического соединения EA021934B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0900795A HU229035B1 (en) 2009-12-21 2009-12-21 Process for producing prasurgel
PCT/HU2010/000148 WO2011077173A1 (en) 2009-12-21 2010-12-21 Improved process for preparing a pharmaceutical compound

Publications (2)

Publication Number Publication Date
EA201290536A1 true EA201290536A1 (ru) 2013-04-30
EA021934B1 EA021934B1 (ru) 2015-09-30

Family

ID=47597748

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290536A EA021934B1 (ru) 2009-12-21 2010-12-21 Улучшенный способ получения фармацевтического соединения

Country Status (8)

Country Link
US (1) US20130030183A1 (ru)
EP (1) EP2588483A1 (ru)
BR (1) BR112012015234A2 (ru)
EA (1) EA021934B1 (ru)
GE (1) GEP20146171B (ru)
HU (1) HU229035B1 (ru)
UA (1) UA108868C2 (ru)
WO (1) WO2011077173A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2601200A4 (en) * 2010-08-06 2014-01-08 Reddys Lab Ltd Dr PREPARATION FROM PRASUGRELHYDROCHLORIDE

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2576901B1 (fr) 1985-01-31 1987-03-20 Sanofi Sa Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique
FI101150B (fi) 1991-09-09 1998-04-30 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi
DE69526443T2 (de) 1994-10-07 2002-12-12 Ube Industries, Ltd. 2-silyloxy-tetrahydrothienopyridin, sein salz und verfahren zu seiner herstellung
RU2161282C1 (ru) 1999-05-13 2000-12-27 Багнюков Сергей Анатольевич Газовый баллончик и способ его заправки
PT1728794E (pt) * 2000-07-06 2008-07-15 Ube Industries Sal de adição maleato de derivados de hidropiridina
EP2007362B1 (en) 2006-04-04 2018-09-05 KG Acquisition LLC Oral dosage forms including an antiplatelet agent and an acid inhibitor
TWI392681B (zh) 2006-04-06 2013-04-11 Daiichi Sankyo Co Ltd 高純度普拉格雷及其酸加成鹽之製法
MX2009009413A (es) 2007-03-02 2009-09-11 Daiichi Sankyo Co Ltd Metodo para la produccion de clorhidrato de prasugrel de alta pureza.
CZ302135B6 (cs) 2007-07-09 2010-11-10 Zentiva, A. S. Zpusob výroby 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4, 5, 6, 7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu)
WO2009062044A2 (en) 2007-11-09 2009-05-14 Dr. Reddy's Laboratories Ltd. Processes for the preparation of prasugrel, and its salts and polymorphs
WO2009066326A2 (en) * 2007-11-19 2009-05-28 Msn Laboratories Limited Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts
CN101245073B (zh) 2008-03-21 2011-03-23 上海医药工业研究院 一种医药中间体及其制备方法
CN101245072B (zh) 2008-03-21 2011-03-30 上海医药工业研究院 制备普拉格雷的中间体及其制备方法
CN101250192B (zh) 2008-03-24 2010-08-11 上海医药工业研究院 5-(α-环丙基羰基-2-氟苄基)-2-氧-2,4,5,6,7,7a-六氢噻吩并[3,2-c]吡啶的制备方法
CN101250193B (zh) 2008-03-28 2010-09-08 上海医药工业研究院 2-烷氧基-5-(α-环丙基羰基-2-氟苄基)-4,5,6,7-四氢噻吩并[3,2-c]吡啶的制备方法
WO2009122440A1 (en) * 2008-03-31 2009-10-08 Torrent Pharmaceuticals Ltd. PROCESS FOR THE PREPARATION OF 2-ACETOXY-5-(α -CYCLOPRPYLCARBONYL -2-FLUOROBENZYL)-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE
US20120202066A1 (en) * 2009-10-07 2012-08-09 Manne Satyanarayana Reddy Processes For Preparing Prasugrel And Pharmaceutically Acceptable Salts Thereof
CZ2009763A3 (cs) 2009-11-16 2011-05-25 Zentiva, K. S. Zpusob výroby vysoce cistého 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu známého pod nechráneným názvem prasugrel a jeho nových farmaceuticky prijatelných solí.

Also Published As

Publication number Publication date
GEP20146171B (en) 2014-09-25
HU229035B1 (en) 2013-07-29
HUP0900795D0 (en) 2010-03-01
EA021934B1 (ru) 2015-09-30
BR112012015234A2 (pt) 2015-09-22
UA108868C2 (ru) 2015-06-25
US20130030183A1 (en) 2013-01-31
WO2011077173A1 (en) 2011-06-30
HUP0900795A2 (en) 2011-10-28
EP2588483A1 (en) 2013-05-08

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU