EA201270671A1 - Применение вторичных производных 8-оксихинолин-7-карбоксамида в качестве противогрибковых агентов - Google Patents

Применение вторичных производных 8-оксихинолин-7-карбоксамида в качестве противогрибковых агентов

Info

Publication number
EA201270671A1
EA201270671A1 EA201270671A EA201270671A EA201270671A1 EA 201270671 A1 EA201270671 A1 EA 201270671A1 EA 201270671 A EA201270671 A EA 201270671A EA 201270671 A EA201270671 A EA 201270671A EA 201270671 A1 EA201270671 A1 EA 201270671A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carboxamide
agents
oxyhinolin
antigrading
application
Prior art date
Application number
EA201270671A
Other languages
English (en)
Other versions
EA024115B1 (ru
Inventor
Стефаниа Гальярди
Симоне Дель Сордо
Федерико Майлланд
Михела Легора
Original Assignee
Полихем С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42027760&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201270671(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Полихем С.А. filed Critical Полихем С.А.
Publication of EA201270671A1 publication Critical patent/EA201270671A1/ru
Publication of EA024115B1 publication Critical patent/EA024115B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Заявленное изобретение относится к вторичным производным 8-оксихинолин-7-карбоксамида общей формулы (I) и их фармацевтически приемлемым солям, предназначенным для применения в качестве противогрибковых агентов. В частности, данные соединения прошли испытания в отношении Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger и Scoputariopsis Brevicaulis. Данные соединения активны в отношении грибков рода Candida, как например Candida Albicans и Candida Glabrata.
EA201270671A 2009-12-29 2010-12-28 Применение вторичных производных 8-оксихинолин-7-карбоксамида в качестве противогрибковых агентов EA024115B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09180899A EP2345642A1 (en) 2009-12-29 2009-12-29 Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents
PCT/EP2010/070791 WO2011080265A1 (en) 2009-12-29 2010-12-28 Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents

Publications (2)

Publication Number Publication Date
EA201270671A1 true EA201270671A1 (ru) 2012-12-28
EA024115B1 EA024115B1 (ru) 2016-08-31

Family

ID=42027760

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270671A EA024115B1 (ru) 2009-12-29 2010-12-28 Применение вторичных производных 8-оксихинолин-7-карбоксамида в качестве противогрибковых агентов

Country Status (31)

Country Link
US (1) US8969380B2 (ru)
EP (2) EP2345642A1 (ru)
JP (1) JP5755244B2 (ru)
KR (1) KR101620377B1 (ru)
CN (2) CN102712597A (ru)
AU (1) AU2010338268B2 (ru)
BR (1) BR112012015735A2 (ru)
CA (1) CA2783216A1 (ru)
CL (1) CL2012001758A1 (ru)
CY (1) CY1114862T1 (ru)
DK (1) DK2519503T3 (ru)
EA (1) EA024115B1 (ru)
ES (1) ES2442899T3 (ru)
GE (1) GEP20156301B (ru)
GT (1) GT201200215A (ru)
HK (1) HK1178522A1 (ru)
HR (1) HRP20131176T1 (ru)
IL (1) IL220428A (ru)
MA (1) MA33828B1 (ru)
MX (1) MX2012007747A (ru)
MY (1) MY162991A (ru)
NI (1) NI201200116A (ru)
NZ (1) NZ600785A (ru)
PL (1) PL2519503T3 (ru)
PT (1) PT2519503E (ru)
RS (1) RS53090B (ru)
SG (1) SG181587A1 (ru)
SI (1) SI2519503T1 (ru)
TN (1) TN2012000321A1 (ru)
UA (1) UA110102C2 (ru)
WO (1) WO2011080265A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2345641A1 (en) * 2009-12-29 2011-07-20 Polichem S.A. New secondary 8-hydroxyquinoline-7-carboxamide derivatives
EP2345643A1 (en) * 2009-12-29 2011-07-20 Polichem S.A. New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof
CN110563642A (zh) * 2019-09-30 2019-12-13 赵洁 抗真菌化合物及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE540842C (de) 1930-08-06 1931-12-28 Chinosol Fabrik Akt Ges Verfahren zur Darstellung der 8-Acetyloxychinolin-7-carbonsaeure
FR2160718A1 (en) * 1971-11-23 1973-07-06 Roussel Uclaf 7-benzyl aminomethyl-8-hydroxy quinolines - bacteriostats and fungistats
GB8419658D0 (en) * 1984-08-01 1984-09-05 Wellcome Found Nitrogen containing heterocyclic compounds
JPH01136152A (ja) * 1987-11-21 1989-05-29 Konica Corp ハロゲン化銀カラー写真感光材料
EP0927164A1 (en) 1996-09-10 1999-07-07 PHARMACIA & UPJOHN COMPANY 8-hydroxy-7-substituted quinolines as anti-viral agents
HUP0302367A2 (hu) 2000-10-12 2003-11-28 Merck & Co., Inc. HIV Integráz inhibitorokként hasznos aza- és poliazanaftalenil-karboxamidok, ezeket tartalmazó gyógyszerkészítmények
JP4287649B2 (ja) * 2000-10-12 2009-07-01 メルク エンド カムパニー インコーポレーテッド Ｈｉｖインテグラーゼ阻害薬として有用なアザ−およびポリアザ−ナフタレニルカルボキサミド類
BR0207809A (pt) 2001-03-01 2004-03-09 Shionogi & Co Compostos heteroarila contendo nitrogênio possuindo atividade inibidora contra integrase de hiv
JP4795022B2 (ja) * 2003-09-30 2011-10-19 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環化合物を含有する新規な抗真菌剤
FR2889192A1 (fr) * 2005-07-27 2007-02-02 Cytomics Systems Sa Composes antifongiques, compositions contenant ces composes et leurs utilisations
JP2009544631A (ja) * 2006-07-25 2009-12-17 エンビボ ファーマシューティカルズ インコーポレイテッド キノリン誘導体
EP2345641A1 (en) * 2009-12-29 2011-07-20 Polichem S.A. New secondary 8-hydroxyquinoline-7-carboxamide derivatives
EP2345643A1 (en) * 2009-12-29 2011-07-20 Polichem S.A. New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof

Also Published As

Publication number Publication date
SG181587A1 (en) 2012-07-30
EP2519503A1 (en) 2012-11-07
AU2010338268B2 (en) 2014-02-20
SI2519503T1 (sl) 2014-01-31
GEP20156301B (en) 2015-06-25
CN105168213A (zh) 2015-12-23
NZ600785A (en) 2013-11-29
EP2519503B1 (en) 2013-10-23
PT2519503E (pt) 2013-12-24
AU2010338268A1 (en) 2012-07-19
KR20120107506A (ko) 2012-10-02
RS53090B (en) 2014-06-30
US20120329797A1 (en) 2012-12-27
AU2010338268A2 (en) 2012-07-26
HRP20131176T1 (hr) 2014-01-17
CL2012001758A1 (es) 2013-03-22
EA024115B1 (ru) 2016-08-31
CA2783216A1 (en) 2011-07-07
MY162991A (en) 2017-07-31
BR112012015735A2 (pt) 2016-05-17
CN102712597A (zh) 2012-10-03
JP5755244B2 (ja) 2015-07-29
CY1114862T1 (el) 2016-12-14
MA33828B1 (fr) 2012-12-03
UA110102C2 (uk) 2015-11-25
TN2012000321A1 (en) 2013-12-12
GT201200215A (es) 2014-03-21
IL220428A0 (en) 2012-08-30
JP2013515756A (ja) 2013-05-09
MX2012007747A (es) 2012-08-01
PL2519503T3 (pl) 2014-04-30
US8969380B2 (en) 2015-03-03
EP2345642A1 (en) 2011-07-20
IL220428A (en) 2015-04-30
HK1178522A1 (en) 2013-09-13
NI201200116A (es) 2013-04-22
WO2011080265A1 (en) 2011-07-07
ES2442899T3 (es) 2014-02-14
KR101620377B1 (ko) 2016-05-12
DK2519503T3 (da) 2013-11-18

Similar Documents

Publication Publication Date Title
EA201270670A1 (ru) Новые третичные производные 8-оксихинолин-7-карбоксамида и их применение
EA201290191A1 (ru) N1-ПИРАЗОЛОСПИРОКЕТОНОВЫЕ ИНГИБИТОРЫ АЦЕТИЛ-KoA-КАРБОКСИЛАЗЫ
EA201101214A1 (ru) Полиеновые противогрибковые композиции
MY183312A (en) Pharmaceutical formulation
WO2013188783A8 (en) Deuterated derivatives of ruxolitinib
WO2012006313A3 (en) Herbicidal compositions and methods of use
MX2011012739A (es) Derivados fluorados de aminotriazol.
EA201500628A1 (ru) Индолкарбоксамидные производные в качестве антагонистов p2xрецепторов
EA201492091A1 (ru) Фармацевтические композиции для местного применения, содержащие тербинафид и мочевину
WO2013019093A3 (en) Novel aniline derivatives and use thereof
EA201290229A1 (ru) Производные спиролактама и их применение
EA201270671A1 (ru) Применение вторичных производных 8-оксихинолин-7-карбоксамида в качестве противогрибковых агентов
EA201270672A1 (ru) Новые вторичные производные 8-оксихинолин-7-карбоксамида
UA109804C2 (xx) 2-метоксипіридин-4-ільні похідні
WO2014049563A3 (en) Use of a combination of taurine or a derivate thereof and a grape extract for improving the quality of the nails
TR201009399A2 (tr) Hızlı çözünen efervesan rosuvastatin formülasyonları.
EA201071308A1 (ru) Фармацевтические композиции для лечения бородавок
TH127237A (th) อนุพันธ์เซคันดารี่ 8-ไฮดรอกซิควิโนลีน-7-คาร์บอกซาไมด์สำหรับการใช้เป็นสารต้านเชื้อรา
TH135147A (th) อนุพันธ์เซคันดารี่ 8-ไฮดรอกซิควิโนลีน-7-คาร์บอกซาไมด์ชนิดใหม่
TH127237B (th) อนุพันธ์เซคันดารี่ 8-ไฮดรอกซิควิโนลีน-7-คาร์บอกซาไมด์สำหรับการใช้เป็นสารต้านเชื้อรา

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU