EA201100653A1 - Лиганды, связывающиеся с интерлейкином-13 (il-13) - Google Patents
Лиганды, связывающиеся с интерлейкином-13 (il-13)Info
- Publication number
- EA201100653A1 EA201100653A1 EA201100653A EA201100653A EA201100653A1 EA 201100653 A1 EA201100653 A1 EA 201100653A1 EA 201100653 A EA201100653 A EA 201100653A EA 201100653 A EA201100653 A EA 201100653A EA 201100653 A1 EA201100653 A1 EA 201100653A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- ligands
- interlaykin
- interleukin
- disclosed
- ligands connecting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Otolaryngology (AREA)
- Plant Pathology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
Abstract
Раскрыты лиганды, имеющие специфичность связывания в отношении интерлейкина-13 (IL-13) или в отношении интерлейкина-4 (IL-4) и IL-13. Также раскрыты способы применения этих лигандов. В частности, описано применение этих лигандов для лечения IL-13-опосредованных состояний, таких как легочные состояния, например аллергическая астма. Лиганды имеют активную кинетику связывания с IL-13. Описаны лиганды, перекрестно-реактивные в отношении человеческого IL-13 и IL-13 одного или более чем одного примата. Лиганды хорошо экспрессируются в прокариотических клетках.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11801308P | 2008-11-26 | 2008-11-26 | |
PCT/EP2008/067789 WO2010060486A1 (en) | 2008-11-26 | 2008-12-17 | Ligands that bind il-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201100653A1 true EA201100653A1 (ru) | 2011-12-30 |
Family
ID=40993100
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201100653A EA201100653A1 (ru) | 2008-11-26 | 2008-12-17 | Лиганды, связывающиеся с интерлейкином-13 (il-13) |
Country Status (14)
Country | Link |
---|---|
US (1) | US20110236380A1 (ru) |
EP (1) | EP2358754A1 (ru) |
JP (1) | JP2012509658A (ru) |
KR (1) | KR20110092328A (ru) |
CN (1) | CN102292351A (ru) |
AU (1) | AU2008364461A1 (ru) |
BR (1) | BRPI0823231A2 (ru) |
CA (1) | CA2744588A1 (ru) |
EA (1) | EA201100653A1 (ru) |
IL (1) | IL212812A0 (ru) |
MX (1) | MX2011005541A (ru) |
SG (1) | SG171733A1 (ru) |
WO (1) | WO2010060486A1 (ru) |
ZA (1) | ZA201103692B (ru) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA33052B1 (fr) | 2009-02-19 | 2012-02-01 | Glaxo Group Ltd | Variants de liaison anti-albumine sérique améliorés |
AR075505A1 (es) | 2009-02-19 | 2011-04-06 | Glaxo Group Ltd | Variantes de union a anti- albumina de suero mejoradas |
US20130273055A1 (en) * | 2010-11-16 | 2013-10-17 | Eric Borges | Agents and methods for treating diseases that correlate with bcma expression |
AR090339A1 (es) * | 2012-03-27 | 2014-11-05 | Genentech Inc | Metodos de pronostico, diagnostico y tratamiento de la fibrosis pulmonar idiopatica |
CN113563478A (zh) | 2013-09-24 | 2021-10-29 | 梅迪塞纳医疗股份有限公司 | 白介素-4受体结合融合蛋白及其应用 |
KR20200051005A (ko) | 2017-09-07 | 2020-05-12 | 머크 샤프 앤드 돔 코포레이션 | 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004308494B2 (en) * | 2003-12-23 | 2010-03-18 | Genentech, Inc. | Novel anti-IL 13 antibodies and uses thereof |
GB0600488D0 (en) * | 2006-01-11 | 2006-02-22 | Glaxo Group Ltd | Immunoglobulins |
WO2009138413A1 (en) * | 2008-05-15 | 2009-11-19 | Domantis Limited | Single domain antibodies that bind il-13 |
WO2007085815A2 (en) * | 2006-01-24 | 2007-08-02 | Domantis Limited | Ligands that bind il-4 and/or il-13 |
EP2222709B1 (en) * | 2007-11-30 | 2016-11-23 | Glaxo Group Limited | Antigen-binding constructs |
TW200938222A (en) * | 2007-12-13 | 2009-09-16 | Glaxo Group Ltd | Compositions for pulmonary delivery |
-
2008
- 2008-12-17 AU AU2008364461A patent/AU2008364461A1/en not_active Abandoned
- 2008-12-17 EA EA201100653A patent/EA201100653A1/ru unknown
- 2008-12-17 JP JP2011536744A patent/JP2012509658A/ja active Pending
- 2008-12-17 CN CN2008801327564A patent/CN102292351A/zh active Pending
- 2008-12-17 MX MX2011005541A patent/MX2011005541A/es not_active Application Discontinuation
- 2008-12-17 EP EP08875473A patent/EP2358754A1/en not_active Withdrawn
- 2008-12-17 CA CA2744588A patent/CA2744588A1/en not_active Abandoned
- 2008-12-17 WO PCT/EP2008/067789 patent/WO2010060486A1/en active Application Filing
- 2008-12-17 KR KR1020117014679A patent/KR20110092328A/ko not_active Application Discontinuation
- 2008-12-17 US US13/131,438 patent/US20110236380A1/en not_active Abandoned
- 2008-12-17 SG SG2011035094A patent/SG171733A1/en unknown
- 2008-12-17 BR BRPI0823231-8A patent/BRPI0823231A2/pt not_active IP Right Cessation
-
2011
- 2011-05-11 IL IL212812A patent/IL212812A0/en unknown
- 2011-05-19 ZA ZA2011/03692A patent/ZA201103692B/en unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0823231A2 (pt) | 2015-06-16 |
US20110236380A1 (en) | 2011-09-29 |
SG171733A1 (en) | 2011-07-28 |
KR20110092328A (ko) | 2011-08-17 |
WO2010060486A1 (en) | 2010-06-03 |
MX2011005541A (es) | 2011-09-21 |
ZA201103692B (en) | 2012-10-31 |
AU2008364461A1 (en) | 2010-06-03 |
JP2012509658A (ja) | 2012-04-26 |
EP2358754A1 (en) | 2011-08-24 |
IL212812A0 (en) | 2011-07-31 |
CA2744588A1 (en) | 2010-06-03 |
CN102292351A (zh) | 2011-12-21 |
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