EA201100228A1 - Структурные варианты антител для улучшения терапевтических характеристик - Google Patents
Структурные варианты антител для улучшения терапевтических характеристикInfo
- Publication number
- EA201100228A1 EA201100228A1 EA201100228A EA201100228A EA201100228A1 EA 201100228 A1 EA201100228 A1 EA 201100228A1 EA 201100228 A EA201100228 A EA 201100228A EA 201100228 A EA201100228 A EA 201100228A EA 201100228 A1 EA201100228 A1 EA 201100228A1
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- Eurasian Patent Office
- Prior art keywords
- antibodies
- less
- improved
- antigen binding
- fusion proteins
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
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- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Настоящее изобретение предлагает замещенные гуманизированные, химерные или человеческие антитела анти-CD20 или их антигенсвязывающие фрагменты и биспецифичные антитела или слитые белки, содержащие замещенные антитела или их антигенсвязывающие фрагменты. Антитела, слитые белки или фрагменты полезны для лечения В-клеточных нарушений, таких как В-клеточные злокачественные опухоли и аутоиммунные заболевания, а также реакции "трансплантат против хозяина", отторжение трансплантата органов и гемолитическая анемия и криоглобулинемия. Аминокислотные замены, в частности замена аспартатного остатка в положении 101 Кабат из VCDR3 (CDRH3), приводят к улучшению терапевтических свойств, таких как снижение скоростей диссоциации, улучшение CDC активности, улучшение апоптоза, уменьшение количеств В-клеток и улучшение терапевтической эффективности при очень низких дозах. Велтузумаб, гуманизированное антитело анти-CD20, которое включает такие изменения последовательности, демонстрирует улучшение терапевтической эффективности по сравнению с аналогичными антителами различных CDRH3 последовательностей, что позволяет достичь терапевтического эффекта при дозах, равных 200 мг или менее, более предпочтительно 100 мг или менее, более предпочтительно 80 мг или менее, более предпочтительно 50 мг или менее, наиболее предпочтительно 30 мг или менее голого антитела при введении внутривенно или подкожно.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8239908P | 2008-07-21 | 2008-07-21 | |
PCT/US2009/051321 WO2010011697A1 (en) | 2008-07-21 | 2009-07-21 | Structural variants of antibodies for improved therapeutic characteristics |
Publications (1)
Publication Number | Publication Date |
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EA201100228A1 true EA201100228A1 (ru) | 2011-08-30 |
Family
ID=41570576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201100228A EA201100228A1 (ru) | 2008-07-21 | 2009-07-21 | Структурные варианты антител для улучшения терапевтических характеристик |
Country Status (16)
Country | Link |
---|---|
US (2) | US7919273B2 (ru) |
EP (1) | EP2318048B1 (ru) |
JP (1) | JP6049163B2 (ru) |
KR (1) | KR20110033233A (ru) |
CN (1) | CN102159243B (ru) |
AU (1) | AU2009274129B2 (ru) |
BR (1) | BRPI0917204A2 (ru) |
CA (1) | CA2731255C (ru) |
EA (1) | EA201100228A1 (ru) |
HK (1) | HK1155388A1 (ru) |
IL (1) | IL210307B (ru) |
MX (1) | MX2011000891A (ru) |
NZ (1) | NZ590330A (ru) |
UA (1) | UA108735C2 (ru) |
WO (1) | WO2010011697A1 (ru) |
ZA (1) | ZA201100013B (ru) |
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-
2009
- 2009-07-21 BR BRPI0917204A patent/BRPI0917204A2/pt not_active IP Right Cessation
- 2009-07-21 UA UAA201101684A patent/UA108735C2/uk unknown
- 2009-07-21 CN CN200980136900.6A patent/CN102159243B/zh active Active
- 2009-07-21 MX MX2011000891A patent/MX2011000891A/es active IP Right Grant
- 2009-07-21 EA EA201100228A patent/EA201100228A1/ru unknown
- 2009-07-21 US US12/506,992 patent/US7919273B2/en active Active
- 2009-07-21 EP EP09800909.5A patent/EP2318048B1/en active Active
- 2009-07-21 NZ NZ590330A patent/NZ590330A/xx unknown
- 2009-07-21 JP JP2011520147A patent/JP6049163B2/ja active Active
- 2009-07-21 AU AU2009274129A patent/AU2009274129B2/en active Active
- 2009-07-21 CA CA2731255A patent/CA2731255C/en active Active
- 2009-07-21 WO PCT/US2009/051321 patent/WO2010011697A1/en active Application Filing
- 2009-07-21 KR KR1020117001522A patent/KR20110033233A/ko active Search and Examination
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2010
- 2010-12-28 IL IL210307A patent/IL210307B/en active IP Right Grant
-
2011
- 2011-01-03 ZA ZA2011/00013A patent/ZA201100013B/en unknown
- 2011-03-01 US US13/037,784 patent/US20110236304A1/en not_active Abandoned
- 2011-09-15 HK HK11109726.9A patent/HK1155388A1/zh unknown
Also Published As
Publication number | Publication date |
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HK1155388A1 (zh) | 2012-05-18 |
IL210307B (en) | 2020-11-30 |
ZA201100013B (en) | 2011-09-28 |
AU2009274129A1 (en) | 2010-01-28 |
UA108735C2 (uk) | 2015-06-10 |
IL210307A0 (en) | 2011-03-31 |
CA2731255A1 (en) | 2010-01-28 |
CA2731255C (en) | 2018-06-05 |
KR20110033233A (ko) | 2011-03-30 |
MX2011000891A (es) | 2011-06-01 |
CN102159243A (zh) | 2011-08-17 |
US20110236304A1 (en) | 2011-09-29 |
NZ590330A (en) | 2012-08-31 |
US7919273B2 (en) | 2011-04-05 |
WO2010011697A1 (en) | 2010-01-28 |
BRPI0917204A2 (pt) | 2015-12-01 |
AU2009274129B2 (en) | 2016-02-25 |
CN102159243B (zh) | 2015-08-19 |
EP2318048A4 (en) | 2013-05-01 |
JP6049163B2 (ja) | 2016-12-21 |
EP2318048A1 (en) | 2011-05-11 |
US20100034738A1 (en) | 2010-02-11 |
JP2011528720A (ja) | 2011-11-24 |
EP2318048B1 (en) | 2019-05-29 |
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