EA201070919A1 - Цельные интравагинальные кольца, содержащие прогестерон, и способы изготовления и применения таких колец - Google Patents

Цельные интравагинальные кольца, содержащие прогестерон, и способы изготовления и применения таких колец

Info

Publication number
EA201070919A1
EA201070919A1 EA201070919A EA201070919A EA201070919A1 EA 201070919 A1 EA201070919 A1 EA 201070919A1 EA 201070919 A EA201070919 A EA 201070919A EA 201070919 A EA201070919 A EA 201070919A EA 201070919 A1 EA201070919 A1 EA 201070919A1
Authority
EA
Eurasian Patent Office
Prior art keywords
rings
methods
progesterons
manufacturing
application
Prior art date
Application number
EA201070919A
Other languages
English (en)
Other versions
EA021615B1 (ru
Inventor
Салах Ю. Ахмед
Цзясян Цао
Ану Махашабде
Дайан Д. Харрисон
Original Assignee
Тева Вимен'С Хелс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40939073&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201070919(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Тева Вимен'С Хелс, Инк. filed Critical Тева Вимен'С Хелс, Инк.
Publication of EA201070919A1 publication Critical patent/EA201070919A1/ru
Publication of EA021615B1 publication Critical patent/EA021615B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/08—Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/0001—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor characterised by the choice of material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/72—Heating or cooling
    • B29C45/7207—Heating or cooling of the moulded articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2083/00—Use of polymers having silicon, with or without sulfur, nitrogen, oxygen, or carbon only, in the main chain, as moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0035—Medical or pharmaceutical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Mechanical Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Изобретение относится к цельным интравагинальным кольцам, содержащим прогестерон, способам изготовления и применения таких колец. Интравагинальные кольца содержат прогестерон, полисилоксановый эластомер и фармацевтически приемлемый углеводород или глицериновые эфиры жирной кислоты.
EA201070919A 2008-02-04 2009-02-03 Цельное интравагинальное кольцо, содержащее прогестерон, и способ изготовления и применения такого кольца EA021615B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2611508P 2008-02-04 2008-02-04
US13945408P 2008-12-19 2008-12-19
PCT/US2009/000672 WO2009099586A2 (en) 2008-02-04 2009-02-03 Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof

Publications (2)

Publication Number Publication Date
EA201070919A1 true EA201070919A1 (ru) 2011-04-29
EA021615B1 EA021615B1 (ru) 2015-07-30

Family

ID=40939073

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201491815A EA031017B1 (ru) 2008-02-04 2009-02-03 Способ поддержания или замещения фазы жёлтого тела
EA201070919A EA021615B1 (ru) 2008-02-04 2009-02-03 Цельное интравагинальное кольцо, содержащее прогестерон, и способ изготовления и применения такого кольца

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201491815A EA031017B1 (ru) 2008-02-04 2009-02-03 Способ поддержания или замещения фазы жёлтого тела

Country Status (26)

Country Link
US (5) US8580293B2 (ru)
EP (2) EP2359807B1 (ru)
JP (2) JP5507467B2 (ru)
KR (3) KR101730517B1 (ru)
CN (2) CN102098991B (ru)
AR (1) AR070561A1 (ru)
AU (1) AU2009210779B2 (ru)
BR (1) BRPI0905946B8 (ru)
CA (2) CA3016642A1 (ru)
CL (1) CL2009000242A1 (ru)
DK (2) DK2249757T3 (ru)
EA (2) EA031017B1 (ru)
ES (2) ES2645630T3 (ru)
HR (1) HRP20171319T1 (ru)
HU (1) HUE035634T2 (ru)
IL (2) IL207376A (ru)
LT (1) LT2249757T (ru)
MX (1) MX337634B (ru)
NZ (3) NZ596844A (ru)
PL (2) PL2359807T3 (ru)
PT (2) PT2249757T (ru)
SG (2) SG187529A1 (ru)
SI (2) SI2359807T1 (ru)
TW (3) TWI655947B (ru)
WO (1) WO2009099586A2 (ru)
ZA (2) ZA201307321B (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2359807T1 (sl) 2008-02-04 2017-10-30 Ferring B.V. Monolitni intravaginalni obroč, ki vsebuje progesteron ter postopki za njegovo izdelavo in uporabo
CN103179926A (zh) * 2010-06-22 2013-06-26 特卫华妇女健康有限公司 包含抗胆碱剂的阴道内装置及其制备方法
US8580294B2 (en) 2010-10-19 2013-11-12 International Partnership For Microbicides Platinum-catalyzed intravaginal rings
EP2641602A1 (en) * 2012-03-23 2013-09-25 PregLem S.A. Method for treating gynecological diseases
JP2016508789A (ja) 2013-02-08 2016-03-24 クーファルマ アクチエボラグ 膣内避妊具および該膣内避妊具における有効成分の拡散速度を減少させる方法
CN103394128A (zh) * 2013-08-02 2013-11-20 苏州市马尔泰新材料有限公司 一种含有川芎的模具材料
CN103445892A (zh) * 2013-08-02 2013-12-18 苏州市马尔泰新材料有限公司 一种含有甲酯树脂和雌酚的阴道模具
CN103394127A (zh) * 2013-08-02 2013-11-20 苏州市马尔泰新材料有限公司 一种含有中西医药的阴道模具材料
CN103431930A (zh) * 2013-08-02 2013-12-11 苏州市马尔泰新材料有限公司 一种含有甲酯树脂的阴道模具
CN103405810A (zh) * 2013-08-02 2013-11-27 苏州市马尔泰新材料有限公司 一种含有甲基丙烯酸甲酯树脂的阴道模具
US10137031B2 (en) 2013-11-14 2018-11-27 International Partnership For Microbicides, Inc. Combination therapy intravaginal rings
DK2982352T3 (en) * 2014-06-28 2018-11-26 Laboratorios Andromaco S A CERVICALLY PESSAR CONTAINING PROGESTERON FOR EXTENDED, LONG AND CONTINUOUS RELEASE USED TO PREVENT EARLY BIRTHS
CN104546267B (zh) * 2015-01-13 2017-01-04 安徽农业大学 一种犬用宫外节育装置及其节育方法
RU2018126790A (ru) * 2015-12-21 2020-01-23 Байер Ой Способ изготовления вагинального кольца
EP3542786A1 (en) * 2018-03-21 2019-09-25 ITF Research Pharma, S.L.U. Progesterone intravaginal devices
US10918649B2 (en) 2019-06-21 2021-02-16 The Population Council, Inc. System for providing birth control
WO2021068239A1 (zh) 2019-10-12 2021-04-15 国家卫生健康委科学技术研究所 用于黄体支持的阴道缓释给药系统及其制备方法与应用
US20220186312A1 (en) * 2020-12-11 2022-06-16 Guzip Biomarkers Corporation Predictive method for assessing the success of embryo implantation

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL74665C (ru) 1949-04-07
US2863846A (en) 1950-05-04 1958-12-09 Dow Corning Organo silyl-silica filled siloxane elastomers and process for producing same
US2890188A (en) 1951-12-17 1959-06-09 Dow Corning Siloxane elastomers compounded with hydroxylated silanes
NL91756C (ru) 1953-11-19
US3022951A (en) 1957-05-14 1962-02-27 Ibm Full adder
US3545439A (en) 1968-01-04 1970-12-08 Upjohn Co Medicated devices and methods
US3948262A (en) 1969-04-01 1976-04-06 Alza Corporation Novel drug delivery device
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
IL48277A (en) 1974-10-18 1978-03-10 Schering Ag Vaginal ring
DE3040978A1 (de) 1980-10-28 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Vaginalring
US4629449A (en) 1982-07-29 1986-12-16 Alza Corporation Vaginal dispenser for dispensing beneficial hormone
US4816257A (en) 1985-09-20 1989-03-28 Research & Education Institute, Harbor-Ucla Medical Center Inc. Method for producing an in vivo environment suitable for human embryo transfer
SE8602666D0 (sv) * 1986-06-16 1986-06-16 Leo Ab Intravaginal devices
US5188835A (en) * 1986-06-16 1993-02-23 Kabi Pharmacia Ab Intravaginal devices
FR2618329B1 (fr) 1987-07-22 1997-03-28 Dow Corning Sa Procede de fabrication d'un anneau capable d'assurer la liberation d'un agent therapeutique, et anneau fabrique par ce procede
US5116619A (en) 1988-08-30 1992-05-26 Lee Roy Morgan Vaginal progesterone tablet
US5084277A (en) 1988-08-30 1992-01-28 Greco John C Vaginal progesterone tablet
DE3838815A1 (de) 1988-11-17 1990-05-23 Hoechst Ag Verfahren zum herstellen eines intravaginalen applikationssystems
US6264638B1 (en) 1989-12-07 2001-07-24 Ultrafem, Inc. Intravaginal drug delivery system and discharge collection device
US5340585A (en) * 1991-04-12 1994-08-23 University Of Southern California Method and formulations for use in treating benign gynecological disorders
US5393528A (en) 1992-05-07 1995-02-28 Staab; Robert J. Dissolvable device for contraception or delivery of medication
IT1256393B (it) 1992-11-17 1995-12-04 Inverni Della Beffa Spa Forme matriciali multistrato per il rilascio controllato di principi attivi
FI95768C (fi) 1993-06-17 1996-03-25 Leiras Oy Emättimensisäinen antosysteemi
US5543150A (en) 1993-09-15 1996-08-06 Columbia Laboratories, Inc. Method of progesterone delivery and affect thereof
US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6544546B1 (en) 1995-07-04 2003-04-08 Akzo Nobel, N.V. Ring-shaped devices
GB9522403D0 (en) 1995-11-01 1996-01-03 Hoechst Roussel Ltd Intravaginal drug delivery device
US5744463A (en) 1996-06-03 1998-04-28 Bair; Glenn O. Treatment of side effects of progestins and progesterone analogues used for birth control
US5869081A (en) * 1996-06-28 1999-02-09 The Population Council Progesterone vaginal ring for treatment of infertility
US5972372A (en) 1996-07-31 1999-10-26 The Population Council, Inc. Intravaginal rings with insertable drug-containing core
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US5985861A (en) 1996-11-04 1999-11-16 Columbia Laboratories, Inc. Progesterone for treating or reducing ischemia
US5814329A (en) 1996-11-12 1998-09-29 Polytherapeutics, Inc. Hydrophilic polystyrene graft copolymer vehicle for intravaginal administration of pharmacologically active agents
US6416778B1 (en) 1997-01-24 2002-07-09 Femmepharma Pharmaceutical preparations and methods for their regional administration
US5993856A (en) 1997-01-24 1999-11-30 Femmepharma Pharmaceutical preparations and methods for their administration
US6056972A (en) 1997-02-26 2000-05-02 Dimera, Llc Method for reducing coronary artery reactivity
ES2187024T3 (es) 1997-05-07 2003-05-16 Galen Chemicals Ltd Dispositivo intravaginales de liberacion de farmacos para la adimistracion testosterona y de precursores de testosterona.
US6197327B1 (en) * 1997-06-11 2001-03-06 Umd, Inc. Device and method for treatment of dysmenorrhea
US6039968A (en) 1997-06-24 2000-03-21 Hoechst Marion Roussel Intravaginal drug delivery device
US6245757B1 (en) 1997-10-03 2001-06-12 Research Corporation Technologies, Inc. Use of progestins to treat ischemic event
US6306914B1 (en) 1997-10-21 2001-10-23 Columbia Laboratories, Inc. Progestin therapy for maintaining amenorrhea
NZ330596A (en) 1998-06-05 2001-02-23 Dec Res Intravaginal devices allowing for increased uptake of active ingredients
EP1100669B1 (en) 1998-05-01 2005-12-21 Duramed Pharmaceuticals, Inc. Method for injection molding manufacture of controlled release devices and controlled release device
KR20010083057A (ko) 1998-06-19 2001-08-31 추후제출 항-감염 및 피임성을 갖는 의료 장치
US7001609B1 (en) 1998-10-02 2006-02-21 Regents Of The University Of Minnesota Mucosal originated drug delivery systems and animal applications
US6063395A (en) 1998-11-12 2000-05-16 Leiras Oy Drug delivery device especially for the delivery of progestins and estrogens
US6056976A (en) 1998-11-12 2000-05-02 Leiras Oy Elastomer, its preparation and use
US20050197651A1 (en) 2001-04-25 2005-09-08 Chen Hai L. Vaginal ring preparation and its application
CN1210079C (zh) 2001-04-25 2005-07-13 上海市计划生育科学研究所 阴道环制剂及其应用
JP2005503389A (ja) * 2001-08-31 2005-02-03 シエーリング オサケユイチア 薬物送達システム
AU2003208679A1 (en) 2002-02-08 2003-09-02 Advanced Animal Technology Limited Control of a biological function
AU2003226746A1 (en) * 2002-03-27 2003-10-08 Galen (Chemicals) Limited Intravaginal matrix drug delivery devices
NZ540318A (en) 2002-10-31 2007-09-28 Umd Inc Therapeutic compositions for drug delivery to and through covering epithelia
US20040089308A1 (en) 2002-11-13 2004-05-13 Welch Robert A. Cervical ring to deliver medication
FR2849380A1 (fr) 2002-12-27 2004-07-02 Ernest Loumaye NOUVELLE UTILISATION D'UN AGONISTE DU GnRH
AU2004233997C1 (en) 2003-04-29 2014-01-30 Massachusetts Institiute Of Technology Methods and devices for the sustained release of multiple drugs
US8404272B2 (en) 2003-06-26 2013-03-26 Poly-Med, Inc. Fiber-reinforced composite rings for intravaginal controlled drug delivery
US20070043332A1 (en) 2003-07-10 2007-02-22 Galen (Chemiclas) Liimited Intravaginal drug delivery devices
US20050255157A1 (en) * 2004-05-11 2005-11-17 Glenmark Pharmaceuticals Limited Sustained release, mucoadhesive vaginal pharmaceutical compositions
US7707169B2 (en) 2004-06-10 2010-04-27 Siemens Corporation Specification-based automation methods for medical content extraction, data aggregation and enrichment
EP1768625B1 (en) * 2004-07-09 2011-02-09 The Population Council, Inc. Sustained release compositions containing progesterone receptor modulators
AR043476A1 (es) 2004-09-09 2005-08-03 Dvoskin Victor Oscar Dispositivo de administracion regulada de sustancias para la insercion en una cavidad corporal y procedimiento para fabricar un medio de soporte de dichas sustancias
US7517914B2 (en) 2005-04-04 2009-04-14 Boston Scientificscimed, Inc. Controlled degradation materials for therapeutic agent delivery
US8399012B2 (en) 2006-04-17 2013-03-19 Kimberly-Clark Worldwide, Inc. Degradable therapeutic delivery device
US8377994B2 (en) 2006-05-10 2013-02-19 Evonik Degussa GmeH Use of roll compacted pyrogenically produced silicon dioxide in pharmaceutical compositions
US8828981B2 (en) 2007-02-06 2014-09-09 George Creasy Progesterone for the treatment or prevention of spontaneous preterm birth
US20080214512A1 (en) 2007-03-01 2008-09-04 Christian Seitz Pharmaceutical preparation containing a gestagen, and kit and method for treating endometriosis using the preparation
BRPI0809164B8 (pt) 2007-03-22 2023-02-28 Berg Llc Composição para administração tópica e composição farmacêutica compreendendo a referida composição
WO2008140794A1 (en) 2007-05-11 2008-11-20 The Texas A & M University System Hormone normalization therapy and uses thereof
SI2359807T1 (sl) 2008-02-04 2017-10-30 Ferring B.V. Monolitni intravaginalni obroč, ki vsebuje progesteron ter postopki za njegovo izdelavo in uporabo

Also Published As

Publication number Publication date
SG10201605171QA (en) 2016-08-30
DK2249757T3 (en) 2017-10-16
ZA201307320B (en) 2017-03-29
US20160279147A1 (en) 2016-09-29
KR20140048321A (ko) 2014-04-23
KR101730517B1 (ko) 2017-04-26
HRP20171319T1 (hr) 2017-10-20
US11413294B2 (en) 2022-08-16
MX2010008545A (es) 2010-12-20
US20140030311A1 (en) 2014-01-30
PT2359807T (pt) 2017-11-07
TWI599359B (zh) 2017-09-21
AU2009210779A1 (en) 2009-08-13
BRPI0905946B8 (pt) 2021-05-25
JP5507467B2 (ja) 2014-05-28
CN102098991B (zh) 2014-10-22
KR20160055980A (ko) 2016-05-18
PT2249757T (pt) 2017-11-15
ZA201307321B (en) 2017-09-27
WO2009099586A2 (en) 2009-08-13
SI2359807T1 (sl) 2017-10-30
CA2713943A1 (en) 2009-08-13
KR20100133969A (ko) 2010-12-22
IL207376A0 (en) 2010-12-30
SG187529A1 (en) 2013-02-28
JP2014167001A (ja) 2014-09-11
US8580293B2 (en) 2013-11-12
NZ587758A (en) 2012-05-25
US20200405732A1 (en) 2020-12-31
EP2249757B1 (en) 2017-08-09
US20230158044A1 (en) 2023-05-25
PL2359807T3 (pl) 2017-12-29
EA021615B1 (ru) 2015-07-30
LT2249757T (lt) 2017-09-25
CN104146948B (zh) 2018-01-02
BRPI0905946B1 (pt) 2020-09-29
CN104146948A (zh) 2014-11-19
PL2249757T3 (pl) 2017-12-29
CN102098991A (zh) 2011-06-15
AR070561A1 (es) 2010-04-21
EP2359807B1 (en) 2017-07-26
TWI549681B (zh) 2016-09-21
EP2249757A4 (en) 2011-07-20
BRPI0905946A2 (pt) 2015-06-30
TWI655947B (zh) 2019-04-11
US20090202612A1 (en) 2009-08-13
ES2645630T3 (es) 2017-12-07
EA201491815A1 (ru) 2015-03-31
CL2009000242A1 (es) 2010-01-04
JP6124411B2 (ja) 2017-05-10
NZ611268A (en) 2015-03-27
CA2713943C (en) 2018-10-23
IL207376A (en) 2012-09-24
SI2249757T1 (sl) 2017-10-30
US10548904B2 (en) 2020-02-04
MX337634B (es) 2016-03-14
JP2011510984A (ja) 2011-04-07
EP2249757A2 (en) 2010-11-17
TW200938204A (en) 2009-09-16
US10537584B2 (en) 2020-01-21
DK2359807T3 (en) 2017-10-16
HUE035634T2 (en) 2018-05-28
ES2648640T3 (es) 2018-01-04
EA031017B1 (ru) 2018-11-30
IL221988A (en) 2015-03-31
AU2009210779B2 (en) 2015-04-02
TW201526898A (zh) 2015-07-16
TW201630610A (zh) 2016-09-01
CA3016642A1 (en) 2009-08-13
EP2359807A1 (en) 2011-08-24
WO2009099586A3 (en) 2010-01-14
NZ596844A (en) 2014-03-28

Similar Documents

Publication Publication Date Title
EA201070919A1 (ru) Цельные интравагинальные кольца, содержащие прогестерон, и способы изготовления и применения таких колец
CY1123549T1 (el) Σταθερη φαρμακευτικη συνθεση και μεθοδοι χρησης αυτης
NI201200174A (es) Derivados de carbamato de hexafluoroisopropilo, su preparación y su aplicación en terapéutica.
EA201290988A1 (ru) Стереоселективный синтез фосфорсодержащих активных соединений
HN2012001223A (es) Antagonistas de pcsk 9
WO2011106322A3 (en) Biomarkers for acute ischemic stroke
CL2013000063A1 (es) Un método para tratar a un sujeto que comprende administrar n-etil-n-fenil1,2-dihidroxi-4-hodroxi-5-cloro-1-metil-2-oxoquinolina-3-carboxamida opcionalmente deuterada, para el tratamiento de una enfermedad autoinmunitaria; una mezcla de los mismos; composición farmaceutica y su proceso de preparacion.
MA34818B1 (fr) Anticorps anti-pcsk9 et procédés d'utilisation
ECSP12011793A (es) Nuevos compuestos eficaces como inhibidores de la xantina-oxidasa, método para la preparación de los mismos y composición farmacéutica que los contiene
UY32049A (es) Inhibidores de cmet
AR081678A1 (es) Metodos y composiciones para administracion intratecal de arisulfatasa a
EA201270590A1 (ru) Ингибиторы акт
MX2013006875A (es) Anticuepos anti-notch1.
EA201170356A1 (ru) Полиморфные и аморфные формы лакозамида и аморфные композиции
EA201600495A1 (ru) Пролекарство адреномедуллина на основе полиэтиленгликоля и его применение
EA201390660A1 (ru) Модифицированные никотиновые соединения и связанные способы
EA201201296A1 (ru) Способы лечения диабетических язв стопы
UA102097C2 (ru) Способ лечения воспалительного заболевания с применением соединения, которое нейтрализует gm-csf, и соединения, которое нейтрализует il-17
EA201500270A1 (ru) Фторметилзамещенные пирролкарбоксамиды
CL2014002318A1 (es) Procedimiento para la separación de ésteres de alquilo (divisional de solicitud n° 1387-2010)
WO2011136493A3 (ko) 치열교정용 구개고정구
UA110332C2 (en) Use of 2,3-dihydroxypropyldodecanoate for treatment of seborrhea
UY31335A1 (es) Tratamiento de sintomas vasomotores
CL2012003202A1 (es) Metodo para tratar una infeccion gastrointestinal recurrente de clostridium difficile, que comprende la administracion de fidaxomicina y donde el sujeto ha sido sometido a un tratamiento previo para combatir dicha infeccion.
WO2011079188A3 (en) Protein modification from the oxidation of clickable polyunsaturated fatty acid analogs

Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment