EA201070687A1 - Способ ингибирования лейкозных стволовых клеток - Google Patents
Способ ингибирования лейкозных стволовых клетокInfo
- Publication number
- EA201070687A1 EA201070687A1 EA201070687A EA201070687A EA201070687A1 EA 201070687 A1 EA201070687 A1 EA 201070687A1 EA 201070687 A EA201070687 A EA 201070687A EA 201070687 A EA201070687 A EA 201070687A EA 201070687 A1 EA201070687 A1 EA 201070687A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- stem cells
- inhibiting
- binding molecule
- antigen
- leukine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
Предложен способ ингибирования лейкозных стволовых клеток, экспрессирующих IL-3Rα (CD123), включающий контакт клеток с антигенсвязывающей молекулой, содержащей Fc область или модифицированную Fc область, имеющую усиленную Fc эффекторную функцию, причем антигенсвязывающая молекула связывается селективно с IL-3Rα (CD123). Изобретение включает лечение гематологического ракового состояния у пациента путем введения эффективного количества антигенсвязывающей молекулы.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99681907P | 2007-12-06 | 2007-12-06 | |
PCT/AU2008/001797 WO2009070844A1 (en) | 2007-12-06 | 2008-12-04 | Method of inhibition of leukemic stem cells |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201070687A1 true EA201070687A1 (ru) | 2010-12-30 |
Family
ID=40717202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201070687A EA201070687A1 (ru) | 2007-12-06 | 2008-12-04 | Способ ингибирования лейкозных стволовых клеток |
Country Status (13)
Country | Link |
---|---|
US (6) | US20110052574A1 (ru) |
EP (1) | EP2231187A4 (ru) |
JP (1) | JP2011505386A (ru) |
KR (1) | KR20100094527A (ru) |
CN (1) | CN101896200A (ru) |
AU (1) | AU2008331436A1 (ru) |
BR (1) | BRPI0819887A2 (ru) |
CA (1) | CA2706337A1 (ru) |
EA (1) | EA201070687A1 (ru) |
IL (1) | IL205951A0 (ru) |
MX (1) | MX2010006213A (ru) |
WO (1) | WO2009070844A1 (ru) |
ZA (1) | ZA201003515B (ru) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100209341A1 (en) | 2009-02-18 | 2010-08-19 | Csl Limited | Treatment of chronic inflammatory conditions |
CA2764432C (en) * | 2009-04-27 | 2017-10-24 | Kyowa Hakko Kirin Co., Ltd. | Interleukin-3 receptor alpha chain-binding antibody to treat leukemia |
AU2010302961A1 (en) * | 2009-10-01 | 2012-04-19 | Csl Limited | Method of treatment of philadelphia chromosome positive leukaemia |
EP2332994A1 (en) * | 2009-12-09 | 2011-06-15 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Trispecific therapeutics against acute myeloid leukaemia |
KR101842907B1 (ko) * | 2010-02-17 | 2018-03-28 | 씨에스엘 리미티드 | 제 ⅰ형 인터페론을 생산하는 세포를 표적화하기 위한 조성물 및 방법 |
AU2013200910B2 (en) * | 2010-02-17 | 2015-06-11 | Csl Limited | Composition and methods for targeting type 1 interferon producing cells |
CA2789515A1 (en) * | 2010-02-18 | 2010-08-26 | Csl Limited | Treatment of chronic inflammatory conditions |
ES2530977T3 (es) | 2010-06-15 | 2015-03-09 | Csl Ltd | Método inmunoterapéutico que implica a unos anticuerpos contra el CD123 (IL-3R) y a un complejo inmunoestimulante |
AU2012202125B2 (en) * | 2010-08-17 | 2015-03-19 | Csl Limited | Humanized Anti-Interleukin 3 Receptor Alpha Chain Antibodies |
NZ604510A (en) * | 2010-08-17 | 2013-10-25 | Csl Ltd | Dilutable biocidal compositions and methods of use |
AU2011253598B1 (en) * | 2010-08-17 | 2012-01-19 | Csl Limited | Humanized anti-interleukin 3 receptor alpha chain antibodies |
AU2013270674B2 (en) * | 2012-06-07 | 2017-12-07 | Children's Hospital Los Angeles | Methods for treating neutropenia using retinoid agonists |
UY35340A (es) | 2013-02-20 | 2014-09-30 | Novartis Ag | Marcaje efectivo de leucemia humana usando células diseñadas con un receptor quimérico de antígeno anti-cd123 |
WO2014138805A1 (en) * | 2013-03-14 | 2014-09-18 | Csl Limited | Anti il-3r alpha agents and uses thereof |
CN103740639A (zh) * | 2013-09-02 | 2014-04-23 | 北京大学人民医院 | 构建人源化Ph染色体阳性急性淋巴细胞白血病小鼠模型的方法 |
MX2016010699A (es) | 2014-02-18 | 2017-10-11 | Children's Hospital Los Angeles | Composiciones y metodos para tratar neutropenia. |
JP7084138B2 (ja) | 2014-08-19 | 2022-06-14 | ノバルティス アーゲー | 癌処置に使用するための抗cd123キメラ抗原受容体(car) |
KR20160111672A (ko) * | 2015-03-17 | 2016-09-27 | 한밭대학교 산학협력단 | 규칙적으로 배열된 미세 부호를 포함하는 인쇄물에 대한 구동 시스템,방법 및 그 제작 방법 |
JP2018513856A (ja) * | 2015-04-08 | 2018-05-31 | ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. | Cd123に結合する抗体治療剤 |
TW201709932A (zh) * | 2015-06-12 | 2017-03-16 | 西雅圖遺傳學公司 | Cd123抗體及其共軛物 |
US20180320136A1 (en) * | 2015-11-03 | 2018-11-08 | GlycoMimitics, Inc. | Methods and compositions for the production of monoclonal antibodies, hematopoietic stem cells, and methods of using the same |
KR20180123047A (ko) | 2016-03-24 | 2018-11-14 | 바이엘 파마 악티엔게젤샤프트 | 효소적으로 절단가능한 기를 갖는 세포독성 활성제의 전구약물 |
EP3919518A1 (en) | 2016-06-15 | 2021-12-08 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
CN107840889A (zh) * | 2016-09-19 | 2018-03-27 | 上海吉倍生物技术有限公司 | 高亲和力的抗cd123抗体及其应用 |
EP3558387B1 (de) | 2016-12-21 | 2021-10-20 | Bayer Pharma Aktiengesellschaft | Spezifische antikörper-wirkstoff-konjugate (adcs) mit ksp-inhibitoren |
PE20191235A1 (es) | 2016-12-21 | 2019-09-11 | Bayer Pharma AG | Conjugados de ligando-farmaco (adcs) con grupos escindibles enzimaticamente |
CN110312533B (zh) | 2016-12-21 | 2023-11-03 | 拜耳公司 | 具有酶促可裂解的基团的细胞毒性活性剂的前药 |
JP2021512103A (ja) | 2018-01-31 | 2021-05-13 | バイエル アクチェンゲゼルシャフトBayer Aktiengesellschaft | Nampt阻害剤を含む抗体薬物複合体(adcs) |
WO2021013693A1 (en) | 2019-07-23 | 2021-01-28 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (adcs) with nampt inhibitors |
CN112042597B (zh) * | 2020-07-22 | 2022-04-29 | 南京普恩瑞生物科技有限公司 | 一种双人源化肿瘤异种移植模型的构建方法 |
CN111920802B (zh) * | 2020-09-11 | 2024-01-23 | 华侨大学 | 穿心莲内酯在制备防治成人t细胞白血病药物的应用 |
MX2023007901A (es) | 2020-12-31 | 2023-07-11 | Sanofi Sa | Acopladores de celulas asesinas naturales (nk) multifuncionales que se unen a nkp46 y a cd123. |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6177078B1 (en) * | 1995-12-29 | 2001-01-23 | Medvet Science Pty Limited | Monoclonal antibody antagonists to IL-3 |
EP1263463B1 (en) * | 2000-03-06 | 2011-05-25 | University of Kentucky Research Foundation | Use of an antibody or an immunotoxin that selectively binds to cd123 to impair hematologic cancer progenitor cells |
DK2345671T3 (en) * | 2002-09-27 | 2016-02-15 | Xencor Inc | Optimized Fc variants and methods for their formation |
US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
WO2008127735A1 (en) * | 2007-04-13 | 2008-10-23 | Stemline Therapeutics, Inc. | Il3ralpha antibody conjugates and uses thereof |
-
2008
- 2008-12-04 EA EA201070687A patent/EA201070687A1/ru unknown
- 2008-12-04 CA CA2706337A patent/CA2706337A1/en not_active Abandoned
- 2008-12-04 JP JP2010536288A patent/JP2011505386A/ja not_active Abandoned
- 2008-12-04 US US12/745,607 patent/US20110052574A1/en not_active Abandoned
- 2008-12-04 MX MX2010006213A patent/MX2010006213A/es not_active Application Discontinuation
- 2008-12-04 EP EP08855750A patent/EP2231187A4/en not_active Withdrawn
- 2008-12-04 AU AU2008331436A patent/AU2008331436A1/en not_active Abandoned
- 2008-12-04 KR KR1020107013653A patent/KR20100094527A/ko not_active Application Discontinuation
- 2008-12-04 BR BRPI0819887A patent/BRPI0819887A2/pt not_active IP Right Cessation
- 2008-12-04 WO PCT/AU2008/001797 patent/WO2009070844A1/en active Application Filing
- 2008-12-04 CN CN2008801197128A patent/CN101896200A/zh active Pending
-
2010
- 2010-05-18 ZA ZA2010/03515A patent/ZA201003515B/en unknown
- 2010-05-25 IL IL205951A patent/IL205951A0/en unknown
-
2012
- 2012-12-04 US US13/693,326 patent/US20130230510A1/en not_active Abandoned
-
2014
- 2014-11-25 US US14/552,789 patent/US20150152185A1/en not_active Abandoned
-
2016
- 2016-08-10 US US15/233,260 patent/US20170029515A1/en not_active Abandoned
-
2017
- 2017-05-05 US US15/587,618 patent/US20180079818A1/en not_active Abandoned
-
2019
- 2019-07-19 US US16/517,114 patent/US20200207861A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL205951A0 (en) | 2010-11-30 |
JP2011505386A (ja) | 2011-02-24 |
AU2008331436A1 (en) | 2009-06-11 |
WO2009070844A1 (en) | 2009-06-11 |
US20180079818A1 (en) | 2018-03-22 |
CN101896200A (zh) | 2010-11-24 |
ZA201003515B (en) | 2011-08-31 |
US20150152185A1 (en) | 2015-06-04 |
KR20100094527A (ko) | 2010-08-26 |
US20110052574A1 (en) | 2011-03-03 |
US20200207861A1 (en) | 2020-07-02 |
MX2010006213A (es) | 2010-09-07 |
US20170029515A1 (en) | 2017-02-02 |
EP2231187A1 (en) | 2010-09-29 |
EP2231187A4 (en) | 2013-02-20 |
US20130230510A1 (en) | 2013-09-05 |
CA2706337A1 (en) | 2009-06-11 |
BRPI0819887A2 (pt) | 2017-05-23 |
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