NO20090069L - Malrettede forbindelser rettet mot binding til PDGFR-alfa og deres anvendelse - Google Patents
Malrettede forbindelser rettet mot binding til PDGFR-alfa og deres anvendelseInfo
- Publication number
- NO20090069L NO20090069L NO20090069A NO20090069A NO20090069L NO 20090069 L NO20090069 L NO 20090069L NO 20090069 A NO20090069 A NO 20090069A NO 20090069 A NO20090069 A NO 20090069A NO 20090069 L NO20090069 L NO 20090069L
- Authority
- NO
- Norway
- Prior art keywords
- alpha
- pdgfr
- antibodies
- targeted
- compounds targeting
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Målrettede bindemidler mot antigenet PDGFR-alfa og bruk av slike midler er beskrevet her. Mer spesifikt angår oppfinnelsen hele humane monoklonale antistoffer målrettet mot antigenet PDGFR-alfa, og bruk av disse antistoffene. Aspekter ifølge oppfinnelsen angår også hybridomer eller andre cellelinjer som uttrykker slike antistoffer. De beskrevne målrettede bindemidlene og antistoffene er anvendelige som diagnostikk og til behandling av sykdommer forbundet med aktiviteten og/eller overekspresjon av PDGFR-alfa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83564706P | 2006-08-03 | 2006-08-03 | |
PCT/US2007/075117 WO2008112003A2 (en) | 2006-08-03 | 2007-08-02 | Targeted binding agents directed to pdgfr-alpha and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20090069L true NO20090069L (no) | 2009-02-25 |
Family
ID=39146823
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20090069A NO20090069L (no) | 2006-08-03 | 2009-01-06 | Malrettede forbindelser rettet mot binding til PDGFR-alfa og deres anvendelse |
Country Status (24)
Country | Link |
---|---|
US (3) | US20090324601A1 (no) |
EP (3) | EP2049571B1 (no) |
JP (1) | JP5437804B2 (no) |
KR (1) | KR101531422B1 (no) |
CN (2) | CN103588881A (no) |
AR (1) | AR062268A1 (no) |
AU (1) | AU2007348940B2 (no) |
BR (1) | BRPI0715223A2 (no) |
CA (1) | CA2657898A1 (no) |
CL (1) | CL2007002225A1 (no) |
DK (1) | DK2049571T3 (no) |
ES (1) | ES2402380T3 (no) |
HK (1) | HK1128481A1 (no) |
IL (2) | IL196209A (no) |
MX (2) | MX2009001021A (no) |
NO (1) | NO20090069L (no) |
NZ (2) | NZ596381A (no) |
PL (1) | PL2049571T3 (no) |
PT (1) | PT2049571E (no) |
SI (1) | SI2049571T1 (no) |
TW (1) | TWI503329B (no) |
UY (1) | UY30525A1 (no) |
WO (1) | WO2008112003A2 (no) |
ZA (1) | ZA200900461B (no) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CL2007002225A1 (es) * | 2006-08-03 | 2008-04-18 | Astrazeneca Ab | Agente de union especifico para un receptor del factor de crecimiento derivado de plaquetas (pdgfr-alfa); molecula de acido nucleico que lo codifica; vector y celula huesped que la comprenden; conjugado que comprende al agente; y uso del agente de un |
WO2008144345A2 (en) * | 2007-05-17 | 2008-11-27 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators |
EP2257571B1 (en) | 2008-03-10 | 2015-03-04 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of cytomegalovirus infections |
JP2013177317A (ja) * | 2010-06-24 | 2013-09-09 | Meneki Seibutsu Kenkyusho:Kk | 抗pdgf受容体抗体 |
BR112012033457A2 (pt) * | 2010-07-02 | 2017-04-04 | Medimmune Llc | formulações de anticorpo. |
WO2012106281A2 (en) | 2011-01-31 | 2012-08-09 | The General Hospital Corporation | Multimodal trail molecules and uses in cellular therapies |
WO2013061083A2 (en) * | 2011-10-28 | 2013-05-02 | Fredax Ab | Therapeutic agents and uses thereof |
SG11201404354UA (en) * | 2012-02-17 | 2014-10-30 | Seattle Genetics Inc | ANTIBODIES TO INTEGRIN αVβ6 AND USE OF SAME TO TREAT CANCER |
NZ700274A (en) | 2012-04-24 | 2016-10-28 | Thrombogenics Nv | Anti-pdgf-c antibodies |
EP2877572B1 (en) | 2012-07-24 | 2018-11-28 | The General Hospital Corporation | Oncolytic virus therapy for resistant tumors |
US9605074B2 (en) * | 2012-08-30 | 2017-03-28 | The General Hospital Corporation | Multifunctional nanobodies for treating cancer |
BR112015010722A2 (pt) * | 2012-11-09 | 2017-08-22 | Pfizer | Anticorpos específicos de fator de crescimento derivado de plaquetas de isoforma b e composições e usos dos mesmos |
GB201318793D0 (en) * | 2013-10-24 | 2013-12-11 | Plaquetec Ltd | Vascular Biomarkers |
PT3071595T (pt) | 2013-11-19 | 2019-06-11 | Fredax Ab | Anticorpo anti calicreína-2 humanizado |
UA124379C2 (uk) * | 2015-08-11 | 2021-09-08 | Усі Байолоджікс Айрленд Лімітед | Нові антитіла проти білка pd-1 |
CN109134655B (zh) * | 2018-11-28 | 2019-02-26 | 上海复宏汉霖生物技术股份有限公司 | 一种抗PDGFRα的单克隆抗体及其制备方法和应用 |
KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
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