EA201070245A1 - НОВЫЕ ИНГИБИТОРЫ γ-СЕКРЕТАЗЫ - Google Patents

НОВЫЕ ИНГИБИТОРЫ γ-СЕКРЕТАЗЫ

Info

Publication number
EA201070245A1
EA201070245A1 EA201070245A EA201070245A EA201070245A1 EA 201070245 A1 EA201070245 A1 EA 201070245A1 EA 201070245 A EA201070245 A EA 201070245A EA 201070245 A EA201070245 A EA 201070245A EA 201070245 A1 EA201070245 A1 EA 201070245A1
Authority
EA
Eurasian Patent Office
Prior art keywords
straight
carbon atoms
alkyl group
branched alkyl
phenyl
Prior art date
Application number
EA201070245A
Other languages
English (en)
Other versions
EA017495B1 (ru
Inventor
Ацухиро Абе
Хидеаки Симизу
Сейго Савада
Хироси Кодайра
Original Assignee
Кабусики Кайся Якулт Хонса
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кабусики Кайся Якулт Хонса filed Critical Кабусики Кайся Якулт Хонса
Publication of EA201070245A1 publication Critical patent/EA201070245A1/ru
Publication of EA017495B1 publication Critical patent/EA017495B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к новому соединению, которое обладает превосходным действием, направленным на ингибирование γ-секретазы и специфическое ингибирование продуцирования Аβ. Настоящее изобретение относится к соединению указанной ниже формулы (1) или к его фармацевтически приемлемой солигде Rпредставляет собой прямую или разветвленную алкильную группу, имеющую от 1 до 4 атомов углерода, или фенильную группу; Rпредставляет собой прямую или разветвленную алкильную группу, имеющую от 1 до 4 атомов углерода, которая может быть замещена одной или несколькими фенильными или галогенфенильными группами; Rпредставляет собой прямую или разветвленную алкильную группу, имеющую от 1 до 4 атомов углерода, которая может быть замещена одной или несколькими гидроксильными группами; Rпредставляет собой прямую или разветвленную алкильную группу, имеющую от 1 до 4 атомов углерода; и символ «*» означает хиральный центр.
EA201070245A 2007-08-09 2008-07-01 ИНГИБИТОРЫ γ-СЕКРЕТАЗЫ EA017495B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007207521 2007-08-09
PCT/JP2008/001728 WO2009019815A1 (ja) 2007-08-09 2008-07-01 新規γセクレターゼ阻害剤

Publications (2)

Publication Number Publication Date
EA201070245A1 true EA201070245A1 (ru) 2010-10-29
EA017495B1 EA017495B1 (ru) 2012-12-28

Family

ID=40341060

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070245A EA017495B1 (ru) 2007-08-09 2008-07-01 ИНГИБИТОРЫ γ-СЕКРЕТАЗЫ

Country Status (8)

Country Link
US (1) US8501813B2 (ru)
EP (1) EP2177529B1 (ru)
JP (1) JP5374370B2 (ru)
KR (1) KR20100045458A (ru)
CN (1) CN101970458B (ru)
CA (1) CA2695877A1 (ru)
EA (1) EA017495B1 (ru)
WO (1) WO2009019815A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ594561A (en) * 2009-03-19 2013-03-28 Bristol Myers Squibb Co A novel alpha-(n-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
CN106414718A (zh) 2013-06-11 2017-02-15 哈佛学院校长同事会 SC-β细胞以及用于产生其的组合物和方法
JP2016204397A (ja) * 2016-09-14 2016-12-08 国立大学法人京都大学 アルツハイマー病予防薬
AU2019320072A1 (en) 2018-08-10 2021-02-25 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
IL311636A (en) 2021-11-01 2024-05-01 Vertex Pharma Differentiation of stem cell-derived pancreatic islets

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040121947A1 (en) 2000-12-28 2004-06-24 Oklahoma Medical Research Foundation Compounds which inhibit beta-secretase activity and methods of use thereof
EP1404718A2 (en) * 2000-12-28 2004-04-07 Oklahoma Medical Research Foundation Inhibitors of memapsin 2 and use thereof
JP4547152B2 (ja) 2001-10-23 2010-09-22 オクラホマ メディカル リサーチ ファウンデーション β−セクレターゼ阻害剤および使用方法
AU2003235283A1 (en) 2002-04-24 2003-11-10 Hiroshi Mori Gamma-secretase inhibitors

Also Published As

Publication number Publication date
CN101970458B (zh) 2013-08-28
EP2177529A4 (en) 2011-04-20
US20110071224A1 (en) 2011-03-24
KR20100045458A (ko) 2010-05-03
CA2695877A1 (en) 2009-02-12
CN101970458A (zh) 2011-02-09
US8501813B2 (en) 2013-08-06
EA017495B1 (ru) 2012-12-28
JPWO2009019815A1 (ja) 2010-10-28
EP2177529A1 (en) 2010-04-21
JP5374370B2 (ja) 2013-12-25
WO2009019815A1 (ja) 2009-02-12
EP2177529B1 (en) 2013-03-27

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU