EA201001408A1 - Производные пиразинона как стимуляторы секреции инсулина, способы их получения и их применение для лечения диабетов - Google Patents
Производные пиразинона как стимуляторы секреции инсулина, способы их получения и их применение для лечения диабетовInfo
- Publication number
- EA201001408A1 EA201001408A1 EA201001408A EA201001408A EA201001408A1 EA 201001408 A1 EA201001408 A1 EA 201001408A1 EA 201001408 A EA201001408 A EA 201001408A EA 201001408 A EA201001408 A EA 201001408A EA 201001408 A1 EA201001408 A1 EA 201001408A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- insulin secretion
- pyrazinon
- methods
- receiving
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Настоящее изобретение относится к производным пиразинона формулы (I)где n, R1, R2, R3 и R4 являются такими, как определено в п.1, как стимуляторам секреции инсулина. Изобретение также относится к получению и применению этих производных пиразинона для профилактики и/или лечения диабетов и связанных патологий.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08004193 | 2008-03-05 | ||
PCT/EP2009/000213 WO2009109259A1 (en) | 2008-03-05 | 2009-01-15 | Pyrazinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201001408A1 true EA201001408A1 (ru) | 2011-06-30 |
EA021325B1 EA021325B1 (ru) | 2015-05-29 |
Family
ID=40565210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201001408A EA021325B1 (ru) | 2008-03-05 | 2009-01-15 | Производные пиразинона как стимуляторы секреции инсулина, способы их получения и их применение для лечения диабетов |
Country Status (18)
Country | Link |
---|---|
US (2) | US8637522B2 (ru) |
EP (1) | EP2250156B1 (ru) |
JP (1) | JP5530370B2 (ru) |
KR (1) | KR101637381B1 (ru) |
CN (1) | CN101945858B (ru) |
AR (1) | AR070798A1 (ru) |
AU (1) | AU2009221328B2 (ru) |
BR (1) | BRPI0908544A2 (ru) |
CA (1) | CA2717753C (ru) |
DK (1) | DK2250156T3 (ru) |
EA (1) | EA021325B1 (ru) |
ES (1) | ES2543598T3 (ru) |
HU (1) | HUE025132T2 (ru) |
IL (1) | IL207719A (ru) |
MX (1) | MX2010009575A (ru) |
PT (1) | PT2250156E (ru) |
WO (1) | WO2009109259A1 (ru) |
ZA (1) | ZA201007060B (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
CN102260268B (zh) * | 2011-06-19 | 2013-04-03 | 漆又毛 | 苄硫基乙酰胺基乙酰吡嗪三唑衍生物及制备与应用 |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH609989A5 (en) * | 1974-06-21 | 1979-03-30 | Hoffmann La Roche | Process for the preparation of acyl derivatives |
EP0008864A1 (en) * | 1978-08-15 | 1980-03-19 | FISONS plc | Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them |
EP0927171B1 (en) | 1996-09-16 | 2002-02-20 | Du Pont Pharmaceuticals Company | Pyrazinones and triazinones and their derivatives thereof |
CA2626220A1 (en) * | 2005-12-21 | 2007-06-28 | Janssen Pharmaceutica N.V. | Novel substituted pyrazinone derivatives for use in mch-1 mediated diseases |
US20090011994A1 (en) * | 2007-07-06 | 2009-01-08 | Bristol-Myers Squibb Company | Non-basic melanin concentrating hormone receptor-1 antagonists and methods |
-
2009
- 2009-01-15 CA CA2717753A patent/CA2717753C/en active Active
- 2009-01-15 KR KR1020107022241A patent/KR101637381B1/ko active IP Right Grant
- 2009-01-15 MX MX2010009575A patent/MX2010009575A/es active IP Right Grant
- 2009-01-15 PT PT97182042T patent/PT2250156E/pt unknown
- 2009-01-15 US US12/920,932 patent/US8637522B2/en active Active
- 2009-01-15 CN CN200980105290.3A patent/CN101945858B/zh active Active
- 2009-01-15 BR BRPI0908544A patent/BRPI0908544A2/pt not_active Application Discontinuation
- 2009-01-15 ES ES09718204.2T patent/ES2543598T3/es active Active
- 2009-01-15 AU AU2009221328A patent/AU2009221328B2/en active Active
- 2009-01-15 WO PCT/EP2009/000213 patent/WO2009109259A1/en active Application Filing
- 2009-01-15 EA EA201001408A patent/EA021325B1/ru not_active IP Right Cessation
- 2009-01-15 EP EP20090718204 patent/EP2250156B1/en active Active
- 2009-01-15 JP JP2010549025A patent/JP5530370B2/ja active Active
- 2009-01-15 HU HUE09718204A patent/HUE025132T2/en unknown
- 2009-01-15 DK DK09718204.2T patent/DK2250156T3/en active
- 2009-03-05 AR ARP090100782A patent/AR070798A1/es unknown
-
2010
- 2010-08-19 IL IL207719A patent/IL207719A/en active IP Right Grant
- 2010-10-04 ZA ZA2010/07060A patent/ZA201007060B/en unknown
-
2013
- 2013-12-17 US US14/109,225 patent/US9102632B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
BRPI0908544A2 (pt) | 2015-09-29 |
CN101945858B (zh) | 2014-05-21 |
EA021325B1 (ru) | 2015-05-29 |
PT2250156E (pt) | 2015-09-09 |
HUE025132T2 (en) | 2016-01-28 |
US8637522B2 (en) | 2014-01-28 |
MX2010009575A (es) | 2010-09-24 |
JP2011513344A (ja) | 2011-04-28 |
IL207719A0 (en) | 2010-12-30 |
WO2009109259A1 (en) | 2009-09-11 |
IL207719A (en) | 2015-05-31 |
JP5530370B2 (ja) | 2014-06-25 |
EP2250156A1 (en) | 2010-11-17 |
KR20100123900A (ko) | 2010-11-25 |
CA2717753C (en) | 2016-09-13 |
AR070798A1 (es) | 2010-05-05 |
DK2250156T3 (en) | 2015-08-03 |
ES2543598T3 (es) | 2015-08-20 |
US20140100235A1 (en) | 2014-04-10 |
CN101945858A (zh) | 2011-01-12 |
US20110015210A1 (en) | 2011-01-20 |
ZA201007060B (en) | 2011-06-29 |
CA2717753A1 (en) | 2009-09-11 |
EP2250156B1 (en) | 2015-05-06 |
AU2009221328A1 (en) | 2009-09-11 |
KR101637381B1 (ko) | 2016-07-07 |
AU2009221328B2 (en) | 2014-02-27 |
US9102632B2 (en) | 2015-08-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |