EA200802017A1 - Микрочастицы, содержащие сшитый полимер - Google Patents

Микрочастицы, содержащие сшитый полимер

Info

Publication number
EA200802017A1
EA200802017A1 EA200802017A EA200802017A EA200802017A1 EA 200802017 A1 EA200802017 A1 EA 200802017A1 EA 200802017 A EA200802017 A EA 200802017A EA 200802017 A EA200802017 A EA 200802017A EA 200802017 A1 EA200802017 A1 EA 200802017A1
Authority
EA
Eurasian Patent Office
Prior art keywords
moieties
group
heteroatoms
independently
chosen
Prior art date
Application number
EA200802017A
Other languages
English (en)
Inventor
Эйльвин Йорг Анджело Атанасайус Диас
Одри Пети
Original Assignee
ДСМ АйПи АССЕТС Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ДСМ АйПи АССЕТС Б.В. filed Critical ДСМ АйПи АССЕТС Б.В.
Publication of EA200802017A1 publication Critical patent/EA200802017A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
    • C08G18/4269—Lactones
    • C08G18/4277—Caprolactone and/or substituted caprolactone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4854—Polyethers containing oxyalkylene groups having four carbon atoms in the alkylene group
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/67—Unsaturated compounds having active hydrogen
    • C08G18/671—Unsaturated compounds having only one group containing active hydrogen
    • C08G18/672—Esters of acrylic or alkyl acrylic acid having only one group containing active hydrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/81—Unsaturated isocyanates or isothiocyanates
    • C08G18/8108—Unsaturated isocyanates or isothiocyanates having only one isocyanate or isothiocyanate group
    • C08G18/8116—Unsaturated isocyanates or isothiocyanates having only one isocyanate or isothiocyanate group esters of acrylic or alkylacrylic acid having only one isocyanate or isothiocyanate group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Polymerisation Methods In General (AREA)
  • Polyamides (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Настоящее изобретение относится к микрочастицами, содержащим сшитый полимер, причём полимер состоит из соединения, способного к сшиванию, представленного формулойгде Х представляет собой остаток полифункционального соединения, способного полимеризоваться по радикальному механизму (имеющего, по меньшей мере, функциональность, равную n); каждый Y независимо необязательно присутствует и, если присутствует, каждый Y независимо представляет собой остаток, выбранный из группы О, S и NR; каждый Rнезависимо выбран из группы водорода и замещённых и незамещённых алифатических, циклоалифатических и ароматических углеводородных групп, причём эти группы необязательно содержат один или более остатков, выбранных из группы остатков сложных эфиров, остатков простых эфиров, остатков сложных тиоэфиров, остатков простых тиоэфиров, карбаматных остатков, тиокарбаматных остатков, амидных остатков и других остатков, содержащих один или более гетероатомов, выбранных из S, О, Р и N, причём каждый R, в частности, независимо выбирают из группы водорода и замещённых и незамещённых алкильных групп, причём алкильные группы необязательно содержат один или более гетероатомов, в частности один или более гетероатомов, выбранных из Р, S, О и N; каждый Z независимо выбран из О и S; каждый Rнезависимо выбран из группы замещённых и незамещённых алифатических, циклоалифатических и ароматических углеводородных групп, причём эти группы необязательно содержат один или более остатков, выбранных из группы остатков сложных эфиров, остатков простых эфиров, остатков сложных тиоэфиров, остатков простых тиоэфиров, карбаматных остатков, тиокарбаматных остатков, амидных остатков и
EA200802017A 2006-03-21 2007-03-21 Микрочастицы, содержащие сшитый полимер EA200802017A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06075678 2006-03-21
PCT/EP2007/002514 WO2007107358A1 (en) 2006-03-21 2007-03-21 Microparticles comprising a crosslinked polymer

Publications (1)

Publication Number Publication Date
EA200802017A1 true EA200802017A1 (ru) 2009-04-28

Family

ID=36369939

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200802017A EA200802017A1 (ru) 2006-03-21 2007-03-21 Микрочастицы, содержащие сшитый полимер

Country Status (11)

Country Link
US (1) US20100233083A1 (ru)
EP (1) EP1996640B1 (ru)
JP (2) JP2009530457A (ru)
CN (1) CN101405320B (ru)
AT (1) ATE440879T1 (ru)
AU (1) AU2007228951A1 (ru)
BR (1) BRPI0711035A2 (ru)
CA (1) CA2645203A1 (ru)
DE (1) DE602007002176D1 (ru)
EA (1) EA200802017A1 (ru)
WO (1) WO2007107358A1 (ru)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9666321B2 (en) 2015-04-09 2017-05-30 International Business Machines Corporation Optical capture and isolation of circulating tumor cells in a micro-fluidic device utilizing size selective trapping with optical cogwheel tweezers
US9827590B2 (en) 2015-06-17 2017-11-28 International Business Machines Corporation Method of glass fabric production including resin adhesion for printed circuit board formation

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100022414A1 (en) 2008-07-18 2010-01-28 Raindance Technologies, Inc. Droplet Libraries
EP2481815B1 (en) 2006-05-11 2016-01-27 Raindance Technologies, Inc. Microfluidic devices
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US20090081276A1 (en) * 2007-08-13 2009-03-26 Eben Alsberg Bioresorbable implant composition
JP5934657B2 (ja) 2010-02-12 2016-06-15 レインダンス テクノロジーズ， インコーポレイテッド デジタル検体分析
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
EP3709018A1 (en) 2011-06-02 2020-09-16 Bio-Rad Laboratories, Inc. Microfluidic apparatus for identifying components of a chemical reaction
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
EP3387128A4 (en) * 2015-12-07 2019-12-04 Bio-Rad Laboratories, Inc. MULTIPLEXING IN PARTITIONS USING MICROPARTICLES

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4480069A (en) * 1983-01-05 1984-10-30 Ford Motor Company Non-aqueous dispersions based on capped stabilizers and vinyl monomers I
CA2087125A1 (en) * 1992-01-23 1993-07-24 Mridula Nair Chemically fixed micelles
US5807944A (en) * 1996-06-27 1998-09-15 Ciba Vision Corporation Amphiphilic, segmented copolymer of controlled morphology and ophthalmic devices including contact lenses made therefrom
US6042820A (en) * 1996-12-20 2000-03-28 Connaught Laboratories Limited Biodegradable copolymer containing α-hydroxy acid and α-amino acid units
WO2001037803A2 (en) * 1999-11-15 2001-05-31 Biocure, Inc. Responsive polymeric hollow particles
KR20020006688A (ko) * 2000-01-25 2002-01-24 고지마 아끼로, 오가와 다이스께 광경화성 수지 조성물
US6686432B2 (en) * 2002-02-15 2004-02-03 Ppg Industries Ohio, Inc. Alternating copolymers of isobutylene type monomers
US20050013869A1 (en) * 2003-07-18 2005-01-20 Chaw Cheng Shu Sustained release formulation for carbamates and a method therefor

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9666321B2 (en) 2015-04-09 2017-05-30 International Business Machines Corporation Optical capture and isolation of circulating tumor cells in a micro-fluidic device utilizing size selective trapping with optical cogwheel tweezers
US9734927B2 (en) 2015-04-09 2017-08-15 International Business Machines Corporation Optical capture and isolation of circulating tumor cells in a micro-fluidic device utilizing size selective trapping with optical cogwheel tweezers
US9827590B2 (en) 2015-06-17 2017-11-28 International Business Machines Corporation Method of glass fabric production including resin adhesion for printed circuit board formation

Also Published As

Publication number Publication date
EP1996640B1 (en) 2009-08-26
EP1996640A1 (en) 2008-12-03
DE602007002176D1 (de) 2009-10-08
CN101405320A (zh) 2009-04-08
ATE440879T1 (de) 2009-09-15
AU2007228951A1 (en) 2007-09-27
JP2013209420A (ja) 2013-10-10
CN101405320B (zh) 2012-05-30
US20100233083A1 (en) 2010-09-16
BRPI0711035A2 (pt) 2011-08-23
CA2645203A1 (en) 2007-09-27
WO2007107358A1 (en) 2007-09-27
JP2009530457A (ja) 2009-08-27

Similar Documents

Publication Publication Date Title
EA200802017A1 (ru) Микрочастицы, содержащие сшитый полимер
TW200635585A (en) Monocyclic substituted methanones
EA200600509A1 (ru) Соединения пиримидотиофена
TW200600971A (en) Calixresorcinarene compounds, photoresist base materials, and compositions thereof
TW200619207A (en) HDAC inhibitor
DE602006005075D1 (de) Absorbierbare alpha-cyanacrylat-zusammensetzungen
MXPA04000411A (es) Tiazolidinonas arilo sustituidas y uso de las mismas.
WO2005092858A3 (en) Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as orl1-receptor antagonist
TW200730496A (en) Oxime ester photoinitiators
TW200604558A (en) (Meth)acrylamide monomers containing hydroxy and silicone functionalities
TW200834234A (en) Radiation-sensitive resin compositions
WO2005105732A8 (en) Substituted methyl aryl or heteroaryl amide compounds
TW200606580A (en) A chemically amplified positive resist composition, (meth)acrylate derivative and a process for producing the same
EA200000327A2 (ru) Новые соединения аминотриазола, способ их получения и содержащие их фармацевтические композиции
MX2010013275A (es) Compuesto novedoso de uracilo o su sal que tiene actividad inhibidora de desoxiuridin trifosfatasa de humano.
AU2003222106A1 (en) Thiopene-based tricyclic compounds and pharmaceutical compositions comprising same
UA89672C2 (en) Sulfonylamino(thio)carbonyl compounds
BRPI0519071A2 (pt) composiÇço
ATE540667T1 (de) Verbindungen mit kühlender wirkung
WO2005097100A3 (en) Antibacterial agents
EA014959B3 (ru) Ингибиторы глицинового переносчика-1
TW200500806A (en) Resist composition and patterning process
WO2008152306A3 (fr) Nouveaux substrats de peptidase
ATE425196T1 (de) Wässrige beschichtungszusammensetzungen
WO2005023962A8 (en) Photorefractive composition