EA200801960A1 - Соли дулоксетина - Google Patents

Соли дулоксетина

Info

Publication number
EA200801960A1
EA200801960A1 EA200801960A EA200801960A EA200801960A1 EA 200801960 A1 EA200801960 A1 EA 200801960A1 EA 200801960 A EA200801960 A EA 200801960A EA 200801960 A EA200801960 A EA 200801960A EA 200801960 A1 EA200801960 A1 EA 200801960A1
Authority
EA
Eurasian Patent Office
Prior art keywords
duloxetine
acid
salts
formula
new salts
Prior art date
Application number
EA200801960A
Other languages
English (en)
Inventor
Тибор Мезеи
Дьюла Шимиг
Энико Мольнар
Миклош Сабо
Дьюла Лукач
Марта Порч-Маккаи
Эрика Силадьи
Тибор Бако
Original Assignee
Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг filed Critical Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг
Publication of EA200801960A1 publication Critical patent/EA200801960A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Задачей настоящего изобретения является создание новых солей дулоксетина формулы (I) с органическими кислотами, способа их получения и содержащих их лекарственных препаратов. Новые соли, по существу, не содержат примесь формулы (II) и обладают высокой чистотой и высокой стабильностью. Новые соли дулоксетина получают путем взаимодействия свободного основания дулоксетина, растворенного в органическом растворителе, с приблизительно эквимолярным количеством органической кислоты. Особенно предпочтительные кристаллические соли представляют собой соли, образованные с фумаровой кислотой, лимонной кислотой или (-)-миндальной кислотой.
EA200801960A 2006-03-13 2007-03-13 Соли дулоксетина EA200801960A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0600198A HU228458B1 (en) 2006-03-13 2006-03-13 Duloxetine salts for producing pharmaceutical compositions
PCT/HU2007/000025 WO2007105021A2 (en) 2006-03-13 2007-03-13 Duloxetine salts

Publications (1)

Publication Number Publication Date
EA200801960A1 true EA200801960A1 (ru) 2008-12-30

Family

ID=89986640

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801960A EA200801960A1 (ru) 2006-03-13 2007-03-13 Соли дулоксетина

Country Status (6)

Country Link
US (1) US20090209617A1 (ru)
EP (1) EP2001464A2 (ru)
CN (1) CN101404997A (ru)
EA (1) EA200801960A1 (ru)
HU (1) HU228458B1 (ru)
WO (1) WO2007105021A2 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2016066A4 (en) * 2006-05-10 2010-11-24 Reddys Lab Ltd Dr PROCESS FOR PREPARING DULOXETINE
EP2107057A1 (en) 2008-04-04 2009-10-07 Ranbaxy Laboratories Limited Process for the preparation of pure duloxetine hydrochloride
WO2011123837A2 (en) * 2010-04-01 2011-10-06 University Of Georgia Research Foundation, Inc. Method and system using computer simulation for the quantitative analysis of glycan biosynthesis
WO2016046673A1 (en) * 2014-09-28 2016-03-31 Mohan M Alapati Compositions and methods for the treatment of neurological diseases
WO2020206078A1 (en) * 2019-04-05 2020-10-08 University Of North Texas Health Science Center At Fort Worth Antidepressants for the treatment or prevention of memory loss and/or cognitive decline or dysfunction in aging
CN112697919B (zh) * 2020-12-22 2023-02-28 北京和合医学诊断技术股份有限公司 度洛西汀的检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2042346A1 (en) * 1990-05-17 1991-11-18 Michael Alexander Staszak Chiral synthesis of 1-aryl-3-aminopropan-1-ols
GB0229583D0 (en) * 2002-12-19 2003-01-22 Cipla Ltd A process for preparing duloxetine and intermediates for use therein
DE602006021628D1 (de) 2005-12-12 2011-06-09 Medichem Sa Verbesserte synthese und zubereitungen von duloxetinsalzen

Also Published As

Publication number Publication date
HUP0600198A3 (en) 2008-10-28
HU0600198D0 (en) 2006-05-29
HU228458B1 (en) 2013-03-28
CN101404997A (zh) 2009-04-08
EP2001464A2 (en) 2008-12-17
WO2007105021A3 (en) 2007-11-22
US20090209617A1 (en) 2009-08-20
WO2007105021A2 (en) 2007-09-20
HUP0600198A2 (en) 2008-09-29

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