EA200801681A1 - Новые многократно замещенные соединения пиридиниламиноалкилен- и пиридинилоксиалкиленциклопропанамина, способ их получения и фармацевтические композиции, которые их содержат - Google Patents

Новые многократно замещенные соединения пиридиниламиноалкилен- и пиридинилоксиалкиленциклопропанамина, способ их получения и фармацевтические композиции, которые их содержат

Info

Publication number
EA200801681A1
EA200801681A1 EA200801681A EA200801681A EA200801681A1 EA 200801681 A1 EA200801681 A1 EA 200801681A1 EA 200801681 A EA200801681 A EA 200801681A EA 200801681 A EA200801681 A EA 200801681A EA 200801681 A1 EA200801681 A1 EA 200801681A1
Authority
EA
Eurasian Patent Office
Prior art keywords
atom
alkyl
pyridinyloxyalkylencyclopropanamine
pyridinylininoalkylene
contain
Prior art date
Application number
EA200801681A
Other languages
English (en)
Other versions
EA015227B1 (ru
Inventor
Соло Голдштейн
Клод Гиллонно
Ив Шартон
Брайан Локхарт
Пьерр Лестаж
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA200801681A1 publication Critical patent/EA200801681A1/ru
Publication of EA015227B1 publication Critical patent/EA015227B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Соединения формулы (I), в которой n представляет собой целое число от 1 до 6 включительно, Х представляет собой атом кислорода или NR6 группу, Y представляет собой атом углерода или атом азота, Z представляет собой атом углерода или атом азота, Rи Rпредставляют собой атом водорода или алкильную или арилалкильнуюгруппу, Rи Rпредставляют собой атом водорода или алкильную группу, Rпредставляет собой атом водорода или алкил, галоген, гидрокси, алкокси, циано, нитро, ацил, алкоксикарбонил, тригалоалкил, тригалоалкокси или необязательно замещенную аминогруппу, Rпредставляет собой атом водорода или алкильную или арилалкильную группу, Ra, Rb, Re, Rd и Re имеют значения, указанные в описании. Лекарственные средства.
EA200801681A 2006-01-30 2007-01-30 Замещенные соединения пиридиниламиноалкилен- и пиридинилоксиалкиленциклопропанамина, способ их получения и фармацевтические композиции, содержащие их EA015227B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0600784A FR2896800B1 (fr) 2006-01-30 2006-01-30 Nouveaux composes pyridinylaminoalkylene-et pyridinyloxyalkylene-cyclopropanamines polysubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
PCT/FR2007/000170 WO2007085750A1 (fr) 2006-01-30 2007-01-30 Nouveaux composes pyridinylaminoalkylene- et pyridinyloxyalkylene- cyclopropanamines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
EA200801681A1 true EA200801681A1 (ru) 2009-02-27
EA015227B1 EA015227B1 (ru) 2011-06-30

Family

ID=37102591

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801681A EA015227B1 (ru) 2006-01-30 2007-01-30 Замещенные соединения пиридиниламиноалкилен- и пиридинилоксиалкиленциклопропанамина, способ их получения и фармацевтические композиции, содержащие их

Country Status (29)

Country Link
US (1) US20100317698A1 (ru)
EP (1) EP1979321B9 (ru)
JP (1) JP2009525311A (ru)
KR (1) KR101050910B1 (ru)
CN (1) CN101374814B (ru)
AR (1) AR059221A1 (ru)
AT (1) ATE437857T1 (ru)
AU (1) AU2007209235B2 (ru)
BR (1) BRPI0710443A2 (ru)
CA (1) CA2640482C (ru)
CY (1) CY1109477T1 (ru)
DE (1) DE602007001779D1 (ru)
DK (1) DK1979321T3 (ru)
EA (1) EA015227B1 (ru)
ES (1) ES2330899T3 (ru)
FR (1) FR2896800B1 (ru)
GE (1) GEP20105090B (ru)
HK (1) HK1126190A1 (ru)
HR (1) HRP20090523T1 (ru)
MA (1) MA30222B1 (ru)
MY (1) MY149068A (ru)
NO (1) NO20083753L (ru)
PL (1) PL1979321T3 (ru)
PT (1) PT1979321E (ru)
RS (1) RS51065B (ru)
SI (1) SI1979321T1 (ru)
UA (1) UA88116C2 (ru)
WO (1) WO2007085750A1 (ru)
ZA (1) ZA200806399B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110091501A (ko) * 2008-10-14 2011-08-11 싸이코제닉스 아이엔씨. 니코틴성 아세틸콜린 수용체 리간드 및 이들의 용도
EP2714041B1 (en) 2011-05-24 2016-10-19 Merck Sharp & Dohme Corp. Aryloxymethyl cyclopropane derivatives as pde10 inhibitors
CA2960188A1 (en) * 2014-09-05 2016-03-10 Celgene Quanticel Research, Inc. Inhibitors of lysine specific demethylase-1
US20180311238A1 (en) * 2017-04-28 2018-11-01 Saniona A/S Selective Agonist Of a6 Containing nAChRs
CN110483392A (zh) * 2018-05-14 2019-11-22 上海海和药物研究开发有限公司 合成n-保护的喹啉-7-基氧基甲基环丙基胺衍生物的方法及合成中间体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5326100A (en) * 1999-06-07 2000-12-28 Targacept, Inc. Pharmaceutical compositions and methods for use
JP2001261652A (ja) * 2000-03-21 2001-09-26 Suntory Ltd 二置換イミノヘテロサイクリック化合物
FR2810664B1 (fr) * 2000-06-27 2004-12-24 Adir Nouveaux composes cyclopropaniques 1,1 et 1,2-dissubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7098331B2 (en) * 2003-03-05 2006-08-29 Targacept, Inc. Arylvinylazacycloalkane compounds and methods of preparation and use thereof
FR2889188B1 (fr) * 2005-07-28 2007-09-07 Servier Lab Nouveaux composes 1,1-pyridinylaminocyclopropanamines polysubstitues, leur procede de preparation et les compositions phamaceutiques qui les contiennent
FR2889187B1 (fr) * 2005-07-28 2007-09-07 Servier Lab Nouveaux composes 1,1-pyridinyloxycyclopropanamines polysusbstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
AU2007209235A1 (en) 2007-08-02
CY1109477T1 (el) 2014-08-13
MA30222B1 (fr) 2009-02-02
GEP20105090B (en) 2010-10-11
PL1979321T3 (pl) 2009-10-30
EP1979321B9 (fr) 2010-02-17
CN101374814B (zh) 2011-05-25
DE602007001779D1 (de) 2009-09-10
KR20080090564A (ko) 2008-10-08
DK1979321T3 (da) 2009-11-02
US20100317698A1 (en) 2010-12-16
HK1126190A1 (en) 2009-08-28
AU2007209235B2 (en) 2011-03-03
CA2640482C (fr) 2011-04-19
EA015227B1 (ru) 2011-06-30
ES2330899T3 (es) 2009-12-16
CA2640482A1 (fr) 2007-08-02
ZA200806399B (en) 2009-11-25
SI1979321T1 (sl) 2009-12-31
KR101050910B1 (ko) 2011-07-20
RS51065B (sr) 2010-10-31
PT1979321E (pt) 2009-08-31
WO2007085750A1 (fr) 2007-08-02
EP1979321A1 (fr) 2008-10-15
MY149068A (en) 2013-07-15
CN101374814A (zh) 2009-02-25
BRPI0710443A2 (pt) 2011-08-16
AR059221A1 (es) 2008-03-19
FR2896800A1 (fr) 2007-08-03
EP1979321B1 (fr) 2009-07-29
UA88116C2 (ru) 2009-09-10
HRP20090523T1 (hr) 2009-11-30
JP2009525311A (ja) 2009-07-09
ATE437857T1 (de) 2009-08-15
NO20083753L (no) 2008-10-10
FR2896800B1 (fr) 2008-04-11

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU