EA200801615A1 - Оптические изомеры дигидро-2,3-бензодиазепинов и их стереоселективный синтез - Google Patents

Оптические изомеры дигидро-2,3-бензодиазепинов и их стереоселективный синтез

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Publication number
EA200801615A1
EA200801615A1 EA200801615A EA200801615A EA200801615A1 EA 200801615 A1 EA200801615 A1 EA 200801615A1 EA 200801615 A EA200801615 A EA 200801615A EA 200801615 A EA200801615 A EA 200801615A EA 200801615 A1 EA200801615 A1 EA 200801615A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dihydro
steriocelective
benzodiazepines
synthesis
optical isomers
Prior art date
Application number
EA200801615A
Other languages
English (en)
Other versions
EA016087B1 (ru
Inventor
Иштван Линг
Йожеф Баркоци
Зольтан Грефф
Габор Сенаши
Габор Гиглер
Саболч Кертес
Дьюла Сюч
Михай Альберт
Габор Капуш
Геза Сабо
Миклош Вег
Марта Агоштон
Дьёрдь Леваи
Кристина Мориц
Ласло Габор Харшинг
Original Assignee
Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0501211A external-priority patent/HU230760B1/hu
Priority claimed from HU0501212A external-priority patent/HU230808B1/hu
Application filed by Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг filed Critical Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг
Publication of EA200801615A1 publication Critical patent/EA200801615A1/ru
Publication of EA016087B1 publication Critical patent/EA016087B1/ru

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к дигидро-2,3-бензодиазепиновым соединениям общей формулы (I), обладающим высокой энантиомерной чистотой, содержащим центр асимметрии в позиции 4 дигидро-2,3-бензодиазепинового соединения, и их получению, а также применяемым промежуточным соединениям. Эти соединения обладают антиконвульсивным, расслабляющим мышцы и нейропротективным эффектом, благодаря их неконкурентным антагонистическим свойствам в отношении рецепторов АМРА (альфа-амино-3-гидрокси-5-метил-4-изоксазолпропионовой кислоты).
EA200801615A 2005-12-30 2006-12-29 Оптические изомеры дигидро-2,3-бензодиазепинов и их стереоселективный синтез EA016087B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0501211A HU230760B1 (hu) 2005-12-30 2005-12-30 Dihidro-2,3-benzodiazepin-származékok optikai izomerjei, eljárás ezek sztereoszelektív szintézisére, alkalmazásuk, az ezeket tartalmazó gyógyszerkészítmények és az eljárás közbenső termékei
HU0501212A HU230808B1 (hu) 2005-12-30 2005-12-30 Dihidro-2,3-benzodiazepin optikai izomerjei és ezek sztereoszelektív szintézise
PCT/HU2006/000130 WO2007077469A1 (en) 2005-12-30 2006-12-29 Optical isomers of dihydro-2,3-benzodiazepines and their stereoselective synthesis

Publications (2)

Publication Number Publication Date
EA200801615A1 true EA200801615A1 (ru) 2008-10-30
EA016087B1 EA016087B1 (ru) 2012-02-28

Family

ID=89986500

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801615A EA016087B1 (ru) 2005-12-30 2006-12-29 Оптические изомеры дигидро-2,3-бензодиазепинов и их стереоселективный синтез

Country Status (7)

Country Link
US (1) US20090233913A1 (ru)
EP (1) EP1979308A1 (ru)
JP (1) JP2009522245A (ru)
AU (1) AU2006334172A1 (ru)
CA (1) CA2633804A1 (ru)
EA (1) EA016087B1 (ru)
WO (1) WO2007077469A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2881996A1 (en) * 2012-08-16 2014-02-20 Bayer Pharma Aktiengesellschaft 2,3-benzodiazepines

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
US6288057B1 (en) * 1994-08-31 2001-09-11 Eli Lilly And Company Physical form of dihydro-2,3-benzodiazepine derivative
TR199501071A2 (tr) * 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem.
DE19604920A1 (de) * 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
HU9600871D0 (en) * 1996-04-04 1996-05-28 Gyogyszerkutato Intezet New 2,3-benzodiazepine derivatives
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
HU225100B1 (hu) * 2000-12-21 2006-06-28 Egyt Gyogyszervegyeszeti Gyar 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
US6858605B2 (en) * 2003-02-04 2005-02-22 Ivax Drug Research Institute, Ltd. Substituted 2,3-benzodiazepine derivatives

Also Published As

Publication number Publication date
WO2007077469A1 (en) 2007-07-12
CA2633804A1 (en) 2007-07-12
EP1979308A1 (en) 2008-10-15
US20090233913A1 (en) 2009-09-17
JP2009522245A (ja) 2009-06-11
EA016087B1 (ru) 2012-02-28
AU2006334172A1 (en) 2007-07-12

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU