EA200800780A1 - Производные пиримидина и их применение в качестве открывателей калиевых каналов kcnq - Google Patents
Производные пиримидина и их применение в качестве открывателей калиевых каналов kcnqInfo
- Publication number
- EA200800780A1 EA200800780A1 EA200800780A EA200800780A EA200800780A1 EA 200800780 A1 EA200800780 A1 EA 200800780A1 EA 200800780 A EA200800780 A EA 200800780A EA 200800780 A EA200800780 A EA 200800780A EA 200800780 A1 EA200800780 A1 EA 200800780A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- openers
- pyrimidine derivatives
- application
- potassium channel
- kcnq potassium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200501262 | 2005-09-09 | ||
| PCT/DK2006/050039 WO2007065449A1 (fr) | 2005-09-09 | 2006-09-07 | Derives de pyrimidine et leur emploi en tant qu'agents ouvrant les canaux potassiques kcnq |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200800780A1 true EA200800780A1 (ru) | 2008-06-30 |
Family
ID=37199174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200800780A EA200800780A1 (ru) | 2005-09-09 | 2006-09-07 | Производные пиримидина и их применение в качестве открывателей калиевых каналов kcnq |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1937653A1 (fr) |
| JP (1) | JP2009507052A (fr) |
| KR (1) | KR20080043314A (fr) |
| CN (1) | CN101258133A (fr) |
| AR (1) | AR055420A1 (fr) |
| AU (1) | AU2006322461A1 (fr) |
| BR (1) | BRPI0615631A2 (fr) |
| CA (1) | CA2621854A1 (fr) |
| EA (1) | EA200800780A1 (fr) |
| IL (1) | IL189545A0 (fr) |
| MX (1) | MX2008002294A (fr) |
| NO (1) | NO20081713L (fr) |
| UA (1) | UA93387C2 (fr) |
| WO (1) | WO2007065449A1 (fr) |
| ZA (1) | ZA200802174B (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100256145A1 (en) * | 2007-08-01 | 2010-10-07 | H. Lundbeck A/S | Use of kcnq potassium channel openers for reducing symptoms of or treating disorders or conditions wherein the dopaminergic system is disrupted |
| US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| WO2010097379A1 (fr) * | 2009-02-24 | 2010-09-02 | Neurosearch A/S | Dérivés pyrimidine substitués et leur utilisation médicale |
| AU2011275393B2 (en) * | 2010-07-08 | 2014-04-10 | Pfizer Inc. | Piperidinyl pyrimidine amides as Kv7 potassium channel openers |
| CA2815131C (fr) * | 2010-10-20 | 2020-06-09 | Gruenenthal Gmbh | 6-amino-nicotinamides substitues en tant que modulateurs des kcnq2/3 |
| CN103508960B (zh) * | 2012-06-29 | 2017-12-12 | 江苏先声药业有限公司 | 苯并杂环衍生物 |
| CN103508943B (zh) * | 2012-06-29 | 2017-06-09 | 江苏先声药业有限公司 | 作为钾通道调节剂的化合物 |
| MX2017005044A (es) | 2014-10-24 | 2017-07-04 | Ono Pharmaceutical Co | Activador de canales de kcnq2-5. |
| JP2022543230A (ja) * | 2019-08-02 | 2022-10-11 | ハー・ルンドベック・アクチエゼルスカベット | てんかん又はてんかん発作において使用するためのＫｖ７カリウムチャネル開口薬としてのアルコール誘導体 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005508833A (ja) * | 2001-02-20 | 2005-04-07 | ブリストル−マイヤーズ スクイブ カンパニー | Ｋｃｎｑカリウムチャネル・モジュレーターとしての２，４−ジ置換ピリミジン−５−カルボキサミド誘導体 |
| AU2003202115A1 (en) * | 2002-02-12 | 2003-09-04 | Pfizer Inc. | Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh) |
| US20080261918A1 (en) * | 2004-12-17 | 2008-10-23 | Graham Andrew Showell | Silicon Compounds and Their Use |
-
2006
- 2006-09-07 KR KR1020087004306A patent/KR20080043314A/ko not_active Application Discontinuation
- 2006-09-07 CA CA002621854A patent/CA2621854A1/fr not_active Abandoned
- 2006-09-07 ZA ZA200802174A patent/ZA200802174B/xx unknown
- 2006-09-07 WO PCT/DK2006/050039 patent/WO2007065449A1/fr active Application Filing
- 2006-09-07 EA EA200800780A patent/EA200800780A1/ru unknown
- 2006-09-07 BR BRPI0615631-2A patent/BRPI0615631A2/pt not_active IP Right Cessation
- 2006-09-07 CN CNA2006800327125A patent/CN101258133A/zh active Pending
- 2006-09-07 JP JP2008529473A patent/JP2009507052A/ja not_active Withdrawn
- 2006-09-07 EP EP06846967A patent/EP1937653A1/fr not_active Withdrawn
- 2006-09-07 UA UAA200803570A patent/UA93387C2/ru unknown
- 2006-09-07 MX MX2008002294A patent/MX2008002294A/es active IP Right Grant
- 2006-09-07 AU AU2006322461A patent/AU2006322461A1/en not_active Abandoned
- 2006-09-08 AR ARP060103924A patent/AR055420A1/es not_active Application Discontinuation
-
2008
- 2008-02-14 IL IL189545A patent/IL189545A0/en unknown
- 2008-04-09 NO NO20081713A patent/NO20081713L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007065449A1 (fr) | 2007-06-14 |
| KR20080043314A (ko) | 2008-05-16 |
| AU2006322461A1 (en) | 2007-06-14 |
| NO20081713L (no) | 2008-06-04 |
| CN101258133A (zh) | 2008-09-03 |
| UA93387C2 (ru) | 2011-02-10 |
| ZA200802174B (en) | 2009-10-28 |
| IL189545A0 (en) | 2008-06-05 |
| EP1937653A1 (fr) | 2008-07-02 |
| AR055420A1 (es) | 2007-08-22 |
| MX2008002294A (es) | 2008-03-14 |
| BRPI0615631A2 (pt) | 2011-05-24 |
| JP2009507052A (ja) | 2009-02-19 |
| CA2621854A1 (fr) | 2007-06-14 |
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