ZA200802174B - Pyrimidine derivatives and their use as KCNQ potassium channels openers - Google Patents

Pyrimidine derivatives and their use as KCNQ potassium channels openers

Info

Publication number
ZA200802174B
ZA200802174B ZA200802174A ZA200802174A ZA200802174B ZA 200802174 B ZA200802174 B ZA 200802174B ZA 200802174 A ZA200802174 A ZA 200802174A ZA 200802174 A ZA200802174 A ZA 200802174A ZA 200802174 B ZA200802174 B ZA 200802174B
Authority
ZA
South Africa
Prior art keywords
pyrimidine derivatives
potassium channels
kcnq potassium
channels openers
openers
Prior art date
Application number
ZA200802174A
Other languages
English (en)
Inventor
Khanzhin Nikolay
Greve Daniel Rodriguez
Rottlaender Mario
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of ZA200802174B publication Critical patent/ZA200802174B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200802174A 2005-09-09 2006-09-07 Pyrimidine derivatives and their use as KCNQ potassium channels openers ZA200802174B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200501262 2005-09-09

Publications (1)

Publication Number Publication Date
ZA200802174B true ZA200802174B (en) 2009-10-28

Family

ID=37199174

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200802174A ZA200802174B (en) 2005-09-09 2006-09-07 Pyrimidine derivatives and their use as KCNQ potassium channels openers

Country Status (15)

Country Link
EP (1) EP1937653A1 (fr)
JP (1) JP2009507052A (fr)
KR (1) KR20080043314A (fr)
CN (1) CN101258133A (fr)
AR (1) AR055420A1 (fr)
AU (1) AU2006322461A1 (fr)
BR (1) BRPI0615631A2 (fr)
CA (1) CA2621854A1 (fr)
EA (1) EA200800780A1 (fr)
IL (1) IL189545A0 (fr)
MX (1) MX2008002294A (fr)
NO (1) NO20081713L (fr)
UA (1) UA93387C2 (fr)
WO (1) WO2007065449A1 (fr)
ZA (1) ZA200802174B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2694887A1 (fr) * 2007-08-01 2009-02-05 Henriette Husum Bak-Jensen Utilisation d'agents d'ouverture kncq des canaux potassiques pour reduire des symptomes ou traiter des troubles et des etats dans lesquels le systeme dopaminergique est detruit
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
WO2010097379A1 (fr) * 2009-02-24 2010-09-02 Neurosearch A/S Dérivés pyrimidine substitués et leur utilisation médicale
EP2590961A1 (fr) * 2010-07-08 2013-05-15 Pfizer Inc Amides pipéridinyl pyrimidine en tant qu'ouvreurs du canal potassique ko7
MX367623B (es) * 2010-10-20 2019-08-29 Gruenenthal Gmbh 6-amino-nicotinamidas sustituidas como moduladores de kcnq2/3.
CN103508960B (zh) * 2012-06-29 2017-12-12 江苏先声药业有限公司 苯并杂环衍生物
CN103508943B (zh) * 2012-06-29 2017-06-09 江苏先声药业有限公司 作为钾通道调节剂的化合物
EP3210969B1 (fr) 2014-10-24 2021-04-28 ONO Pharmaceutical Co., Ltd. Activateur des canaux kcnq2-5
US20220280455A1 (en) * 2019-08-02 2022-09-08 H. Lundbeck A/S Alcohol derivatives as kv7 potassium channel openers for use in epilepsy or seizures

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002066036A1 (fr) * 2001-02-20 2002-08-29 Bristol-Myers Squibb Company Derives de 2,4-disubstitue pyrimidine-5-carboxamide en tant que modulateur des canaux potassium kcnq
WO2003068769A1 (fr) * 2002-02-12 2003-08-21 Pfizer Inc. Composes non-peptidiques influant sur l'action de la gnrh
US20080261918A1 (en) * 2004-12-17 2008-10-23 Graham Andrew Showell Silicon Compounds and Their Use

Also Published As

Publication number Publication date
JP2009507052A (ja) 2009-02-19
UA93387C2 (ru) 2011-02-10
BRPI0615631A2 (pt) 2011-05-24
AU2006322461A1 (en) 2007-06-14
KR20080043314A (ko) 2008-05-16
CN101258133A (zh) 2008-09-03
CA2621854A1 (fr) 2007-06-14
IL189545A0 (en) 2008-06-05
AR055420A1 (es) 2007-08-22
MX2008002294A (es) 2008-03-14
EP1937653A1 (fr) 2008-07-02
EA200800780A1 (ru) 2008-06-30
WO2007065449A1 (fr) 2007-06-14
NO20081713L (no) 2008-06-04

Similar Documents

Publication Publication Date Title
IL186939A0 (en) Pyrimidine derivatives and their use as
AP2008004486A0 (en) Pyrimidine derivatives
IL189545A0 (en) Pyrimidine derivatives and their use as kcnq potassium channels openers
IL181433A0 (en) Pyrimidine derivatives
GB0525080D0 (en) Pyrimidine derivatives
GB0525083D0 (en) Pyrimidine derivatives
IL181386A0 (en) Pyrimidine derivatives
EP2223921B8 (fr) Dérivés de 2-Thiophén-2-yl-oxazole, 2-Thiophén-2-yl-thiazole et 2-Thiophén-2-yl-1H-imidazole en tant que agents antivirales
HK1104553A1 (en) Pyrimidine derivatives
EP1724267A4 (fr) Derive de pyrimidine
GB0415364D0 (en) Pyrimidine derivatives
HRP20130719T1 (en) Novel pyridine derivative and pyrimidine derivative (3)
IL185914A0 (en) Pyrimidine compounds and methods of use
ZA200806153B (en) Pyrimidine derivatives
EP1951680A4 (fr) Nouveaux derives de 2-aminopyrimidinone et leur utilisation
GB0525081D0 (en) Pyrimidine derivatives
GB0614579D0 (en) Pyrimidine derivatives
EP1847541A4 (fr) Dérivé de pyrimidine condensée et utilisation de celui-ci
ZA200804335B (en) Substituted bicyclic pyrimidone derivatives
IL207452A0 (en) Pyrrolo pyrimidine derivatives, compositions comprising the same and uses thereof
EP1951681A4 (fr) Nouveaux derives de 2-aminopyrimidine derivatives et leur utilisation
ZA200810565B (en) Pyrimidine derivatives and their use as pesticides
GB0415367D0 (en) Pyrimidine derivatives
HK1143152A1 (en) 2-thiophen-2-yl-oxazole, 2-thiophen-2-yl-thiazole and 2-thiophen-2-yl-1h- imidazole derivatives as antiviral agents
AU2005900326A0 (en) Roller reamer