EA200301167A1 - NAPHTIAZINE POSITIVE ALLOSTERIC MODULATORS OF AMPA RECEPTORS - Google Patents
NAPHTIAZINE POSITIVE ALLOSTERIC MODULATORS OF AMPA RECEPTORSInfo
- Publication number
- EA200301167A1 EA200301167A1 EA200301167A EA200301167A EA200301167A1 EA 200301167 A1 EA200301167 A1 EA 200301167A1 EA 200301167 A EA200301167 A EA 200301167A EA 200301167 A EA200301167 A EA 200301167A EA 200301167 A1 EA200301167 A1 EA 200301167A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- positive allosteric
- allosteric modulators
- naphtiazine
- ampa receptors
- international
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
В заявке описаны новые позитивные аллостерические модуляторы АМРА-рецепторов, соответствующие общей формуле (I)в которой R, R, R, Rи Rмогут иметь указанные в описании и формуле изобретения значения, а также описаны способ их получения и их применение в составе фармацевтических композиций.Международная заявка была опубликована вместе с отчетом о международном поиске.The application describes new positive allosteric modulators of AMPA receptors corresponding to general formula (I) in which R, R, R, R and R may have the meanings indicated in the description and the claims, as well as the method for their preparation and their use in pharmaceutical compositions. The international application was published with the international search report.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10123952A DE10123952A1 (en) | 2001-05-17 | 2001-05-17 | New naphtho-1,2-thiazine compounds, useful as neuroprotectants for treating e.g. epilepsy or Alzheimer's disease, are allosteric modulators of AMPA receptors |
| PCT/EP2002/005338 WO2002100411A1 (en) | 2001-05-17 | 2002-05-15 | Naphtothiazine positive allosteric ampa receptor modulators (paarm) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200301167A1 true EA200301167A1 (en) | 2004-06-24 |
| EA006608B1 EA006608B1 (en) | 2006-02-24 |
Family
ID=7685080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200301167A EA006608B1 (en) | 2001-05-17 | 2002-05-15 | Naphtothiazine positive allosteric ampareceptor modulators (paarm) |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1404340A1 (en) |
| JP (1) | JP2004529980A (en) |
| KR (1) | KR20040007572A (en) |
| CN (1) | CN1533278A (en) |
| AR (1) | AR036332A1 (en) |
| BG (1) | BG108324A (en) |
| BR (1) | BR0209796A (en) |
| CA (1) | CA2449189A1 (en) |
| CO (1) | CO5550460A2 (en) |
| CZ (1) | CZ20033112A3 (en) |
| DE (1) | DE10123952A1 (en) |
| EA (1) | EA006608B1 (en) |
| EC (1) | ECSP034852A (en) |
| EE (1) | EE200300566A (en) |
| HR (1) | HRP20030933A2 (en) |
| HU (1) | HUP0401273A3 (en) |
| IL (1) | IL158642A0 (en) |
| MX (1) | MXPA03010373A (en) |
| NO (1) | NO20035088D0 (en) |
| NZ (1) | NZ530154A (en) |
| PL (1) | PL364053A1 (en) |
| SK (1) | SK14222003A3 (en) |
| UY (1) | UY27290A1 (en) |
| WO (1) | WO2002100411A1 (en) |
| YU (1) | YU90403A (en) |
| ZA (1) | ZA200308466B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8039468B2 (en) * | 2006-08-31 | 2011-10-18 | The Governors Of The University Of Alberta | Method of inhibition of respiratory depression using positive allosteric AMPA receptor modulators |
| CN111518058B (en) * | 2020-05-29 | 2021-03-09 | 四川大学华西医院 | Oxathiazine compound and application thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998012185A1 (en) * | 1996-09-17 | 1998-03-26 | The Regents Of The University Of California | Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor |
| AU4711899A (en) * | 1998-06-25 | 2000-01-10 | Merck & Co., Inc. | Naphtho(1,8-de)thiasin-2-yl methyl carbapenem antibacterials |
| DE10004572A1 (en) * | 2000-02-02 | 2001-08-09 | Boehringer Ingelheim Pharma | New positive allosteric AMPA receptor modulators (PAARM), processes for their production and their use as medicines |
-
2001
- 2001-05-17 DE DE10123952A patent/DE10123952A1/en not_active Withdrawn
-
2002
- 2002-05-15 BR BR0209796-6A patent/BR0209796A/en not_active Expired - Fee Related
- 2002-05-15 PL PL02364053A patent/PL364053A1/en not_active Application Discontinuation
- 2002-05-15 SK SK1422-2003A patent/SK14222003A3/en unknown
- 2002-05-15 YU YU90403A patent/YU90403A/en unknown
- 2002-05-15 KR KR10-2003-7014965A patent/KR20040007572A/en not_active Application Discontinuation
- 2002-05-15 UY UY27290A patent/UY27290A1/en not_active Application Discontinuation
- 2002-05-15 CN CNA028100832A patent/CN1533278A/en active Pending
- 2002-05-15 HU HU0401273A patent/HUP0401273A3/en unknown
- 2002-05-15 WO PCT/EP2002/005338 patent/WO2002100411A1/en not_active Application Discontinuation
- 2002-05-15 CA CA002449189A patent/CA2449189A1/en not_active Abandoned
- 2002-05-15 MX MXPA03010373A patent/MXPA03010373A/en unknown
- 2002-05-15 NZ NZ530154A patent/NZ530154A/en unknown
- 2002-05-15 EA EA200301167A patent/EA006608B1/en not_active IP Right Cessation
- 2002-05-15 EP EP02750931A patent/EP1404340A1/en not_active Withdrawn
- 2002-05-15 EE EEP200300566A patent/EE200300566A/en unknown
- 2002-05-15 IL IL15864202A patent/IL158642A0/en unknown
- 2002-05-15 CZ CZ20033112A patent/CZ20033112A3/en unknown
- 2002-05-15 JP JP2003503232A patent/JP2004529980A/en not_active Abandoned
- 2002-05-17 AR ARP020101827A patent/AR036332A1/en not_active Suspension/Interruption
-
2003
- 2003-10-30 ZA ZA200308466A patent/ZA200308466B/en unknown
- 2003-11-07 BG BG108324A patent/BG108324A/en active Pending
- 2003-11-14 HR HR20030933A patent/HRP20030933A2/en not_active Application Discontinuation
- 2003-11-14 NO NO20035088A patent/NO20035088D0/en not_active Application Discontinuation
- 2003-11-17 EC EC2003004852A patent/ECSP034852A/en unknown
- 2003-12-01 CO CO03105591A patent/CO5550460A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20035088L (en) | 2003-11-14 |
| WO2002100411A1 (en) | 2002-12-19 |
| UY27290A1 (en) | 2002-12-31 |
| EE200300566A (en) | 2004-02-16 |
| EP1404340A1 (en) | 2004-04-07 |
| SK14222003A3 (en) | 2004-05-04 |
| PL364053A1 (en) | 2004-12-13 |
| KR20040007572A (en) | 2004-01-24 |
| IL158642A0 (en) | 2004-05-12 |
| NZ530154A (en) | 2005-09-30 |
| CZ20033112A3 (en) | 2004-03-17 |
| DE10123952A1 (en) | 2002-11-21 |
| BG108324A (en) | 2004-12-30 |
| NO20035088D0 (en) | 2003-11-14 |
| HUP0401273A3 (en) | 2006-11-28 |
| EA006608B1 (en) | 2006-02-24 |
| YU90403A (en) | 2006-05-25 |
| CN1533278A (en) | 2004-09-29 |
| HRP20030933A2 (en) | 2004-04-30 |
| ZA200308466B (en) | 2004-05-24 |
| HUP0401273A2 (en) | 2004-10-28 |
| ECSP034852A (en) | 2003-12-24 |
| MXPA03010373A (en) | 2004-03-16 |
| BR0209796A (en) | 2004-06-01 |
| AR036332A1 (en) | 2004-09-01 |
| CA2449189A1 (en) | 2002-12-19 |
| CO5550460A2 (en) | 2005-08-31 |
| JP2004529980A (en) | 2004-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |