CO5550460A2 - POSITIVE NAFTOTIAZINE AMPA ALOSTERIC RECEPTORS MODULATORS (PAARM) - Google Patents
POSITIVE NAFTOTIAZINE AMPA ALOSTERIC RECEPTORS MODULATORS (PAARM)Info
- Publication number
- CO5550460A2 CO5550460A2 CO03105591A CO03105591A CO5550460A2 CO 5550460 A2 CO5550460 A2 CO 5550460A2 CO 03105591 A CO03105591 A CO 03105591A CO 03105591 A CO03105591 A CO 03105591A CO 5550460 A2 CO5550460 A2 CO 5550460A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- nr6r7
- so2h
- group
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
1.- Compuestos de la fórmula general (I) en dondeR1 significa un radical elegido del grupo consistente en hidrógeno, un grupo alquilo C1-C6 eventualmente sustituido con uno o varios átomos de halógeno, -SO2H, -SO2- -alquilo C1-C6, -SO-alquilo C1-C6, -CO-alquilo C1-C6, -O, fenil-alquilo C1-C4, -alquil C1-C4-NR6R7 y -alquil C1-C4-O-alquilo C1-C4, y cicloalquilo C3-C6, R2, R3, iguales o diferentes, significan un radical elegido del grupo consistente en hidrógeno, un grupo alquilo C1-C6 eventualmente sustituido con uno o varios átomos de halógeno, halógeno, -NO2, -SO2H, -SO2-alquilo C1-C6, -SO-alquilo C1-C6, -CO-alquilo C1-C6, -OH, -O-alquiloC1-C6, -S-alquilo C1-C6, alquil C1-C4-NR6R7 y -alquil C1-C4-O-alquilo C1-C4, y cicloalquilo C3-C6, oR1 y R2, juntos, significan un puente de alquileno C4-C6 ,R6, R7, iguales o diferentes, significan hidrógeno, alquilo C1-C4 o -CO-alquilo C1-C4, R4, iguales o diferentes, significa un radical elegido del grupo consistente en un grupo alquilo C1-C6 eventualmente sustituido con uno o varios átomos de halógeno, fenil-alquilo C1-C4, halógeno, -CN, -NO2, -SO2H, -SO3H, -SO2-alquilo C1-C6, -SO-alquilo C1-C6, -SO2-NR6R7, -COOH, -CO-alquilo C1-C6, TO-CO-alquilo C1-C4, -CO-O-alquilo C1-C4, -O-CO-O-alquilo C1-C4, -CO-NR6R7, -OH, -O-alquilo C1-C6, -S-alquilo C1-C6, -NR6R7 yun radical arilo, eventualmente sustituido, una vez o varias veces, con átomos de halógeno, -NO2, -SO2H o alquilo C1-C4, R5, iguales o diferentes, significa un radical elegido del grupo consistente en un grupo alquilo C1-C6 eventualmente sustituido con uno o varios átomos de halógeno, fenil-alquilo C1-C4, halógeno, -CN, -NO2, -SO2H, -SO3H, -SO2-alquilo C1-C6, -SO-alquilo C1-C6, -SO2-NR6R7, -COOH, -CO-alquilo C1-C6, -O-CO-alquilo C1-C4, -CO-O-alquilo C1-C4, -O-CO-O-alquilo C1-C4, -CO-NR6R7, -OH, -O-alquilo C1-C6, -S-alquilo C1-C6, -NR6R7 y un radical arilo, eventualmente sustituido, una vez o varias veces, con átomos de halógeno, -NO2, -SO2H o alquilo C1-C4, yn, m, iguales o diferentes, significan 0, 1, 2 o 3,con la condición de que esté excluida nafto[1,8-de]-2,3-dihidro-1,1-dióxido-1,2-tiazina, eventualmente en forma de sus distintos enantiómeros y diastereoisómeros, así como de sus sales fármacológicamente inocuas.1. Compounds of the general formula (I) wherein R1 means a radical selected from the group consisting of hydrogen, a C1-C6 alkyl group optionally substituted with one or more halogen atoms, -SO2H, -SO2- -C1-C6 alkyl , -SO-C1-C6 alkyl, -CO-C1-C6 alkyl, -O, phenyl-C1-C4 alkyl, -C1-C4-NR6R7 alkyl and -C1-C4-O-C1-C4 alkyl, and cycloalkyl C3-C6, R2, R3, the same or different, mean a radical chosen from the group consisting of hydrogen, a C1-C6 alkyl group optionally substituted with one or more halogen atoms, halogen, -NO2, -SO2H, -SO2-alkyl C1-C6, -SO-C1-C6 alkyl, -CO-C1-C6 alkyl, -OH, -O-C1-C6 alkyl, -S-C1-C6 alkyl, C1-C4 alkyl-NR6R7 and -C1-C4 alkyl -O-C1-C4 alkyl, and C3-C6 cycloalkyl, oR1 and R2, together, mean a C4-C6, R6, R7 alkylene bridge, the same or different, mean hydrogen, C1-C4 alkyl or -CO-C1 alkyl -C4, R4, the same or different, means a radical chosen from the group consisting of a C1-alkyl group- C6 optionally substituted with one or more halogen atoms, phenyl-C1-C4 alkyl, halogen, -CN, -NO2, -SO2H, -SO3H, -SO2-C1-C6 alkyl, -SO-C1-C6 alkyl, -SO2 -NR6R7, -COOH, -CO-C1-C6 alkyl, TO-CO-C1-C4 alkyl, -CO-O-C1-C4 alkyl, -O-CO-O-C1-C4 alkyl, -CO-NR6R7, -OH, -O-C1-C6 alkyl, -S-C1-C6 alkyl, -NR6R7 and an aryl radical, optionally substituted, once or several times, with halogen atoms, -NO2, -SO2H or C1-C4 alkyl, R5, the same or different, means a radical chosen from the group consisting of a C1-C6 alkyl group optionally substituted with one or more halogen atoms, phenyl-C1-C4 alkyl, halogen, -CN, -NO2, -SO2H, -SO3H , -SO2-C1-C6 alkyl, -SO-C1-C6 alkyl, -SO2-NR6R7, -COOH, -CO-C1-C6 alkyl, -O-CO-C1-C4 alkyl, -CO-O-C1 alkyl -C4, -O-CO-O-C1-C4 alkyl, -CO-NR6R7, -OH, -O-C1-C6 alkyl, -S-C1-C6 alkyl, -NR6R7 and an aryl radical, optionally substituted, a once or several times, with halogen atoms, -NO2, -SO2H or C1-C4 alkyl, and n, m, the same or different, mean 0, 1, 2 or 3, with the proviso that naphtho [1,8-de] -2,3-dihydro-1,1-dioxide-1,2-thiazine is excluded , possibly in the form of their different enantiomers and diastereoisomers, as well as their pharmacologically safe salts.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10123952A DE10123952A1 (en) | 2001-05-17 | 2001-05-17 | New naphtho-1,2-thiazine compounds, useful as neuroprotectants for treating e.g. epilepsy or Alzheimer's disease, are allosteric modulators of AMPA receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5550460A2 true CO5550460A2 (en) | 2005-08-31 |
Family
ID=7685080
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO03105591A CO5550460A2 (en) | 2001-05-17 | 2003-12-01 | POSITIVE NAFTOTIAZINE AMPA ALOSTERIC RECEPTORS MODULATORS (PAARM) |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP1404340A1 (en) |
JP (1) | JP2004529980A (en) |
KR (1) | KR20040007572A (en) |
CN (1) | CN1533278A (en) |
AR (1) | AR036332A1 (en) |
BG (1) | BG108324A (en) |
BR (1) | BR0209796A (en) |
CA (1) | CA2449189A1 (en) |
CO (1) | CO5550460A2 (en) |
CZ (1) | CZ20033112A3 (en) |
DE (1) | DE10123952A1 (en) |
EA (1) | EA006608B1 (en) |
EC (1) | ECSP034852A (en) |
EE (1) | EE200300566A (en) |
HR (1) | HRP20030933A2 (en) |
HU (1) | HUP0401273A3 (en) |
IL (1) | IL158642A0 (en) |
MX (1) | MXPA03010373A (en) |
NO (1) | NO20035088D0 (en) |
NZ (1) | NZ530154A (en) |
PL (1) | PL364053A1 (en) |
SK (1) | SK14222003A3 (en) |
UY (1) | UY27290A1 (en) |
WO (1) | WO2002100411A1 (en) |
YU (1) | YU90403A (en) |
ZA (1) | ZA200308466B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8039468B2 (en) * | 2006-08-31 | 2011-10-18 | The Governors Of The University Of Alberta | Method of inhibition of respiratory depression using positive allosteric AMPA receptor modulators |
CN111518058B (en) * | 2020-05-29 | 2021-03-09 | 四川大学华西医院 | Oxathiazine compound and application thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998012185A1 (en) * | 1996-09-17 | 1998-03-26 | The Regents Of The University Of California | Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor |
AU4711899A (en) * | 1998-06-25 | 2000-01-10 | Merck & Co., Inc. | Naphtho(1,8-de)thiasin-2-yl methyl carbapenem antibacterials |
DE10004572A1 (en) * | 2000-02-02 | 2001-08-09 | Boehringer Ingelheim Pharma | New positive allosteric AMPA receptor modulators (PAARM), processes for their production and their use as medicines |
-
2001
- 2001-05-17 DE DE10123952A patent/DE10123952A1/en not_active Withdrawn
-
2002
- 2002-05-15 BR BR0209796-6A patent/BR0209796A/en not_active Expired - Fee Related
- 2002-05-15 PL PL02364053A patent/PL364053A1/en not_active Application Discontinuation
- 2002-05-15 SK SK1422-2003A patent/SK14222003A3/en unknown
- 2002-05-15 YU YU90403A patent/YU90403A/en unknown
- 2002-05-15 KR KR10-2003-7014965A patent/KR20040007572A/en not_active Application Discontinuation
- 2002-05-15 UY UY27290A patent/UY27290A1/en not_active Application Discontinuation
- 2002-05-15 CN CNA028100832A patent/CN1533278A/en active Pending
- 2002-05-15 HU HU0401273A patent/HUP0401273A3/en unknown
- 2002-05-15 WO PCT/EP2002/005338 patent/WO2002100411A1/en not_active Application Discontinuation
- 2002-05-15 CA CA002449189A patent/CA2449189A1/en not_active Abandoned
- 2002-05-15 MX MXPA03010373A patent/MXPA03010373A/en unknown
- 2002-05-15 NZ NZ530154A patent/NZ530154A/en unknown
- 2002-05-15 EA EA200301167A patent/EA006608B1/en not_active IP Right Cessation
- 2002-05-15 EP EP02750931A patent/EP1404340A1/en not_active Withdrawn
- 2002-05-15 EE EEP200300566A patent/EE200300566A/en unknown
- 2002-05-15 IL IL15864202A patent/IL158642A0/en unknown
- 2002-05-15 CZ CZ20033112A patent/CZ20033112A3/en unknown
- 2002-05-15 JP JP2003503232A patent/JP2004529980A/en not_active Abandoned
- 2002-05-17 AR ARP020101827A patent/AR036332A1/en not_active Suspension/Interruption
-
2003
- 2003-10-30 ZA ZA200308466A patent/ZA200308466B/en unknown
- 2003-11-07 BG BG108324A patent/BG108324A/en active Pending
- 2003-11-14 HR HR20030933A patent/HRP20030933A2/en not_active Application Discontinuation
- 2003-11-14 NO NO20035088A patent/NO20035088D0/en not_active Application Discontinuation
- 2003-11-17 EC EC2003004852A patent/ECSP034852A/en unknown
- 2003-12-01 CO CO03105591A patent/CO5550460A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
EA200301167A1 (en) | 2004-06-24 |
NO20035088L (en) | 2003-11-14 |
WO2002100411A1 (en) | 2002-12-19 |
UY27290A1 (en) | 2002-12-31 |
EE200300566A (en) | 2004-02-16 |
EP1404340A1 (en) | 2004-04-07 |
SK14222003A3 (en) | 2004-05-04 |
PL364053A1 (en) | 2004-12-13 |
KR20040007572A (en) | 2004-01-24 |
IL158642A0 (en) | 2004-05-12 |
NZ530154A (en) | 2005-09-30 |
CZ20033112A3 (en) | 2004-03-17 |
DE10123952A1 (en) | 2002-11-21 |
BG108324A (en) | 2004-12-30 |
NO20035088D0 (en) | 2003-11-14 |
HUP0401273A3 (en) | 2006-11-28 |
EA006608B1 (en) | 2006-02-24 |
YU90403A (en) | 2006-05-25 |
CN1533278A (en) | 2004-09-29 |
HRP20030933A2 (en) | 2004-04-30 |
ZA200308466B (en) | 2004-05-24 |
HUP0401273A2 (en) | 2004-10-28 |
ECSP034852A (en) | 2003-12-24 |
MXPA03010373A (en) | 2004-03-16 |
BR0209796A (en) | 2004-06-01 |
AR036332A1 (en) | 2004-09-01 |
CA2449189A1 (en) | 2002-12-19 |
JP2004529980A (en) | 2004-09-30 |
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