EA200300741A1 - Способ получения малеата амлодипина - Google Patents

Способ получения малеата амлодипина

Info

Publication number
EA200300741A1
EA200300741A1 EA200300741A EA200300741A EA200300741A1 EA 200300741 A1 EA200300741 A1 EA 200300741A1 EA 200300741 A EA200300741 A EA 200300741A EA 200300741 A EA200300741 A EA 200300741A EA 200300741 A1 EA200300741 A1 EA 200300741A1
Authority
EA
Eurasian Patent Office
Prior art keywords
obtaining
amlodipine
amlodipina
maleat
product
Prior art date
Application number
EA200300741A
Other languages
English (en)
Other versions
EA008141B1 (ru
Inventor
Франтишек Пиха
Павел Сланина
Францискус Бернардус Джемма Беннекер
Original Assignee
Пфайзер Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Лимитед filed Critical Пфайзер Лимитед
Priority claimed from PCT/NL2001/000607 external-priority patent/WO2002053542A1/en
Publication of EA200300741A1 publication Critical patent/EA200300741A1/ru
Publication of EA008141B1 publication Critical patent/EA008141B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Способ получения малеата амлодипина, включающий взаимодействие амлодипина или его соли - продукта присоединения кислоты с малеиновой кислотой в кислой среде, с получением при этом продукта малеата амлодипина. Способ позволяет получить малеат амлодипина, по существу не содержащий аспартат амлодипина.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300741A 2000-12-29 2001-08-15 Способ получения малеата амлодипина EA008141B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25861200P 2000-12-29 2000-12-29
US80934301A 2001-03-16 2001-03-16
PCT/NL2001/000607 WO2002053542A1 (en) 2000-12-29 2001-08-15 Process for making amlodipine maleate

Publications (2)

Publication Number Publication Date
EA200300741A1 true EA200300741A1 (ru) 2003-10-30
EA008141B1 EA008141B1 (ru) 2007-04-27

Family

ID=41639550

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300741A EA008141B1 (ru) 2000-12-29 2001-08-15 Способ получения малеата амлодипина

Country Status (4)

Country Link
KR (1) KR20030066782A (ru)
EA (1) EA008141B1 (ru)
GE (1) GEP20063946B (ru)
OA (1) OA13133A (ru)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
PL189666B1 (pl) * 1998-04-09 2005-09-30 Adamed Sp Z Oo Sposób otrzymywania benzenosulfonianu amlodypiny

Also Published As

Publication number Publication date
OA13133A (en) 2006-12-13
EA008141B1 (ru) 2007-04-27
KR20030066782A (ko) 2003-08-09
GEP20063946B (en) 2006-10-25

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