EA200300422A1 - Натриевые соли 5-[4-[2-( n-метил-n-(2-пиридил)амино)этокси]бензил]тиазолидин-2,4-диона - Google Patents

Натриевые соли 5-[4-[2-( n-метил-n-(2-пиридил)амино)этокси]бензил]тиазолидин-2,4-диона

Info

Publication number
EA200300422A1
EA200300422A1 EA200300422A EA200300422A EA200300422A1 EA 200300422 A1 EA200300422 A1 EA 200300422A1 EA 200300422 A EA200300422 A EA 200300422A EA 200300422 A EA200300422 A EA 200300422A EA 200300422 A1 EA200300422 A1 EA 200300422A1
Authority
EA
Eurasian Patent Office
Prior art keywords
thiazolidin
pyridyl
benzyl
amino
methyl
Prior art date
Application number
EA200300422A
Other languages
English (en)
Other versions
EA005109B1 (ru
Inventor
Эндрю Саймон Крейг
Майкл Миллан
Original Assignee
Смитклайн Бичам Плс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смитклайн Бичам Плс filed Critical Смитклайн Бичам Плс
Publication of EA200300422A1 publication Critical patent/EA200300422A1/ru
Publication of EA005109B1 publication Critical patent/EA005109B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Соединение, представляющее собой натриевую соль 5-[4-[2-(N-метил-N-(2-пиридил)амино)этокси]бензил]тиазолидин-2,4-диона или ее фармацевтически приемлемый сольват, отличающееся тем, что натриевая соль является негигроскопичной или мало гигроскопичной; фармацевтическая композиция, содержащая такое соединение, и применение соединения в медицине.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300422A 2000-09-29 2001-09-28 Натриевая соль 5-[4-[2-(n-метил-n-(2-пиридил)амино)этокси]бензил]тиазолидин-2,4-диона EA005109B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0023971.5A GB0023971D0 (en) 2000-09-29 2000-09-29 Novel pharmaceutical
PCT/GB2001/004334 WO2002026735A1 (en) 2000-09-29 2001-09-28 Sodium salts of 5-'4-'2-(n-methyl-n-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione

Publications (2)

Publication Number Publication Date
EA200300422A1 true EA200300422A1 (ru) 2003-08-28
EA005109B1 EA005109B1 (ru) 2004-10-28

Family

ID=9900428

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300422A EA005109B1 (ru) 2000-09-29 2001-09-28 Натриевая соль 5-[4-[2-(n-метил-n-(2-пиридил)амино)этокси]бензил]тиазолидин-2,4-диона

Country Status (27)

Country Link
US (4) US20040014752A1 (ru)
EP (2) EP1332142A1 (ru)
JP (1) JP2004509959A (ru)
KR (1) KR100917953B1 (ru)
CN (4) CN101125853A (ru)
AP (1) AP1738A (ru)
AU (2) AU2001292028B2 (ru)
BG (1) BG107679A (ru)
BR (1) BR0114308A (ru)
CA (1) CA2423975A1 (ru)
CZ (1) CZ302181B6 (ru)
DZ (1) DZ3480A1 (ru)
EA (1) EA005109B1 (ru)
EC (1) ECSP034528A (ru)
GB (1) GB0023971D0 (ru)
HU (1) HUP0301188A3 (ru)
IL (2) IL155051A0 (ru)
MA (1) MA25912A1 (ru)
MX (1) MXPA03002868A (ru)
NO (2) NO20031435L (ru)
NZ (1) NZ524933A (ru)
OA (1) OA12399A (ru)
PL (1) PL363701A1 (ru)
SK (1) SK3782003A3 (ru)
UA (1) UA74842C2 (ru)
WO (1) WO2002026735A1 (ru)
ZA (1) ZA200302439B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8133637B2 (en) * 2005-10-06 2012-03-13 Headwaters Technology Innovation, Llc Fuel cells and fuel cell catalysts incorporating a nanoring support
US7435741B2 (en) * 2006-05-09 2008-10-14 Teva Pharmaceutical Industries, Ltd. 2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
WO2011075514A1 (en) * 2009-12-15 2011-06-23 Metabolic Solutions Development Company Ppar-sparing thiazolidinediones and combinations for the treatment of neurodegenerative diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE186724T1 (de) * 1987-09-04 1999-12-15 Beecham Group Plc Substituierte thiazolidindionderivate
GB9124513D0 (en) * 1991-11-19 1992-01-08 Smithkline Beecham Plc Novel process
GB9218830D0 (en) * 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
GB9308487D0 (en) * 1993-04-23 1993-06-09 Smithkline Beecham Plc Novel compounds
GB9723295D0 (en) * 1997-11-04 1998-01-07 Smithkline Beecham Plc Novel process
CN1253236A (zh) * 1998-11-11 2000-05-17 李扬远 一种以重力差释放引力能的方法
CN1183130C (zh) * 1999-09-24 2005-01-05 中国人民解放军军事医学科学院毒物药物研究所 噻唑烷类衍生物及其医药用途
HU225919B1 (en) * 1999-12-18 2007-12-28 Richter Gedeon Nyrt Thiazolidine-derivatives, process for their preparation pharmaceutical and intermediates
GB0006133D0 (en) * 2000-03-14 2000-05-03 Smithkline Beecham Plc Novel pharmaceutical

Also Published As

Publication number Publication date
MXPA03002868A (es) 2004-12-06
CZ2003850A3 (cs) 2004-03-17
US20050277679A9 (en) 2005-12-15
AU2001292028B2 (en) 2005-04-21
US20070185167A1 (en) 2007-08-09
NZ524933A (en) 2004-12-24
BR0114308A (pt) 2003-10-14
US20060004058A1 (en) 2006-01-05
EP1813612A1 (en) 2007-08-01
ZA200302439B (en) 2004-04-28
NO20031435L (no) 2003-05-27
WO2002026735A1 (en) 2002-04-04
EA005109B1 (ru) 2004-10-28
JP2004509959A (ja) 2004-04-02
HUP0301188A2 (hu) 2003-11-28
PL363701A1 (en) 2004-11-29
CA2423975A1 (en) 2002-04-04
EP1332142A1 (en) 2003-08-06
KR20030039377A (ko) 2003-05-17
NO20031435D0 (no) 2003-03-28
CN1915992A (zh) 2007-02-21
CN1915992B (zh) 2010-05-12
ECSP034528A (es) 2003-05-26
HUP0301188A3 (en) 2005-04-28
AP2003002767A0 (en) 2003-03-31
KR100917953B1 (ko) 2009-09-21
CN101125853A (zh) 2008-02-20
SK3782003A3 (en) 2004-06-08
GB0023971D0 (en) 2000-11-15
CZ302181B6 (cs) 2010-12-01
CN101125852A (zh) 2008-02-20
OA12399A (en) 2004-09-06
AU9202801A (en) 2002-04-08
AP1738A (en) 2007-05-07
CN1466585A (zh) 2004-01-07
BG107679A (bg) 2003-12-31
IL155051A0 (en) 2003-10-31
MA25912A1 (fr) 2003-10-01
IL188116A0 (en) 2008-03-20
US20040214866A1 (en) 2004-10-28
NO20076517L (no) 2003-04-29
DZ3480A1 (fr) 2002-04-04
UA74842C2 (en) 2006-02-15
US20040014752A1 (en) 2004-01-22
CN100345846C (zh) 2007-10-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU