EA200300097A1 - Производные имидазола - Google Patents

Производные имидазола

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Publication number
EA200300097A1
EA200300097A1 EA200300097A EA200300097A EA200300097A1 EA 200300097 A1 EA200300097 A1 EA 200300097A1 EA 200300097 A EA200300097 A EA 200300097A EA 200300097 A EA200300097 A EA 200300097A EA 200300097 A1 EA200300097 A1 EA 200300097A1
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EA
Eurasian Patent Office
Prior art keywords
formula
compounds
syndrome
pharmaceutical compositions
conditions
Prior art date
Application number
EA200300097A
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English (en)
Inventor
Майкл Кирк Ахлиджанян
Кристофер Блэйр Купер
Кристофер Джон Хелал
Лит-Фуй Лау
Франк Сэмьюэль Меннити
Марк Аллен Саннер
Патриция Энн Сеймур
Анабелла Виллалобос
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Пфайзер Продактс Инк.
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Publication of EA200300097A1 publication Critical patent/EA200300097A1/ru

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

В изобретении предлагаются соединения формулы (1), где R, R, Rи Rимеют значения, определенные в описании, и их фармацевтически приемлемые соли. Соединения формулы (1), как показано, обладают способностью ингибировать активность cdk5, cdk2 и GSK-3. Предлагаются фармацевтические композиции и способы, включающие соединения формулы (1), для лечения и профилактики заболеваний и состояний, включающих нетипичный клеточный рост, такой как рак, и нейродегенеративные заболевания и состояния и те, на которые влияет дофаминэргическая нейротрансмиссия. Описываются также фармацевтические композиции и способы, включающие соединения формулы (1), для лечения мужского бесплодия и подвижности сперматозоидов; сахарного диабета; нарушения толерантности к глюкозе; метаболического синдрома или синдрома X; синдрома поликистоза яичников; адипогенеза и ожирения; миогенеза и хрупкости, например связанного с возрастом снижения физической активности; острой саркопении, например атрофии мышц, и/или кахексии, связанной с ожогами, постельным режимом, иммобилизацией конечности или крупной торакальной, абдоминальной и/или ортопедической хирургической операцией; сепсиса; потери волос; истончения волос и облысения и иммунодефицита.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300097A 2000-07-31 2001-07-25 Производные имидазола EA200300097A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22172400P 2000-07-31 2000-07-31
PCT/IB2001/001335 WO2002010141A1 (en) 2000-07-31 2001-07-25 Imidazole derivatives

Publications (1)

Publication Number Publication Date
EA200300097A1 true EA200300097A1 (ru) 2003-06-26

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EA200300097A EA200300097A1 (ru) 2000-07-31 2001-07-25 Производные имидазола

Country Status (35)

Country Link
EP (1) EP1305295A1 (ru)
JP (2) JP4166084B2 (ru)
KR (1) KR20030019644A (ru)
CN (1) CN1444567A (ru)
AP (1) AP2001002232A0 (ru)
AR (1) AR032629A1 (ru)
AU (1) AU2001270944A1 (ru)
BG (1) BG107469A (ru)
BR (1) BR0112862A (ru)
CA (1) CA2418115A1 (ru)
CR (1) CR6861A (ru)
CZ (1) CZ2003225A3 (ru)
DO (1) DOP2001000220A (ru)
EA (1) EA200300097A1 (ru)
EC (1) ECSP034445A (ru)
EE (1) EE200300049A (ru)
GT (1) GT200100147A (ru)
HR (1) HRP20030048A2 (ru)
HU (1) HUP0303069A3 (ru)
IL (1) IL153787A0 (ru)
IS (1) IS6662A (ru)
MA (1) MA26932A1 (ru)
MX (1) MXPA03000939A (ru)
NO (1) NO20030472L (ru)
NZ (1) NZ523272A (ru)
OA (1) OA12345A (ru)
PA (1) PA8523701A1 (ru)
PE (1) PE20020337A1 (ru)
PL (1) PL365134A1 (ru)
SK (1) SK1042003A3 (ru)
SV (1) SV2002000571A (ru)
TN (1) TNSN01114A1 (ru)
UY (1) UY26862A1 (ru)
WO (1) WO2002010141A1 (ru)
ZA (1) ZA200300819B (ru)

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