EA200300047A1 - Прозрачное водное анестезирующее средство - Google Patents

Прозрачное водное анестезирующее средство

Info

Publication number
EA200300047A1
EA200300047A1 EA200300047A EA200300047A EA200300047A1 EA 200300047 A1 EA200300047 A1 EA 200300047A1 EA 200300047 A EA200300047 A EA 200300047A EA 200300047 A EA200300047 A EA 200300047A EA 200300047 A1 EA200300047 A1 EA 200300047A1
Authority
EA
Eurasian Patent Office
Prior art keywords
anesthetic
propofol
transparent water
tool
hydroxypropyl
Prior art date
Application number
EA200300047A
Other languages
English (en)
Other versions
EA005589B1 (ru
Inventor
Срикантх Аннаппа Паи
Сангеета Ханурмеш Риванкар
Шилпа Судхакар Кочарекар
Original Assignee
Бхарат Сирумс Энд Вэксинс Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бхарат Сирумс Энд Вэксинс Лтд. filed Critical Бхарат Сирумс Энд Вэксинс Лтд.
Publication of EA200300047A1 publication Critical patent/EA200300047A1/ru
Publication of EA005589B1 publication Critical patent/EA005589B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Описаны стерильные фармацевтические стабильные прозрачные водные составы пропофола (2,6-диизопропилфенола), пригодные для парентерального введения. Составы, как правило, содержат комплекс пропофола с 2-гидрокосипропил-β-циклодекстрином при соотношении по массе 1:30-1:60. Такой комплекс пропофола с 2-гидроксипропил-β-циклодекстрином обеспечивает получение прозрачного водного состава, стабильного при обработке в автоклаве. Такой состав эффективен в качестве анестезирующего средства. Описан также способ получения таких синергических составов.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300047A 2000-06-21 2000-12-14 Прозрачное водное анестезирующее средство EA005589B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN573MU2000 IN187686B (ru) 2000-06-21 2000-06-21
PCT/IN2000/000124 WO2001097796A1 (en) 2000-06-21 2000-12-14 Clear aqueous anaesthetic composition

Publications (2)

Publication Number Publication Date
EA200300047A1 true EA200300047A1 (ru) 2003-06-26
EA005589B1 EA005589B1 (ru) 2005-04-28

Family

ID=11097257

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300047A EA005589B1 (ru) 2000-06-21 2000-12-14 Прозрачное водное анестезирующее средство

Country Status (26)

Country Link
US (1) US7138387B2 (ru)
EP (1) EP1299095B1 (ru)
JP (1) JP4907833B2 (ru)
KR (1) KR100810066B1 (ru)
CN (1) CN1254237C (ru)
AP (1) AP2002002674A0 (ru)
AT (1) ATE267592T1 (ru)
AU (2) AU3597201A (ru)
BG (1) BG107463A (ru)
BR (1) BR0017268A (ru)
CA (1) CA2414064C (ru)
DE (1) DE60011149T2 (ru)
DK (1) DK1299095T3 (ru)
EA (1) EA005589B1 (ru)
ES (1) ES2222271T3 (ru)
HU (1) HUP0301646A3 (ru)
IL (1) IL153387A0 (ru)
IN (1) IN187686B (ru)
MX (1) MXPA02012611A (ru)
NO (1) NO20025999D0 (ru)
NZ (1) NZ523643A (ru)
PL (1) PL359624A1 (ru)
PT (1) PT1299095E (ru)
WO (1) WO2001097796A1 (ru)
YU (1) YU2703A (ru)
ZA (1) ZA200300336B (ru)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN188917B (ru) * 2000-12-07 2002-11-23 Bharat Surums & Vaccines Ltd
US7034013B2 (en) 2001-03-20 2006-04-25 Cydex, Inc. Formulations containing propofol and a sulfoalkyl ether cyclodextrin
NZ533536A (en) * 2001-12-28 2006-11-30 Mgi Gp Inc Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol such as O-phosphonooxymethyl propofol
US20050239746A1 (en) * 2002-02-01 2005-10-27 Penkler Lawrence J Pharmaceutical composition
US7550155B2 (en) 2002-07-29 2009-06-23 Transform Pharmaceuticals Inc. Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses
PL375874A1 (en) * 2002-07-29 2005-12-12 Transform Pharmaceuticals, Inc. Aqueous 2,6-diisopropylphenol pharmaceutical compositions
SI1585548T1 (sl) * 2002-12-09 2018-11-30 Abraxis Bioscience, Llc Sestave in metode odmerjanja farmakoloških sredstev
EP1704858A4 (en) * 2004-01-14 2008-06-04 Otsuka Pharma Co Ltd PROPOFOL-CONTAINING FAT-EMULSION PREPARATION
CN101090736A (zh) * 2004-09-13 2007-12-19 印度血清及疫苗有限公司 具抗微生物的防腐效果的用于静脉给药的稳定乳剂组合物
JP2009504634A (ja) * 2005-08-12 2009-02-05 ブハラット セルムズ アンド ヴァクシンズ リミテッド プロポフォールを含む水性麻酔剤組成物
WO2007128866A2 (en) * 2006-05-09 2007-11-15 Novobion Oy Novel chemical compositions
EP2712900A1 (en) * 2008-03-11 2014-04-02 3M Innovative Properties Company Phototools having a protective layer
WO2010148288A2 (en) * 2009-06-19 2010-12-23 Lyotropic Therapeutics, Inc. Pharmaceutical formulations with low aqueous levels of free unbound drug
EP2456823A4 (en) 2009-07-21 2012-12-26 3M Innovative Properties Co CURABLE COMPOSITION, METHOD FOR COATING A PHOTO TOOL, AND COATED PHOTO TOOL
KR101781659B1 (ko) 2009-09-16 2017-09-25 쓰리엠 이노베이티브 프로퍼티즈 컴파니 플루오르화된 코팅 및 그로 제조된 포토툴
EP2478034A1 (en) 2009-09-16 2012-07-25 3M Innovative Properties Company Fluorinated coating and phototools made therewith
US8268067B2 (en) * 2009-10-06 2012-09-18 3M Innovative Properties Company Perfluoropolyether coating composition for hard surfaces
EP2345427A1 (de) * 2010-01-14 2011-07-20 SapioTec GmbH Flurankomplex
EP2484350B1 (de) * 2011-02-04 2016-04-20 Roewer, Norbert, Univ.-Prof. Dr. med. Pharmazeutische Zubereitung, enthaltend einen Komplex eines Propofolsalzes mit einem Cyclodextrin
AU2013273764B2 (en) * 2011-11-29 2016-05-05 Zoetis Services Llc Pharmaceutical compositions
EP3446692A1 (en) 2011-11-29 2019-02-27 Jurox Pty. Ltd. Methods of preserving injectable pharmaceutical compositions comprising a cyclodextrin and a hydrophobic drug
CN103263404B (zh) * 2012-04-28 2017-12-01 中国人民解放军军事医学科学院放射与辐射医学研究所 一种复合麻醉药物
US10646439B2 (en) * 2016-01-29 2020-05-12 Cuda Anesthetics, Llc Aqueous pharmaceutical formulation comprising propofol
FR3117337B1 (fr) 2020-12-10 2023-04-28 Centre Hospitalier Univ De Lille Composition pharmaceutique contenant du propofol, une cyclodextrine ou un dérivé de cyclodextrine et un sel pharmaceuticalement acceptable

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA962214B (en) * 1995-04-10 1996-10-07 Farmarc Nederland Bv Pharmaceutical composition

Also Published As

Publication number Publication date
US7138387B2 (en) 2006-11-21
PL359624A1 (en) 2004-08-23
IL153387A0 (en) 2003-07-06
DK1299095T3 (da) 2004-10-11
JP2003535893A (ja) 2003-12-02
ATE267592T1 (de) 2004-06-15
HUP0301646A2 (hu) 2003-09-29
CN1454085A (zh) 2003-11-05
MXPA02012611A (es) 2004-07-30
PT1299095E (pt) 2004-10-29
EP1299095B1 (en) 2004-05-26
EP1299095A1 (en) 2003-04-09
BG107463A (en) 2003-11-28
AU2001235972B2 (en) 2005-07-21
CA2414064C (en) 2013-01-08
IN187686B (ru) 2002-06-08
WO2001097796A1 (en) 2001-12-27
NO20025999L (no) 2002-12-13
US20040014718A1 (en) 2004-01-22
ZA200300336B (en) 2004-04-08
DE60011149T2 (de) 2005-07-07
BR0017268A (pt) 2003-05-27
DE60011149D1 (de) 2004-07-01
NO20025999D0 (no) 2002-12-13
JP4907833B2 (ja) 2012-04-04
EA005589B1 (ru) 2005-04-28
CA2414064A1 (en) 2001-12-27
KR100810066B1 (ko) 2008-03-05
AP2002002674A0 (en) 2002-12-31
AU3597201A (en) 2002-01-02
HUP0301646A3 (en) 2005-06-28
KR20030023875A (ko) 2003-03-20
NZ523643A (en) 2004-05-28
CN1254237C (zh) 2006-05-03
YU2703A (sh) 2006-03-03
ES2222271T3 (es) 2005-02-01

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU