EA200200878A1 - Бициклические соединения, проявляющие антагонизм к рецептору витронектина, способ их получения и содержащие их фармацевтические композиции - Google Patents

Бициклические соединения, проявляющие антагонизм к рецептору витронектина, способ их получения и содержащие их фармацевтические композиции

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EA200200878A1
EA200200878A1 EA200200878A EA200200878A EA200200878A1 EA 200200878 A1 EA200200878 A1 EA 200200878A1 EA 200200878 A EA200200878 A EA 200200878A EA 200200878 A EA200200878 A EA 200200878A EA 200200878 A1 EA200200878 A1 EA 200200878A1
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Eurasian Patent Office
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group
stands
substituted
denotes
alkyl
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EA200200878A
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English (en)
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EA005155B1 (ru
Inventor
Патрик Касара
Франсуаз Перрон-Сьерра
Ганем Атасси
Гордон Тюкке
Доминик Сент-Дизье
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Ле Лаборатуар Сервье
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Publication of EA200200878A1 publication Critical patent/EA200200878A1/ru
Publication of EA005155B1 publication Critical patent/EA005155B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Соединение формулы (I)в которой G обозначает фенильную группу, которая может быть замещенной, или гетероциклическую группу, которая может быть замещенной, a Gи Gобозначают N или С,T- обозначает -СН-СН-, -СН=СН- или =СН-СН- и Тобозначает связь или Tобозначает -CH- или =СН- и тогда ТобозначаетилиRобозначает группу -(CH)-COOR,Rи Rобозначают водород, алкил, арильную группу, которая может быть замещенной, или арилалкильную группу, которая может быть замещенной,А обозначает -СО-, -СН-, =СН- или -СН= и W обозначает -СН-, =С- или -С=, либо А обозначает -СО- или -СН- и W обозначает N,Х обозначает -CO-X-, -CO-NR-X-, -NR-CO-X-, -O-X-, -SO-NR-X- или -S(O)-X-,Y обозначает -Y-, -Y-Y- или -Y-Y-Y-, где Yобозначает алкиленовую, алкениленовую или алкиниленовую группу и Yобозначает ариленовую, гетероариленовую, циклоалкиленовую или гетероциклоалкиленовую группу,Z обозначает -Z-, Z-NR- и Z-NR-CO-, где Zобозначает гетероарил, гетероциклоалкил, гетероарилалкил, гетероциклоалкилалкил, сшитый арилгетероарил, сшитый арилгетероциклоалкил, сшитый гетероарилгетероциклоалкил, сшитый гетероциклоалкилгетероалил или сшитый гетероарилгетероарил, каждый из которых может быть замещенным, либо группуZ-NR- или Z-NR-CO,где Zобозначает группу Z, алкил или гетероалкил и Zобозначает Zили алкил. Медицинские препараты.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200878A 2000-03-07 2001-03-06 Бициклические соединения, проявляющие антагонизм к рецептору витронектина, способ их получения и содержащие их фармацевтические композиции EA005155B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0002902A FR2806082B1 (fr) 2000-03-07 2000-03-07 Nouveaux composes bicycliques antagonistes des recepteurs de la vitronectine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2001/000650 WO2001079172A1 (fr) 2000-03-07 2001-03-06 Composes bicycliques antagonistes des recepteurs de la vitronectine, leur procede de preparation et les compositions qui les contiennent

Publications (2)

Publication Number Publication Date
EA200200878A1 true EA200200878A1 (ru) 2002-12-26
EA005155B1 EA005155B1 (ru) 2004-12-30

Family

ID=8847803

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200878A EA005155B1 (ru) 2000-03-07 2001-03-06 Бициклические соединения, проявляющие антагонизм к рецептору витронектина, способ их получения и содержащие их фармацевтические композиции

Country Status (27)

Country Link
US (1) US6846833B2 (ru)
EP (1) EP1268429B1 (ru)
JP (1) JP3974780B2 (ru)
KR (1) KR100530523B1 (ru)
CN (1) CN1216866C (ru)
AR (1) AR029485A1 (ru)
AT (1) ATE273957T1 (ru)
AU (2) AU2001293374B2 (ru)
BR (1) BR0108998A (ru)
CA (1) CA2402686C (ru)
CZ (1) CZ301808B6 (ru)
DE (1) DE60105001T2 (ru)
DK (1) DK1268429T3 (ru)
EA (1) EA005155B1 (ru)
ES (1) ES2227265T3 (ru)
FR (1) FR2806082B1 (ru)
HK (1) HK1052345B (ru)
HU (1) HU229343B1 (ru)
MX (1) MXPA02008633A (ru)
NO (1) NO324052B1 (ru)
NZ (1) NZ520805A (ru)
PL (1) PL356886A1 (ru)
PT (1) PT1268429E (ru)
SI (1) SI1268429T1 (ru)
SK (1) SK286882B6 (ru)
WO (1) WO2001079172A1 (ru)
ZA (1) ZA200206354B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2806082B1 (fr) * 2000-03-07 2002-05-17 Adir Nouveaux composes bicycliques antagonistes des recepteurs de la vitronectine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US9034910B2 (en) 2008-06-09 2015-05-19 Allergan, Inc. Methods of treating alpha adrenergic mediated conditions
ES2672777T3 (es) * 2008-06-09 2018-06-18 Allergan, Inc. Métodos de tratamiento de estados con mediación alfa-adrenérgica
KR102281647B1 (ko) 2020-12-09 2021-07-30 메디케어제약 주식회사 피페라진-퀴놀린 유도체의 제조방법

Family Cites Families (15)

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US6403578B1 (en) * 1993-12-21 2002-06-11 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
JPH10504808A (ja) * 1994-06-29 1998-05-12 スミスクライン・ビーチャム・コーポレイション ビトロネクチン受容体拮抗物質
US6008214A (en) * 1994-08-22 1999-12-28 Smithkline Beecham Corporation Bicyclic compounds
ES2171768T3 (es) * 1996-03-20 2002-09-16 Hoechst Ag Inhibidores de la resorcion osea y antagonistas de receptores de vitronectina.
UA60311C2 (ru) * 1996-10-02 2003-10-15 Смітклайн Бічам Корпорейшн Антагонисты рецептора витронектина
CO4920232A1 (es) * 1997-01-08 2000-05-29 Smithkline Beecham Corp Acidos aceticos dibenzo [a,d] cicloheptano con actividad antagonista del receptor de vitronectin
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WO1999005107A1 (en) * 1997-07-25 1999-02-04 Smithkline Beecham Corporation Vitronectin receptor antagonist
PE122699A1 (es) * 1997-09-19 2000-02-12 Smithkline Beecham Corp Antagonistas de receptores de vitronectina
US6524553B2 (en) * 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
EP0960882A1 (en) * 1998-05-19 1999-12-01 Hoechst Marion Roussel Deutschland GmbH Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists
FR2786182B1 (fr) * 1998-11-24 2001-01-12 Hoechst Marion Roussel Inc Nouveaux derives d'acylguanidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
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FR2806082B1 (fr) * 2000-03-07 2002-05-17 Adir Nouveaux composes bicycliques antagonistes des recepteurs de la vitronectine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
AU9337401A (en) 2001-10-30
CZ301808B6 (cs) 2010-06-30
US20030229109A1 (en) 2003-12-11
KR100530523B1 (ko) 2005-11-23
ATE273957T1 (de) 2004-09-15
NO324052B1 (no) 2007-08-06
MXPA02008633A (es) 2003-02-24
SK12702002A3 (sk) 2003-03-04
EP1268429A1 (fr) 2003-01-02
CA2402686C (fr) 2008-02-05
EA005155B1 (ru) 2004-12-30
HUP0300181A2 (en) 2003-05-28
BR0108998A (pt) 2002-12-17
AR029485A1 (es) 2003-07-02
PT1268429E (pt) 2004-10-29
HU229343B1 (en) 2013-11-28
DE60105001D1 (de) 2004-09-23
SI1268429T1 (en) 2004-12-31
PL356886A1 (en) 2004-07-12
HUP0300181A3 (en) 2005-07-28
DK1268429T3 (da) 2004-12-27
KR20020075806A (ko) 2002-10-05
EP1268429B1 (fr) 2004-08-18
US6846833B2 (en) 2005-01-25
ZA200206354B (en) 2003-08-08
SK286882B6 (sk) 2009-07-06
AU2001293374B2 (en) 2005-02-17
WO2001079172A1 (fr) 2001-10-25
NO20024275D0 (no) 2002-09-06
FR2806082A1 (fr) 2001-09-14
CN1216866C (zh) 2005-08-31
CZ20022992A3 (cs) 2003-02-12
CN1411444A (zh) 2003-04-16
FR2806082B1 (fr) 2002-05-17
JP3974780B2 (ja) 2007-09-12
DE60105001T2 (de) 2005-08-18
NZ520805A (en) 2004-12-24
HK1052345A1 (en) 2003-09-11
NO20024275L (no) 2002-09-06
CA2402686A1 (fr) 2001-10-25
JP2003531140A (ja) 2003-10-21
HK1052345B (zh) 2005-12-30
ES2227265T3 (es) 2005-04-01

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