EA200100940A1 - Водорастворимые трансплатиновые комплексы, обладающие противораковым действием, способ их получения и способ лечения - Google Patents
Водорастворимые трансплатиновые комплексы, обладающие противораковым действием, способ их получения и способ леченияInfo
- Publication number
- EA200100940A1 EA200100940A1 EA200100940A EA200100940A EA200100940A1 EA 200100940 A1 EA200100940 A1 EA 200100940A1 EA 200100940 A EA200100940 A EA 200100940A EA 200100940 A EA200100940 A EA 200100940A EA 200100940 A1 EA200100940 A1 EA 200100940A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- treatment
- soluble
- production
- water
- Prior art date
Links
- 238000000034 method Methods 0.000 title 2
- 230000001093 anti-cancer Effects 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 239000013522 chelant Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 229910052697 platinum Inorganic materials 0.000 abstract 1
- 230000017105 transposition Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
Изобретение относится к лечению опухолей с помощью нового водорастворимого транс-платинового координационного соединения, имеющего общую структурную формулу[PtBXm(NR*)],где Х - лиганд анионного типа,m - 1 или 2,R* выбран из группы, состоящей из водорода и низших алкилов, R* может быть одинаковым или разным,В - планарная гетероциклическая кольцевая группа, включающая, по крайней мере, один атом азота в качестве составного элемента кольца и подвесную хелатную группу, и атом азота группы В, ковалентно связанный с атомом платины, в транс-положении по отношению к группе NR*.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/263,222 US6001872A (en) | 1999-03-05 | 1999-03-05 | Water soluble transplatinum complexes with anti-cancer activity and method of using same |
PCT/US2000/005383 WO2000051600A1 (en) | 1999-03-05 | 2000-03-02 | Water soluble transplatinum complexes with anti-cancer activity and method of using same |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200100940A1 true EA200100940A1 (ru) | 2002-04-25 |
EA004589B1 EA004589B1 (ru) | 2004-06-24 |
Family
ID=23000879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200100940A EA004589B1 (ru) | 1999-03-05 | 2000-03-02 | Водорастворимые комплексы трансплатины, проявляющие противораковую активность, и их применение |
Country Status (12)
Country | Link |
---|---|
US (1) | US6001872A (ru) |
EP (1) | EP1158974A4 (ru) |
JP (1) | JP2002538116A (ru) |
KR (1) | KR20010102495A (ru) |
AU (1) | AU763823B2 (ru) |
BR (1) | BR0009246A (ru) |
CA (1) | CA2366048A1 (ru) |
CZ (1) | CZ20013181A3 (ru) |
EA (1) | EA004589B1 (ru) |
MX (1) | MXPA01008991A (ru) |
WO (1) | WO2000051600A1 (ru) |
ZA (1) | ZA200107313B (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6001872A (en) * | 1999-03-05 | 1999-12-14 | Virginia Commonwealth University | Water soluble transplatinum complexes with anti-cancer activity and method of using same |
KR100314720B1 (ko) * | 1999-03-26 | 2001-11-26 | 박호군 | 포스파젠 삼합체에 도입된 백금 착물, 그의 제조방법 및 그를 유효성분으로 하는 항암제 |
ES2257178B1 (es) * | 2004-09-30 | 2007-08-16 | Universidad Autonoma De Madrid | Compuestos de platino de formula trans-(ptc12(isopropilamina)(4-(hidroximetil)-piridina)) y trans-(ptc12(isopropilamina)(3-hidroximetil)-piridina y su aplicacion como farmaco antitumoral. |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5562925A (en) * | 1970-04-20 | 1996-10-08 | Research Corporation Tech. Inc. | Anti-tumor method |
US5107007A (en) * | 1989-09-01 | 1992-04-21 | The University Of Vermont And State Agricultural College | Bis-platinum complexes as chemotherapeutic agents |
US5770591A (en) * | 1986-07-25 | 1998-06-23 | The University Of Vermont And State Agricultural College | Bis-platinum complexes as chemotherapeutic agents |
US5026694A (en) * | 1987-04-13 | 1991-06-25 | The British Columbia Cancer Foundation | Platinum complexes with one radiosensitizing ligand |
US4937358A (en) * | 1987-06-23 | 1990-06-26 | American Cyanamid Company | Synthesis of cisplatin analogs |
US4996337A (en) * | 1987-06-23 | 1991-02-26 | American Cyanamid Company | Synthesis of cisplatin analogs |
JPH08176176A (ja) * | 1994-12-26 | 1996-07-09 | Ss Pharmaceut Co Ltd | 白金錯体及びこれを含有する悪性腫瘍治療剤 |
GB9502799D0 (en) * | 1995-02-14 | 1995-04-05 | Johnson Matthey Plc | Improvements in platinum complexes |
US6001872A (en) * | 1999-03-05 | 1999-12-14 | Virginia Commonwealth University | Water soluble transplatinum complexes with anti-cancer activity and method of using same |
-
1999
- 1999-03-05 US US09/263,222 patent/US6001872A/en not_active Expired - Fee Related
-
2000
- 2000-03-02 AU AU38628/00A patent/AU763823B2/en not_active Ceased
- 2000-03-02 JP JP2000602068A patent/JP2002538116A/ja active Pending
- 2000-03-02 KR KR1020017011259A patent/KR20010102495A/ko not_active Application Discontinuation
- 2000-03-02 EA EA200100940A patent/EA004589B1/ru not_active IP Right Cessation
- 2000-03-02 WO PCT/US2000/005383 patent/WO2000051600A1/en not_active Application Discontinuation
- 2000-03-02 EP EP00917695A patent/EP1158974A4/en not_active Withdrawn
- 2000-03-02 BR BR0009246-0A patent/BR0009246A/pt not_active IP Right Cessation
- 2000-03-02 CZ CZ20013181A patent/CZ20013181A3/cs unknown
- 2000-03-02 CA CA002366048A patent/CA2366048A1/en not_active Abandoned
- 2000-03-02 MX MXPA01008991A patent/MXPA01008991A/es unknown
-
2001
- 2001-09-04 ZA ZA200107313A patent/ZA200107313B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU3862800A (en) | 2000-09-21 |
CA2366048A1 (en) | 2000-09-08 |
CZ20013181A3 (cs) | 2002-01-16 |
EP1158974A1 (en) | 2001-12-05 |
US6001872A (en) | 1999-12-14 |
EP1158974A4 (en) | 2002-06-05 |
WO2000051600A1 (en) | 2000-09-08 |
BR0009246A (pt) | 2002-01-22 |
AU763823B2 (en) | 2003-07-31 |
ZA200107313B (en) | 2002-06-11 |
MXPA01008991A (es) | 2002-09-18 |
JP2002538116A (ja) | 2002-11-12 |
KR20010102495A (ko) | 2001-11-15 |
EA004589B1 (ru) | 2004-06-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |