EA199900067A1 - Очищенный поверхностный антиген сперматозоидов, моноклональное антитело для него и их применения - Google Patents
Очищенный поверхностный антиген сперматозоидов, моноклональное антитело для него и их примененияInfo
- Publication number
- EA199900067A1 EA199900067A1 EA199900067A EA199900067A EA199900067A1 EA 199900067 A1 EA199900067 A1 EA 199900067A1 EA 199900067 A EA199900067 A EA 199900067A EA 199900067 A EA199900067 A EA 199900067A EA 199900067 A1 EA199900067 A1 EA 199900067A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- monoclonal antibody
- application
- spermatosis
- antigen
- saga
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 229940124462 contraceptive vaccine Drugs 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000000934 spermatocidal agent Substances 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/367—Infertility, e.g. sperm disorder, ovulatory dysfunction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gynecology & Obstetrics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Моноклональное антитело (S19), экспрессируемое Депозитом НВ 12144, АТСС, эффективно агглютинирует поверхностный гликопротеин сперматозоидов, белок SAGA-1. Это mAb находит применение в качестве связывающего агента в спермициде, обнаруживая высокую степень эффективности в потенциале связывания сперматозоидов. Связанный белок, идентифицированный как SAGA-1, является иммуногеном в противозачаточной вакцине, а также стандартом для определения титра антител после вакцинации. Это моноклональное антитело может быть также использовано в качестве диагностического средства для определения присутствия и количества сперматозоидов в разнообразных пробах.Международная заявка была опубликована вместе с отчетом о международном поиске
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/671,622 US5830472A (en) | 1996-06-28 | 1996-06-28 | Purified sperm surface antigen, monoclonal antibody therefor and applications therefor |
PCT/US1997/010813 WO1998000164A1 (en) | 1996-06-28 | 1997-06-30 | Purified sperm surface antigen, monoclonal antibody therefor and applications therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
EA199900067A1 true EA199900067A1 (ru) | 1999-08-26 |
EA003531B1 EA003531B1 (ru) | 2003-06-26 |
Family
ID=24695254
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199900067A EA003531B1 (ru) | 1996-06-28 | 1997-06-30 | Моноклональное антитело s19 к поверхностному антигену сперматозоидов, антиген, выявляемый таким антителом, и содержащие его вакцина и спермицид |
Country Status (16)
Country | Link |
---|---|
US (1) | US5830472A (ru) |
EP (1) | EP0964696A4 (ru) |
JP (1) | JP2001506841A (ru) |
CN (1) | CN1227497A (ru) |
AU (1) | AU722559B2 (ru) |
BR (1) | BR9710089A (ru) |
CA (1) | CA2258717A1 (ru) |
CZ (1) | CZ293040B6 (ru) |
EA (1) | EA003531B1 (ru) |
HU (1) | HUP9904620A3 (ru) |
IL (1) | IL127764A (ru) |
NO (1) | NO986050L (ru) |
PL (1) | PL186809B1 (ru) |
SK (1) | SK281505B6 (ru) |
UA (1) | UA74765C2 (ru) |
WO (1) | WO1998000164A1 (ru) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1162880A1 (en) * | 1999-03-23 | 2001-12-19 | University of Virginia | Human sperm surface antigens |
GB9913556D0 (en) * | 1999-06-11 | 1999-08-11 | Zeneca Ltd | Assays |
AU6227800A (en) * | 1999-07-23 | 2001-02-13 | University Of Virginia Patent Foundation | Recombinant antibody directed against human sperm antigen |
US20020151089A1 (en) * | 1999-09-15 | 2002-10-17 | Chapman William H. | Separating components of biological samples |
AU1778701A (en) * | 1999-11-17 | 2001-05-30 | University Of Virginia Patent Foundation | Sperm cell selection system |
US7125550B2 (en) * | 2000-01-19 | 2006-10-24 | University Of Virginia Patent Foundation | Human sperm specific lysozyme-like proteins |
EP1255831A2 (en) * | 2000-01-19 | 2002-11-13 | The University Of Virginia Patent Foundation | Sperm specific proteins |
CA2398710A1 (en) | 2000-01-20 | 2001-07-26 | University Of Virginia Patent Foundation | Egg specific surface proteins |
US6541206B1 (en) * | 2000-06-19 | 2003-04-01 | Gabor B. Huszar | Objective biochemical method for assessment of sperm quality |
US20030207393A1 (en) * | 2001-01-19 | 2003-11-06 | Herr John C. | Cbp86, a sperm specific protein |
WO2005079243A2 (en) * | 2004-02-06 | 2005-09-01 | University Of Virginia Patent Foundation | Compositions and methods for identifying sperm for forensic applications |
US8817965B2 (en) | 2006-07-21 | 2014-08-26 | Bce Inc. | Method, system and apparatus for handling establishment of a communication session |
US20080187549A1 (en) * | 2007-02-07 | 2008-08-07 | Morey William A | Polyantigenic-based (multiple antigens) modi or set of methods for developing infertility vaccines |
US20080290037A1 (en) * | 2007-05-23 | 2008-11-27 | Applera Corporation | Methods and Apparatuses for Separating Biological Particles |
US20090136962A1 (en) * | 2007-11-27 | 2009-05-28 | Herr John C | Diagnostic markers for cancer |
EP2494985A1 (en) * | 2008-04-07 | 2012-09-05 | Auburn University | Zona pellucida binding peptides, expression vectors, compositions, and methods for species-specific immunocontraception of animals |
GB0911885D0 (en) * | 2009-07-08 | 2009-08-19 | Oxford Biodynamics Ltd | Screening method for cell aging |
IL208820A0 (en) | 2010-10-19 | 2011-01-31 | Rachel Teitelbaum | Biologic female contraceptives |
US10877033B2 (en) | 2013-06-18 | 2020-12-29 | Oxford University Innovation Limited | Method of detecting the presence or absence of autoantibodies |
CN103852583A (zh) * | 2014-03-18 | 2014-06-11 | 南京医科大学 | 一种快速检测Boule蛋白的胶体金试剂条及检测方法 |
CN106153938B (zh) * | 2015-04-09 | 2018-05-11 | 中国医学科学院基础医学研究所 | 抗ACTL7a和GAPDH-2抗体的检测方法、试剂盒及其用途 |
KR101916959B1 (ko) * | 2015-07-13 | 2018-11-08 | 김동구 | 정자의 성 감별용 항체 및 이의 용도 |
CN106526162A (zh) * | 2016-11-03 | 2017-03-22 | 天津市宝坻区人民医院 | 一种抗精子抗体检测方法 |
CN117987376B (zh) * | 2024-03-26 | 2024-06-25 | 玛特瑞尔(吉林)生物技术有限公司 | 人精子顶体蛋白sp-10单克隆抗体、杂交瘤细胞株及其应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5227160A (en) * | 1988-07-15 | 1993-07-13 | The Biomembrane Institute | Monoclonal antibody nuh2 capable of inactivating motility of human sperm, antigen defined by said monoclonal antibody and methods of using said monoclonal antibody and antigen |
US5436157A (en) * | 1989-03-03 | 1995-07-25 | The University Of Virginia Alumni Patents Foundation | Human intra-acrosomal sperm antigen |
US5605803A (en) * | 1989-03-03 | 1997-02-25 | University Of Virginia Alumni Patents Foundation | Human sperm diagnostic |
-
1996
- 1996-06-28 US US08/671,622 patent/US5830472A/en not_active Expired - Fee Related
-
1997
- 1997-06-30 SK SK1795-98A patent/SK281505B6/sk unknown
- 1997-06-30 CN CN97197175A patent/CN1227497A/zh active Pending
- 1997-06-30 PL PL97330842A patent/PL186809B1/pl not_active IP Right Cessation
- 1997-06-30 WO PCT/US1997/010813 patent/WO1998000164A1/en not_active Application Discontinuation
- 1997-06-30 HU HU9904620A patent/HUP9904620A3/hu unknown
- 1997-06-30 IL IL12776497A patent/IL127764A/en not_active IP Right Cessation
- 1997-06-30 EP EP97930179A patent/EP0964696A4/en not_active Withdrawn
- 1997-06-30 JP JP50421698A patent/JP2001506841A/ja not_active Ceased
- 1997-06-30 EA EA199900067A patent/EA003531B1/ru unknown
- 1997-06-30 BR BR9710089-7A patent/BR9710089A/pt not_active Application Discontinuation
- 1997-06-30 CA CA002258717A patent/CA2258717A1/en not_active Abandoned
- 1997-06-30 AU AU34071/97A patent/AU722559B2/en not_active Ceased
- 1997-06-30 CZ CZ19984284A patent/CZ293040B6/cs not_active IP Right Cessation
- 1997-06-30 UA UA99010427A patent/UA74765C2/uk unknown
-
1998
- 1998-12-22 NO NO986050A patent/NO986050L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU3407197A (en) | 1998-01-21 |
JP2001506841A (ja) | 2001-05-29 |
NO986050D0 (no) | 1998-12-22 |
WO1998000164A1 (en) | 1998-01-08 |
HUP9904620A2 (hu) | 2000-05-28 |
NO986050L (no) | 1999-02-08 |
SK281505B6 (sk) | 2001-04-09 |
EA003531B1 (ru) | 2003-06-26 |
CZ428498A3 (cs) | 1999-06-16 |
UA74765C2 (en) | 2006-02-15 |
CZ293040B6 (cs) | 2004-01-14 |
BR9710089A (pt) | 2000-06-06 |
EP0964696A4 (en) | 2005-01-05 |
SK179598A3 (en) | 2000-04-10 |
PL186809B1 (pl) | 2004-02-27 |
HUP9904620A3 (en) | 2001-08-28 |
EP0964696A1 (en) | 1999-12-22 |
CN1227497A (zh) | 1999-09-01 |
PL330842A1 (en) | 1999-06-07 |
US5830472A (en) | 1998-11-03 |
IL127764A (en) | 2001-11-25 |
AU722559B2 (en) | 2000-08-03 |
IL127764A0 (en) | 1999-10-28 |
CA2258717A1 (en) | 1998-01-08 |
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