EA199900067A1 - Очищенный поверхностный антиген сперматозоидов, моноклональное антитело для него и их применения - Google Patents

Очищенный поверхностный антиген сперматозоидов, моноклональное антитело для него и их применения

Info

Publication number
EA199900067A1
EA199900067A1 EA199900067A EA199900067A EA199900067A1 EA 199900067 A1 EA199900067 A1 EA 199900067A1 EA 199900067 A EA199900067 A EA 199900067A EA 199900067 A EA199900067 A EA 199900067A EA 199900067 A1 EA199900067 A1 EA 199900067A1
Authority
EA
Eurasian Patent Office
Prior art keywords
monoclonal antibody
application
spermatosis
antigen
saga
Prior art date
Application number
EA199900067A
Other languages
English (en)
Other versions
EA003531B1 (ru
Inventor
Джон С. Херр
Алан Б. Дикман
Элизабет Нортон
Энн Вестбрук-Кейс
Original Assignee
Дзе Юниверсити Оф Вирджиния Пэтент Фаундейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Юниверсити Оф Вирджиния Пэтент Фаундейшн filed Critical Дзе Юниверсити Оф Вирджиния Пэтент Фаундейшн
Publication of EA199900067A1 publication Critical patent/EA199900067A1/ru
Publication of EA003531B1 publication Critical patent/EA003531B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/367—Infertility, e.g. sperm disorder, ovulatory dysfunction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Моноклональное антитело (S19), экспрессируемое Депозитом НВ 12144, АТСС, эффективно агглютинирует поверхностный гликопротеин сперматозоидов, белок SAGA-1. Это mAb находит применение в качестве связывающего агента в спермициде, обнаруживая высокую степень эффективности в потенциале связывания сперматозоидов. Связанный белок, идентифицированный как SAGA-1, является иммуногеном в противозачаточной вакцине, а также стандартом для определения титра антител после вакцинации. Это моноклональное антитело может быть также использовано в качестве диагностического средства для определения присутствия и количества сперматозоидов в разнообразных пробах.Международная заявка была опубликована вместе с отчетом о международном поиске
EA199900067A 1996-06-28 1997-06-30 Моноклональное антитело s19 к поверхностному антигену сперматозоидов, антиген, выявляемый таким антителом, и содержащие его вакцина и спермицид EA003531B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/671,622 US5830472A (en) 1996-06-28 1996-06-28 Purified sperm surface antigen, monoclonal antibody therefor and applications therefor
PCT/US1997/010813 WO1998000164A1 (en) 1996-06-28 1997-06-30 Purified sperm surface antigen, monoclonal antibody therefor and applications therefor

Publications (2)

Publication Number Publication Date
EA199900067A1 true EA199900067A1 (ru) 1999-08-26
EA003531B1 EA003531B1 (ru) 2003-06-26

Family

ID=24695254

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900067A EA003531B1 (ru) 1996-06-28 1997-06-30 Моноклональное антитело s19 к поверхностному антигену сперматозоидов, антиген, выявляемый таким антителом, и содержащие его вакцина и спермицид

Country Status (16)

Country Link
US (1) US5830472A (ru)
EP (1) EP0964696A4 (ru)
JP (1) JP2001506841A (ru)
CN (1) CN1227497A (ru)
AU (1) AU722559B2 (ru)
BR (1) BR9710089A (ru)
CA (1) CA2258717A1 (ru)
CZ (1) CZ293040B6 (ru)
EA (1) EA003531B1 (ru)
HU (1) HUP9904620A3 (ru)
IL (1) IL127764A (ru)
NO (1) NO986050L (ru)
PL (1) PL186809B1 (ru)
SK (1) SK281505B6 (ru)
UA (1) UA74765C2 (ru)
WO (1) WO1998000164A1 (ru)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1162880A1 (en) * 1999-03-23 2001-12-19 University of Virginia Human sperm surface antigens
GB9913556D0 (en) * 1999-06-11 1999-08-11 Zeneca Ltd Assays
AU6227800A (en) * 1999-07-23 2001-02-13 University Of Virginia Patent Foundation Recombinant antibody directed against human sperm antigen
US20020151089A1 (en) * 1999-09-15 2002-10-17 Chapman William H. Separating components of biological samples
AU1778701A (en) * 1999-11-17 2001-05-30 University Of Virginia Patent Foundation Sperm cell selection system
US7125550B2 (en) * 2000-01-19 2006-10-24 University Of Virginia Patent Foundation Human sperm specific lysozyme-like proteins
EP1255831A2 (en) * 2000-01-19 2002-11-13 The University Of Virginia Patent Foundation Sperm specific proteins
CA2398710A1 (en) 2000-01-20 2001-07-26 University Of Virginia Patent Foundation Egg specific surface proteins
US6541206B1 (en) * 2000-06-19 2003-04-01 Gabor B. Huszar Objective biochemical method for assessment of sperm quality
US20030207393A1 (en) * 2001-01-19 2003-11-06 Herr John C. Cbp86, a sperm specific protein
WO2005079243A2 (en) * 2004-02-06 2005-09-01 University Of Virginia Patent Foundation Compositions and methods for identifying sperm for forensic applications
US8817965B2 (en) 2006-07-21 2014-08-26 Bce Inc. Method, system and apparatus for handling establishment of a communication session
US20080187549A1 (en) * 2007-02-07 2008-08-07 Morey William A Polyantigenic-based (multiple antigens) modi or set of methods for developing infertility vaccines
US20080290037A1 (en) * 2007-05-23 2008-11-27 Applera Corporation Methods and Apparatuses for Separating Biological Particles
US20090136962A1 (en) * 2007-11-27 2009-05-28 Herr John C Diagnostic markers for cancer
EP2494985A1 (en) * 2008-04-07 2012-09-05 Auburn University Zona pellucida binding peptides, expression vectors, compositions, and methods for species-specific immunocontraception of animals
GB0911885D0 (en) * 2009-07-08 2009-08-19 Oxford Biodynamics Ltd Screening method for cell aging
IL208820A0 (en) 2010-10-19 2011-01-31 Rachel Teitelbaum Biologic female contraceptives
US10877033B2 (en) 2013-06-18 2020-12-29 Oxford University Innovation Limited Method of detecting the presence or absence of autoantibodies
CN103852583A (zh) * 2014-03-18 2014-06-11 南京医科大学 一种快速检测Boule蛋白的胶体金试剂条及检测方法
CN106153938B (zh) * 2015-04-09 2018-05-11 中国医学科学院基础医学研究所 抗ACTL7a和GAPDH-2抗体的检测方法、试剂盒及其用途
KR101916959B1 (ko) * 2015-07-13 2018-11-08 김동구 정자의 성 감별용 항체 및 이의 용도
CN106526162A (zh) * 2016-11-03 2017-03-22 天津市宝坻区人民医院 一种抗精子抗体检测方法
CN117987376B (zh) * 2024-03-26 2024-06-25 玛特瑞尔(吉林)生物技术有限公司 人精子顶体蛋白sp-10单克隆抗体、杂交瘤细胞株及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227160A (en) * 1988-07-15 1993-07-13 The Biomembrane Institute Monoclonal antibody nuh2 capable of inactivating motility of human sperm, antigen defined by said monoclonal antibody and methods of using said monoclonal antibody and antigen
US5436157A (en) * 1989-03-03 1995-07-25 The University Of Virginia Alumni Patents Foundation Human intra-acrosomal sperm antigen
US5605803A (en) * 1989-03-03 1997-02-25 University Of Virginia Alumni Patents Foundation Human sperm diagnostic

Also Published As

Publication number Publication date
AU3407197A (en) 1998-01-21
JP2001506841A (ja) 2001-05-29
NO986050D0 (no) 1998-12-22
WO1998000164A1 (en) 1998-01-08
HUP9904620A2 (hu) 2000-05-28
NO986050L (no) 1999-02-08
SK281505B6 (sk) 2001-04-09
EA003531B1 (ru) 2003-06-26
CZ428498A3 (cs) 1999-06-16
UA74765C2 (en) 2006-02-15
CZ293040B6 (cs) 2004-01-14
BR9710089A (pt) 2000-06-06
EP0964696A4 (en) 2005-01-05
SK179598A3 (en) 2000-04-10
PL186809B1 (pl) 2004-02-27
HUP9904620A3 (en) 2001-08-28
EP0964696A1 (en) 1999-12-22
CN1227497A (zh) 1999-09-01
PL330842A1 (en) 1999-06-07
US5830472A (en) 1998-11-03
IL127764A (en) 2001-11-25
AU722559B2 (en) 2000-08-03
IL127764A0 (en) 1999-10-28
CA2258717A1 (en) 1998-01-08

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