EA199900003A1 - Антивирусные соединения - Google Patents

Антивирусные соединения

Info

Publication number
EA199900003A1
EA199900003A1 EA199900003A EA199900003A EA199900003A1 EA 199900003 A1 EA199900003 A1 EA 199900003A1 EA 199900003 A EA199900003 A EA 199900003A EA 199900003 A EA199900003 A EA 199900003A EA 199900003 A1 EA199900003 A1 EA 199900003A1
Authority
EA
Eurasian Patent Office
Prior art keywords
virus
connections
application
international
koksaki
Prior art date
Application number
EA199900003A
Other languages
English (en)
Other versions
EA001389B1 (ru
Inventor
Луи Н. Юнгхейм
Шон К. Миллер
Вейн А. Спитцер
Марк Дж. Теббе
Франц Виктор
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199900003A1 publication Critical patent/EA199900003A1/ru
Publication of EA001389B1 publication Critical patent/EA001389B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Настоящая заявка предлагает ряд бензимидазольных соединений, которые ингибируют рост пикорнавирусов, таких как риновирусы, энтеровирусы, полиовирусы, вирусы Коксаки групп А и В, ЕСНО-вирус и вирус Менго, и флавивирусы, такие как вирус гепатита С и вирус бычьей диареи.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900003A 1996-06-06 1997-06-05 Антивирусные соединения EA001389B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1922496P 1996-06-06 1996-06-06
PCT/US1997/008846 WO1997046235A1 (en) 1996-06-06 1997-06-05 Anti-viral compounds

Publications (2)

Publication Number Publication Date
EA199900003A1 true EA199900003A1 (ru) 1999-06-24
EA001389B1 EA001389B1 (ru) 2001-02-26

Family

ID=21792091

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900003A EA001389B1 (ru) 1996-06-06 1997-06-05 Антивирусные соединения

Country Status (10)

Country Link
US (1) US5821242A (ru)
EP (1) EP0938310A4 (ru)
JP (1) JP2001502661A (ru)
KR (1) KR20000016405A (ru)
CN (1) CN1220603A (ru)
AU (1) AU3286297A (ru)
BR (1) BR9709432A (ru)
CA (1) CA2254993A1 (ru)
EA (1) EA001389B1 (ru)
WO (1) WO1997046235A1 (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891874A (en) * 1996-06-05 1999-04-06 Eli Lilly And Company Anti-viral compound
WO1998031363A1 (en) * 1997-01-22 1998-07-23 Eli Lilly And Company Anti-viral compounds
JP2001513084A (ja) 1997-02-25 2001-08-28 ザ ガバメント オブ ザ ユナイテッド ステーツ オブ アメリカ，レプリゼンテッド バイ ザ セクレタリー，デパートメント オブ ヘルス アンド ヒューマン サービシズ 逆転写酵素の非ヌクレオシド阻害剤としての置換ベンズイミダゾール
CA2293508A1 (en) * 1997-06-04 1998-12-10 Louis Nickolaus Jungheim Anti-viral compounds
SK17482000A3 (sk) * 1998-05-20 2005-03-04 Eli Lilly And Company Antivírusové zlúčeniny, spôsob inhibície vírusov a farmaceutický prípravok
BR9913333A (pt) 1998-08-25 2001-05-15 Univ Yale Inibição e tratamento do vìrus da hepatite b e flavivìrus com helioxatina e seus análogos
CN1777432B (zh) 2003-02-19 2011-06-08 耶鲁大学 用于hiv感染的抗病毒核苷类似物
US7754718B2 (en) 2004-05-05 2010-07-13 Yale University Antiviral helioxanthin analogs
MX2010013019A (es) * 2008-05-27 2011-03-21 Biota Scient Management Pty Ltd Sales antivirales.
PE20131351A1 (es) * 2010-09-30 2013-12-04 Boehringer Ingelheim Int Formas en estado solido de un potente inhibidor del vch
US9487476B2 (en) 2011-10-12 2016-11-08 Yale University Catechol diethers as potent anti-HIV agents
WO2017181317A1 (en) * 2016-04-18 2017-10-26 Eli Lilly And Company Treatment for nonalcoholic steatohepatitis and fibrosis
CN109265504B (zh) * 2018-11-08 2021-07-02 河南省科学院高新技术研究中心 4-氨基酸取代嘧啶核苷化合物及其药物用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289782A (en) * 1979-04-17 1981-09-15 Eli Lilly And Company Antiviral 1-sulfonylbenzimidazoles
US4401817A (en) * 1981-04-20 1983-08-30 Eli Lilly And Company Carbonyl-substituted 1-sulfonylbenzimidazoles
US4420479A (en) * 1982-04-08 1983-12-13 Eli Lilly And Company Olefinic benzimidazoles, formulations, and antiviral methods
US4434288A (en) * 1982-04-08 1984-02-28 Eli Lilly And Company Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminobenzimidazoles
US4492708A (en) * 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles
JPS58188868A (ja) * 1983-04-08 1983-11-04 イ−ライ・リリ−・アンド・カンパニ− オレフイン系ベンズイミダゾ−ル類
US5216003A (en) * 1992-01-02 1993-06-01 G. D. Searle & Co. Diacid-containing benzimidazole compounds for treatment of neurotoxic injury
US5545653A (en) * 1995-06-07 1996-08-13 Eli Lilly And Company Anti-viral compounds
BR9709528A (pt) * 1996-06-05 1999-08-10 Lilly Co Eli Compostos antivirais
US5891874A (en) * 1996-06-05 1999-04-06 Eli Lilly And Company Anti-viral compound

Also Published As

Publication number Publication date
KR20000016405A (ko) 2000-03-25
CA2254993A1 (en) 1997-12-11
EP0938310A4 (en) 2001-03-21
EP0938310A1 (en) 1999-09-01
BR9709432A (pt) 1999-08-10
EA001389B1 (ru) 2001-02-26
US5821242A (en) 1998-10-13
CN1220603A (zh) 1999-06-23
AU3286297A (en) 1998-01-05
JP2001502661A (ja) 2001-02-27
WO1997046235A1 (en) 1997-12-11

Similar Documents

Publication Publication Date Title
EA199801077A1 (ru) Соединения, обладающие антивирусной активностью
EA199900003A1 (ru) Антивирусные соединения
ATE355380T1 (de) Methode zur selektiven inaktivierung der viralen replication
EA199900936A1 (ru) Фунгицидные трифторметилалкиламинотриазолопиримидины
EA200200688A1 (ru) Антагонисты фактора, высвобождающего кортикотропин
EA199801031A1 (ru) Ингибиторы протеинфарнезилтрансферазы
EA199900758A1 (ru) Малые молекулы, полезные при лечении воспалительных заболеваний
EA199801078A1 (ru) Соединения, обладающие антивирусной активностью
EA199900388A1 (ru) Ингибиторы серин-протеаз, в частности ns3 протеазы вируса гепатита c (hvc)
TW200730476A (en) N-(5-membered aromatic ring)-amido anti-viral compounds
MX9203454A (es) Compuestos anti sida diaromaticos substituidos.
DE69934104D1 (de) Inhibitoren von serin proteasen, insbesondere von hepatitis c virus ns3 protease
EA200400991A1 (ru) Фармацевтические композиции, содержащие ингибиторы протеазы вируса гепатита c
AR240255A1 (es) Un metodo de preservacion de virus vivos.
EA200400241A1 (ru) Направленные к мишени мультимерные контрастные вещества, основанные на пептидах
BRPI0511834A (pt) métodos por tratar hepatite c
EA199900598A1 (ru) Производные 1-арил- и пиридилпиразола с пестицидными свойствами
ATE231557T1 (de) Detektion des hepatis-c virus.
EA200000196A1 (ru) Универсальная плазма крови
ATE555794T1 (de) Heilmittel gegen hepatitis
EA199901024A1 (ru) Фармацевтическая антивирусная композиция, содержащая глицирризиновую кислоту и, по меньшей мере, один белок, обладающий антивирусной активностью
EA200000519A1 (ru) 2-АРИЛБЕНЗО[b]ТИОФЕНЫ, ПОЛЕЗНЫЕ ДЛЯ ЛЕЧЕНИЯ СИНДРОМА ЭСТРОГЕННОЙ НЕДОСТАТОЧНОСТИ
NO20006109L (no) Analytisk metode som benytter multippel virusmerking
EA200000520A1 (ru) 2-АРИЛ-3-АРОИЛБЕНЗО[b]ТИОФЕНЫ, ПОЛЕЗНЫЕ ДЛЯ ЛЕЧЕНИЯ СИНДРОМА ЭСТРОГЕННОЙ НЕДОСТАТОЧНОСТИ
ATE491952T1 (de) Screening auf inhibitoren des eindringens von hepatitis-c-virus

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU