EA199800936A1 - Грануляты гидролизованной целлюлозы для фармацевтических препаратов - Google Patents

Грануляты гидролизованной целлюлозы для фармацевтических препаратов

Info

Publication number
EA199800936A1
EA199800936A1 EA199800936A EA199800936A EA199800936A1 EA 199800936 A1 EA199800936 A1 EA 199800936A1 EA 199800936 A EA199800936 A EA 199800936A EA 199800936 A EA199800936 A EA 199800936A EA 199800936 A1 EA199800936 A1 EA 199800936A1
Authority
EA
Eurasian Patent Office
Prior art keywords
granules
weight
pharmaceutical preparations
amount
compressed
Prior art date
Application number
EA199800936A
Other languages
English (en)
Other versions
EA000853B1 (ru
Inventor
Марк С. Каретни
Дэвид Ф. Эркобони
Рональд С. мл. Валдика
Говард Дж. Стамато
Original Assignee
Фмк Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фмк Корпорейшн filed Critical Фмк Корпорейшн
Publication of EA199800936A1 publication Critical patent/EA199800936A1/ru
Publication of EA000853B1 publication Critical patent/EA000853B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Настоящее изобретение предусматривает способ получения высушенного распылительной сушкой гранулированного состава, поддающегося прессованию, который применяют для получения фармацевтических таблеток, в котором гидролизованную целлюлозу применяют в качестве добавки для грануляции к полученным гранулятам и фармацевтическим таблеткам, прессованным из таких гранул. В этих составах применяют фармацевтический активный ингредиент в количестве от 1 до 97% по весу, гидролизованную целлюлозу в количестве от около 3 до 99% по весу в пересчете на сухой вес гранулятов и необязательные общепринятые добавки для грануляции и/или таблетирования, например поверхностно-активные вещества, вещества, способствующие распаду, и антиадгезивы/добавки, повышающие текучесть.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800936A 1996-04-17 1997-04-15 Грануляты гидролизованной целлюлозы для фармацевтических препаратов EA000853B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/785,228 US5858409A (en) 1996-04-17 1996-04-17 Hydrolyzed cellulose granulations for pharmaceuticals
PCT/US1997/006313 WO1997038678A1 (en) 1996-04-17 1997-04-15 Hydrolyzed cellulose granulations for pharmaceuticals

Publications (2)

Publication Number Publication Date
EA199800936A1 true EA199800936A1 (ru) 1999-04-29
EA000853B1 EA000853B1 (ru) 2000-06-26

Family

ID=25134825

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800936A EA000853B1 (ru) 1996-04-17 1997-04-15 Грануляты гидролизованной целлюлозы для фармацевтических препаратов

Country Status (12)

Country Link
US (1) US5858409A (ru)
EP (1) EP0942715A4 (ru)
KR (1) KR20000005514A (ru)
AU (1) AU2671597A (ru)
BR (1) BR9708721A (ru)
EA (1) EA000853B1 (ru)
IL (1) IL126496A (ru)
NO (1) NO326912B1 (ru)
NZ (1) NZ332295A (ru)
TW (1) TW541180B (ru)
WO (1) WO1997038678A1 (ru)
ZA (1) ZA973031B (ru)

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US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US6471994B1 (en) 1995-01-09 2002-10-29 Edward Mendell Co., Inc. Pharmaceutical excipient having improved compressibility
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US6211246B1 (en) * 1999-06-10 2001-04-03 Mcneil-Ppc, Inc. Rapidly absorbed liquid compositions
US6143285A (en) * 1999-06-23 2000-11-07 Combe Incorporated Body powder composition
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WO2002036077A2 (en) * 2000-11-06 2002-05-10 Andrx Pharmaceuticals, Inc. Once a day antihistamine and decongestant formulation
ATE374641T1 (de) * 2001-01-26 2007-10-15 Schering Corp Kombinationen vom ppar-aktivator fenofibrat mit dem hemmer der sterol-absorption ezetimibe zur behandlung von kardiovaskulären indikationen
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
ATE345793T1 (de) * 2001-09-21 2006-12-15 Schering Corp Behandlung von xanthom mittels azetidinon- derivate als hemmer der sterol absorption
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US20030206978A1 (en) * 2001-11-29 2003-11-06 Bob Sherwood Agglomerated particles including an active agent coprocessed with silicified microcrystalline cellulose
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KR100758045B1 (ko) * 2002-02-01 2007-09-11 화이자 프로덕츠 인크. 압력 노즐을 이용하여 균질한 분무 건조된 비결정질 고체약물 분산제를 제조하는 방법
US6958161B2 (en) 2002-04-12 2005-10-25 F H Faulding & Co Limited Modified release coated drug preparation
US8092831B2 (en) * 2002-11-08 2012-01-10 Andrx Pharmaceuticals, Llc Antihistamine and decongestant system
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EP1601669B1 (en) * 2003-03-07 2008-12-24 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
ES2311806T3 (es) * 2003-03-07 2009-02-16 Schering Corporation Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
CL2004001884A1 (es) 2003-08-04 2005-06-03 Pfizer Prod Inc Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
US7201920B2 (en) 2003-11-26 2007-04-10 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of opioid containing dosage forms
US20070036859A1 (en) * 2005-08-11 2007-02-15 Perry Ronald L Sustained release antihistamine and decongestant composition
GB0613925D0 (en) 2006-07-13 2006-08-23 Unilever Plc Improvements relating to nanodispersions
US20100160363A1 (en) * 2008-12-19 2010-06-24 Aaipharma Services Corp. Extended-release pharmaceutical formulations
US20100159001A1 (en) * 2008-12-19 2010-06-24 Cardinal John R Extended-Release Pharmaceutical Formulations
ES2569925T3 (es) * 2009-09-30 2016-05-13 Acura Pharmaceuticals, Inc. Métodos y composiciones de disuasión del abuso
TWI461213B (zh) * 2009-11-05 2014-11-21 Fmc Corp 作為藥物賦形劑之微晶纖維素及磷酸鈣之組合物
TW201129386A (en) * 2009-11-05 2011-09-01 Fmc Corp Microcrystalline cellulose and calcium phosphate compositions useful as pharmaceutical excipients
RU2673818C2 (ru) 2012-11-30 2018-11-30 Экьюра Фармасьютикалз, Инк. Саморегулируемое высвобождение фармацевтического ингредиента
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Also Published As

Publication number Publication date
TW541180B (en) 2003-07-11
KR20000005514A (ko) 2000-01-25
BR9708721A (pt) 1999-08-03
ZA973031B (en) 1997-11-04
US5858409A (en) 1999-01-12
EA000853B1 (ru) 2000-06-26
AU2671597A (en) 1997-11-07
IL126496A (en) 2001-11-25
NO984838L (no) 1998-10-19
NO984838D0 (no) 1998-10-16
IL126496A0 (en) 1999-08-17
EP0942715A4 (en) 2006-01-18
NO326912B1 (no) 2009-03-16
EP0942715A1 (en) 1999-09-22
NZ332295A (en) 2000-03-27
WO1997038678A1 (en) 1997-10-23

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU