EA039877B1 - Радиолиганды для визуализации фермента ido1 - Google Patents
Радиолиганды для визуализации фермента ido1 Download PDFInfo
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- EA039877B1 EA039877B1 EA201990198A EA201990198A EA039877B1 EA 039877 B1 EA039877 B1 EA 039877B1 EA 201990198 A EA201990198 A EA 201990198A EA 201990198 A EA201990198 A EA 201990198A EA 039877 B1 EA039877 B1 EA 039877B1
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- Eurasian Patent Office
- Prior art keywords
- ido1
- compound
- tissues
- radiolabeled
- imaging
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
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- A—HUMAN NECESSITIES
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- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Quinoline Compounds (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US201662364020P | 2016-07-19 | 2016-07-19 | |
| PCT/US2017/042510 WO2018017529A1 (en) | 2016-07-19 | 2017-07-18 | Radioligands for imaging the ido1 enzyme |
Publications (2)
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| EA201990198A1 EA201990198A1 (ru) | 2019-06-28 |
| EA039877B1 true EA039877B1 (ru) | 2022-03-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| EA201990198A EA039877B1 (ru) | 2016-07-19 | 2017-07-18 | Радиолиганды для визуализации фермента ido1 |
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| JP2019528300A (ja) * | 2016-08-26 | 2019-10-10 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | インドールアミン２，３−ジオキシゲナーゼの阻害剤およびその使用方法 |
| WO2019006292A1 (en) * | 2017-06-30 | 2019-01-03 | Bristol-Myers Squibb Company | SUBSTITUTED QUINOLINYCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED PROCESSES FOR THE PREPARATION THEREOF |
| KR20200088410A (ko) * | 2017-11-21 | 2020-07-22 | 광동 오포 모바일 텔레커뮤니케이션즈 코포레이션 리미티드 | 정보 전송 방법, 네트워크 디바이스 및 단말기 디바이스 |
| EP3720843A1 (en) * | 2017-12-05 | 2020-10-14 | GlaxoSmithKline Intellectual Property Development Limited | Modulators of indoleamine 2,3-dioxygenase |
| CN110357813A (zh) * | 2018-04-09 | 2019-10-22 | 信达生物制药(苏州)有限公司 | 一种新型吲哚胺2,3-双加氧酶抑制剂及其制备方法和用途 |
| AR120935A1 (es) * | 2020-01-02 | 2022-03-30 | Hutchison Medipharma Ltd | Derivados de amida y usos de los mismos |
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| WO2016040458A2 (en) * | 2014-09-09 | 2016-03-17 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Pet probes of radiofluorinated carboximidamides for ido-targeted imaging |
| WO2016073770A1 (en) * | 2014-11-05 | 2016-05-12 | Flexus Biosciences, Inc. | Immunoregulatory agents |
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| CN101182359A (zh) * | 2007-11-09 | 2008-05-21 | 中山大学 | 人吲哚胺2,3-双加氧酶多克隆抗体及其制备方法和应用 |
| WO2011109262A2 (en) * | 2010-03-01 | 2011-09-09 | Tau Therapeutics Llc | Cancer diagnosis and imaging |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016040458A2 (en) * | 2014-09-09 | 2016-03-17 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Pet probes of radiofluorinated carboximidamides for ido-targeted imaging |
| WO2016073770A1 (en) * | 2014-11-05 | 2016-05-12 | Flexus Biosciences, Inc. | Immunoregulatory agents |
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| BR112019000499A2 (pt) | 2019-04-24 |
| US20190282714A1 (en) | 2019-09-19 |
| US20220305144A1 (en) | 2022-09-29 |
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| AU2017298262B2 (en) | 2024-07-18 |
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| CA3031079A1 (en) | 2018-01-25 |
| KR102513886B1 (ko) | 2023-03-27 |
| WO2018017529A1 (en) | 2018-01-25 |
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| AU2017298262A1 (en) | 2019-03-07 |
| EP3487516A1 (en) | 2019-05-29 |
| CN109475594A (zh) | 2019-03-15 |
| EA201990198A1 (ru) | 2019-06-28 |
| JP6987840B2 (ja) | 2022-01-05 |
| SG11201900336YA (en) | 2019-02-27 |
| IL264187B (en) | 2021-06-30 |
| MX2019000508A (es) | 2019-03-28 |
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