EA039877B1 - Радиолиганды для визуализации фермента ido1 - Google Patents
Радиолиганды для визуализации фермента ido1 Download PDFInfo
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- EA039877B1 EA039877B1 EA201990198A EA201990198A EA039877B1 EA 039877 B1 EA039877 B1 EA 039877B1 EA 201990198 A EA201990198 A EA 201990198A EA 201990198 A EA201990198 A EA 201990198A EA 039877 B1 EA039877 B1 EA 039877B1
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- Eurasian Patent Office
- Prior art keywords
- ido1
- compound
- tissues
- radiolabeled
- imaging
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
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- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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| US201662364020P | 2016-07-19 | 2016-07-19 | |
| PCT/US2017/042510 WO2018017529A1 (en) | 2016-07-19 | 2017-07-18 | Radioligands for imaging the ido1 enzyme |
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| EA201990198A1 EA201990198A1 (ru) | 2019-06-28 |
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| EA201990198A EA039877B1 (ru) | 2016-07-19 | 2017-07-18 | Радиолиганды для визуализации фермента ido1 |
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| EP3503916A1 (en) * | 2016-08-26 | 2019-07-03 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| WO2019006292A1 (en) * | 2017-06-30 | 2019-01-03 | Bristol-Myers Squibb Company | SUBSTITUTED QUINOLINYCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED PROCESSES FOR THE PREPARATION THEREOF |
| JP2021510044A (ja) * | 2017-11-21 | 2021-04-08 | オッポ広東移動通信有限公司Ｇｕａｎｇｄｏｎｇ Ｏｐｐｏ Ｍｏｂｉｌｅ Ｔｅｌｅｃｏｍｍｕｎｉｃａｔｉｏｎｓ Ｃｏｒｐ．， Ｌｔｄ． | 情報伝送方法、ネットワークデバイス及び端末デバイス |
| WO2019111107A1 (en) * | 2017-12-05 | 2019-06-13 | Glaxosmithkline Intellectual Property Development Limited | Modulators of indoleamine 2,3-dioxygenase |
| CN110357813A (zh) * | 2018-04-09 | 2019-10-22 | 信达生物制药(苏州)有限公司 | 一种新型吲哚胺2,3-双加氧酶抑制剂及其制备方法和用途 |
| AR120935A1 (es) * | 2020-01-02 | 2022-03-30 | Hutchison Medipharma Ltd | Derivados de amida y usos de los mismos |
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| WO2016040458A2 (en) * | 2014-09-09 | 2016-03-17 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Pet probes of radiofluorinated carboximidamides for ido-targeted imaging |
| WO2016073770A1 (en) * | 2014-11-05 | 2016-05-12 | Flexus Biosciences, Inc. | Immunoregulatory agents |
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| CN101182359A (zh) * | 2007-11-09 | 2008-05-21 | 中山大学 | 人吲哚胺2,3-双加氧酶多克隆抗体及其制备方法和应用 |
| CN102781316B (zh) * | 2010-03-01 | 2016-07-06 | 陶制药有限责任公司 | 癌症诊断和成像 |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016040458A2 (en) * | 2014-09-09 | 2016-03-17 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Pet probes of radiofluorinated carboximidamides for ido-targeted imaging |
| WO2016073770A1 (en) * | 2014-11-05 | 2016-05-12 | Flexus Biosciences, Inc. | Immunoregulatory agents |
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| IL264187B (en) | 2021-06-30 |
| EA201990198A1 (ru) | 2019-06-28 |
| AU2017298262B2 (en) | 2024-07-18 |
| BR112019000499A2 (pt) | 2019-04-24 |
| KR102513886B1 (ko) | 2023-03-27 |
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