EA038233B1 - ДЕЙТЕРИРОВАННЫЕ СОЕДИНЕНИЯ ИМИДАЗО[4,5-c]ХИНОЛИН-2-ОНА И ИХ ПРИМЕНЕНИЕ В ЛЕЧЕНИИ РАКА - Google Patents
ДЕЙТЕРИРОВАННЫЕ СОЕДИНЕНИЯ ИМИДАЗО[4,5-c]ХИНОЛИН-2-ОНА И ИХ ПРИМЕНЕНИЕ В ЛЕЧЕНИИ РАКА Download PDFInfo
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- EA038233B1 EA038233B1 EA201992090A EA201992090A EA038233B1 EA 038233 B1 EA038233 B1 EA 038233B1 EA 201992090 A EA201992090 A EA 201992090A EA 201992090 A EA201992090 A EA 201992090A EA 038233 B1 EA038233 B1 EA 038233B1
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- Eurasian Patent Office
- Prior art keywords
- cancer
- compound
- pharmaceutically acceptable
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- acceptable salt
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201762472080P | 2017-03-16 | 2017-03-16 | |
| PCT/EP2018/056516 WO2018167203A1 (en) | 2017-03-16 | 2018-03-15 | Deuterated imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
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| EA201992090A1 EA201992090A1 (ru) | 2020-03-06 |
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| LV15575A (lv) | 2019-12-20 | 2021-06-20 | Latvijas Organiskās Sintēzes Institūts | Selenofēnhromēnu deiterēti analogi, to iegūšana un izmantošana |
| US20230256110A1 (en) | 2020-06-24 | 2023-08-17 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and atm inhibitor |
| WO2022060377A1 (en) * | 2020-09-21 | 2022-03-24 | Wei Zhong | Substituted 1-(3,3-difluoropiperidin-4-yl)-imidazo[4,5-c] quinolin-2-one compounds with blood-brain barrier penetrable capability |
| EP3992191A1 (en) | 2020-11-03 | 2022-05-04 | Deutsches Krebsforschungszentrum | Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors |
| WO2022128833A1 (en) | 2020-12-15 | 2022-06-23 | Merck Patent Gmbh | Solid transition metal-ligand complexes |
| TW202340189A (zh) * | 2022-01-26 | 2023-10-16 | 大陸商正大天晴藥業集團股份有限公司 | 含有肼基的化合物 |
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- 2018-03-15 EP EP18713818.5A patent/EP3596076A1/en not_active Withdrawn
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| NI201900094A (es) | 2020-03-18 |
| MA49884A (fr) | 2020-06-24 |
| CL2019002527A1 (es) | 2019-11-22 |
| CN110431139A (zh) | 2019-11-08 |
| EA201992090A1 (ru) | 2020-03-06 |
| TW201843151A (zh) | 2018-12-16 |
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| US20200087300A1 (en) | 2020-03-19 |
| ECSP19066134A (es) | 2019-09-30 |
| BR112019018723A2 (pt) | 2020-04-07 |
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| IL269272A (en) | 2019-11-28 |
| JOP20190209A1 (ar) | 2019-09-12 |
| UA124554C2 (uk) | 2021-10-05 |
| CA3055258A1 (en) | 2018-09-20 |
| SG11201908065YA (en) | 2019-09-27 |
| AU2018234985A1 (en) | 2019-10-24 |
| EP3596076A1 (en) | 2020-01-22 |
| MX2019010898A (es) | 2019-11-07 |
| JP2020514344A (ja) | 2020-05-21 |
| US20210347775A1 (en) | 2021-11-11 |
| KR20190129923A (ko) | 2019-11-20 |
| AU2018234985B2 (en) | 2020-04-02 |
| CR20190429A (es) | 2019-11-12 |
| PH12019502086A1 (en) | 2020-03-09 |
| PE20191486A1 (es) | 2019-10-18 |
| CN110431139B (zh) | 2022-07-05 |
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