EA038019B1 - Иммуномодуляторы для пэт-визуализации - Google Patents

Иммуномодуляторы для пэт-визуализации Download PDF

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Publication number
EA038019B1
EA038019B1 EA201892635A EA201892635A EA038019B1 EA 038019 B1 EA038019 B1 EA 038019B1 EA 201892635 A EA201892635 A EA 201892635A EA 201892635 A EA201892635 A EA 201892635A EA 038019 B1 EA038019 B1 EA 038019B1
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EA
Eurasian Patent Office
Prior art keywords
ethoxy
disease
compound
imaging
subject
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EA201892635A
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English (en)
Russian (ru)
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EA201892635A1 (ru
Inventor
Дэвид Дж. Доннелли
Кеннет М. Бой
Юньхуай Чжан
Джониюн Ким
Адриенне Пена
Original Assignee
Бристол-Маерс Сквибб Компани
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Publication of EA201892635A1 publication Critical patent/EA201892635A1/ru
Publication of EA038019B1 publication Critical patent/EA038019B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03Computed tomography [CT]
    • A61B6/037Emission tomography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/12Arrangements for detecting or locating foreign bodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EA201892635A 2016-05-19 2017-05-17 Иммуномодуляторы для пэт-визуализации EA038019B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662338872P 2016-05-19 2016-05-19
PCT/US2017/033004 WO2017201111A1 (en) 2016-05-19 2017-05-17 Pet-imaging immunomodulators

Publications (2)

Publication Number Publication Date
EA201892635A1 EA201892635A1 (ru) 2019-04-30
EA038019B1 true EA038019B1 (ru) 2021-06-23

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EA201892635A EA038019B1 (ru) 2016-05-19 2017-05-17 Иммуномодуляторы для пэт-визуализации

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US (2) US11103605B2 (enExample)
EP (2) EP3458111B1 (enExample)
JP (1) JP6953444B2 (enExample)
KR (1) KR102378288B1 (enExample)
CN (1) CN109414514B (enExample)
AU (1) AU2017268291B2 (enExample)
BR (1) BR112018073642A2 (enExample)
CA (1) CA3024844A1 (enExample)
CY (1) CY1124241T1 (enExample)
DK (1) DK3458111T3 (enExample)
EA (1) EA038019B1 (enExample)
ES (1) ES2864091T3 (enExample)
HR (1) HRP20210644T8 (enExample)
HU (1) HUE054306T2 (enExample)
IL (1) IL262962B (enExample)
LT (1) LT3458111T (enExample)
MA (1) MA53402A (enExample)
MX (1) MX2018014028A (enExample)
PL (1) PL3458111T3 (enExample)
PT (1) PT3458111T (enExample)
RS (1) RS61742B1 (enExample)
SG (1) SG11201810177VA (enExample)
SI (1) SI3458111T1 (enExample)
SM (1) SMT202100238T1 (enExample)
WO (1) WO2017201111A1 (enExample)

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BR112019016336A2 (pt) 2017-02-10 2020-03-31 Regeneron Pharmaceuticals, Inc. Conjugado de anticorpo radiorrotulado, método para imageamento de um tecido que expressa lag3 e para tratar um tumor, e, composto.
WO2018237153A1 (en) 2017-06-23 2018-12-27 Bristol-Myers Squibb Company Immunomodulators acting as antagonists of pd-1
KR102880156B1 (ko) 2017-07-24 2025-11-05 리제너론 파마슈티칼스 인코포레이티드 항cd8 항체 및 이의 용도
JP7257393B2 (ja) 2017-10-03 2023-04-13 ブリストル-マイヤーズ スクイブ カンパニー 免疫調節剤
CN110504017B (zh) * 2019-07-30 2022-06-10 哈尔滨医科大学 一种示踪剂的制备和使用方法
JP2023510737A (ja) 2020-01-06 2023-03-15 ブリストル-マイヤーズ スクイブ カンパニー 免疫調節剤
EP4121442A1 (en) * 2020-03-16 2023-01-25 Bristol-Myers Squibb Company Immunomodulators
CN115362166A (zh) 2020-03-30 2022-11-18 百时美施贵宝公司 免疫调节剂
US12159403B2 (en) * 2021-06-18 2024-12-03 The United States Government As Represented By The Department Of Veteran Affairs Combination of features from biopsies and scans to predict prognosis in SCLC
WO2024129479A2 (en) * 2022-12-12 2024-06-20 Merck Sharp & Dohme Llc Cyclic peptides as pet imaging agents of granzyme b

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Also Published As

Publication number Publication date
AU2017268291A1 (en) 2019-01-17
IL262962A (en) 2018-12-31
HRP20210644T8 (hr) 2021-06-25
CN109414514A (zh) 2019-03-01
US11103605B2 (en) 2021-08-31
EP3827849A1 (en) 2021-06-02
HUE054306T2 (hu) 2021-08-30
CA3024844A1 (en) 2017-11-23
EP3458111A1 (en) 2019-03-27
LT3458111T (lt) 2021-05-25
ES2864091T3 (es) 2021-10-13
CN109414514B (zh) 2022-03-11
KR20190009330A (ko) 2019-01-28
US20210386876A1 (en) 2021-12-16
HRP20210644T1 (hr) 2021-05-28
RS61742B1 (sr) 2021-05-31
SI3458111T1 (sl) 2021-07-30
MX2018014028A (es) 2019-04-04
BR112018073642A2 (pt) 2019-02-26
MA53402A (fr) 2021-06-02
CY1124241T1 (el) 2022-07-22
EP3458111B1 (en) 2021-03-03
IL262962B (en) 2020-04-30
JP2019520328A (ja) 2019-07-18
AU2017268291B2 (en) 2022-09-29
PL3458111T3 (pl) 2021-06-28
EA201892635A1 (ru) 2019-04-30
US20190117801A1 (en) 2019-04-25
WO2017201111A1 (en) 2017-11-23
PT3458111T (pt) 2021-04-09
SMT202100238T1 (it) 2021-05-07
DK3458111T3 (da) 2021-04-26
KR102378288B1 (ko) 2022-03-23
JP6953444B2 (ja) 2021-10-27
SG11201810177VA (en) 2018-12-28

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