EA038019B1 - Иммуномодуляторы для пэт-визуализации - Google Patents

Иммуномодуляторы для пэт-визуализации Download PDF

Info

Publication number
EA038019B1
EA038019B1 EA201892635A EA201892635A EA038019B1 EA 038019 B1 EA038019 B1 EA 038019B1 EA 201892635 A EA201892635 A EA 201892635A EA 201892635 A EA201892635 A EA 201892635A EA 038019 B1 EA038019 B1 EA 038019B1
Authority
EA
Eurasian Patent Office
Prior art keywords
ethoxy
disease
compound
imaging
subject
Prior art date
Application number
EA201892635A
Other languages
English (en)
Russian (ru)
Other versions
EA201892635A1 (ru
Inventor
Дэвид Дж. Доннелли
Кеннет М. Бой
Юньхуай Чжан
Джониюн Ким
Адриенне Пена
Original Assignee
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA201892635A1 publication Critical patent/EA201892635A1/ru
Publication of EA038019B1 publication Critical patent/EA038019B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/037—Emission tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/12—Arrangements for detecting or locating foreign bodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EA201892635A 2016-05-19 2017-05-17 Иммуномодуляторы для пэт-визуализации EA038019B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662338872P 2016-05-19 2016-05-19
PCT/US2017/033004 WO2017201111A1 (en) 2016-05-19 2017-05-17 Pet-imaging immunomodulators

Publications (2)

Publication Number Publication Date
EA201892635A1 EA201892635A1 (ru) 2019-04-30
EA038019B1 true EA038019B1 (ru) 2021-06-23

Family

ID=59021563

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892635A EA038019B1 (ru) 2016-05-19 2017-05-17 Иммуномодуляторы для пэт-визуализации

Country Status (25)

Country Link
US (2) US11103605B2 (enExample)
EP (2) EP3827849A1 (enExample)
JP (1) JP6953444B2 (enExample)
KR (1) KR102378288B1 (enExample)
CN (1) CN109414514B (enExample)
AU (1) AU2017268291B2 (enExample)
BR (1) BR112018073642A2 (enExample)
CA (1) CA3024844A1 (enExample)
CY (1) CY1124241T1 (enExample)
DK (1) DK3458111T3 (enExample)
EA (1) EA038019B1 (enExample)
ES (1) ES2864091T3 (enExample)
HR (1) HRP20210644T8 (enExample)
HU (1) HUE054306T2 (enExample)
IL (1) IL262962B (enExample)
LT (1) LT3458111T (enExample)
MA (1) MA53402A (enExample)
MX (1) MX2018014028A (enExample)
PL (1) PL3458111T3 (enExample)
PT (1) PT3458111T (enExample)
RS (1) RS61742B1 (enExample)
SG (1) SG11201810177VA (enExample)
SI (1) SI3458111T1 (enExample)
SM (1) SMT202100238T1 (enExample)
WO (1) WO2017201111A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9856292B2 (en) 2014-11-14 2018-01-02 Bristol-Myers Squibb Company Immunomodulators
US10143746B2 (en) 2016-03-04 2018-12-04 Bristol-Myers Squibb Company Immunomodulators
US10358463B2 (en) 2016-04-05 2019-07-23 Bristol-Myers Squibb Company Immunomodulators
US11857352B2 (en) 2016-09-06 2024-01-02 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection
RS67792B1 (sr) 2016-12-01 2026-03-31 Regeneron Pharma Radio-obeležena anti-pd-l1 antitela za imuno-pet snimanje
BR112019012986A2 (pt) * 2016-12-23 2019-12-03 Univ Johns Hopkins imageamento de tumores e de células imunes com base na expressão de pd-l1
BR112019016336A2 (pt) 2017-02-10 2020-03-31 Regeneron Pharmaceuticals, Inc. Conjugado de anticorpo radiorrotulado, método para imageamento de um tecido que expressa lag3 e para tratar um tumor, e, composto.
CN110997698B (zh) 2017-06-23 2023-12-26 百时美施贵宝公司 充当pd-1拮抗剂的免疫调节剂
CN110997013B (zh) 2017-07-24 2022-09-20 瑞泽恩制药公司 抗cd8抗体和其用途
EP3692053A1 (en) 2017-10-03 2020-08-12 Bristol-Myers Squibb Company Immunomodulators
CN110504017B (zh) * 2019-07-30 2022-06-10 哈尔滨医科大学 一种示踪剂的制备和使用方法
CN114340684B (zh) 2019-09-16 2025-09-12 瑞泽恩制药公司 用于免疫pet成像的放射性标记的met结合蛋白
CN114929728A (zh) 2020-01-06 2022-08-19 百时美施贵宝公司 免疫调节剂
CN115485288A (zh) * 2020-03-16 2022-12-16 百时美施贵宝公司 免疫调节剂
KR20220161407A (ko) 2020-03-30 2022-12-06 브리스톨-마이어스 스큅 컴퍼니 면역조정제
US12159403B2 (en) * 2021-06-18 2024-12-03 The United States Government As Represented By The Department Of Veteran Affairs Combination of features from biopsies and scans to predict prognosis in SCLC
AU2023395853A1 (en) * 2022-12-12 2025-06-19 Merck Sharp & Dohme Llc Cyclic peptides as pet imaging agents of granzyme b

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013010573A1 (en) * 2011-07-18 2013-01-24 Universitaet Muenster Compounds with matrix-metalloproteinase inhibitory activity
WO2014151634A1 (en) * 2013-03-15 2014-09-25 Bristol-Myers Squibb Company Macrocyclic inhibitors of the pd-1/pd-l1 and cd80(b7-1)/pd-l1 protein/protein interactions
WO2016077518A1 (en) * 2014-11-14 2016-05-19 Bristol-Myers Squibb Company Macrocyclic peptides useful as immunomodulators
WO2016086021A1 (en) * 2014-11-25 2016-06-02 Bristol-Myers Squibb Company Novel pd-l1 binding polypeptides for imaging

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5374548A (en) 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
MX9203291A (es) 1985-06-26 1992-08-01 Liposome Co Inc Metodo para acoplamiento de liposomas.
US5776093A (en) 1985-07-05 1998-07-07 Immunomedics, Inc. Method for imaging and treating organs and tissues
US5101827A (en) 1985-07-05 1992-04-07 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US4735210A (en) 1985-07-05 1988-04-05 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US5128119A (en) 1989-06-12 1992-07-07 Immunomedics, Inc. Methods for technetium/rhenium labeling of f(ab1)2 fragments
US5328679A (en) 1988-04-01 1994-07-12 Immunomedics, Inc. Methods for technetium/rhenium labeling of proteins
US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
US5746996A (en) 1994-06-03 1998-05-05 Immunomedics, Inc. Thiolation of peptides for radionuclide-based radiodetection and radiotherapy
IL113610A0 (en) 1994-06-03 1995-08-31 Immunomedics Inc A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same
US5753206A (en) 1995-06-07 1998-05-19 Immunomedics, Inc. Radiometal-binding analogues of luteinizing hormone releasing hormone
US5869451A (en) 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
AU717020B2 (en) 1996-05-03 2000-03-16 Immunomedics Inc. Targeted combination immunotherapy of cancer
ATE380038T1 (de) 1996-07-12 2007-12-15 Immunomedics Inc Radiometall-bindende peptide analoge
US6277818B1 (en) 1998-10-29 2001-08-21 Angstrom Pharmaceuticals, Inc. Cyclic peptide ligands that target urokinase plasminogen activator receptor
DE69837095T2 (de) 1997-09-03 2007-11-22 Immunomedics, Inc. Fluorierung von proteinen und peptiden für positronemissionstomographie
US9090668B2 (en) 2007-03-26 2015-07-28 The University Of Tokyo Process for synthesizing cyclic peptide compound
WO2010098788A2 (en) 2008-08-25 2010-09-02 Amplimmune, Inc. Pd-i antagonists and methods for treating infectious disease
US8907053B2 (en) 2010-06-25 2014-12-09 Aurigene Discovery Technologies Limited Immunosuppression modulating compounds
JP5818237B2 (ja) 2010-09-09 2015-11-18 国立大学法人 東京大学 N−メチルアミノ酸およびその他の特殊アミノ酸を含む特殊ペプチド化合物ライブラリーの翻訳構築と活性種探索法
JP6206943B2 (ja) 2010-12-03 2017-10-04 国立大学法人 東京大学 ペプチドライブラリーの製造方法、ペプチドライブラリー、及びスクリーニング方法
EP2717895A1 (en) 2011-06-08 2014-04-16 Aurigene Discovery Technologies Limited Therapeutic compounds for immunomodulation
CN104245726A (zh) 2012-03-29 2014-12-24 奥瑞基尼探索技术有限公司 来自人pd1的bc环的免疫调节环状化合物
JP2013253842A (ja) 2012-06-06 2013-12-19 Univ Of Tokyo pH依存的に標的分子に結合するペプチドのスクリーニング方法
MX355396B (es) 2012-06-06 2018-04-18 Polyphor Ag Peptido - mimeticos de la horquilla beta.
KR20150131269A (ko) 2013-03-15 2015-11-24 제넨테크, 인크. Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법
MX2016002970A (es) 2013-09-06 2016-10-07 Aurigene Discovery Tech Ltd Compuestos peptidomimeticos ciclicos como inmunomoduladores.
WO2015044900A1 (en) 2013-09-27 2015-04-02 Aurigene Discovery Technologies Limited Therapeutic immunomodulating compounds
MA40132B1 (fr) 2014-09-11 2019-04-30 Bristol Myers Squibb Co Inhibiteurs macrocycliques des interactions protéine/protéine pd-1/pd-l1 et cd80(b7-1)/pd-li
US9732119B2 (en) 2014-10-10 2017-08-15 Bristol-Myers Squibb Company Immunomodulators
WO2016086036A2 (en) 2014-11-25 2016-06-02 Bristol-Myers Squibb Company Methods and compositions for 18f-radiolabeling of biologics
US9861680B2 (en) 2014-12-18 2018-01-09 Bristol-Myers Squibb Company Immunomodulators
US9944678B2 (en) 2014-12-19 2018-04-17 Bristol-Myers Squibb Company Immunomodulators
US20160222060A1 (en) 2015-02-04 2016-08-04 Bristol-Myers Squibb Company Immunomodulators
US9809625B2 (en) 2015-03-18 2017-11-07 Bristol-Myers Squibb Company Immunomodulators
US10143746B2 (en) 2016-03-04 2018-12-04 Bristol-Myers Squibb Company Immunomodulators
US10358463B2 (en) 2016-04-05 2019-07-23 Bristol-Myers Squibb Company Immunomodulators
WO2017210335A1 (en) 2016-06-01 2017-12-07 Bristol-Myers Squibb Company Imaging methods using 18f-radiolabeled biologics
KR102526034B1 (ko) 2016-11-07 2023-04-25 브리스톨-마이어스 스큅 컴퍼니 면역조정제
CN110997698B (zh) 2017-06-23 2023-12-26 百时美施贵宝公司 充当pd-1拮抗剂的免疫调节剂
EP3692053A1 (en) 2017-10-03 2020-08-12 Bristol-Myers Squibb Company Immunomodulators

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013010573A1 (en) * 2011-07-18 2013-01-24 Universitaet Muenster Compounds with matrix-metalloproteinase inhibitory activity
WO2014151634A1 (en) * 2013-03-15 2014-09-25 Bristol-Myers Squibb Company Macrocyclic inhibitors of the pd-1/pd-l1 and cd80(b7-1)/pd-l1 protein/protein interactions
WO2016077518A1 (en) * 2014-11-14 2016-05-19 Bristol-Myers Squibb Company Macrocyclic peptides useful as immunomodulators
WO2016086021A1 (en) * 2014-11-25 2016-06-02 Bristol-Myers Squibb Company Novel pd-l1 binding polypeptides for imaging

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ROY L. MAUTE, SYDNEY R. GORDON, AARON T. MAYER, MELISSA N. MCCRACKEN, ARUTSELVAN NATARAJAN, NAN GUO RING, RICHARD KIMURA, JONATHAN: "Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 112, no. 47, 1 November 2015 (2015-11-01), US, pages E6506 - E6514, XP002772779, ISSN: 0027-8424, DOI: 10.1073/pnas.1519623112 *

Also Published As

Publication number Publication date
MA53402A (fr) 2021-06-02
HRP20210644T1 (hr) 2021-05-28
IL262962A (en) 2018-12-31
PT3458111T (pt) 2021-04-09
JP6953444B2 (ja) 2021-10-27
DK3458111T3 (da) 2021-04-26
HUE054306T2 (hu) 2021-08-30
EP3827849A1 (en) 2021-06-02
CN109414514B (zh) 2022-03-11
US20210386876A1 (en) 2021-12-16
CY1124241T1 (el) 2022-07-22
ES2864091T3 (es) 2021-10-13
BR112018073642A2 (pt) 2019-02-26
SI3458111T1 (sl) 2021-07-30
MX2018014028A (es) 2019-04-04
CN109414514A (zh) 2019-03-01
US11103605B2 (en) 2021-08-31
SG11201810177VA (en) 2018-12-28
KR20190009330A (ko) 2019-01-28
US20190117801A1 (en) 2019-04-25
HRP20210644T8 (hr) 2021-06-25
RS61742B1 (sr) 2021-05-31
LT3458111T (lt) 2021-05-25
IL262962B (en) 2020-04-30
CA3024844A1 (en) 2017-11-23
EP3458111A1 (en) 2019-03-27
JP2019520328A (ja) 2019-07-18
KR102378288B1 (ko) 2022-03-23
AU2017268291A1 (en) 2019-01-17
EA201892635A1 (ru) 2019-04-30
WO2017201111A1 (en) 2017-11-23
SMT202100238T1 (it) 2021-05-07
EP3458111B1 (en) 2021-03-03
AU2017268291B2 (en) 2022-09-29
PL3458111T3 (pl) 2021-06-28

Similar Documents

Publication Publication Date Title
KR102378288B1 (ko) Pet-영상화 면역조정제
EP4537851A1 (en) Trifunctional compound and use thereof
EP4590345A2 (en) High-purity copper radiopharmaceutical compositions and diagnostic and therapeutic uses thereof
JP2017503763A (ja) Gcc発現細胞を撮像するための化合物及び組成物
WO2020238795A1 (zh) 一种靶向HER2的rk多肽放射性药物及其制备方法
Park et al. Recent advances in radiopharmaceutical application of matched-pair radiometals
Lamba et al. Synthetic 18F labeled biomolecules that are selective and promising for PET imaging: Major advances and applications
Wang et al. Peptide-based immuno-PET/CT monitoring of dynamic PD-L1 expression during glioblastoma radiotherapy
KR20070106731A (ko) 방사성표지된 갈륨 복합체, 그의 합성방법 및 악성종양에서 egfr 발현의 pet 영상화를 위한 그의 용도
CN117813326A (zh) 基于放射的导蛋白-1的检测、伴随测试和治疗方法
EP4380628A1 (en) Methods for biological material labeling and medical imaging
Zeglis et al. Radiopharmaceuticals for imaging in oncology with special emphasis on positron-emitting agents
Yao et al. Dual Targeting of Integrin αvβ3 and VEGF Receptor Improves PET Imaging of Breast Cancer
CN103275188B (zh) 放射性标记t140类多肽化合物及其制备方法和应用
CN119661694A (zh) 一种靶向mt1-mmp的pet显像剂及其制备方法和应用
Sarrett The Development of Novel Radioimmunoconjugates for the PET Imaging and Radioimmunotherapy of Cancer
Ngo Integrating Metabolic, Neo-Angiogenic, and HER2-Targeted Imaging to Characterize Breast Cancer in Preclinical Models
Cassells et al. –Preclinical evaluation of a terbium-161 labelled half-life extended anti-c-Met Nanobody®(vHH)
Patel Development of Radiotracers for Neuroimaging
Kersemans SYNTHESIS, IN VITRO/IN VIVO EVALUATION OF 2-IODO-L-PHENYLALANINE AND ITS D-ISOMER AS TUMOUR TRACERS IN ONCOLOGY.
Buck et al. Preclinical and clinical tumor imaging with SPECT/CT and PET/CT
CN110551075A (zh) 放射性标记亚谷氨基酸类化合物及其在制备pet显像剂的应用
Mishra et al. GALLIUM-68-LABELED PEPTIDE PET QUANTIFIES TUMOR EXPOSURE OF PD-L1
Bauwens et al. Radioiodinated Phenylalkyl Malonic Acid Derivatives as pH-S nsitive SPECT
Chopra 64 Cu-Labeled cysteine–tagged epidermal growth factor [64 Cu] Cys-EGF