EA036745B1 - Способы лечения инфекций, вызываемых вирусами гепатита b и гепатита d - Google Patents
Способы лечения инфекций, вызываемых вирусами гепатита b и гепатита d Download PDFInfo
- Publication number
- EA036745B1 EA036745B1 EA201790160A EA201790160A EA036745B1 EA 036745 B1 EA036745 B1 EA 036745B1 EA 201790160 A EA201790160 A EA 201790160A EA 201790160 A EA201790160 A EA 201790160A EA 036745 B1 EA036745 B1 EA 036745B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hbv
- nucleic acid
- pharmaceutically acceptable
- thiophosphate
- acid polymer
- Prior art date
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| SG11202104636XA (en) * | 2018-11-08 | 2021-06-29 | Aligos Therapeutics Inc | S-antigen transport inhibiting oligonucleotide polymers and methods |
| US11166976B2 (en) * | 2018-11-08 | 2021-11-09 | Aligos Therapeutics, Inc. | S-antigen transport inhibiting oligonucleotide polymers and methods |
| WO2021119325A1 (en) * | 2019-12-12 | 2021-06-17 | Aligos Therapeutics, Inc. | S-antigen transport inhibiting oligonucleotide polymers and methods |
| WO2021223398A1 (zh) * | 2020-05-07 | 2021-11-11 | 西安新通药物研究股份有限公司 | 治疗肝病的晶型及其应用 |
| CN112010905B (zh) * | 2020-05-07 | 2021-09-03 | 西安新通药物研究股份有限公司 | 甲磺酸帕拉德福韦晶型及其应用 |
| CN114057816B (zh) * | 2020-07-30 | 2025-02-11 | 浙江柏拉阿图医药科技有限公司 | 富含腺嘌呤硫代磷酸酯化寡核苷酸及其抗肝炎病毒的应用 |
| WO2022109129A1 (en) * | 2020-11-20 | 2022-05-27 | Aligos Therapeutics, Inc. | Conjugates of s-antigen transport inhibiting oligonucleotide polymers having enhanced liver targeting |
| TW202245809A (zh) | 2020-12-18 | 2022-12-01 | 美商詹森藥物公司 | 用於治療b型肝炎病毒感染之組合療法 |
| WO2022152869A1 (en) | 2021-01-15 | 2022-07-21 | Janssen Sciences Ireland Unlimited Company | Use of oligonucleotides for individuals with hepatic impairment |
| WO2022261046A1 (en) * | 2021-06-07 | 2022-12-15 | Antios Therapeutics, Inc. | Compositions and methods of treating hepatitis d and hepatitis b/hepatitis d co-infections with phosphoramidate clevudine prodrugs |
| JP2024527380A (ja) | 2021-07-09 | 2024-07-24 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー３）、リミテッド | 腎機能障害を有する個体へのオリゴヌクレオチドの使用 |
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| WO2012075114A2 (en) * | 2010-12-01 | 2012-06-07 | Ablitech, Inc. | Nucleic acid-polymer conjugates and uses thereof |
| WO2013170386A1 (en) * | 2012-05-18 | 2013-11-21 | Replicor Inc. | Oligonucleotide chelate complex-polypeptide compositions and methods |
| WO2014032176A1 (en) * | 2012-08-30 | 2014-03-06 | Replicor Inc. | Methods for the treatment of hepatitis b and hepatitis d infections |
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| US5482836A (en) * | 1993-01-14 | 1996-01-09 | The Regents Of The University Of California | DNA purification by triplex-affinity capture and affinity capture electrophoresis |
| BR0314236A (pt) | 2002-09-13 | 2005-08-09 | Replicor Inc | Formulação de oligonucleotìdeo, composição farmacêutica, kit, composto antiviral, preparação de oligonucleotìdeo e métodos para seleção de um oligonucleotìdeo antiviral para uso como um agente antiviral, para profilaxia ou tratamento de uma infecção viral em um paciente, para tratamento profilático de câncer causado por oncovìrus, para identificação de um composto que altera a ligação de um oligonucleotìdeo a pelo menos um componente viral, para purificação da ligação de oligonucleotìdeos a pelo menos um componente viral e para enriquecimento de oligonucleotìdeos a partir de um agrupamento de oligonucleotìdeos |
| WO2006091798A2 (en) * | 2005-02-22 | 2006-08-31 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Vaccines and methods for prevention and treatment of drug-resistant hiv-1 and hepatitis b virus |
| SG187165A1 (en) | 2010-08-20 | 2013-02-28 | Replicor Inc | Oligonucleotide chelate complexes |
| US9260471B2 (en) * | 2010-10-29 | 2016-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) |
| AR091065A1 (es) * | 2012-05-18 | 2014-12-30 | Replicor Inc | Una formulacion farmaceutica que comprende un quelato de oligonucleotidos antiviral para el tratamiento de una infeccion antiviral |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012075114A2 (en) * | 2010-12-01 | 2012-06-07 | Ablitech, Inc. | Nucleic acid-polymer conjugates and uses thereof |
| WO2013170386A1 (en) * | 2012-05-18 | 2013-11-21 | Replicor Inc. | Oligonucleotide chelate complex-polypeptide compositions and methods |
| WO2014032176A1 (en) * | 2012-08-30 | 2014-03-06 | Replicor Inc. | Methods for the treatment of hepatitis b and hepatitis d infections |
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