EA035866B1 - Применение производных 2,4-тиазолидиндиона для лечения расстройств центральной нервной системы и способ лечения с использованием таких производных - Google Patents

Применение производных 2,4-тиазолидиндиона для лечения расстройств центральной нервной системы и способ лечения с использованием таких производных Download PDF

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Publication number
EA035866B1
EA035866B1 EA201691997A EA201691997A EA035866B1 EA 035866 B1 EA035866 B1 EA 035866B1 EA 201691997 A EA201691997 A EA 201691997A EA 201691997 A EA201691997 A EA 201691997A EA 035866 B1 EA035866 B1 EA 035866B1
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Eurasian Patent Office
Prior art keywords
compound
compounds
mixture
ethoxy
thiazolidine
Prior art date
Application number
EA201691997A
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English (en)
Russian (ru)
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EA201691997A1 (ru
Inventor
Ана Мария Гарсия Кольасо
Дэвид Джон Аугустус Экланд
Мария Пилар Пискуэта Лаланса
Марк Мартинель Педемонте
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Минорикс Терапьютикс С.Л.
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Publication of EA201691997A1 publication Critical patent/EA201691997A1/ru
Publication of EA035866B1 publication Critical patent/EA035866B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Dispersion Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA201691997A 2014-04-02 2015-04-01 Применение производных 2,4-тиазолидиндиона для лечения расстройств центральной нервной системы и способ лечения с использованием таких производных EA035866B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14382130 2014-04-02
PCT/EP2015/057224 WO2015150476A1 (en) 2014-04-02 2015-04-01 2,4-thiazolidinedione derivatives in the treatment of central nervous system disorders

Publications (2)

Publication Number Publication Date
EA201691997A1 EA201691997A1 (ru) 2017-02-28
EA035866B1 true EA035866B1 (ru) 2020-08-21

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Family Applications (2)

Application Number Title Priority Date Filing Date
EA201691997A EA035866B1 (ru) 2014-04-02 2015-04-01 Применение производных 2,4-тиазолидиндиона для лечения расстройств центральной нервной системы и способ лечения с использованием таких производных
EA202091120A EA202091120A3 (ru) 2014-04-02 2015-04-01 Производные 2,4-тиазолинидона в лечении расстройств центральной нервной системы

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA202091120A EA202091120A3 (ru) 2014-04-02 2015-04-01 Производные 2,4-тиазолинидона в лечении расстройств центральной нервной системы

Country Status (24)

Country Link
US (3) US9782395B2 (OSRAM)
EP (2) EP3388064B1 (OSRAM)
JP (2) JP6745726B2 (OSRAM)
KR (1) KR102418167B1 (OSRAM)
CN (1) CN106470991B (OSRAM)
AU (1) AU2015239112C1 (OSRAM)
CA (1) CA2943373C (OSRAM)
CL (1) CL2016002508A1 (OSRAM)
CY (2) CY1120454T1 (OSRAM)
DK (2) DK3388064T3 (OSRAM)
EA (2) EA035866B1 (OSRAM)
ES (2) ES2678046T3 (OSRAM)
HR (2) HRP20180983T1 (OSRAM)
HU (2) HUE055351T2 (OSRAM)
IL (1) IL248037B (OSRAM)
LT (2) LT3388064T (OSRAM)
MX (1) MX373234B (OSRAM)
NZ (1) NZ725492A (OSRAM)
PL (2) PL3388064T3 (OSRAM)
PT (2) PT3125888T (OSRAM)
SG (1) SG11201608218QA (OSRAM)
SI (2) SI3125888T1 (OSRAM)
WO (1) WO2015150476A1 (OSRAM)
ZA (1) ZA201607286B (OSRAM)

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US8722710B2 (en) 2007-09-26 2014-05-13 Deuterx, Llc Deuterium-enriched pioglitazone
US20130158077A1 (en) 2011-12-19 2013-06-20 Ares Trading S.A. Pharmaceutical compositions
JP6800013B2 (ja) 2013-03-14 2020-12-16 ポクセル・ソシエテ・アノニムPoxel SA 重水素化2,4−チアゾリジンジオン及び治療方法
EP3094328B1 (en) 2014-01-15 2020-08-19 Poxel SA Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
SG11201608218QA (en) * 2014-04-02 2016-10-28 Minoryx Therapeutics S L 2,4-thiazolidinedione derivatives in the treatment of central nervous system disorders
AU2017370003B2 (en) * 2016-12-01 2023-04-13 Minoryx Therapeutics S.L. 5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine- 2,4-dione for treating nonalcoholic fatty liver disease
HUE059604T2 (hu) * 2016-12-23 2022-11-28 Minoryx Therapeutics S L Eljárás 5-[[4-[2-[5-(1-hidroxietil)-2-piridinil]etoxi]fenil]metil]-2,4-tiazolidindion és sói elõállítására
KR20210031435A (ko) * 2018-06-06 2021-03-19 미노릭스 테라퓨틱스 에스.엘. 치료학적 유효량의 5-[[4-[2-[5-(1-히드록시에틸)피리딘-2-일]에톡시]페닐]메틸]-1,3-티아졸리딘-2,4-디온을 투여하는 방법
SI3801515T1 (sl) * 2018-06-06 2025-07-31 Minoryx Therapeutics S.L. 5-[[4-[2-[5-(1-hidroksietil)piridin-2-il]etoksi]fenil]metil]-1,3-tiazolidin-2,4-dion in soli za uporabo pri zdravljenju mitohondrijske bolezni
BR112020024939A2 (pt) 2018-06-06 2021-03-09 Minoryx Therapeutics S.L. Uso de 5-[[4-[2-[5-acetilpiridin-2-il]etoxi]benzil]-1,3-tiazolidina-2,4-diona e seus sais
AU2021265345A1 (en) 2020-04-30 2022-12-08 Minoryx Therapeutics S.L. Leriglitazone for treating lung inflammation and interstitial lung disease
US11319313B2 (en) 2020-06-30 2022-05-03 Poxel Sa Crystalline forms of deuterium-enriched pioglitazone
US11767317B1 (en) 2020-06-30 2023-09-26 Poxel Sa Methods of synthesizing enantiopure deuterium-enriched pioglitazone
EP4642456A1 (en) 2022-12-28 2025-11-05 Minoryx Therapeutics S.L. Optimized dosing of leriglitazone
WO2024231881A2 (en) 2023-05-09 2024-11-14 Minoryx Therapeutics S.L. Polymorphic forms and formulations of leriglitazone

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WO2013040419A1 (en) * 2011-09-14 2013-03-21 The Trustees Of Columbia University In The City Of New York Compositions and methods for treating hyperprolinemia-associated mental disorders
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SG11201608218QA (en) * 2014-04-02 2016-10-28 Minoryx Therapeutics S L 2,4-thiazolidinedione derivatives in the treatment of central nervous system disorders

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WO1992018501A1 (en) * 1991-04-11 1992-10-29 The Upjohn Company Thiazolidinedione derivatives, production and use thereof
WO2013040419A1 (en) * 2011-09-14 2013-03-21 The Trustees Of Columbia University In The City Of New York Compositions and methods for treating hyperprolinemia-associated mental disorders
US20130274295A1 (en) * 2012-03-23 2013-10-17 Fundacio Institut D'investigacio Biomedica De Bellvitge (Idibell) Pioglitazone for use in the treatment of adrenoleukodystrophy
WO2014152843A1 (en) * 2013-03-14 2014-09-25 Deuterx, Llc Deuterium-enriched 2,4-thiazolidinediones and methods of treatment

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SOHDA T, IKEDA H, MEGURO K: "STUDIES ON ANTIDIABETIC AGENTS. XII. SYNTHESIS AND ACTIVITY OF THE METABOLITES OF (PLUS OR MINUS)-5-�P-�2-(5-ETHYL-2-PYRIDYL)ETHOXY�BENZYL�-2,4-THIAZOLIDINEDIONE (PIOGLITAZONE)", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 43, no. 12, 1 December 1995 (1995-12-01), JP, pages 2168 - 2172, XP008057606, ISSN: 0009-2363 *
ST�PHANE FOURCADE, JONE L�PEZ-ERAUSKIN, MONTSERRAT RUIZ, ISIDRE FERRER, AURORA PUJOL: "Mitochondrial dysfunction and oxidative damage cooperatively fuel axonal degeneration in X-linked adrenoleukodystrophy", BIOCHIMIE, ELSEVIER MASSON SAS, vol. 98, 1 March 2014 (2014-03-01), pages 143 - 149, XP055118520, ISSN: 03009084, DOI: 10.1016/j.biochi.2013.09.012 *
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Publication number Publication date
CA2943373A1 (en) 2015-10-08
EP3125888A1 (en) 2017-02-08
AU2015239112A1 (en) 2016-11-10
US20180133202A1 (en) 2018-05-17
AU2015239112C1 (en) 2020-08-20
EA202091120A2 (ru) 2020-08-31
SG11201608218QA (en) 2016-10-28
PT3125888T (pt) 2018-07-20
US10179126B2 (en) 2019-01-15
ZA201607286B (en) 2021-07-28
PL3125888T3 (pl) 2018-09-28
EP3388064A1 (en) 2018-10-17
CL2016002508A1 (es) 2017-04-21
CA2943373C (en) 2023-01-10
IL248037A0 (en) 2016-11-30
JP2020117539A (ja) 2020-08-06
EA202091120A3 (ru) 2020-12-30
IL248037B (en) 2020-09-30
MX2016012687A (es) 2017-04-27
EP3125888B1 (en) 2018-05-23
DK3388064T3 (da) 2021-04-19
AU2015239112B2 (en) 2020-05-07
SI3388064T1 (sl) 2021-08-31
HRP20210518T1 (hr) 2021-05-14
MX373234B (es) 2020-05-08
US20190255032A1 (en) 2019-08-22
CY1120454T1 (el) 2019-07-10
HUE055351T2 (hu) 2022-05-28
WO2015150476A1 (en) 2015-10-08
US9782395B2 (en) 2017-10-10
ES2872335T3 (es) 2021-11-02
LT3388064T (lt) 2021-05-25
LT3125888T (lt) 2018-07-10
JP6745726B2 (ja) 2020-08-26
NZ725492A (en) 2023-06-30
EA201691997A1 (ru) 2017-02-28
JP2017511339A (ja) 2017-04-20
DK3125888T3 (en) 2018-06-25
BR112016022974A2 (pt) 2017-12-26
SI3125888T1 (en) 2018-08-31
CN106470991A (zh) 2017-03-01
EP3388064B1 (en) 2021-03-10
CN106470991B (zh) 2020-07-31
CY1124088T1 (el) 2022-05-27
HUE039555T2 (hu) 2019-01-28
US20160235729A1 (en) 2016-08-18
PT3388064T (pt) 2021-05-14
PL3388064T3 (pl) 2021-07-19
KR20160145639A (ko) 2016-12-20
HRP20180983T1 (hr) 2018-08-10
KR102418167B1 (ko) 2022-07-08
ES2678046T3 (es) 2018-08-08

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