EA034616B1 - СТАБИЛЬНЫЙ СОСТАВ В ВИДЕ РАСТВОРА АНТИТЕЛА HUM13B8-b К IL-23p19 И СПОСОБ ЛЕЧЕНИЯ АУТОИММУННОГО ЗАБОЛЕВАНИЯ, ВОСПАЛИТЕЛЬНОГО ЗАБОЛЕВАНИЯ ИЛИ ПРОЛИФЕРАТИВНОГО НАРУШЕНИЯ - Google Patents

СТАБИЛЬНЫЙ СОСТАВ В ВИДЕ РАСТВОРА АНТИТЕЛА HUM13B8-b К IL-23p19 И СПОСОБ ЛЕЧЕНИЯ АУТОИММУННОГО ЗАБОЛЕВАНИЯ, ВОСПАЛИТЕЛЬНОГО ЗАБОЛЕВАНИЯ ИЛИ ПРОЛИФЕРАТИВНОГО НАРУШЕНИЯ Download PDF

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Publication number
EA034616B1
EA034616B1 EA201591133A EA201591133A EA034616B1 EA 034616 B1 EA034616 B1 EA 034616B1 EA 201591133 A EA201591133 A EA 201591133A EA 201591133 A EA201591133 A EA 201591133A EA 034616 B1 EA034616 B1 EA 034616B1
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Eurasian Patent Office
Prior art keywords
antibody
hum13b8
antibodies
sequence
formulations
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EA201591133A
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English (en)
Russian (ru)
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EA201591133A1 (ru
Inventor
Рамеш С. Каши
Аникет Бадкар
Original Assignee
Мэрк Шарп Энд Доме Корп.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50934859&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA034616(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Мэрк Шарп Энд Доме Корп. filed Critical Мэрк Шарп Энд Доме Корп.
Publication of EA201591133A1 publication Critical patent/EA201591133A1/ru
Publication of EA034616B1 publication Critical patent/EA034616B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591Stabilisation, fragmentation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515Complete light chain, i.e. VL + CL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EA201591133A 2012-12-13 2013-12-09 СТАБИЛЬНЫЙ СОСТАВ В ВИДЕ РАСТВОРА АНТИТЕЛА HUM13B8-b К IL-23p19 И СПОСОБ ЛЕЧЕНИЯ АУТОИММУННОГО ЗАБОЛЕВАНИЯ, ВОСПАЛИТЕЛЬНОГО ЗАБОЛЕВАНИЯ ИЛИ ПРОЛИФЕРАТИВНОГО НАРУШЕНИЯ EA034616B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261737035P 2012-12-13 2012-12-13
PCT/US2013/073825 WO2014093203A1 (en) 2012-12-13 2013-12-09 SOLUTION FORMULATIONS OF ENGINEERED ANTI-IL-23p19 ANTIBODIES

Publications (2)

Publication Number Publication Date
EA201591133A1 EA201591133A1 (ru) 2015-10-30
EA034616B1 true EA034616B1 (ru) 2020-02-27

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EA201591133A EA034616B1 (ru) 2012-12-13 2013-12-09 СТАБИЛЬНЫЙ СОСТАВ В ВИДЕ РАСТВОРА АНТИТЕЛА HUM13B8-b К IL-23p19 И СПОСОБ ЛЕЧЕНИЯ АУТОИММУННОГО ЗАБОЛЕВАНИЯ, ВОСПАЛИТЕЛЬНОГО ЗАБОЛЕВАНИЯ ИЛИ ПРОЛИФЕРАТИВНОГО НАРУШЕНИЯ

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US (3) US20150329632A1 (OSRAM)
EP (1) EP2931313B1 (OSRAM)
JP (1) JP6266012B2 (OSRAM)
KR (1) KR102004585B1 (OSRAM)
CN (1) CN104870016B (OSRAM)
AU (1) AU2013359767B2 (OSRAM)
BR (1) BR112015013540B1 (OSRAM)
CA (1) CA2894869C (OSRAM)
CL (1) CL2015001608A1 (OSRAM)
CY (1) CY1121895T1 (OSRAM)
DK (1) DK2931313T3 (OSRAM)
EA (1) EA034616B1 (OSRAM)
ES (1) ES2732861T3 (OSRAM)
HR (1) HRP20191137T1 (OSRAM)
HU (1) HUE045668T2 (OSRAM)
IL (3) IL278295B2 (OSRAM)
LT (1) LT2931313T (OSRAM)
MX (1) MX357936B (OSRAM)
MY (1) MY187921A (OSRAM)
NZ (1) NZ708443A (OSRAM)
PE (1) PE20151524A1 (OSRAM)
PH (1) PH12015501296A1 (OSRAM)
PL (1) PL2931313T3 (OSRAM)
PT (1) PT2931313T (OSRAM)
RS (1) RS59057B1 (OSRAM)
SI (1) SI2931313T1 (OSRAM)
SM (1) SMT201900414T1 (OSRAM)
TR (1) TR201909584T4 (OSRAM)
UA (1) UA117466C2 (OSRAM)
WO (1) WO2014093203A1 (OSRAM)
ZA (1) ZA201504408B (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI738632B (zh) 2014-11-07 2021-09-11 瑞士商諾華公司 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
WO2018181876A1 (ja) * 2017-03-31 2018-10-04 Meiji Seikaファルマ株式会社 水性製剤及び注射器入り水性製剤、並びに、抗体タンパク脱凝集剤及び抗体タンパク脱凝集方法
JP7516250B2 (ja) 2018-03-05 2024-07-16 ヤンセン バイオテツク,インコーポレーテツド 抗il-23特異的抗体を用いたクローン病の治療方法
CA3118306A1 (en) 2018-11-21 2020-05-28 Regeneron Pharmaceuticals, Inc. High concentration protein formulation
US12098195B2 (en) 2018-11-27 2024-09-24 Innovent Biologics (Suzhou) Co., Ltd. Anti-IL-23p19 antibody and use thereof in treating diseases
KR102735988B1 (ko) 2019-02-18 2024-12-03 일라이 릴리 앤드 캄파니 치료 항체 제제
JP7530376B2 (ja) * 2019-02-20 2024-08-07 アムジエン・インコーポレーテツド タンパク質の安定性を決定する方法
MX2021012652A (es) * 2019-04-15 2022-01-24 Sun Pharmaceutical Ind Ltd Metodos para el tratamiento de sujetos con artritis psoriasica.
MX2021014302A (es) 2019-05-23 2022-01-04 Janssen Biotech Inc Metodo para tratar la enfermedad inflamatoria del intestino con una terapia de combinacion de anticuerpos contra il-23 y tnf alfa.
TW202535466A (zh) * 2019-09-09 2025-09-16 德商百靈佳殷格翰國際股份有限公司 抗-il-23p19抗體調配物
CN115135671A (zh) * 2019-12-20 2022-09-30 新石生物制药有限公司 抗白介素-23 p19的抗体及其使用方法
JP2023525825A (ja) * 2020-05-13 2023-06-19 イノベント バイオロジクス(スーチョウ)カンパニー,リミティド 抗IL-23p19抗体を含む製剤、その調製方法および使用
CN115768466A (zh) 2020-05-21 2023-03-07 詹森生物科技公司 用抗IL-23和TNFα抗体的联合疗法治疗炎性肠病的方法
WO2025071362A1 (ko) * 2023-09-27 2025-04-03 삼성바이오에피스 주식회사 항-il-23 항체의 안정한 액상 제형

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090311253A1 (en) * 2008-06-03 2009-12-17 Abbott Laboratories Dual Variable Domain Immunoglobulins and Uses Thereof
US20110229490A1 (en) * 2008-08-27 2011-09-22 Schering Corporation Lyophilized Formulations of Engineered Anti-IL-23p19 Antibodies

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60041393D1 (de) 1999-03-11 2009-03-05 Schering Corp Cytokine aus säugetieren, verwandte reagenzien und verfahren
ES2300276T5 (es) 1999-09-09 2017-06-02 Merck Sharp & Dohme Corp. P40 de interleuquina-12 de mamífero e interleuquina B30. Sus combinaciones. Anticuerpos. Usos en composiciones farmacéuticas
JP4317010B2 (ja) 2001-07-25 2009-08-19 ピーディーエル バイオファーマ,インコーポレイティド IgG抗体の安定な凍結乾燥医薬製剤
ATE556591T1 (de) * 2001-11-08 2012-05-15 Abbott Biotherapeutics Corp Stabile pharmazeutische flüssigformulierung von igg-antikörpern
US7132100B2 (en) 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
WO2004071517A2 (en) 2003-02-06 2004-08-26 Schering Corporation Uses of il-23 related reagents
EP1592440A4 (en) 2003-02-10 2007-07-11 Elan Pharm Inc IMMUNOGLOBULIN PREPARATION AND METHOD OF PRODUCING THE SAME
TWI439285B (zh) 2003-03-10 2014-06-01 Merck Sharp & Dohme Il-23激動劑及拮抗劑之用途及相關試劑
HRP20050934B1 (hr) * 2003-04-04 2014-09-26 Genentech, Inc. Formulacije s visokom koncentracijom antitijela i proteina
JP4903061B2 (ja) 2004-02-17 2012-03-21 シェーリング コーポレイション Il−23活性を調節する方法;関連する試薬
CA2562771C (en) 2004-04-12 2013-04-09 Medimmune, Inc. Anti-il-9 antibody formulations and uses thereof
JO3000B1 (ar) * 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
GT200600031A (es) 2005-01-28 2006-08-29 Formulacion anticuerpo anti a beta
PT1896073E (pt) 2005-06-30 2013-05-28 Janssen Biotech Inc Composições, métodos e aplicações de anticorpos anti-il-23
ES2347690T3 (es) 2005-08-25 2010-11-03 Eli Lilly And Company Anticuerpos anti-il-23.
ME02705B (me) 2005-08-31 2017-10-20 Merck Sharp & Dohme Inženjerisana anti-il-23 antitela
PT2548577T (pt) 2005-12-29 2017-05-29 Janssen Biotech Inc Anticorpos humanos anti-il-23, composições, métodos e usos
JP2009540018A (ja) 2006-06-13 2009-11-19 ザイモジェネティクス, インコーポレイテッド Il−17およびil−23アンタゴニストならびにその使用方法
TW200833357A (en) 2006-10-20 2008-08-16 Amgen Inc Stable polypeptide formulations
TW200837080A (en) 2007-01-09 2008-09-16 Wyeth Corp Anti-IL-13 antibody formulations and uses thereof
TWI426918B (zh) 2007-02-12 2014-02-21 Merck Sharp & Dohme Il-23拮抗劑於治療感染之用途
SI2426144T1 (sl) 2007-02-23 2019-02-28 Merck Sharp & Dohme Corp. Umetno proizvedena anti-IL23P19 antitelesa
CN101663320A (zh) 2007-02-23 2010-03-03 先灵公司 工程改造的抗IL-23p19抗体
WO2008121615A2 (en) * 2007-03-30 2008-10-09 Medimmune, Inc. Antibody formulation
US20090208492A1 (en) 2007-06-14 2009-08-20 Elan Pharmaceuticals, Inc. Lyophilized Immunoglobulin Formulations and Methods of Preparation
WO2009114040A2 (en) 2007-09-28 2009-09-17 Centocor Ortho Biotech Inc. Anti-il-12/23p40 antibodies, epitopes, formulations, compositions, methods and uses
AR068723A1 (es) 2007-10-05 2009-12-02 Glaxo Group Ltd Proteina que se une a antigenos que se une a il-23 humana y sus usos
AU2008340429C1 (en) 2007-12-21 2016-09-08 F. Hoffmann-La Roche Ag Antibody formulation
US10188600B2 (en) * 2008-09-19 2019-01-29 Pfizer Inc. Stable liquid antibody formulation
EP2350649A4 (en) * 2008-11-28 2012-11-14 Abbott Lab STABLE ANTIBODY COMPOSITIONS AND METHODS FOR STABILIZING THE SAME
CA2783715A1 (en) * 2009-12-29 2011-07-07 F. Hoffmann-La Roche Ag Novel antibody formulation
AU2012236479B2 (en) 2011-03-31 2016-10-20 Merck Sharp & Dohme Llc Stable formulations of antibodies to human programmed death receptor PD-1 and related treatments
MX363700B (es) * 2012-03-07 2019-03-29 Cadila Healthcare Ltd Formulaciones farmaceuticas de anticuerpos tnf-alfa.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090311253A1 (en) * 2008-06-03 2009-12-17 Abbott Laboratories Dual Variable Domain Immunoglobulins and Uses Thereof
US20110229490A1 (en) * 2008-08-27 2011-09-22 Schering Corporation Lyophilized Formulations of Engineered Anti-IL-23p19 Antibodies

Also Published As

Publication number Publication date
EP2931313B1 (en) 2019-05-08
BR112015013540A8 (pt) 2018-04-17
ZA201504408B (en) 2017-09-27
KR102004585B1 (ko) 2019-07-26
SMT201900414T1 (it) 2019-09-09
US20210188964A1 (en) 2021-06-24
MY187921A (en) 2021-10-28
PH12015501296B1 (en) 2015-08-24
IL239150A0 (en) 2015-07-30
PH12015501296A1 (en) 2015-08-24
IL278295B1 (en) 2023-11-01
BR112015013540A2 (pt) 2017-11-14
EA201591133A1 (ru) 2015-10-30
EP2931313A1 (en) 2015-10-21
HRP20191137T1 (hr) 2019-09-20
BR112015013540B1 (pt) 2021-04-27
PT2931313T (pt) 2019-07-10
US20150329632A1 (en) 2015-11-19
IL278295B2 (en) 2024-03-01
HUE045668T2 (hu) 2020-01-28
SI2931313T1 (sl) 2019-09-30
CA2894869A1 (en) 2014-06-19
RS59057B1 (sr) 2019-08-30
IL239150B (en) 2020-11-30
NZ708443A (en) 2018-05-25
LT2931313T (lt) 2019-09-25
EP2931313A4 (en) 2016-08-03
ES2732861T3 (es) 2019-11-26
DK2931313T3 (da) 2019-07-15
KR20150092763A (ko) 2015-08-13
CY1121895T1 (el) 2020-10-14
AU2013359767B2 (en) 2018-04-05
CL2015001608A1 (es) 2015-10-30
UA117466C2 (uk) 2018-08-10
CN104870016B (zh) 2018-05-08
PE20151524A1 (es) 2015-11-06
CN104870016A (zh) 2015-08-26
MX2015007213A (es) 2016-08-03
AU2013359767A1 (en) 2015-07-23
TR201909584T4 (tr) 2019-07-22
US20240239884A1 (en) 2024-07-18
JP2016505572A (ja) 2016-02-25
MX357936B (es) 2018-07-31
JP6266012B2 (ja) 2018-01-24
WO2014093203A1 (en) 2014-06-19
PL2931313T3 (pl) 2019-10-31
CA2894869C (en) 2021-06-15
HK1215194A1 (en) 2016-08-19
IL307581A (en) 2023-12-01
IL278295A (OSRAM) 2020-12-31

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