EA033007B1 - ПОЛИПЕПТИД, СОДЕРЖАЩИЙ ЛИПИДИРОВАННЫЙ ГЕТЕРОДИМЕР МУТАНТНЫХ ФРАГМЕНТОВ OspA, СПОСОБ ПОЛУЧЕНИЯ ПОЛИПЕПТИДА И ЕГО ПРИМЕНЕНИЯ - Google Patents

ПОЛИПЕПТИД, СОДЕРЖАЩИЙ ЛИПИДИРОВАННЫЙ ГЕТЕРОДИМЕР МУТАНТНЫХ ФРАГМЕНТОВ OspA, СПОСОБ ПОЛУЧЕНИЯ ПОЛИПЕПТИДА И ЕГО ПРИМЕНЕНИЯ

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Publication number
EA033007B1
EA033007B1 EA201590162A EA201590162A EA033007B1 EA 033007 B1 EA033007 B1 EA 033007B1 EA 201590162 A EA201590162 A EA 201590162A EA 201590162 A EA201590162 A EA 201590162A EA 033007 B1 EA033007 B1 EA 033007B1
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EA
Eurasian Patent Office
Prior art keywords
polypeptide
ospa
lipidated
heterodimer
producing
Prior art date
Application number
EA201590162A
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English (en)
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EA201590162A1 (ru
Inventor
Пер Комстедт
Урбан Лундберг
Андреас Майнке
Маркус Ханнер
Вольфганг Шюлер
Бенджамин Вайзел
Кристоф Райниш
Брижитт Громанн
Роберт Шлегль
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Валнева Аустриа Гмбх
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Application filed by Валнева Аустриа Гмбх filed Critical Валнева Аустриа Гмбх
Publication of EA201590162A1 publication Critical patent/EA201590162A1/ru
Publication of EA033007B1 publication Critical patent/EA033007B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1207—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Изобретение относится к полипептиду, содержащему липидированный гетеродимер мутантных фрагментов внешнего поверхностного белка A (OspA) с последовательностью SEQ ID NO: 186 (Lip-S1D1-S2D1) или его любой функциональный вариант с последовательностью, идентичной по меньшей мере на 80% последовательности SEQ ID NO: 186, причем указанный полипептид имеет защитную активность против Borrelia, которая отличается от контрольной активности плацебо по меньшей мере на 50%. Также изобретение относится к полинуклеотиду, кодирующему заявленный полипептид, фармацевтической композиции или вакцине, содержащей заявленный полипептид, и применению указанных полипептида, фармацевтической композиции или вакцины в качестве лекарственного средства для лечения или профилактики инфекции Borrelia, в частности, в соответствующем способе.
EA201590162A 2012-07-06 2013-07-08 ПОЛИПЕПТИД, СОДЕРЖАЩИЙ ЛИПИДИРОВАННЫЙ ГЕТЕРОДИМЕР МУТАНТНЫХ ФРАГМЕНТОВ OspA, СПОСОБ ПОЛУЧЕНИЯ ПОЛИПЕПТИДА И ЕГО ПРИМЕНЕНИЯ EA033007B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261668627P 2012-07-06 2012-07-06
US13/802,991 US8986704B2 (en) 2012-07-06 2013-03-14 Mutant fragments of OspA and methods and uses relating thereto
PCT/EP2013/064403 WO2014006226A1 (en) 2012-07-06 2013-07-08 MUTANT FRAGMENTS OF OspA AND METHODS AND USES RELATING THERETO

Publications (2)

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EA201590162A1 EA201590162A1 (ru) 2015-06-30
EA033007B1 true EA033007B1 (ru) 2019-08-30

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Application Number Title Priority Date Filing Date
EA201991059A EA201991059A1 (ru) 2012-07-06 2013-07-08 МУТАНТНЫЕ ФРАГМЕНТЫ OspA И СВЯЗАННЫЕ С НИМИ СПОСОБЫ И ПРИМЕНЕНИЕ
EA201590162A EA033007B1 (ru) 2012-07-06 2013-07-08 ПОЛИПЕПТИД, СОДЕРЖАЩИЙ ЛИПИДИРОВАННЫЙ ГЕТЕРОДИМЕР МУТАНТНЫХ ФРАГМЕНТОВ OspA, СПОСОБ ПОЛУЧЕНИЯ ПОЛИПЕПТИДА И ЕГО ПРИМЕНЕНИЯ

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US (9) US8986704B2 (ru)
EP (3) EP3689372A1 (ru)
JP (1) JP6276258B2 (ru)
KR (2) KR102393038B1 (ru)
CN (2) CN104487084B (ru)
AU (2) AU2013285364B2 (ru)
CA (1) CA2876541C (ru)
CY (1) CY1120772T1 (ru)
DK (1) DK2869839T3 (ru)
EA (2) EA201991059A1 (ru)
ES (2) ES2800873T3 (ru)
HK (4) HK1248244A1 (ru)
HR (1) HRP20181689T1 (ru)
HU (1) HUE041286T2 (ru)
LT (1) LT2869839T (ru)
MX (1) MX364623B (ru)
NZ (2) NZ733026A (ru)
PL (1) PL2869839T3 (ru)
PT (1) PT2869839T (ru)
RS (1) RS57847B1 (ru)
SI (1) SI2869839T1 (ru)
TR (1) TR201815419T4 (ru)
WO (1) WO2014006226A1 (ru)
ZA (1) ZA201409222B (ru)

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WO2015104396A1 (en) * 2014-01-09 2015-07-16 Valneva Austria Gmbh Mutant fragments of ospa and methods and uses relating thereto
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WO2016022958A2 (en) * 2014-08-07 2016-02-11 The Trustees Of Columbia University In The City Of New York Tick-associated virus sequences and uses thereof
JP6995756B2 (ja) * 2015-12-23 2022-02-04 ノバルティス アーゲー レチノイン酸を含む水中油型エマルジョン
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CN111269919B (zh) * 2020-03-19 2021-07-13 四川农业大学 玉米基因ZmLIP2及其应用
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HUE041286T2 (hu) 2019-05-28
CN104487084B (zh) 2017-09-22
HK1248244A1 (zh) 2018-10-12
US20170101446A1 (en) 2017-04-13
HK1257893A1 (zh) 2019-11-01
LT2869839T (lt) 2018-11-12
EA201590162A1 (ru) 2015-06-30
EP3360568A1 (en) 2018-08-15
US20140010835A1 (en) 2014-01-09
CN104487084A (zh) 2015-04-01
ZA201409222B (en) 2016-08-31
US20220185851A1 (en) 2022-06-16
JP6276258B2 (ja) 2018-02-07
CA2876541C (en) 2022-03-01
HRP20181689T1 (hr) 2018-12-28
CN107602676B (zh) 2021-06-04
TR201815419T4 (tr) 2018-11-21
US8986704B2 (en) 2015-03-24
US20150232517A1 (en) 2015-08-20
US20200239525A1 (en) 2020-07-30
US11208439B2 (en) 2021-12-28
JP2015522270A (ja) 2015-08-06
HK1207982A1 (en) 2016-02-19
US10544194B2 (en) 2020-01-28
KR20200141096A (ko) 2020-12-17
RS57847B1 (sr) 2018-12-31
US20170107263A1 (en) 2017-04-20
ES2800873T3 (es) 2021-01-04
EP2869839A1 (en) 2015-05-13
EP3360568B1 (en) 2020-03-04
CN107602676A (zh) 2018-01-19
AU2017218974A1 (en) 2017-09-07
KR102190981B1 (ko) 2020-12-15
MX364623B (es) 2019-05-03
ES2688883T3 (es) 2018-11-07
NZ733026A (en) 2019-09-27
MX2015000013A (es) 2015-06-04
AU2013285364A1 (en) 2015-01-29
PL2869839T3 (pl) 2018-12-31
EA201991059A1 (ru) 2020-01-31
KR20150036191A (ko) 2015-04-07
CA2876541A1 (en) 2014-01-09
DK2869839T3 (en) 2018-10-15
EP3689372A1 (en) 2020-08-05
WO2014006226A1 (en) 2014-01-09
EP2869839B1 (en) 2018-09-05
HK1209370A1 (en) 2016-04-01
CY1120772T1 (el) 2019-12-11
SI2869839T1 (sl) 2018-11-30
AU2017218974B2 (en) 2019-05-30
US9926343B2 (en) 2018-03-27
AU2017218974C1 (en) 2020-02-20
PT2869839T (pt) 2018-11-12
US20150250865A1 (en) 2015-09-10
US11466058B2 (en) 2022-10-11
AU2013285364B2 (en) 2017-06-15
US20230295245A1 (en) 2023-09-21
NZ703597A (en) 2017-06-30
US20180327460A1 (en) 2018-11-15
KR102393038B1 (ko) 2022-04-29

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