EA032261B1 - Способы получения твердых форм менахинолов - Google Patents

Способы получения твердых форм менахинолов Download PDF

Info

Publication number
EA032261B1
EA032261B1 EA201791845A EA201791845A EA032261B1 EA 032261 B1 EA032261 B1 EA 032261B1 EA 201791845 A EA201791845 A EA 201791845A EA 201791845 A EA201791845 A EA 201791845A EA 032261 B1 EA032261 B1 EA 032261B1
Authority
EA
Eurasian Patent Office
Prior art keywords
bacillus
vitamin
formula
menaquinol
temperature
Prior art date
Application number
EA201791845A
Other languages
English (en)
Russian (ru)
Other versions
EA201791845A1 (ru
Inventor
Давиде Бьянки
Симона Дали
Никколо Миралья
Антонелла Трентин
Федерика Кольцани
Франческа Боллини
Чезаре ПОНЦОНЕ
Original Assignee
Гносис С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гносис С.п.А. filed Critical Гносис С.п.А.
Publication of EA201791845A1 publication Critical patent/EA201791845A1/ru
Publication of EA032261B1 publication Critical patent/EA032261B1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/06Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by conversion of non-aromatic six-membered rings or of such rings formed in situ into aromatic six-membered rings, e.g. by dehydrogenation
    • C07C37/07Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by conversion of non-aromatic six-membered rings or of such rings formed in situ into aromatic six-membered rings, e.g. by dehydrogenation with simultaneous reduction of C=O group in that ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/68Purification; separation; Use of additives, e.g. for stabilisation
    • C07C37/70Purification; separation; Use of additives, e.g. for stabilisation by physical treatment
    • C07C37/84Purification; separation; Use of additives, e.g. for stabilisation by physical treatment by crystallisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/205Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
    • C07C39/225Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a condensed ring system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/66Preparation of oxygen-containing organic compounds containing the quinoid structure
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07Bacillus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185Escherichia
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/38Pseudomonas
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EA201791845A 2015-03-20 2016-03-18 Способы получения твердых форм менахинолов EA032261B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITUB20150528 2015-03-20
PCT/IB2016/051528 WO2016151447A1 (en) 2015-03-20 2016-03-18 Solid forms of menaquinols

Publications (2)

Publication Number Publication Date
EA201791845A1 EA201791845A1 (ru) 2018-02-28
EA032261B1 true EA032261B1 (ru) 2019-04-30

Family

ID=53284441

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791845A EA032261B1 (ru) 2015-03-20 2016-03-18 Способы получения твердых форм менахинолов

Country Status (15)

Country Link
US (1) US10563270B2 (https=)
EP (1) EP3270902A1 (https=)
JP (1) JP2018514507A (https=)
KR (1) KR20170128333A (https=)
CN (1) CN107428645A (https=)
AU (1) AU2016238473B2 (https=)
BR (1) BR112017019750A2 (https=)
CA (1) CA2979997A1 (https=)
EA (1) EA032261B1 (https=)
GE (2) GEP20197040B (https=)
IL (1) IL254502B (https=)
MX (1) MX2017011934A (https=)
PH (1) PH12017501692A1 (https=)
WO (1) WO2016151447A1 (https=)
ZA (1) ZA201706282B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019237054A1 (en) 2018-06-08 2019-12-12 Epizon Pharma, Inc. Methods and compositions for preventing or treating calciphylaxis
MX2020013302A (es) 2018-06-08 2021-05-12 Epizon Pharma Inc Métodos y composiciones para prevenir o tratar calcificación de tejido.
US10822295B2 (en) 2018-09-12 2020-11-03 Epizon Pharma, Inc. Menaquinol compositions and methods of treatment
EP4001421A1 (en) * 2020-11-16 2022-05-25 Endektovet Ltd Method for obtaining oil extract of menaquinone-7 from fermentation broth
CN112778092B (zh) * 2020-12-31 2023-03-24 玉溪健坤生物药业有限公司 一种还原型维生素k2的制备方法及其用途
CN115304464B (zh) * 2022-09-02 2023-03-14 新拓洋生物工程有限公司 一种维生素k2(35)的提取方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003137716A (ja) * 2001-10-30 2003-05-14 Eau De Faveur:Kk 皮膚の外用剤
JP2006083132A (ja) * 2004-09-17 2006-03-30 Kaneka Corp 還元型ビタミンkの製造方法
EP2060256A1 (en) * 2007-11-16 2009-05-20 Gnosis S.p.A. Pharmaceutical and nutraceutical compositions based on menaquinols

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI310029B (https=) * 2001-07-13 2009-05-21 Kaneka Corp
TWI329510B (en) * 2001-10-10 2010-09-01 Kaneka Corp Method of stabilizing reduced coenzyme q10
RU2606767C2 (ru) * 2011-05-20 2017-01-10 Фрисланд Брандз Б.В. Композиция, содержащая витамин k2

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003137716A (ja) * 2001-10-30 2003-05-14 Eau De Faveur:Kk 皮膚の外用剤
JP2006083132A (ja) * 2004-09-17 2006-03-30 Kaneka Corp 還元型ビタミンkの製造方法
EP2060256A1 (en) * 2007-11-16 2009-05-20 Gnosis S.p.A. Pharmaceutical and nutraceutical compositions based on menaquinols

Also Published As

Publication number Publication date
IL254502A0 (en) 2017-11-30
WO2016151447A1 (en) 2016-09-29
CN107428645A (zh) 2017-12-01
MX2017011934A (es) 2018-02-09
EA201791845A1 (ru) 2018-02-28
PH12017501692A1 (en) 2018-03-19
GEAP201914586A (en) 2019-07-25
US20180066326A1 (en) 2018-03-08
JP2018514507A (ja) 2018-06-07
CA2979997A1 (en) 2016-09-29
ZA201706282B (en) 2019-01-30
US10563270B2 (en) 2020-02-18
IL254502B (en) 2020-09-30
AU2016238473A1 (en) 2017-08-24
GEP20197040B (en) 2019-11-11
BR112017019750A2 (en) 2018-05-29
EP3270902A1 (en) 2018-01-24
AU2016238473B2 (en) 2020-03-12
KR20170128333A (ko) 2017-11-22

Similar Documents

Publication Publication Date Title
EA032261B1 (ru) Способы получения твердых форм менахинолов
CA2835788C (en) Amorphous minocycline base and process for its preparation
JP5392854B2 (ja) キサントフモールに富んだホップ抽出物
JPS6013780A (ja) 茶カテキン類の製造方法
JP2020055825A (ja) 多価不飽和ヒドロキシ脂肪酸の薬学的に許容される塩
JP2002253288A (ja) ホスファチドの製造と使用
JP6694029B2 (ja) 3−ホルミルリファマイシンsv及び3−ホルミルリファマイシンsの3−(4−シンナミル−1−ピペラジニル)アミノ誘導体を含有する医薬製剤並びにこれらの製造方法
CN101781345B (zh) 田蓟苷的制备方法
RU2411939C1 (ru) Способ получения 2,3,6,7-тетрагидроксинафтазарина
AU2019214168B2 (en) Crystal form of small molecule immune compound, preparation method therefor and pharmaceutical composition containing same
JP4095153B2 (ja) シアタン誘導体及びこれを有効成分とする神経成長因子産生誘導剤
CN110746419B (zh) 化合物及其制备方法和应用、药物
RU2515936C2 (ru) Высокочистый пентамицин
WO2018074776A1 (ko) 후발효차 유래의 신규한 캄페롤계 화합물
CN114773184A (zh) 一种从迷迭香中制备高纯度鼠尾草酸钠盐的方法
CN103467369B (zh) 尼莫地平杂质ⅰ的制备方法
JP6856223B2 (ja) ヒト毛乳頭細胞増殖用組成物
JP2001299289A (ja) リグナン類含有胡麻処理物の製造方法
EP3502124A1 (en) Crystal of sulfate of polymyxin b1, b2, or mixture thereof, and manufacturing method of same
BG109099A (bg) Метод за получаване на силибинин
BE569202A (https=)

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU